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Gene: ENSG00000095002 |
Summary for MSH2 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000095002 | Gene symbol | MSH2 |
| Gene name | mutS homolog 2 | |
| HGNC | 7325 | |
| Entrez ID | 4436 | |
| Gene type | protein_coding | |
| Synonyms | MSH2|HNPCC|HNPCC1|MSH-2 | |
| UniProtAcc | P43246 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for MSH2 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| MSH2 | 1.96e+03 | 1.10e+00 | 1.46e-01 | 7.54e+00 | 4.88e-14 | 4.58e-13 | LUAD |
| MSH2 | 7.91e+02 | 1.27e+00 | 2.11e-01 | 6.01e+00 | 1.90e-09 | 2.50e-08 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for MSH2 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for MSH2 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| CHOL | cg02458113 | chr2:47403981 | CGI:chr2:47402928-47403652 | promoter,gene body | 5.74e-02 | 2.24e-01 | -3.54e+00 | 4.02e-04 | 8.32e-03 | -1.67e-01 |
| CHOL | cg09740554 | chr2:47404006 | CGI:chr2:47402928-47403652 | promoter,gene body | 8.08e-02 | 2.58e-01 | -3.32e+00 | 9.08e-04 | 1.01e-02 | -1.77e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Top |
Exon skipping events with PSI in TCGA for MSH2 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for MSH2 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for MSH2 |
| TFs related to MSH2. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ACC | ALX3 | MSH2 | 4.49e+00 | 9.81e-01 | 3.75e+00 | 1.34e-02 | Male-biased |
| ACC | ALX4 | MSH2 | 4.60e+00 | 9.82e-01 | 3.86e+00 | 1.32e-02 | Male-biased |
| ACC | DRGX | MSH2 | 4.29e+00 | 9.83e-01 | 3.50e+00 | 1.03e-02 | Male-biased |
| ACC | POU6F2 | MSH2 | 4.23e+00 | 9.83e-01 | 3.41e+00 | 9.13e-03 | Male-biased |
| ACC | ZNF418 | MSH2 | 3.91e+00 | 9.86e-01 | 2.17e+00 | 1.71e-04 | Male-biased |
| ACC | ZNF580 | MSH2 | 4.07e+00 | 9.84e-01 | 3.14e+00 | 5.56e-03 | Male-biased |
| ACC | ZNF792 | MSH2 | 2.28e+00 | 6.21e-04 | 3.76e+00 | 9.82e-01 | Female-biased |
| BLCA | BARX2 | MSH2 | 4.40e+00 | 9.82e-01 | 3.60e+00 | 9.84e-03 | Male-biased |
| BLCA | ZNF418 | MSH2 | 4.51e+00 | 9.92e-01 | 3.13e+00 | 1.39e-03 | Male-biased |
| BLCA | ZNF570 | MSH2 | 4.08e+00 | 9.81e-01 | 3.10e+00 | 5.19e-03 | Male-biased |
| BLCA | ZNF580 | MSH2 | 4.33e+00 | 9.84e-01 | 3.44e+00 | 7.10e-03 | Male-biased |
| BLCA | ZNF879 | MSH2 | 4.26e+00 | 9.84e-01 | 3.30e+00 | 5.49e-03 | Male-biased |
| ESCA | ZNF181 | MSH2 | 4.00e+00 | 9.81e-01 | 3.20e+00 | 6.19e-03 | Male-biased |
| ESCA | ZNF22 | MSH2 | 4.15e+00 | 9.88e-01 | 3.20e+00 | 2.63e-03 | Male-biased |
| ESCA | ZNF235 | MSH2 | 4.12e+00 | 9.88e-01 | 3.09e+00 | 1.68e-03 | Male-biased |
| ESCA | ZNF287 | MSH2 | 4.11e+00 | 9.87e-01 | 3.16e+00 | 2.71e-03 | Male-biased |
| ESCA | ZNF33A | MSH2 | 4.09e+00 | 9.83e-01 | 3.30e+00 | 6.42e-03 | Male-biased |
| ESCA | ZNF443 | MSH2 | 4.09e+00 | 9.85e-01 | 3.22e+00 | 4.23e-03 | Male-biased |
| ESCA | ZNF571 | MSH2 | 4.44e+00 | 9.85e-01 | 3.69e+00 | 8.64e-03 | Male-biased |
| LAML | BARX2 | MSH2 | 5.23e+00 | 9.82e-01 | 4.43e+00 | 1.53e-02 | Male-biased |
| LAML | ZNF418 | MSH2 | 5.40e+00 | 9.84e-01 | 4.56e+00 | 1.36e-02 | Male-biased |
| LAML | ZNF580 | MSH2 | 5.28e+00 | 9.85e-01 | 4.43e+00 | 1.28e-02 | Male-biased |
| MESO | ZNF22 | MSH2 | 4.18e+00 | 9.80e-01 | 2.95e+00 | 8.80e-03 | Male-biased |
| MESO | ZNF418 | MSH2 | 4.45e+00 | 9.88e-01 | 3.01e+00 | 4.57e-03 | Male-biased |
| MESO | ZNF879 | MSH2 | 4.41e+00 | 9.89e-01 | 2.87e+00 | 3.18e-03 | Male-biased |
| PAAD | ALX3 | MSH2 | 5.14e+00 | 9.89e-01 | 4.26e+00 | 8.25e-03 | Male-biased |
| PAAD | ALX4 | MSH2 | 5.24e+00 | 9.88e-01 | 4.40e+00 | 9.63e-03 | Male-biased |
| PAAD | BARX2 | MSH2 | 4.89e+00 | 9.94e-01 | 3.79e+00 | 2.58e-03 | Male-biased |
| PAAD | CDC5L | MSH2 | 5.34e+00 | 9.93e-01 | 4.38e+00 | 5.50e-03 | Male-biased |
| PAAD | DMRT3 | MSH2 | 4.91e+00 | 9.91e-01 | 3.97e+00 | 5.84e-03 | Male-biased |
| PAAD | DRGX | MSH2 | 4.91e+00 | 9.89e-01 | 4.01e+00 | 7.06e-03 | Male-biased |
| PAAD | ELK4 | MSH2 | 2.56e+00 | 2.57e-04 | 4.06e+00 | 9.88e-01 | Female-biased |
| PAAD | FEV | MSH2 | 3.12e+00 | 3.68e-03 | 4.11e+00 | 9.85e-01 | Female-biased |
| PAAD | FOXC1 | MSH2 | 4.51e+00 | 9.90e-01 | 3.44e+00 | 2.98e-03 | Male-biased |
| PAAD | FOXJ2 | MSH2 | 4.17e+00 | 9.81e-01 | 3.29e+00 | 7.79e-03 | Male-biased |
| PAAD | FOXP2 | MSH2 | 4.25e+00 | 9.82e-01 | 3.36e+00 | 7.36e-03 | Male-biased |
| PAAD | MECOM | MSH2 | 4.31e+00 | 9.84e-01 | 3.39e+00 | 6.59e-03 | Male-biased |
| PAAD | NKX6-1 | MSH2 | 4.47e+00 | 9.91e-01 | 3.30e+00 | 1.75e-03 | Male-biased |
| PAAD | POU6F2 | MSH2 | 5.02e+00 | 9.93e-01 | 3.99e+00 | 3.70e-03 | Male-biased |
| PAAD | ZNF181 | MSH2 | 2.50e+00 | 3.53e-04 | 3.93e+00 | 9.85e-01 | Female-biased |
| PAAD | ZNF33A | MSH2 | 2.44e+00 | 1.48e-04 | 4.04e+00 | 9.87e-01 | Female-biased |
| PAAD | ZNF418 | MSH2 | 4.90e+00 | 9.91e-01 | 3.93e+00 | 4.95e-03 | Male-biased |
| PAAD | ZNF443 | MSH2 | 2.74e+00 | 4.38e-04 | 4.14e+00 | 9.89e-01 | Female-biased |
| PAAD | ZNF571 | MSH2 | 2.38e+00 | 1.72e-04 | 3.95e+00 | 9.85e-01 | Female-biased |
| PAAD | ZNF580 | MSH2 | 4.84e+00 | 9.94e-01 | 3.69e+00 | 1.95e-03 | Male-biased |
| PAAD | ZNF595 | MSH2 | 4.62e+00 | 9.84e-01 | 3.79e+00 | 1.06e-02 | Male-biased |
| PAAD | ZNF770 | MSH2 | 2.26e+00 | 1.27e-04 | 3.88e+00 | 9.84e-01 | Female-biased |
| READ | ALX3 | MSH2 | 3.83e+00 | 8.04e-03 | 4.71e+00 | 9.87e-01 | Female-biased |
| READ | ALX4 | MSH2 | 3.98e+00 | 9.06e-03 | 4.84e+00 | 9.87e-01 | Female-biased |
| READ | BARX2 | MSH2 | 3.18e+00 | 2.32e-03 | 4.40e+00 | 9.89e-01 | Female-biased |
| READ | CDC5L | MSH2 | 3.95e+00 | 6.94e-03 | 4.87e+00 | 9.89e-01 | Female-biased |
| READ | DMRT3 | MSH2 | 3.42e+00 | 3.07e-03 | 4.56e+00 | 9.90e-01 | Female-biased |
| READ | DRGX | MSH2 | 3.48e+00 | 5.10e-03 | 4.48e+00 | 9.87e-01 | Female-biased |
| READ | HSF5 | MSH2 | 4.20e+00 | 1.06e-02 | 5.02e+00 | 9.86e-01 | Female-biased |
| READ | POU6F2 | MSH2 | 3.38e+00 | 2.64e-03 | 4.55e+00 | 9.91e-01 | Female-biased |
| READ | ZNF418 | MSH2 | 1.61e+00 | 2.76e-05 | 4.16e+00 | 9.87e-01 | Female-biased |
| READ | ZNF580 | MSH2 | 3.06e+00 | 2.10e-03 | 4.30e+00 | 9.88e-01 | Female-biased |
| MSH2 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for MSH2 |
| RBPs related to ES in MSH2. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| READ | RBM6 | exon_skip_325450 | 7.56e+00 | 1.06e-02 | 7.89e+00 | 9.81e-01 | Female-biased |
| MSH2 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000095002 | LINC00638,hsa-mir-340,MSH2 | Male-specific ceRNA | TCGA-LUAD |
| ENSG00000095002 | AL133372.2,hsa-mir-340,MSH2 | Male-specific ceRNA | TCGA-LUAD |
| ENSG00000095002 | AP005136.3,hsa-mir-340,MSH2 | Male-specific ceRNA | TCGA-LUAD |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs4952736 | chr2:45048219:T:C | - | 0.15541305191568 | 0.017860757404163 | BLCA | Female-baised eQTL |
| rs4952732 | chr2:45033354:A:C | - | 0.136163449643986 | 0.0358781562678043 | BLCA | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs797702 | chr2:47720913:C:T | - | -0.0890054989378638 | 0.00243190197848352 | LIHC | Male-baised eQTL |
| rs797701 | chr2:47720923:T:C | - | -0.0890054989378638 | 0.00243190197848352 | LIHC | Male-baised eQTL |
| rs797698 | chr2:47721143:T:C | - | -0.0890054989378638 | 0.00243190197848352 | LIHC | Male-baised eQTL |
| rs797696 | chr2:47721250:A:G | - | -0.0890054989378638 | 0.00243190197848352 | LIHC | Male-baised eQTL |
| rs797695 | chr2:47721559:A:G | - | -0.0889617478191099 | 0.00259940010477226 | LIHC | Male-baised eQTL |
| rs797700 | chr2:47720962:C:T | - | -0.0888449218680162 | 0.00264333160256932 | LIHC | Male-baised eQTL |
| rs797697 | chr2:47721197:G:A | - | -0.0884184157266066 | 0.00311426293902135 | LIHC | Male-baised eQTL |
| rs810016 | chr2:47726049:A:C | - | -0.0861211655579167 | 0.00455078236696042 | LIHC | Male-baised eQTL |
| rs330796 | chr2:47726311:A:T | - | -0.0861211655579167 | 0.00455078236696042 | LIHC | Male-baised eQTL |
| rs330795 | chr2:47727114:G:C | - | -0.0861211655579167 | 0.00455078236696042 | LIHC | Male-baised eQTL |
| rs797685 | chr2:47725638:C:T | - | -0.0846557588259107 | 0.00521062743872776 | LIHC | Male-baised eQTL |
| rs797683 | chr2:47725993:A:C | - | -0.0852188263196949 | 0.00528092991784851 | LIHC | Male-baised eQTL |
| rs797691 | chr2:47724686:T:A | - | -0.0839962604316033 | 0.00660698324819512 | LIHC | Male-baised eQTL |
| rs797690 | chr2:47724754:T:A | - | -0.0839962604316033 | 0.00660698324819512 | LIHC | Male-baised eQTL |
| rs797684 | chr2:47725735:A:G | - | -0.0836786482265589 | 0.00771483287643958 | LIHC | Male-baised eQTL |
| rs330794 | chr2:47728230:A:G | - | -0.0827764515870637 | 0.00878427824579006 | LIHC | Male-baised eQTL |
| rs6545003 | chr2:47727670:C:T | - | 0.0826419038770675 | 0.00900915550440098 | LIHC | Male-baised eQTL |
| rs797689 | chr2:47725092:T:C | - | -0.0825392495082526 | 0.0091857595520356 | LIHC | Male-baised eQTL |
| rs797687 | chr2:47725441:A:C | - | -0.0825392495082526 | 0.0091857595520356 | LIHC | Male-baised eQTL |
| rs797686 | chr2:47725521:C:T | - | -0.0825392495082526 | 0.0091857595520356 | LIHC | Male-baised eQTL |
| rs56709148 | chr2:49744414:C:G | - | 0.109165321370842 | 0.0109388537672062 | LIHC | Male-baised eQTL |
| rs797688 | chr2:47725259:C:A | - | -0.0808431628565129 | 0.0116726591301698 | LIHC | Male-baised eQTL |
| rs72880477 | chr2:49743829:T:C | - | 0.10675459014335 | 0.0159366629767662 | LIHC | Male-baised eQTL |
| rs797694 | chr2:47721714:G:A | - | -0.077861426875971 | 0.0212107263913506 | LIHC | Male-baised eQTL |
| rs6710424 | chr2:49743583:T:C | - | 0.100957287555402 | 0.0284087182266198 | LIHC | Male-baised eQTL |
| rs12328055 | chr2:49744101:G:A | - | 0.100957287555402 | 0.0284087182266198 | LIHC | Male-baised eQTL |
| rs10206788 | chr2:37829260:A:G | - | -0.074381367268917 | 0.0295747993112684 | LIHC | Male-baised eQTL |
| rs13407874 | chr2:57345318:T:C | - | 0.0629117855182146 | 0.0374922109373454 | LGG | Male-baised eQTL |
| rs10183955 | chr2:53293592:C:A | - | 0.0876141653361214 | 0.045339018824269 | LGG | Male-baised eQTL |
| rs10196870 | chr2:53293887:T:C | - | 0.0876141653361214 | 0.045339018824269 | LGG | Male-baised eQTL |
| rs6743780 | chr2:57368273:A:G | - | 0.0613391623278084 | 0.0492716506480822 | LGG | Male-baised eQTL |
| rs35909669 | chr2:46640655:T:G | - | 0.0503850414221859 | 0.0169831947406254 | KIRC | Male-baised eQTL |
| rs10166797 | chr2:54640284:G:T | - | -0.0826025770074093 | 0.0269240406938779 | KIRC | Male-baised eQTL |
| rs11900179 | chr2:50236078:A:G | - | -0.115884894671027 | 0.00275107158969658 | COAD | Male-baised eQTL |
| rs56331967 | chr2:50235275:G:C | - | -0.115832529068878 | 0.0028138761554574 | COAD | Male-baised eQTL |
| rs1915218 | chr2:50230298:A:T | - | -0.108054909090602 | 0.00306065976429414 | COAD | Male-baised eQTL |
| rs62133087 | chr2:50245031:T:C | - | -0.112537874830115 | 0.00404163128808942 | COAD | Male-baised eQTL |
| rs11895273 | chr2:50236121:T:C | - | -0.113721778340426 | 0.0041383519431038 | COAD | Male-baised eQTL |
| rs11903624 | chr2:50222736:T:C | - | -0.106646046134599 | 0.00417163379627077 | COAD | Male-baised eQTL |
| rs11887362 | chr2:50222743:A:T | - | -0.106646046134599 | 0.00417163379627077 | COAD | Male-baised eQTL |
| rs11889906 | chr2:50236562:G:A | - | -0.113652443597404 | 0.00420686100642304 | COAD | Male-baised eQTL |
| rs28582966 | chr2:50236329:A:T | - | -0.115507835183554 | 0.0044762020819516 | COAD | Male-baised eQTL |
| rs60062665 | chr2:50222953:G:A | - | -0.116015344547011 | 0.00476213288761938 | COAD | Male-baised eQTL |
| rs11681950 | chr2:50230870:A:G | - | -0.102195675102963 | 0.00526524901016547 | COAD | Male-baised eQTL |
| rs10490232 | chr2:50231939:C:G | - | -0.101566025782504 | 0.00539879216179782 | COAD | Male-baised eQTL |
| rs72820815 | chr2:50254989:G:C | - | -0.114862775606266 | 0.00567171281228368 | COAD | Male-baised eQTL |
| rs11681755 | chr2:50230505:A:G | - | -0.114434400389849 | 0.00573265557140404 | COAD | Male-baised eQTL |
| rs10169521 | chr2:50221678:A:T | - | -0.104199907927156 | 0.00589659339353795 | COAD | Male-baised eQTL |
| rs13417293 | chr2:50240137:A:T | - | -0.114470368195407 | 0.00592314768013827 | COAD | Male-baised eQTL |
| rs62133088 | chr2:50245216:T:C | - | -0.114470368195407 | 0.00592314768013827 | COAD | Male-baised eQTL |
| rs7576851 | chr2:50247799:T:C | - | -0.114470368195407 | 0.00592314768013827 | COAD | Male-baised eQTL |
| rs10167892 | chr2:50224075:T:C | - | -0.114192366855833 | 0.00672601570700303 | COAD | Male-baised eQTL |
| rs11681846 | chr2:50230707:A:G | - | -0.10009633580516 | 0.00759503911500938 | COAD | Male-baised eQTL |
| rs5543 | chr2:40114465:G:A | - | 0.0720829424202442 | 0.0083060854424518 | COAD | Male-baised eQTL |
| rs7578664 | chr2:50246558:C:T | - | -0.111549022334165 | 0.00931177094546656 | COAD | Male-baised eQTL |
| rs7577177 | chr2:50251058:G:A | - | -0.111549022334165 | 0.00931177094546656 | COAD | Male-baised eQTL |
| rs11897871 | chr2:50251997:G:T | - | -0.111549022334165 | 0.00931177094546656 | COAD | Male-baised eQTL |
| rs10203382 | chr2:50224697:G:A | - | -0.100087874989734 | 0.0102324310039633 | COAD | Male-baised eQTL |
| rs10177338 | chr2:40128799:G:T | - | 0.0726323108970394 | 0.0120932578012418 | COAD | Male-baised eQTL |
| rs67997642 | chr2:40118082:G:A | - | 0.0711563715419923 | 0.0121986369643275 | COAD | Male-baised eQTL |
| rs1520528 | chr2:50223647:G:T | - | -0.09951976100254 | 0.0126482195402789 | COAD | Male-baised eQTL |
| rs17509125 | chr2:50224616:C:T | - | -0.09951976100254 | 0.0126482195402789 | COAD | Male-baised eQTL |
| rs11675607 | chr2:50138589:G:A | - | -0.10438735774267 | 0.0144797852538398 | COAD | Male-baised eQTL |
| rs10207450 | chr2:50155456:G:A | - | -0.102978459633725 | 0.0146026174315018 | COAD | Male-baised eQTL |
| rs13433080 | chr2:40119363:G:A | - | 0.070531183452697 | 0.0148263819446132 | COAD | Male-baised eQTL |
| rs10210059 | chr2:50156000:C:T | - | -0.104707853671782 | 0.0152234652066801 | COAD | Male-baised eQTL |
| rs13415902 | chr2:50262791:C:T | - | -0.0962384071118202 | 0.0166920765775513 | COAD | Male-baised eQTL |
| rs7579558 | chr2:50267623:G:A | - | -0.0959788942214909 | 0.0169880805416333 | COAD | Male-baised eQTL |
| rs62133116 | chr2:50256810:T:A | - | -0.104734264459796 | 0.0181434870228367 | COAD | Male-baised eQTL |
| rs10181939 | chr2:50103586:T:G | - | -0.0644309371481473 | 0.0218736024522317 | COAD | Male-baised eQTL |
| rs13405865 | chr2:40122022:T:G | - | 0.0676576957412393 | 0.0229887827645459 | COAD | Male-baised eQTL |
| rs11886553 | chr2:50129934:T:G | - | -0.0919020472445317 | 0.023939061383389 | COAD | Male-baised eQTL |
| rs10183046 | chr2:40130109:C:G | - | 0.0688961758866921 | 0.0260308036964015 | COAD | Male-baised eQTL |
| rs1067338 | chr2:44397569:G:A | - | -0.0634992737521737 | 0.0289205887869647 | COAD | Male-baised eQTL |
| rs7607484 | chr2:50104123:G:A | - | -0.0616405640404447 | 0.0363310615067264 | COAD | Male-baised eQTL |
| rs1067326 | chr2:44401466:T:A | - | -0.0610219203934989 | 0.0379811180257587 | COAD | Male-baised eQTL |
| rs1067320 | chr2:44405983:A:G | - | -0.0610219203934989 | 0.0379811180257587 | COAD | Male-baised eQTL |
| rs1068714 | chr2:44406924:T:C | - | -0.0610219203934989 | 0.0379811180257587 | COAD | Male-baised eQTL |
| rs1067318 | chr2:44407370:A:C | - | -0.0610219203934989 | 0.0379811180257587 | COAD | Male-baised eQTL |
| rs6726118 | chr2:41607201:G:C | - | 0.11916939450747 | 0.040341956780619 | COAD | Male-baised eQTL |
| rs17025097 | chr2:40104023:A:G | - | 0.0680703616122419 | 0.0405679625658838 | COAD | Male-baised eQTL |
| rs2603252 | chr2:44398028:C:T | - | -0.0605218081866381 | 0.0409951125296845 | COAD | Male-baised eQTL |
| rs1067333 | chr2:44399571:C:A | - | -0.0605218081866381 | 0.0409951125296845 | COAD | Male-baised eQTL |
| rs1067332 | chr2:44399833:G:A | - | -0.0605218081866381 | 0.0409951125296845 | COAD | Male-baised eQTL |
| rs1067331 | chr2:44400487:T:C | - | -0.0605218081866381 | 0.0409951125296845 | COAD | Male-baised eQTL |
| rs1067330 | chr2:44400683:A:G | - | -0.0605218081866381 | 0.0409951125296845 | COAD | Male-baised eQTL |
| rs6718257 | chr2:50113644:G:T | - | -0.0572111252764281 | 0.0423243061724969 | COAD | Male-baised eQTL |
| rs13002734 | chr2:53602972:C:G | - | 0.117818455093475 | 0.0425855098210307 | COAD | Male-baised eQTL |
| rs6737523 | chr2:50269693:C:T | - | -0.0959740790132188 | 0.0433089563825427 | COAD | Male-baised eQTL |
| rs4952358 | chr2:41372175:A:T | - | 0.0625638300415459 | 0.0457564690875926 | COAD | Male-baised eQTL |
| rs17043912 | chr2:52985665:G:A | - | 0.0700757255505639 | 0.0459078695107036 | COAD | Male-baised eQTL |
| rs6747360 | chr2:52851949:C:T | - | -0.0583876712659955 | 0.0464554077087825 | COAD | Male-baised eQTL |
| rs2110921 | chr2:40136576:C:T | - | 0.0636745836912008 | 0.0492447582008105 | COAD | Male-baised eQTL |
| rs4140823 | chr2:40135816:G:A | - | 0.0637004028426859 | 0.0495186317695694 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000095002 |
| CpG Site: cg00042186 | |
| Position to Gene: gene | |
| Male Effect: -0.0605603813524213 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg00042186 | chr2:47521700 | gene | -0.0605603813524213 | 3.25278704665595e-05 | -0.330432102274988 | 4.436238770899507e-07 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of MSH2 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000095002 | MSH2 | C0009402 | Colorectal Carcinoma | 1 | CTD_human |
| ENSG00000095002 | MSH2 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| ENSG00000095002 | MSH2 | C0009405 | Hereditary Nonpolyposis Colorectal Neoplasms | 4 | CTD_human |
| ENSG00000095002 | MSH2 | C0265325 | Turcot syndrome (disorder) | 1 | CTD_human |
| ENSG00000095002 | MSH2 | C0919267 | ovarian neoplasm | 1 | CTD_human |
| ENSG00000095002 | MSH2 | C1140680 | Malignant neoplasm of ovary | 1 | CTD_human |
| ENSG00000095002 | MSH2 | C1321489 | Torre-Muir syndrome | 1 | CTD_human |
| ENSG00000095002 | MSH2 | C1333990 | Hereditary Nonpolyposis Colorectal Cancer | 4 | CTD_human |
| ENSG00000095002 | MSH2 | C2931459 | Lynch syndrome I (site-specific colonic cancer) | 1 | CTD_human |
| ENSG00000095002 | MSH2 | C4552100 | Lynch Syndrome | 4 | CTD_human |
