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Gene: ENSG00000092607 |
Summary for TBX15 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000092607 | Gene symbol | TBX15 |
| Gene name | T-box transcription factor 15 | |
| HGNC | 11594 | |
| Entrez ID | 6913 | |
| Gene type | protein_coding | |
| Synonyms | TBX15| | |
| UniProtAcc | Q96SF7 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for TBX15 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| TBX15 | 4.50e+02 | -2.82e+00 | 3.25e-01 | -8.68e+00 | 3.87e-18 | 6.45e-17 | HNSC |
| TBX15 | 7.67e+02 | -3.89e+00 | 7.09e-01 | -5.49e+00 | 4.06e-08 | 4.02e-07 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| TBX15 | 5.39e+02 | -2.29e+00 | 1.05e-01 | -2.17e+01 | 1.11e-104 | 4.78e-103 | BRCA |
Top |
Sex-biased somatic mutation for TBX15 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for TBX15 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg27262412 | chr1:118988079 | CGI:chr1:118987196-118988089 | promoter,gene body | 4.90e-01 | 6.53e-01 | -2.07e+00 | 3.81e-02 | 4.51e-02 | -1.63e-01 |
| MESO | cg21392341 | chr1:118988054 | CGI:chr1:118987196-118988089 | promoter,gene body | 4.45e-02 | 1.64e-01 | -2.34e+00 | 1.94e-02 | 3.81e-02 | -1.19e-01 |
| MESO | cg24475782 | chr1:118988309 | CGI:chr1:118987196-118988089 | promoter,gene body | 8.39e-02 | 1.89e-01 | -2.32e+00 | 2.06e-02 | 3.90e-02 | -1.05e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg10703826 | chr1:118989493 | CGI:chr1:118989368-118989573 | UTR,promoter,exon,gene body | 2.47e-01 | 8.39e-02 | 3.70e+00 | 2.18e-04 | 4.06e-04 | 1.63e-01 |
| KIRC | cg05940231 | chr1:118989566 | CGI:chr1:118989368-118989573 | promoter | 2.66e-01 | 1.55e-01 | 3.88e+00 | 1.05e-04 | 2.14e-04 | 1.12e-01 |
| KIRC | cg25340966 | chr1:118989572 | CGI:chr1:118989368-118989573 | promoter | 2.17e-01 | 7.58e-02 | 3.21e+00 | 1.33e-03 | 2.00e-03 | 1.42e-01 |
| KIRC | cg24842086 | chr1:118989234 | CGI:chr1:118989368-118989573 | promoter,gene body | 3.22e-01 | 2.07e-01 | 4.87e+00 | 1.09e-06 | 3.93e-06 | 1.15e-01 |
| THCA | cg10703826 | chr1:118989493 | CGI:chr1:118989368-118989573 | UTR,promoter,exon,gene body | 1.81e-01 | 7.80e-02 | 2.03e+00 | 4.22e-02 | 4.47e-02 | 1.03e-01 |
| THCA | cg27262412 | chr1:118988079 | CGI:chr1:118987196-118988089 | promoter,gene body | 2.76e-01 | 1.58e-01 | 3.14e+00 | 1.70e-03 | 4.60e-03 | 1.18e-01 |
| THCA | cg07892597 | chr1:118989470 | CGI:chr1:118989368-118989573 | UTR,promoter,exon,gene body | 4.46e-01 | 3.27e-01 | 2.70e+00 | 6.89e-03 | 1.27e-02 | 1.19e-01 |
| HNSC | cg21392341 | chr1:118988054 | CGI:chr1:118987196-118988089 | promoter,gene body | 1.78e-01 | 4.41e-02 | 1.98e+00 | 4.72e-02 | 4.76e-02 | 1.34e-01 |
| HNSC | cg23371746 | chr1:118990302 | CGI:chr1:118989368-118989573 | promoter | 5.88e-01 | 4.87e-01 | 3.24e+00 | 1.21e-03 | 2.13e-03 | 1.00e-01 |
| HNSC | cg26272623 | chr1:118989697 | CGI:chr1:118989368-118989573 | promoter | 5.47e-01 | 4.41e-01 | 3.68e+00 | 2.35e-04 | 5.31e-04 | 1.06e-01 |
| LUSC | cg21392341 | chr1:118988054 | CGI:chr1:118987196-118988089 | promoter,gene body | 2.46e-01 | 4.74e-02 | 2.22e+00 | 2.65e-02 | 2.99e-02 | 1.98e-01 |
| LUSC | cg24475782 | chr1:118988309 | CGI:chr1:118987196-118988089 | promoter,gene body | 3.45e-01 | 6.87e-02 | 3.82e+00 | 1.36e-04 | 8.00e-04 | 2.77e-01 |
| LUSC | cg21295088 | chr1:118989002 | CGI:chr1:118989368-118989573 | promoter,gene body | 2.46e-01 | 5.01e-02 | 4.43e+00 | 9.53e-06 | 5.26e-04 | 1.96e-01 |
| LUSC | cg04550737 | chr1:118987977 | CGI:chr1:118987196-118988089 | promoter,gene body | 2.53e-01 | 2.26e-02 | 3.49e+00 | 4.91e-04 | 1.64e-03 | 2.31e-01 |
| LUSC | cg14565725 | chr1:118989421 | CGI:chr1:118989368-118989573 | UTR,promoter,exon,gene body | 6.10e-01 | 2.03e-01 | 4.41e+00 | 1.04e-05 | 5.26e-04 | 4.07e-01 |
| LUSC | cg24884142 | chr1:118989433 | CGI:chr1:118989368-118989573 | UTR,promoter,exon,gene body | 5.60e-01 | 1.67e-01 | 4.38e+00 | 1.18e-05 | 5.26e-04 | 3.93e-01 |
| LUSC | cg10703826 | chr1:118989493 | CGI:chr1:118989368-118989573 | UTR,promoter,exon,gene body | 5.70e-01 | 7.56e-02 | 4.37e+00 | 1.24e-05 | 5.26e-04 | 4.94e-01 |
| LUSC | cg05940231 | chr1:118989566 | CGI:chr1:118989368-118989573 | promoter | 5.00e-01 | 1.44e-01 | 4.40e+00 | 1.09e-05 | 5.26e-04 | 3.56e-01 |
| LUSC | cg25340966 | chr1:118989572 | CGI:chr1:118989368-118989573 | promoter | 5.14e-01 | 4.83e-02 | 4.43e+00 | 9.53e-06 | 5.26e-04 | 4.66e-01 |
| LUSC | cg02362103 | chr1:118990150 | CGI:chr1:118989368-118989573 | promoter | 5.67e-01 | 2.07e-01 | 4.40e+00 | 1.06e-05 | 5.26e-04 | 3.60e-01 |
| LUSC | cg23371746 | chr1:118990302 | CGI:chr1:118989368-118989573 | promoter | 5.64e-01 | 2.16e-01 | 4.24e+00 | 2.20e-05 | 5.26e-04 | 3.48e-01 |
| LUSC | cg25755283 | chr1:118988470 | CGI:chr1:118987196-118988089 | promoter,gene body | 3.62e-01 | 1.53e-01 | 3.46e+00 | 5.46e-04 | 1.75e-03 | 2.09e-01 |
| LUSC | cg03760839 | chr1:118989095 | CGI:chr1:118989368-118989573 | promoter,gene body | 7.29e-01 | 4.15e-01 | 4.39e+00 | 1.13e-05 | 5.26e-04 | 3.14e-01 |
| LUSC | cg24842086 | chr1:118989234 | CGI:chr1:118989368-118989573 | promoter,gene body | 5.29e-01 | 2.04e-01 | 4.32e+00 | 1.57e-05 | 5.26e-04 | 3.25e-01 |
| LUSC | cg07892597 | chr1:118989470 | CGI:chr1:118989368-118989573 | UTR,promoter,exon,gene body | 6.51e-01 | 3.59e-01 | 4.38e+00 | 1.21e-05 | 5.26e-04 | 2.92e-01 |
| LUSC | cg26272623 | chr1:118989697 | CGI:chr1:118989368-118989573 | promoter | 5.44e-01 | 3.10e-01 | 4.25e+00 | 2.11e-05 | 5.26e-04 | 2.34e-01 |
| LUSC | cg12664119 | chr1:118989729 | CGI:chr1:118989368-118989573 | promoter | 6.55e-01 | 4.19e-01 | 4.36e+00 | 1.32e-05 | 5.26e-04 | 2.36e-01 |
| LUSC | cg08942939 | chr1:118989919 | CGI:chr1:118989368-118989573 | promoter | 4.94e-01 | 1.56e-01 | 4.31e+00 | 1.67e-05 | 5.26e-04 | 3.38e-01 |
| LUSC | cg03942051 | chr1:118990032 | CGI:chr1:118989368-118989573 | promoter | 4.85e-01 | 2.76e-01 | 3.88e+00 | 1.04e-04 | 7.08e-04 | 2.09e-01 |
| LUSC | cg22820316 | chr1:118990113 | CGI:chr1:118989368-118989573 | promoter | 5.90e-01 | 2.62e-01 | 4.33e+00 | 1.50e-05 | 5.26e-04 | 3.27e-01 |
| LUSC | cg00466334 | chr1:118990227 | CGI:chr1:118989368-118989573 | promoter | 6.73e-01 | 4.59e-01 | 4.28e+00 | 1.86e-05 | 5.26e-04 | 2.14e-01 |
| BLCA | cg26272623 | chr1:118989697 | CGI:chr1:118989368-118989573 | promoter | 5.63e-01 | 4.36e-01 | 3.09e+00 | 2.00e-03 | 3.92e-03 | 1.27e-01 |
| KIRP | cg12664119 | chr1:118989729 | CGI:chr1:118989368-118989573 | promoter | 5.86e-01 | 4.73e-01 | 3.15e+00 | 1.61e-03 | 2.72e-03 | 1.14e-01 |
| KIRP | cg22820316 | chr1:118990113 | CGI:chr1:118989368-118989573 | promoter | 5.47e-01 | 4.32e-01 | 2.47e+00 | 1.36e-02 | 1.66e-02 | 1.15e-01 |
| ESCA | cg05940231 | chr1:118989566 | CGI:chr1:118989368-118989573 | promoter | 5.53e-01 | 3.72e-01 | 2.07e+00 | 3.80e-02 | 4.61e-02 | 1.81e-01 |
| ESCA | cg02362103 | chr1:118990150 | CGI:chr1:118989368-118989573 | promoter | 6.24e-01 | 4.20e-01 | 2.65e+00 | 8.04e-03 | 3.55e-02 | 2.04e-01 |
| CHOL | cg24475782 | chr1:118988309 | CGI:chr1:118987196-118988089 | promoter,gene body | 4.47e-01 | 1.74e-01 | 2.36e+00 | 1.83e-02 | 2.92e-02 | 2.73e-01 |
| CHOL | cg21295088 | chr1:118989002 | CGI:chr1:118989368-118989573 | promoter,gene body | 2.83e-01 | 1.36e-01 | 2.36e+00 | 1.83e-02 | 2.92e-02 | 1.47e-01 |
| CHOL | cg04550737 | chr1:118987977 | CGI:chr1:118987196-118988089 | promoter,gene body | 3.96e-01 | 4.25e-02 | 2.58e+00 | 9.87e-03 | 2.15e-02 | 3.54e-01 |
| CHOL | cg14415885 | chr1:118988499 | CGI:chr1:118987196-118988089 | promoter,gene body | 1.91e-01 | 4.01e-02 | 2.14e+00 | 3.25e-02 | 3.87e-02 | 1.51e-01 |
| CHOL | cg14565725 | chr1:118989421 | CGI:chr1:118989368-118989573 | UTR,promoter,exon,gene body | 6.17e-01 | 1.90e-01 | 3.46e+00 | 5.30e-04 | 8.63e-03 | 4.27e-01 |
| CHOL | cg24884142 | chr1:118989433 | CGI:chr1:118989368-118989573 | UTR,promoter,exon,gene body | 6.31e-01 | 1.65e-01 | 3.54e+00 | 4.02e-04 | 8.32e-03 | 4.67e-01 |
| CHOL | cg10703826 | chr1:118989493 | CGI:chr1:118989368-118989573 | UTR,promoter,exon,gene body | 6.29e-01 | 1.13e-01 | 2.88e+00 | 4.04e-03 | 1.47e-02 | 5.16e-01 |
| CHOL | cg05940231 | chr1:118989566 | CGI:chr1:118989368-118989573 | promoter | 4.68e-01 | 1.70e-01 | 2.65e+00 | 7.96e-03 | 1.92e-02 | 2.98e-01 |
| CHOL | cg25340966 | chr1:118989572 | CGI:chr1:118989368-118989573 | promoter | 4.61e-01 | 6.45e-02 | 2.65e+00 | 7.96e-03 | 1.92e-02 | 3.97e-01 |
| CHOL | cg02362103 | chr1:118990150 | CGI:chr1:118989368-118989573 | promoter | 5.78e-01 | 2.24e-01 | 3.32e+00 | 9.08e-04 | 1.01e-02 | 3.53e-01 |
| CHOL | cg23371746 | chr1:118990302 | CGI:chr1:118989368-118989573 | promoter | 5.93e-01 | 2.71e-01 | 3.02e+00 | 2.51e-03 | 1.19e-02 | 3.22e-01 |
| CHOL | cg27262412 | chr1:118988079 | CGI:chr1:118987196-118988089 | promoter,gene body | 4.68e-01 | 2.36e-01 | 2.06e+00 | 3.90e-02 | 4.26e-02 | 2.31e-01 |
| CHOL | cg25755283 | chr1:118988470 | CGI:chr1:118987196-118988089 | promoter,gene body | 3.98e-01 | 1.65e-01 | 2.80e+00 | 5.09e-03 | 1.63e-02 | 2.33e-01 |
| CHOL | cg03760839 | chr1:118989095 | CGI:chr1:118989368-118989573 | promoter,gene body | 7.12e-01 | 5.70e-01 | 2.21e+00 | 2.70e-02 | 3.50e-02 | 1.42e-01 |
| CHOL | cg24842086 | chr1:118989234 | CGI:chr1:118989368-118989573 | promoter,gene body | 4.56e-01 | 1.80e-01 | 3.10e+00 | 1.96e-03 | 1.07e-02 | 2.76e-01 |
| CHOL | cg07892597 | chr1:118989470 | CGI:chr1:118989368-118989573 | UTR,promoter,exon,gene body | 7.08e-01 | 4.15e-01 | 3.54e+00 | 4.02e-04 | 8.32e-03 | 2.92e-01 |
| CHOL | cg26272623 | chr1:118989697 | CGI:chr1:118989368-118989573 | promoter | 5.58e-01 | 3.32e-01 | 3.10e+00 | 1.96e-03 | 1.07e-02 | 2.26e-01 |
| CHOL | cg12664119 | chr1:118989729 | CGI:chr1:118989368-118989573 | promoter | 6.51e-01 | 4.45e-01 | 2.73e+00 | 6.38e-03 | 1.82e-02 | 2.07e-01 |
| CHOL | cg08942939 | chr1:118989919 | CGI:chr1:118989368-118989573 | promoter | 5.04e-01 | 1.87e-01 | 2.58e+00 | 9.87e-03 | 2.15e-02 | 3.18e-01 |
| CHOL | cg03942051 | chr1:118990032 | CGI:chr1:118989368-118989573 | promoter | 5.36e-01 | 3.48e-01 | 2.29e+00 | 2.23e-02 | 3.24e-02 | 1.87e-01 |
| CHOL | cg22820316 | chr1:118990113 | CGI:chr1:118989368-118989573 | promoter | 5.95e-01 | 3.58e-01 | 2.80e+00 | 5.09e-03 | 1.63e-02 | 2.37e-01 |
| CHOL | cg00466334 | chr1:118990227 | CGI:chr1:118989368-118989573 | promoter | 6.93e-01 | 5.75e-01 | 2.21e+00 | 2.70e-02 | 3.50e-02 | 1.19e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg21392341 | chr1:118988054 | CGI:chr1:118987196-118988089 | promoter,gene body | 3.66e-01 | 4.27e-02 | 1.17e+01 | 7.66e-32 | 1.41e-30 | 3.23e-01 |
| BRCA | cg24475782 | chr1:118988309 | CGI:chr1:118987196-118988089 | promoter,gene body | 3.29e-01 | 5.79e-02 | 1.16e+01 | 3.42e-31 | 5.79e-30 | 2.72e-01 |
| BRCA | cg21295088 | chr1:118989002 | CGI:chr1:118989368-118989573 | promoter,gene body | 2.91e-01 | 1.51e-01 | 8.54e+00 | 1.29e-17 | 5.77e-17 | 1.40e-01 |
| BRCA | cg04550737 | chr1:118987977 | CGI:chr1:118987196-118988089 | promoter,gene body | 3.86e-01 | 3.07e-02 | 1.21e+01 | 1.27e-33 | 3.01e-32 | 3.55e-01 |
| BRCA | cg14565725 | chr1:118989421 | CGI:chr1:118989368-118989573 | UTR,promoter,exon,gene body | 6.21e-01 | 4.37e-01 | 1.07e+01 | 8.06e-27 | 8.19e-26 | 1.84e-01 |
| BRCA | cg24884142 | chr1:118989433 | CGI:chr1:118989368-118989573 | UTR,promoter,exon,gene body | 5.80e-01 | 3.36e-01 | 1.02e+01 | 1.22e-24 | 1.00e-23 | 2.43e-01 |
| BRCA | cg10703826 | chr1:118989493 | CGI:chr1:118989368-118989573 | UTR,promoter,exon,gene body | 5.82e-01 | 3.41e-01 | 9.09e+00 | 9.98e-20 | 5.28e-19 | 2.40e-01 |
| BRCA | cg05940231 | chr1:118989566 | CGI:chr1:118989368-118989573 | promoter | 5.11e-01 | 3.41e-01 | 8.33e+00 | 7.84e-17 | 3.29e-16 | 1.70e-01 |
| BRCA | cg25340966 | chr1:118989572 | CGI:chr1:118989368-118989573 | promoter | 5.04e-01 | 2.92e-01 | 8.37e+00 | 5.80e-17 | 2.46e-16 | 2.12e-01 |
| BRCA | cg02362103 | chr1:118990150 | CGI:chr1:118989368-118989573 | promoter | 5.93e-01 | 4.84e-01 | 7.19e+00 | 6.60e-13 | 2.05e-12 | 1.09e-01 |
| BRCA | cg23371746 | chr1:118990302 | CGI:chr1:118989368-118989573 | promoter | 6.03e-01 | 4.97e-01 | 7.38e+00 | 1.53e-13 | 4.99e-13 | 1.05e-01 |
| BRCA | cg27262412 | chr1:118988079 | CGI:chr1:118987196-118988089 | promoter,gene body | 4.90e-01 | 1.43e-01 | 1.20e+01 | 2.46e-33 | 5.59e-32 | 3.47e-01 |
| BRCA | cg25755283 | chr1:118988470 | CGI:chr1:118987196-118988089 | promoter,gene body | 3.23e-01 | 9.86e-02 | 1.22e+01 | 2.83e-34 | 7.41e-33 | 2.24e-01 |
| BRCA | cg03760839 | chr1:118989095 | CGI:chr1:118989368-118989573 | promoter,gene body | 7.53e-01 | 5.18e-01 | 1.24e+01 | 2.17e-35 | 6.82e-34 | 2.35e-01 |
| BRCA | cg24842086 | chr1:118989234 | CGI:chr1:118989368-118989573 | promoter,gene body | 5.17e-01 | 3.85e-01 | 7.31e+00 | 2.62e-13 | 8.41e-13 | 1.32e-01 |
| BRCA | cg07892597 | chr1:118989470 | CGI:chr1:118989368-118989573 | UTR,promoter,exon,gene body | 6.58e-01 | 4.85e-01 | 1.01e+01 | 3.99e-24 | 3.12e-23 | 1.73e-01 |
| BRCA | cg26272623 | chr1:118989697 | CGI:chr1:118989368-118989573 | promoter | 5.73e-01 | 4.60e-01 | 7.50e+00 | 6.49e-14 | 2.18e-13 | 1.12e-01 |
| BRCA | cg12664119 | chr1:118989729 | CGI:chr1:118989368-118989573 | promoter | 7.06e-01 | 5.89e-01 | 7.93e+00 | 2.26e-15 | 8.48e-15 | 1.18e-01 |
| BRCA | cg03942051 | chr1:118990032 | CGI:chr1:118989368-118989573 | promoter | 5.63e-01 | 4.63e-01 | 6.28e+00 | 3.36e-10 | 8.48e-10 | 1.01e-01 |
| KIRP | cg04550737 | chr1:118987977 | CGI:chr1:118987196-118988089 | promoter,gene body | 1.22e-01 | 1.97e-02 | 2.49e+00 | 1.29e-02 | 2.00e-02 | 1.02e-01 |
| KIRP | cg05940231 | chr1:118989566 | CGI:chr1:118989368-118989573 | promoter | 3.66e-01 | 1.81e-01 | 2.50e+00 | 1.24e-02 | 1.94e-02 | 1.84e-01 |
| KIRP | cg25340966 | chr1:118989572 | CGI:chr1:118989368-118989573 | promoter | 3.12e-01 | 6.04e-02 | 2.34e+00 | 1.91e-02 | 2.60e-02 | 2.52e-01 |
| KIRP | cg02362103 | chr1:118990150 | CGI:chr1:118989368-118989573 | promoter | 4.58e-01 | 2.86e-01 | 2.50e+00 | 1.24e-02 | 1.94e-02 | 1.72e-01 |
| KIRP | cg07892597 | chr1:118989470 | CGI:chr1:118989368-118989573 | UTR,promoter,exon,gene body | 5.37e-01 | 3.67e-01 | 2.53e+00 | 1.13e-02 | 1.83e-02 | 1.71e-01 |
| KIRP | cg26272623 | chr1:118989697 | CGI:chr1:118989368-118989573 | promoter | 4.84e-01 | 3.57e-01 | 1.96e+00 | 4.97e-02 | 4.97e-02 | 1.27e-01 |
Top |
Exon skipping events with PSI in TCGA for TBX15 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for TBX15 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for TBX15 |
| TFs related to TBX15. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| DLBC | ZNF418 | TBX15 | 4.05e+00 | 1.09e-02 | 4.92e+00 | 9.86e-01 | Female-biased |
| SARC | FOXC1 | TBX15 | 4.37e+00 | 9.87e-01 | 3.65e+00 | 3.70e-03 | Male-biased |
| SARC | FOXP2 | TBX15 | 4.05e+00 | 9.81e-01 | 3.34e+00 | 3.86e-03 | Male-biased |
| SARC | HNF1B | TBX15 | 4.75e+00 | 9.88e-01 | 4.14e+00 | 7.60e-03 | Male-biased |
| SARC | SOX15 | TBX15 | 4.55e+00 | 9.90e-01 | 3.81e+00 | 3.36e-03 | Male-biased |
| SARC | SOX17 | TBX15 | 4.28e+00 | 9.81e-01 | 3.69e+00 | 8.27e-03 | Male-biased |
| SARC | SOX18 | TBX15 | 4.60e+00 | 9.91e-01 | 3.80e+00 | 2.39e-03 | Male-biased |
| SARC | TBP | TBX15 | 4.25e+00 | 9.86e-01 | 3.50e+00 | 3.15e-03 | Male-biased |
| SARC | ZFP82 | TBX15 | 4.26e+00 | 9.88e-01 | 3.26e+00 | 8.28e-04 | Male-biased |
| SARC | ZIM3 | TBX15 | 3.94e+00 | 9.80e-01 | 3.08e+00 | 1.64e-03 | Male-biased |
| SARC | ZNF418 | TBX15 | 4.13e+00 | 9.87e-01 | 2.38e+00 | 1.19e-05 | Male-biased |
| SKCM | PLAGL2 | TBX15 | 4.81e+00 | 9.83e-01 | 3.71e+00 | 8.62e-03 | Male-biased |
| THYM | HNF1B | TBX15 | 4.86e+00 | 9.86e-01 | 4.17e+00 | 9.37e-03 | Male-biased |
| THYM | SOX18 | TBX15 | 4.57e+00 | 9.85e-01 | 3.86e+00 | 8.50e-03 | Male-biased |
| THYM | ZFP82 | TBX15 | 4.21e+00 | 9.82e-01 | 3.41e+00 | 5.85e-03 | Male-biased |
| THYM | ZNF418 | TBX15 | 4.19e+00 | 9.88e-01 | 2.63e+00 | 2.55e-04 | Male-biased |
| TBX15 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
 |
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Sex-biased RBP-ES network for TBX15 |
| RBPs related to ES in TBX15. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| TBX15 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000092607 | RNFT1-DT,hsa-mir-539,TBX15 | Male-specific ceRNA | TCGA-HNSC |
| ENSG00000092607 | FZD4-DT,hsa-mir-539,TBX15 | Male-specific ceRNA | TCGA-HNSC |
| ENSG00000092607 | AL161757.4,hsa-mir-5582,TBX15 | Male-specific ceRNA | TCGA-HNSC |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs1216762 | chr1:113055951:C:G | - | 0.0335764851023701 | 0.0137805691698015 | LUAD | Female-baised eQTL |
| rs1216763 | chr1:113055351:C:T | - | 0.0312623925742449 | 0.0336363724409115 | LUAD | Female-baised eQTL |
| rs209893 | chr1:114215469:C:G | - | -0.0567549034387545 | 0.0346597997738559 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs1953099 | chr1:110747920:G:A | - | 0.0929170254044485 | 6.6710664556348e-07 | KIRC | Male-baised eQTL |
| rs66647368 | chr1:110748991:G:A | - | 0.0929170254044485 | 6.6710664556348e-07 | KIRC | Male-baised eQTL |
| rs68011061 | chr1:110749509:T:C | - | 0.0929170254044485 | 6.6710664556348e-07 | KIRC | Male-baised eQTL |
| rs116684661 | chr1:112493437:G:A | - | 0.109581713834675 | 1.10459167970849e-06 | KIRC | Male-baised eQTL |
| rs56076010 | chr1:110614811:T:C | - | 0.0932475386542182 | 1.76018213288467e-06 | KIRC | Male-baised eQTL |
| rs79759984 | chr1:112489149:A:T | - | 0.106905810102606 | 2.13290113505727e-06 | KIRC | Male-baised eQTL |
| rs116179474 | chr1:112484593:T:C | - | 0.106838308789287 | 2.19952151067022e-06 | KIRC | Male-baised eQTL |
| rs2078323 | chr1:111832321:C:T | - | 0.10696616393642 | 2.69453375929319e-06 | KIRC | Male-baised eQTL |
| rs57033525 | chr1:110614596:T:C | - | 0.0903003410260679 | 3.92955824058689e-06 | KIRC | Male-baised eQTL |
| rs141779711 | chr1:112481967:T:A | - | 0.102019912781693 | 5.80263255969972e-06 | KIRC | Male-baised eQTL |
| rs11590526 | chr1:115884946:C:T | - | 0.10062375266207 | 5.89026319129122e-06 | KIRC | Male-baised eQTL |
| rs55658500 | chr1:110610911:C:T | - | 0.0823050411686257 | 1.11172988155773e-05 | KIRC | Male-baised eQTL |
| rs1485592 | chr1:114257089:G:T | - | 0.0926982982141932 | 1.5028552175152e-05 | KIRC | Male-baised eQTL |
| rs4839072 | chr1:110612656:G:A | - | 0.0823172325373958 | 2.93882322274769e-05 | KIRC | Male-baised eQTL |
| rs12411052 | chr1:110615908:A:G | - | 0.0731494557345565 | 0.000218200710663802 | KIRC | Male-baised eQTL |
| rs17026160 | chr1:110590546:G:C | - | 0.0754427095443649 | 0.00066215519729598 | KIRC | Male-baised eQTL |
| rs73008277 | chr1:115113368:C:A | - | 0.080127425455438 | 0.00206809655011049 | KIRC | Male-baised eQTL |
| rs17508449 | chr1:113542523:C:T | - | 0.054118882123236 | 0.00622044604458458 | KIRC | Male-baised eQTL |
| rs12040903 | chr1:112711503:G:A | - | 0.0494338594471657 | 0.00755597702899289 | KIRC | Male-baised eQTL |
| rs12118670 | chr1:115119843:A:G | - | 0.0647550536201213 | 0.00882116438714327 | KIRC | Male-baised eQTL |
| rs55765939 | chr1:110611484:T:C | - | 0.0553834494166546 | 0.0106910468352305 | KIRC | Male-baised eQTL |
| rs10923757 | chr1:119143567:G:T | - | 0.0536168255486868 | 0.0132988263302461 | KIRC | Male-baised eQTL |
| rs113648578 | chr1:113359330:C:T | - | 0.0754866514268855 | 0.0175945879718621 | KIRC | Male-baised eQTL |
| rs12565455 | chr1:113359444:T:C | - | 0.0754866514268855 | 0.0175945879718621 | KIRC | Male-baised eQTL |
| rs11802978 | chr1:113355098:A:T | - | 0.07536341362216 | 0.0180286771415593 | KIRC | Male-baised eQTL |
| rs61817500 | chr1:113357719:A:G | - | 0.07536341362216 | 0.0180286771415593 | KIRC | Male-baised eQTL |
| rs6537821 | chr1:114260903:G:T | - | 0.0449745045700129 | 0.0201856217673071 | KIRC | Male-baised eQTL |
| rs61799386 | chr1:109181874:T:A | - | 0.0553897804822702 | 0.0218303364084951 | KIRC | Male-baised eQTL |
| rs416190 | chr1:114255076:G:A | - | 0.044169480705376 | 0.0219051482516945 | KIRC | Male-baised eQTL |
| rs76869967 | chr1:113348954:G:A | - | 0.0731577158727455 | 0.0238708500950331 | KIRC | Male-baised eQTL |
| rs17031421 | chr1:113351299:C:T | - | 0.0731577158727455 | 0.0238708500950331 | KIRC | Male-baised eQTL |
| rs78947213 | chr1:113343902:G:A | - | 0.0730550143180616 | 0.0243513934547509 | KIRC | Male-baised eQTL |
| rs78856601 | chr1:113346475:T:A | - | 0.0730550143180616 | 0.0243513934547509 | KIRC | Male-baised eQTL |
| rs34721329 | chr1:110560348:C:T | - | 0.046093329021621 | 0.0243561410543492 | KIRC | Male-baised eQTL |
| rs12077952 | chr1:110922993:A:C | - | 0.0367346467751966 | 0.0256238302594111 | KIRC | Male-baised eQTL |
| rs12124010 | chr1:119178051:A:G | - | 0.0500811131572475 | 0.0259417377933441 | KIRC | Male-baised eQTL |
| rs12144676 | chr1:119158270:T:C | - | 0.0497800390963318 | 0.0267387599507449 | KIRC | Male-baised eQTL |
| rs1282020 | chr1:110914865:T:G | - | 0.0356942698537285 | 0.0318770545929176 | KIRC | Male-baised eQTL |
| rs3204955 | chr1:115692656:C:T | - | 0.0422496647908829 | 0.0324166472300073 | KIRC | Male-baised eQTL |
| rs12075552 | chr1:110910008:T:C | - | -0.0357151595350031 | 0.0331967409665657 | KIRC | Male-baised eQTL |
| rs343612 | chr1:110731782:G:T | - | -0.0389562117892399 | 0.0359820474347209 | KIRC | Male-baised eQTL |
| rs3811007 | chr1:115697578:A:T | - | 0.0408560993579094 | 0.0401509104998975 | KIRC | Male-baised eQTL |
| rs6673301 | chr1:115698590:A:G | - | 0.0408560993579094 | 0.0401509104998975 | KIRC | Male-baised eQTL |
| rs12126394 | chr1:115698938:A:C | - | 0.0408560993579094 | 0.0401509104998975 | KIRC | Male-baised eQTL |
| rs2186051 | chr1:113409415:A:G | - | -0.0408444818253136 | 0.0416080345169054 | KIRC | Male-baised eQTL |
| rs41464748 | chr1:116390149:G:A | - | 0.0894100183746058 | 0.0426206274462802 | KIRC | Male-baised eQTL |
| rs11578967 | chr1:115759049:T:G | - | 0.0377043370123154 | 0.0445398582661602 | KIRC | Male-baised eQTL |
| rs7522283 | chr1:112711645:G:C | - | -0.0413382168401506 | 0.0451271313669694 | KIRC | Male-baised eQTL |
| rs6659025 | chr1:115758398:T:C | - | 0.0381088129009173 | 0.0457183558270065 | KIRC | Male-baised eQTL |
| rs10802053 | chr1:115851873:G:C | - | 0.0592652589865975 | 0.0468033830868611 | KIRC | Male-baised eQTL |
| rs10923204 | chr1:115694402:G:T | - | 0.0399769768362515 | 0.0478787740005038 | KIRC | Male-baised eQTL |
| rs4970828 | chr1:109206053:T:C | - | -0.0525831797053804 | 0.0495374761257497 | KIRC | Male-baised eQTL |
| rs3088350 | chr1:109206471:A:T | - | -0.0525831797053804 | 0.0495374761257497 | KIRC | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000092607 |
| CpG Site: cg21295088 | |
| Position to Gene: gene,promoter | |
| Male Effect: 0.0839478947980228 | |
| Female Effect: - | |
 | Gene ID: ENSG00000092607 |
| CpG Site: cg13655674 | |
| Position to Gene: gene | |
| Male Effect: 0.0695074502813934 | |
| Female Effect: - | |
 | Gene ID: ENSG00000092607 |
| CpG Site: cg06158650 | |
| Position to Gene: gene | |
| Male Effect: 0.0677734227458188 | |
| Female Effect: - | |
 | Gene ID: ENSG00000092607 |
| CpG Site: cg24720355 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.486176406164994 | |
 | Gene ID: ENSG00000092607 |
| CpG Site: cg04707332 | |
| Position to Gene: gene | |
| Male Effect: -0.467814642426207 | |
| Female Effect: - | |
 | Gene ID: ENSG00000092607 |
| CpG Site: cg12664119 | |
| Position to Gene: promoter | |
| Male Effect: -0.467814642426207 | |
| Female Effect: - | |
 | Gene ID: ENSG00000092607 |
| CpG Site: cg03760839 | |
| Position to Gene: gene,promoter | |
| Male Effect: -0.269133716667279 | |
| Female Effect: - | |
 | Gene ID: ENSG00000092607 |
| CpG Site: cg27517681 | |
| Position to Gene: gene | |
| Male Effect: -0.232948107041073 | |
| Female Effect: - | |
 | Gene ID: ENSG00000092607 |
| CpG Site: cg07892597 | |
| Position to Gene: gene,exon,promoter,UTR | |
| Male Effect: -0.207562257378672 | |
| Female Effect: - | |
 | Gene ID: ENSG00000092607 |
| CpG Site: cg26272623 | |
| Position to Gene: promoter | |
| Male Effect: -0.123743230833221 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg21295088 | chr1:118989002 | gene,promoter | 0.0839478947980228 | 1.92455181454563e-05 | 0.3661615256915388 | 9.008052343647391e-08 | KIRP |
| cg13655674 | chr1:118979763 | gene | 0.0695074502813934 | 5.09408532358292e-05 | 0.3572827800639834 | 1.9228545709305938e-07 | KIRP |
| cg06158650 | chr1:118980014 | gene | 0.0677734227458188 | 9.13276179125039e-05 | 0.34766020836787837 | 4.2628929214840034e-07 | KIRP |
| cg04707332 | chr1:118985395 | gene | -0.467814642426207 | 8.70974265520067e-14 | -0.5231239254057678 | 4.588583119885371e-17 | LUAD |
| cg12664119 | chr1:118989729 | promoter | -0.467814642426207 | 8.70974265520067e-14 | -0.5231239254057678 | 4.588583119885371e-17 | LUAD |
| cg03760839 | chr1:118989095 | gene,promoter | -0.269133716667279 | 1.57281976726264e-13 | -0.5157337073968079 | 1.4867848172373674e-16 | LUAD |
| cg27517681 | chr1:118986225 | gene | -0.232948107041073 | 1.67842424429944e-09 | -0.450799932587948 | 1.4648760731617937e-12 | LUAD |
| cg07892597 | chr1:118989470 | gene,exon,promoter,UTR | -0.207562257378672 | 2.72715336426155e-07 | -0.39752101703791753 | 7.340835821718991e-10 | LUAD |
| cg26272623 | chr1:118989697 | promoter | -0.123743230833221 | 6.82526797048462e-05 | -0.32211544034384576 | 8.887211843269967e-07 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg24720355 | chr1:118983632 | gene | -0.486176406164994 | 1.59210057312196e-23 | -0.9011198444864396 | 1.7776404096516355e-27 | KIRP |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of TBX15 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000092607 | TBX15 | C0018273 | Growth Disorders | 1 | CTD_human |
| ENSG00000092607 | TBX15 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| ENSG00000092607 | TBX15 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
| ENSG00000092607 | TBX15 | C1850040 | Pelviscapular dysplasia | 1 | CTD_human |
