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Gene: ENSG00000092931 |
Summary for MFSD11 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000092931 | Gene symbol | MFSD11 |
| Gene name | major facilitator superfamily domain containing 11 | |
| HGNC | 25458 | |
| Entrez ID | 79157 | |
| Gene type | protein_coding | |
| Synonyms | MFSD11|FLJ22196|FLJ20226 | |
| UniProtAcc | O43934 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for MFSD11 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for MFSD11 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for MFSD11 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg25583580 | chr17:76735351 | CGI:chr17:76736385-76738140 | promoter | 1.42e-01 | 3.31e-01 | -3.70e+00 | 2.14e-04 | 1.01e-03 | -1.89e-01 |
| LIHC | cg25583580 | chr17:76735351 | CGI:chr17:76736385-76738140 | promoter | 2.27e-01 | 4.02e-01 | -2.57e+00 | 1.03e-02 | 1.25e-02 | -1.76e-01 |
| KIRP | cg25583580 | chr17:76735351 | CGI:chr17:76736385-76738140 | promoter | 5.64e-01 | 4.09e-01 | 2.55e+00 | 1.09e-02 | 1.38e-02 | 1.55e-01 |
| CHOL | cg25583580 | chr17:76735351 | CGI:chr17:76736385-76738140 | promoter | 1.69e-01 | 3.16e-01 | -3.02e+00 | 2.51e-03 | 1.19e-02 | -1.47e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg25583580 | chr17:76735351 | CGI:chr17:76736385-76738140 | promoter | 2.36e-01 | 3.79e-01 | -9.24e+00 | 2.58e-20 | 1.43e-19 | -1.43e-01 |
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Exon skipping events with PSI in TCGA for MFSD11 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for MFSD11 |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
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| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| KIRC | MFSD11-202 | chr17_76779160_+ | 1.81e-01 | 1.40e-01 | 2.92e+00 | 3.51e-03 | 4.08e-02 | 4.15e-02 |
| LUAD | MFSD11-202 | chr17_76779133_+ | 1.52e-01 | 1.79e-01 | -2.18e+00 | 2.96e-02 | 4.27e-02 | -2.68e-02 |
| LGG | MFSD11-202 | chr17_76778873_+ | 3.07e-01 | 2.90e-01 | 1.97e+00 | 4.87e-02 | 4.97e-02 | 1.79e-02 |
| LGG | MFSD11-202 | chr17_76778878_+ | 2.44e-01 | 2.07e-01 | 3.57e+00 | 3.54e-04 | 2.61e-02 | 3.75e-02 |
| THCA | MFSD11-202 | chr17_76778940_+ | 1.55e-01 | 1.23e-01 | 3.02e+00 | 2.49e-03 | 4.77e-02 | 3.22e-02 |
| SARC | MFSD11-202 | chr17_76779132_+ | 2.14e-01 | 1.75e-01 | 2.41e+00 | 1.60e-02 | 4.85e-02 | 3.85e-02 |
| PCPG | MFSD11-202 | chr17_76779175_+ | 1.47e-01 | 1.03e-01 | 2.08e+00 | 3.74e-02 | 4.98e-02 | 4.44e-02 |
| ESCA | MFSD11-202 | chr17_76779133_+ | 1.37e-01 | 1.87e-01 | -2.70e+00 | 7.03e-03 | 4.99e-02 | -5.05e-02 |
| LAML | MFSD11-202 | chr17_76778873_+ | 2.65e-01 | 3.73e-01 | -2.75e+00 | 5.97e-03 | 4.94e-02 | -1.08e-01 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| HNSC | MFSD11-202 | chr17_76778873_+ | 2.17e-01 | 1.67e-01 | 2.25e+00 | 2.47e-02 | 2.89e-02 | 4.99e-02 |
| STAD | MFSD11-202 | chr17_76779160_+ | 1.62e-01 | 2.19e-01 | -2.22e+00 | 2.66e-02 | 3.72e-02 | -5.70e-02 |
| KICH | MFSD11-202 | chr17_76778873_+ | 2.72e-01 | 2.14e-01 | 2.15e+00 | 3.12e-02 | 3.72e-02 | 5.86e-02 |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| BRCA | MFSD11-202 | chr17_76778981_+ | 1.50e-01 | 2.02e-01 | -2.44e+00 | 1.47e-02 | 1.92e-02 | -5.15e-02 |
| LUAD | MFSD11-202 | chr17_76779132_+ | 1.82e-01 | 1.30e-01 | 2.47e+00 | 1.34e-02 | 2.22e-02 | 5.21e-02 |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for MFSD11 |
| TFs related to MFSD11. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| THYM | CDC5L | MFSD11 | 4.46e+00 | 9.81e-01 | 3.81e+00 | 1.09e-02 | Male-biased |
| THYM | FOXP3 | MFSD11 | 4.11e+00 | 9.82e-01 | 3.24e+00 | 4.25e-03 | Male-biased |
| MFSD11 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for MFSD11 |
| RBPs related to ES in MFSD11. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| STAD | PABPC5 | exon_skip_156568 | 7.17e+00 | 9.81e-01 | 6.79e+00 | 7.23e-03 | Male-biased |
| THYM | RBM46 | exon_skip_156568 | 1.02e+01 | 9.91e-01 | 9.90e+00 | 7.44e-03 | Male-biased |
| COAD | RBM46 | exon_skip_156568 | 1.01e+01 | 9.93e-01 | 9.69e+00 | 5.55e-03 | Male-biased |
| DLBC | KHDRBS2 | exon_skip_156581 | 8.77e+00 | 9.84e-01 | 8.43e+00 | 1.08e-02 | Male-biased |
| KIRP | RBM46 | exon_skip_156568 | 9.91e+00 | 3.01e-03 | 1.03e+01 | 9.96e-01 | Female-biased |
| ESCA | RBM46 | exon_skip_156568 | 9.42e+00 | 1.60e-02 | 9.80e+00 | 9.82e-01 | Female-biased |
| READ | PTBP1 | exon_skip_156580 | 6.86e+00 | 5.98e-03 | 7.24e+00 | 9.82e-01 | Female-biased |
| THCA | RBM46 | exon_skip_156568 | 1.01e+01 | 9.81e-01 | 9.81e+00 | 1.68e-02 | Male-biased |
| PCPG | Fusip1 | exon_skip_156580 | 7.02e+00 | 3.22e-03 | 7.44e+00 | 9.86e-01 | Female-biased |
| PCPG | PTBP1 | exon_skip_156580 | 6.94e+00 | 5.03e-03 | 7.32e+00 | 9.83e-01 | Female-biased |
| PCPG | RBM46 | exon_skip_156568 | 1.03e+01 | 9.95e-01 | 9.84e+00 | 3.22e-03 | Male-biased |
| PAAD | RBM46 | exon_skip_156568 | 9.81e+00 | 3.66e-03 | 1.02e+01 | 9.95e-01 | Female-biased |
| KIRC | RBM46 | exon_skip_156568 | 9.97e+00 | 9.87e-01 | 9.67e+00 | 1.08e-02 | Male-biased |
| KICH | RBM46 | exon_skip_156568 | 9.70e+00 | 7.99e-03 | 1.00e+01 | 9.90e-01 | Female-biased |
| SARC | RBM46 | exon_skip_156568 | 1.03e+01 | 9.95e-01 | 9.79e+00 | 3.86e-03 | Male-biased |
| MFSD11 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs9911222 | chr17:82515201:C:T | - | 0.299683672619699 | 0.00187748717237917 | GBM | Female-baised eQTL |
| rs7221906 | chr17:78959066:T:C | - | -0.0952734742834111 | 0.00437475073460615 | LUAD | Female-baised eQTL |
| rs7226150 | chr17:78959339:T:C | - | -0.0935752622049078 | 0.00438655580668436 | LUAD | Female-baised eQTL |
| rs7225413 | chr17:78959415:G:C | - | -0.0935752622049078 | 0.00438655580668436 | LUAD | Female-baised eQTL |
| rs7224841 | chr17:78959226:C:G | - | -0.0835258247772703 | 0.00826377896035402 | LUAD | Female-baised eQTL |
| rs12453449 | chr17:78956147:G:A | - | 0.0954906854597985 | 0.0110045296300614 | LUAD | Female-baised eQTL |
| rs56229089 | chr17:71131711:G:C | - | -0.0633901702968399 | 0.0125163872274725 | LUAD | Female-baised eQTL |
| rs34171878 | chr17:71131680:A:T | - | -0.062173313976183 | 0.0144811810179076 | LUAD | Female-baised eQTL |
| rs11658901 | chr17:78961929:A:G | - | -0.0776962528260252 | 0.0240064265430592 | LUAD | Female-baised eQTL |
| rs7221646 | chr17:68157976:A:T | - | 0.0560739090461464 | 0.0350008947970086 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs11077690 | chr17:73574046:C:G | - | 0.117783851493579 | 0.0420358664788441 | SARC | Male-baised eQTL |
| rs8066016 | chr17:70692866:C:T | - | -0.0621214371992237 | 0.0363701353098778 | KIRP | Male-baised eQTL |
| rs6501402 | chr17:70693262:C:T | - | -0.0616543799032152 | 0.0442667569163641 | KIRP | Male-baised eQTL |
| rs143917207 | chr17:68262243:C:T | - | 0.0512434121367894 | 0.0278113490196017 | KIRC | Male-baised eQTL |
| rs11653512 | chr17:68262197:C:T | - | 0.0499650333965862 | 0.031616059037627 | KIRC | Male-baised eQTL |
| rs11077449 | chr17:68252291:T:C | - | 0.0498603643207679 | 0.0316697631371924 | KIRC | Male-baised eQTL |
| rs10852720 | chr17:68252526:C:T | - | 0.0498603643207679 | 0.0316697631371924 | KIRC | Male-baised eQTL |
| rs8073745 | chr17:68246526:G:A | - | 0.0482980177356741 | 0.0493100007376231 | KIRC | Male-baised eQTL |
| rs78855075 | chr17:80107508:C:T | - | 0.0983491557703192 | 0.0454544455901737 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
 | EX ID: exon_skip_156572 |
| CpG Site: cg09326547 | |
| Position to EX: Distant upstream | |
| Male Effect: -0.175479175086224 | |
| Female Effect: - | |
 | EX ID: exon_skip_156572 |
| CpG Site: cg05121093 | |
| Position to EX: Distant upstream | |
| Male Effect: -0.175479175086224 | |
| Female Effect: - | |
 | EX ID: exon_skip_156572 |
| CpG Site: cg09509528 | |
| Position to EX: Distant upstream | |
| Male Effect: -0.175479175086224 | |
| Female Effect: - | |
 | EX ID: exon_skip_156572 |
| CpG Site: cg17177017 | |
| Position to EX: Distant upstream | |
| Male Effect: -0.175479175086224 | |
| Female Effect: - |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| exon_skip_156572 | chr17:76743397:76743456 | cg09326547 | chr17:76671917 | Distant upstream | -0.175479175086224 | 5.61662262914818e-05 | -0.49255505726307997 | 5.299781900448163e-07 | Frame-shift | SARC |
| exon_skip_156572 | chr17:76743397:76743456 | cg05121093 | chr17:76672007 | Distant upstream | -0.175479175086224 | 5.61662262914818e-05 | -0.5141754331393874 | 1.3514172663699656e-07 | Frame-shift | SARC |
| exon_skip_156572 | chr17:76743397:76743456 | cg09509528 | chr17:76672113 | Distant upstream | -0.175479175086224 | 5.61662262914818e-05 | -0.4953757395149608 | 4.457894158576818e-07 | Frame-shift | SARC |
| exon_skip_156572 | chr17:76743397:76743456 | cg17177017 | chr17:76672170 | Distant upstream | -0.175479175086224 | 5.61662262914818e-05 | -0.4895249780866384 | 6.371143965992463e-07 | Frame-shift | SARC |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of MFSD11 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
