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Gene: ENSG00000095139 |
Summary for ARCN1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000095139 | Gene symbol | ARCN1 |
| Gene name | archain 1 | |
| HGNC | 649 | |
| Entrez ID | 372 | |
| Gene type | protein_coding | |
| Synonyms | ARCN1| | |
| UniProtAcc | P48444 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for ARCN1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for ARCN1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for ARCN1 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Top |
Exon skipping events with PSI in TCGA for ARCN1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for ARCN1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
 |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| STAD | ARCN1-201 | chr11_118586620_+ | 5.80e-01 | 3.83e-01 | 2.30e+00 | 2.13e-02 | 4.96e-02 | 1.97e-01 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for ARCN1 |
| TFs related to ARCN1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BLCA | ZNF180 | ARCN1 | 3.95e+00 | 9.82e-01 | 2.20e+00 | 3.76e-04 | Male-biased |
| BLCA | ZNF418 | ARCN1 | 4.11e+00 | 1.33e-02 | 4.89e+00 | 9.83e-01 | Female-biased |
| BLCA | ZNF441 | ARCN1 | 3.92e+00 | 9.80e-01 | 2.41e+00 | 8.72e-04 | Male-biased |
| BRCA | ZNF418 | ARCN1 | 3.83e+00 | 4.72e-03 | 5.29e+00 | 9.93e-01 | Female-biased |
| PAAD | CDX2 | ARCN1 | 4.53e+00 | 9.82e-01 | 3.72e+00 | 1.13e-02 | Male-biased |
| PAAD | ZNF35 | ARCN1 | 4.83e+00 | 9.86e-01 | 3.99e+00 | 9.70e-03 | Male-biased |
| PAAD | ZNF418 | ARCN1 | 5.52e+00 | 9.95e-01 | 4.50e+00 | 3.98e-03 | Male-biased |
| ARCN1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for ARCN1 |
| RBPs related to ES in ARCN1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| UVM | PTBP1 | exon_skip_65627 | 9.17e+00 | 9.92e-01 | 8.81e+00 | 4.56e-03 | Male-biased |
| UVM | SAMD4A | exon_skip_65634 | 8.45e+00 | 9.81e-01 | 8.17e+00 | 1.21e-02 | Male-biased |
| UVM | TARDBP | exon_skip_65631 | 8.93e+00 | 2.70e-03 | 9.35e+00 | 9.94e-01 | Female-biased |
| THYM | TARDBP | exon_skip_65631 | 9.32e+00 | 9.93e-01 | 8.92e+00 | 4.15e-03 | Male-biased |
| LUAD | STAR-PAP | exon_skip_65636 | 1.25e+01 | 6.06e-03 | 1.29e+01 | 9.94e-01 | Female-biased |
| CHOL | SAMD4A | exon_skip_65634 | 8.53e+00 | 9.87e-01 | 8.07e+00 | 6.15e-03 | Male-biased |
| KIRP | SAMD4A | exon_skip_65634 | 8.42e+00 | 9.81e-01 | 8.10e+00 | 1.16e-02 | Male-biased |
| ESCA | SAMD4A | exon_skip_65634 | 8.88e+00 | 9.90e-01 | 8.36e+00 | 6.03e-03 | Male-biased |
| THCA | KHDRBS1 | exon_skip_65632 | 8.05e+00 | 9.85e-01 | 7.72e+00 | 6.38e-03 | Male-biased |
| THCA | SAMD4A | exon_skip_65634 | 8.57e+00 | 9.91e-01 | 8.18e+00 | 2.78e-03 | Male-biased |
| MESO | SAMD4A | exon_skip_65634 | 8.70e+00 | 9.92e-01 | 8.18e+00 | 2.04e-03 | Male-biased |
| LGG | SAMD4A | exon_skip_65634 | 7.99e+00 | 8.64e-04 | 8.57e+00 | 9.93e-01 | Female-biased |
| GBM | SAMD4A | exon_skip_65634 | 8.79e+00 | 9.94e-01 | 8.22e+00 | 9.64e-04 | Male-biased |
| KIRC | SAMD4A | exon_skip_65634 | 8.29e+00 | 1.09e-02 | 8.60e+00 | 9.83e-01 | Female-biased |
| SKCM | SAMD4A | exon_skip_65634 | 8.11e+00 | 7.75e-04 | 8.77e+00 | 9.94e-01 | Female-biased |
| HNSC | SAMD4A | exon_skip_65634 | 7.96e+00 | 3.06e-04 | 8.64e+00 | 9.94e-01 | Female-biased |
| ARCN1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs56391092 | chr11:120139842:C:T | - | 0.118219796776629 | 0.00847120132680088 | BLCA | Female-baised eQTL |
| rs73004786 | chr11:120188125:G:A | - | 0.11043955415128 | 0.0108048115455938 | BLCA | Female-baised eQTL |
| rs73004764 | chr11:120184618:C:G | - | 0.108665882444813 | 0.0137631162325491 | BLCA | Female-baised eQTL |
| rs60336713 | chr11:120184177:C:T | - | 0.10896357741144 | 0.0154573306072331 | BLCA | Female-baised eQTL |
| rs73004793 | chr11:120190547:T:C | - | 0.104079553457647 | 0.0300936697972188 | BLCA | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs585974 | chr11:125204544:A:G | - | 0.049316328219357 | 0.0404217994671104 | LGG | Male-baised eQTL |
| rs11216607 | chr11:117893926:G:A | - | 0.036734152732441 | 0.038959342106066 | KIRC | Male-baised eQTL |
| rs11216608 | chr11:117894011:A:G | - | 0.0375406007484999 | 0.039870019726042 | KIRC | Male-baised eQTL |
| rs6589632 | chr11:117889110:C:T | - | 0.0368911105868744 | 0.0493938159920167 | KIRC | Male-baised eQTL |
| rs2177196 | chr11:122862164:G:T | - | 0.0692843893120732 | 0.000494821463324054 | BLCA | Male-baised eQTL |
| rs11212984 | chr11:109201682:G:A | - | 0.0647639882257228 | 0.000556436850226463 | BLCA | Male-baised eQTL |
| rs11212985 | chr11:109202865:C:T | - | 0.0647477240540531 | 0.000560285014791764 | BLCA | Male-baised eQTL |
| rs11530739 | chr11:109218808:C:T | - | 0.0643630592450539 | 0.000614111838310098 | BLCA | Male-baised eQTL |
| rs11212983 | chr11:109201083:T:C | - | 0.0638648843572592 | 0.000767862929836696 | BLCA | Male-baised eQTL |
| rs10890965 | chr11:109214664:C:T | - | 0.0633108550825763 | 0.000893175064388686 | BLCA | Male-baised eQTL |
| rs11212989 | chr11:109215095:C:T | - | 0.0633108550825763 | 0.000893175064388686 | BLCA | Male-baised eQTL |
| rs11212980 | chr11:109195301:T:G | - | 0.0591243922015085 | 0.00272121631500107 | BLCA | Male-baised eQTL |
| rs10890960 | chr11:109204337:A:G | - | 0.0583598636857863 | 0.00352409648265317 | BLCA | Male-baised eQTL |
| rs144023950 | chr11:109191089:T:C | - | 0.0561405538396702 | 0.00519252961180526 | BLCA | Male-baised eQTL |
| rs59633468 | chr11:112728107:T:C | - | -0.0527439881617208 | 0.007152447312202 | BLCA | Male-baised eQTL |
| rs1031983 | chr11:109225900:A:G | - | 0.0543605940449041 | 0.00741208437593947 | BLCA | Male-baised eQTL |
| rs12226597 | chr11:109262428:G:A | - | 0.0543280805064705 | 0.00814208498954999 | BLCA | Male-baised eQTL |
| rs34126728 | chr11:109232998:C:A | - | 0.0540071552519398 | 0.00861037895084591 | BLCA | Male-baised eQTL |
| rs10890975 | chr11:109255413:C:T | - | 0.053645681994844 | 0.0100781185988407 | BLCA | Male-baised eQTL |
| rs10890976 | chr11:109255414:A:G | - | 0.053645681994844 | 0.0100781185988407 | BLCA | Male-baised eQTL |
| rs11213009 | chr11:109255448:G:A | - | 0.053645681994844 | 0.0100781185988407 | BLCA | Male-baised eQTL |
| rs7932840 | chr11:109261049:C:T | - | 0.052788148098149 | 0.0110062042364476 | BLCA | Male-baised eQTL |
| rs10890980 | chr11:109262677:G:A | - | 0.052788148098149 | 0.0110062042364476 | BLCA | Male-baised eQTL |
| rs2357580 | chr11:109241564:T:A | - | -0.0516508553003788 | 0.0150759251765597 | BLCA | Male-baised eQTL |
| rs10890968 | chr11:109241762:A:G | - | -0.0516508553003788 | 0.0150759251765597 | BLCA | Male-baised eQTL |
| rs12285207 | chr11:127830410:C:G | - | 0.0802202780009821 | 0.016530824385981 | BLCA | Male-baised eQTL |
| rs485763 | chr11:122374831:C:T | - | -0.046462755020744 | 0.0199629972016808 | BLCA | Male-baised eQTL |
| rs2138833 | chr11:111214879:T:C | - | 0.0678061911912537 | 0.0214688960801042 | BLCA | Male-baised eQTL |
| rs922774 | chr11:109268716:A:G | - | -0.0521227760614408 | 0.0236157635803105 | BLCA | Male-baised eQTL |
| rs76604155 | chr11:111214530:G:A | - | 0.0671359155526526 | 0.0243512876632339 | BLCA | Male-baised eQTL |
| rs654627 | chr11:122379937:G:T | - | -0.045059946223847 | 0.0249944064547542 | BLCA | Male-baised eQTL |
| rs118188470 | chr11:119821316:G:C | - | 0.0830365656825153 | 0.0250604291178273 | BLCA | Male-baised eQTL |
| rs619026 | chr11:122384711:C:T | - | -0.0463592246493955 | 0.0250937357934832 | BLCA | Male-baised eQTL |
| rs76297660 | chr11:111212549:G:C | - | 0.0660311424169646 | 0.0269392041364766 | BLCA | Male-baised eQTL |
| rs12421450 | chr11:111213456:G:T | - | 0.0660311424169646 | 0.0269392041364766 | BLCA | Male-baised eQTL |
| rs12421451 | chr11:111213485:G:A | - | 0.0660311424169646 | 0.0269392041364766 | BLCA | Male-baised eQTL |
| rs553233 | chr11:122369566:T:G | - | -0.0458111629717391 | 0.0274281797750817 | BLCA | Male-baised eQTL |
| rs148253187 | chr11:111217019:C:T | - | 0.0663369856834271 | 0.0310754161054684 | BLCA | Male-baised eQTL |
| rs161133 | chr11:112792873:G:A | - | -0.0431987646489662 | 0.0312270262882717 | BLCA | Male-baised eQTL |
| rs79058754 | chr11:111215326:A:G | - | 0.0651151093234478 | 0.0324164244108791 | BLCA | Male-baised eQTL |
| rs1374698 | chr11:112820526:C:A | - | 0.0434138839810555 | 0.0336725509393734 | BLCA | Male-baised eQTL |
| rs1823202 | chr11:112821116:G:A | - | 0.0434138839810555 | 0.0336725509393734 | BLCA | Male-baised eQTL |
| rs1374697 | chr11:112821314:A:G | - | 0.0434138839810555 | 0.0336725509393734 | BLCA | Male-baised eQTL |
| rs10891449 | chr11:112822012:G:C | - | 0.0434138839810555 | 0.0336725509393734 | BLCA | Male-baised eQTL |
| rs6589262 | chr11:112115767:C:A | - | -0.0852885369981575 | 0.0370329125296572 | BLCA | Male-baised eQTL |
| rs78034287 | chr11:111216605:A:G | - | 0.0643645103577517 | 0.0379271533564296 | BLCA | Male-baised eQTL |
| rs35566832 | chr11:109194706:C:A | - | 0.0461312177785757 | 0.0383712963091917 | BLCA | Male-baised eQTL |
| rs1374699 | chr11:112820460:A:G | - | 0.0426493825685922 | 0.038670189736869 | BLCA | Male-baised eQTL |
| rs10893327 | chr11:125105496:G:A | - | -0.0513413179163059 | 0.0392906305366472 | BLCA | Male-baised eQTL |
| rs7938406 | chr11:112952072:T:C | - | -0.0434558409535101 | 0.0406910097034699 | BLCA | Male-baised eQTL |
| rs12283830 | chr11:127830205:C:T | - | 0.0581654900927164 | 0.0428718395549019 | BLCA | Male-baised eQTL |
| rs534988 | chr11:112815466:G:A | - | -0.0422366458790972 | 0.0447038385987706 | BLCA | Male-baised eQTL |
| rs7933657 | chr11:113680028:C:A | - | 0.0568416075555372 | 0.0477451630825782 | BLCA | Male-baised eQTL |
| rs17532814 | chr11:113679630:C:T | - | 0.0569722703572301 | 0.0478279847591791 | BLCA | Male-baised eQTL |
| rs10892117 | chr11:117454762:T:C | - | -0.0541294724961287 | 0.0493424345367682 | BLCA | Male-baised eQTL |
| rs597820 | chr11:118040652:C:A | - | -0.0612064527027767 | 0.0177745237606773 | LUAD | Male-baised eQTL |
| rs650104 | chr11:118042005:T:C | - | -0.0577051476052008 | 0.0313064630485641 | LUAD | Male-baised eQTL |
| rs689054 | chr11:118042016:T:A | - | -0.0577051476052008 | 0.0313064630485641 | LUAD | Male-baised eQTL |
| rs649827 | chr11:118036044:T:C | - | -0.0576597143006077 | 0.0316236370268317 | LUAD | Male-baised eQTL |
| rs650908 | chr11:118036326:C:G | - | -0.0577013212107782 | 0.034462585842667 | LUAD | Male-baised eQTL |
| rs2518351 | chr11:112229892:C:T | - | -0.0594475876441033 | 0.0388275536687036 | COAD | Male-baised eQTL |
| rs4935828 | chr11:123156007:A:G | - | 0.0621038089682404 | 0.0393527805099552 | COAD | Male-baised eQTL |
| rs2564888 | chr11:112261190:A:G | - | -0.0586609756864911 | 0.0431146011185846 | COAD | Male-baised eQTL |
| rs2163154 | chr11:112235402:C:G | - | -0.058682522268935 | 0.0439087239986349 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of ARCN1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000095139 | ARCN1 | C0004134 | Ataxia | 1 | CTD_human |
| ENSG00000095139 | ARCN1 | C0240991 | Ataxia, Sensory | 1 | CTD_human |
| ENSG00000095139 | ARCN1 | C0278161 | Ataxia, Motor | 1 | CTD_human |
| ENSG00000095139 | ARCN1 | C0427190 | Ataxia, Truncal | 1 | CTD_human |
| ENSG00000095139 | ARCN1 | C0520966 | Abnormal coordination | 1 | CTD_human |
| ENSG00000095139 | ARCN1 | C0750937 | Ataxia, Appendicular | 1 | CTD_human |
| ENSG00000095139 | ARCN1 | C0750940 | Tremor, Rubral | 1 | CTD_human |
