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Gene: ENSG00000095932 |
Summary for SMIM24 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000095932 | Gene symbol | SMIM24 |
| Gene name | small integral membrane protein 24 | |
| HGNC | 37244 | |
| Entrez ID | 284422 | |
| Gene type | protein_coding | |
| Synonyms | SMIM24|HSPC323 | |
| UniProtAcc | O75264 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for SMIM24 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| SMIM24 | 1.00e+02 | 1.15e+00 | 2.00e-01 | 5.75e+00 | 8.72e-09 | 8.58e-07 | LUAD |
| SMIM24 | 7.22e+01 | 2.28e+00 | 5.25e-01 | 4.33e+00 | 1.47e-05 | 9.49e-03 | DLBC |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| SMIM24 | 8.13e+02 | -1.97e+00 | 5.52e-01 | -3.58e+00 | 3.49e-04 | 9.77e-04 | LIHC |
| SMIM24 | 1.69e+04 | 1.24e+00 | 5.23e-01 | 2.37e+00 | 1.79e-02 | 3.36e-02 | KICH |
| SMIM24 | 1.02e+03 | 1.01e+00 | 2.92e-01 | 3.45e+00 | 5.66e-04 | 1.35e-03 | COAD |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| SMIM24 | 1.13e+02 | 3.56e+00 | 3.88e-01 | 9.17e+00 | 4.86e-20 | 7.08e-19 | THCA |
| SMIM24 | 3.83e+01 | 2.37e+00 | 6.21e-01 | 3.81e+00 | 1.38e-04 | 1.80e-03 | BLCA |
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Sex-biased somatic mutation for SMIM24 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for SMIM24 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg18795569 | chr19:3480510 | CGI:chr19:3481784-3482050 | UTR,promoter,exon,gene body | 4.92e-01 | 6.20e-01 | -2.23e+00 | 2.54e-02 | 3.83e-02 | -1.29e-01 |
| SARC | cg05344495 | chr19:3478664 | CGI:chr19:3481784-3482050 | promoter,gene body | 3.67e-01 | 2.32e-01 | 3.23e+00 | 1.25e-03 | 4.16e-03 | 1.35e-01 |
| GBM | cg18795569 | chr19:3480510 | CGI:chr19:3481784-3482050 | UTR,promoter,exon,gene body | 4.21e-01 | 5.48e-01 | -2.51e+00 | 1.19e-02 | 2.72e-02 | -1.27e-01 |
| ACC | cg13389652 | chr19:3481987 | CGI:chr19:3481784-3482050 | promoter | 4.71e-01 | 6.42e-01 | -2.91e+00 | 3.60e-03 | 1.38e-02 | -1.71e-01 |
| ACC | cg14896559 | chr19:3481959 | CGI:chr19:3481784-3482050 | promoter | 3.94e-01 | 5.29e-01 | -2.59e+00 | 9.59e-03 | 2.50e-02 | -1.35e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg05344495 | chr19:3478664 | CGI:chr19:3481784-3482050 | promoter,gene body | 4.50e-01 | 7.42e-01 | -4.23e+00 | 2.32e-05 | 5.66e-05 | -2.92e-01 |
| KIRC | cg17223846 | chr19:3480365 | CGI:chr19:3481784-3482050 | promoter,gene body | 3.22e-01 | 1.70e-01 | 3.49e+00 | 4.76e-04 | 8.06e-04 | 1.52e-01 |
| KIRC | cg22105158 | chr19:3480674 | CGI:chr19:3481784-3482050 | promoter | 2.98e-01 | 1.91e-01 | 5.39e+00 | 6.88e-08 | 3.63e-07 | 1.07e-01 |
| HNSC | cg13389652 | chr19:3481987 | CGI:chr19:3481784-3482050 | promoter | 5.76e-01 | 7.18e-01 | -4.19e+00 | 2.82e-05 | 8.98e-05 | -1.42e-01 |
| LUSC | cg13389652 | chr19:3481987 | CGI:chr19:3481784-3482050 | promoter | 6.47e-01 | 5.12e-01 | 2.66e+00 | 7.78e-03 | 1.14e-02 | 1.35e-01 |
| LUSC | cg05344495 | chr19:3478664 | CGI:chr19:3481784-3482050 | promoter,gene body | 9.83e-02 | 2.77e-01 | -3.79e+00 | 1.50e-04 | 8.37e-04 | -1.78e-01 |
| BLCA | cg05344495 | chr19:3478664 | CGI:chr19:3481784-3482050 | promoter,gene body | 1.31e-01 | 3.14e-01 | -3.61e+00 | 3.09e-04 | 9.17e-04 | -1.83e-01 |
| BLCA | cg06666376 | chr19:3480598 | CGI:chr19:3481784-3482050 | promoter | 5.37e-01 | 6.66e-01 | -2.78e+00 | 5.42e-03 | 8.68e-03 | -1.29e-01 |
| BLCA | cg22105158 | chr19:3480674 | CGI:chr19:3481784-3482050 | promoter | 3.13e-01 | 4.16e-01 | -2.54e+00 | 1.10e-02 | 1.52e-02 | -1.03e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg18795569 | chr19:3480510 | CGI:chr19:3481784-3482050 | UTR,promoter,exon,gene body | 4.92e-01 | 3.26e-01 | 9.77e+00 | 1.45e-22 | 9.80e-22 | 1.66e-01 |
| BRCA | cg13389652 | chr19:3481987 | CGI:chr19:3481784-3482050 | promoter | 8.18e-01 | 6.74e-01 | 9.95e+00 | 2.53e-23 | 1.84e-22 | 1.44e-01 |
| BRCA | cg14896559 | chr19:3481959 | CGI:chr19:3481784-3482050 | promoter | 7.26e-01 | 5.89e-01 | 9.00e+00 | 2.36e-19 | 1.21e-18 | 1.37e-01 |
| BRCA | cg17223846 | chr19:3480365 | CGI:chr19:3481784-3482050 | promoter,gene body | 4.81e-01 | 3.56e-01 | 4.69e+00 | 2.75e-06 | 4.88e-06 | 1.25e-01 |
| BRCA | cg15148078 | chr19:3480563 | CGI:chr19:3481784-3482050 | promoter | 5.41e-01 | 4.00e-01 | 9.93e+00 | 3.16e-23 | 2.27e-22 | 1.41e-01 |
| BRCA | cg06666376 | chr19:3480598 | CGI:chr19:3481784-3482050 | promoter | 7.15e-01 | 5.92e-01 | 9.69e+00 | 3.28e-22 | 2.15e-21 | 1.23e-01 |
| BRCA | cg22105158 | chr19:3480674 | CGI:chr19:3481784-3482050 | promoter | 5.17e-01 | 3.42e-01 | 1.10e+01 | 4.75e-28 | 5.51e-27 | 1.75e-01 |
| LUAD | cg18795569 | chr19:3480510 | CGI:chr19:3481784-3482050 | UTR,promoter,exon,gene body | 4.45e-01 | 3.18e-01 | 3.26e+00 | 1.12e-03 | 3.44e-03 | 1.27e-01 |
| LUAD | cg13389652 | chr19:3481987 | CGI:chr19:3481784-3482050 | promoter | 6.26e-01 | 5.14e-01 | 2.73e+00 | 6.36e-03 | 1.14e-02 | 1.12e-01 |
| LUAD | cg14896559 | chr19:3481959 | CGI:chr19:3481784-3482050 | promoter | 5.52e-01 | 4.42e-01 | 2.94e+00 | 3.31e-03 | 7.21e-03 | 1.10e-01 |
| LUAD | cg15148078 | chr19:3480563 | CGI:chr19:3481784-3482050 | promoter | 4.91e-01 | 3.88e-01 | 2.94e+00 | 3.26e-03 | 7.13e-03 | 1.03e-01 |
| LUAD | cg22105158 | chr19:3480674 | CGI:chr19:3481784-3482050 | promoter | 4.28e-01 | 3.18e-01 | 2.99e+00 | 2.81e-03 | 6.43e-03 | 1.09e-01 |
| THCA | cg05344495 | chr19:3478664 | CGI:chr19:3481784-3482050 | promoter,gene body | 4.60e-01 | 3.41e-01 | 2.92e+00 | 3.56e-03 | 6.24e-03 | 1.19e-01 |
| HNSC | cg05344495 | chr19:3478664 | CGI:chr19:3481784-3482050 | promoter,gene body | 8.53e-02 | 2.41e-01 | -3.44e+00 | 5.85e-04 | 9.05e-03 | -1.55e-01 |
| COAD | cg13389652 | chr19:3481987 | CGI:chr19:3481784-3482050 | promoter | 6.35e-01 | 7.75e-01 | -2.73e+00 | 6.42e-03 | 1.14e-02 | -1.40e-01 |
| COAD | cg03107987 | chr19:3481962 | CGI:chr19:3481784-3482050 | promoter | 5.26e-01 | 6.36e-01 | -3.31e+00 | 9.40e-04 | 2.85e-03 | -1.10e-01 |
| BLCA | cg18795569 | chr19:3480510 | CGI:chr19:3481784-3482050 | UTR,promoter,exon,gene body | 3.19e-01 | 4.22e-01 | -2.47e+00 | 1.34e-02 | 2.10e-02 | -1.03e-01 |
| BLCA | cg14896559 | chr19:3481959 | CGI:chr19:3481784-3482050 | promoter | 4.11e-01 | 5.42e-01 | -2.56e+00 | 1.05e-02 | 1.79e-02 | -1.31e-01 |
| KIRP | cg14896559 | chr19:3481959 | CGI:chr19:3481784-3482050 | promoter | 7.25e-01 | 6.08e-01 | 2.03e+00 | 4.27e-02 | 4.48e-02 | 1.17e-01 |
Top |
Exon skipping events with PSI in TCGA for SMIM24 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for SMIM24 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for SMIM24 |
| TFs related to SMIM24. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| PCPG | DNMT1 | SMIM24 | 2.88e+00 | 3.41e-03 | 3.91e+00 | 9.81e-01 | Female-biased |
| SMIM24 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for SMIM24 |
| RBPs related to ES in SMIM24. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| KIRP | FXR2 | exon_skip_312984 | 9.72e+00 | 9.88e-01 | 9.39e+00 | 1.00e-02 | Male-biased |
| READ | FXR2 | exon_skip_312984 | 1.00e+01 | 9.94e-01 | 9.62e+00 | 4.46e-03 | Male-biased |
| PAAD | FXR2 | exon_skip_312984 | 9.92e+00 | 9.95e-01 | 9.52e+00 | 3.17e-03 | Male-biased |
| KIRC | FXR2 | exon_skip_312984 | 9.68e+00 | 9.56e-03 | 1.00e+01 | 9.89e-01 | Female-biased |
| KICH | FXR2 | exon_skip_312984 | 9.39e+00 | 7.23e-03 | 9.74e+00 | 9.90e-01 | Female-biased |
| SMIM24 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs2485255 | chr19:5726816:G:A | - | -0.0416424846378487 | 0.0445257026683071 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs80116271 | chr19:3160442:G:C | - | 0.0426854847354353 | 0.0440809454005746 | LUAD | Male-baised eQTL |
| rs74404567 | chr19:3161617:A:G | - | 0.0427854825593031 | 0.0443786028731386 | LUAD | Male-baised eQTL |
| rs1637654 | chr19:3161088:G:A | - | 0.042372331803862 | 0.047443573892381 | LUAD | Male-baised eQTL |
| rs17704999 | chr19:6951556:A:G | - | 0.0492972151505776 | 0.0393068516320051 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000095932 |
| CpG Site: cg17223846 | |
| Position to Gene: gene,promoter | |
| Male Effect: - | |
| Female Effect: -0.215013819603546 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg17223846 | chr19:3480365 | gene,promoter | -0.215013819603546 | 2.50931771255087e-05 | -0.33081819581889327 | 2.994529993587686e-07 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of SMIM24 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
