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Gene: ENSG00000092068 |
Summary for SLC7A8 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000092068 | Gene symbol | SLC7A8 |
| Gene name | solute carrier family 7 member 8 | |
| HGNC | 11066 | |
| Entrez ID | 23428 | |
| Gene type | protein_coding | |
| Synonyms | SLC7A8|LPI-PC1|LAT2 | |
| UniProtAcc | Q9UHI5 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| ENSG00000092068 | SLC7A8 | DB00120 | Phenylalanine | SmallMoleculeDrug |
| ENSG00000092068 | SLC7A8 | DB00160 | Alanine | SmallMoleculeDrug |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for SLC7A8 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| SLC7A8 | 2.10e+03 | -1.31e+00 | 2.37e-01 | -5.52e+00 | 3.30e-08 | 1.13e-06 | KIRP |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| SLC7A8 | 8.46e+03 | 1.13e+00 | 1.21e-01 | 9.29e+00 | 1.57e-20 | 5.40e-20 | BRCA |
| SLC7A8 | 2.97e+03 | 1.57e+00 | 4.14e-01 | 3.79e+00 | 1.52e-04 | 6.88e-04 | READ |
Top |
Sex-biased somatic mutation for SLC7A8 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for SLC7A8 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| ACC | cg23099740 | chr14:23184344 | CGI:chr14:23094769-23095515 | promoter | 6.21e-01 | 7.28e-01 | -2.17e+00 | 3.01e-02 | 4.15e-02 | -1.07e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg27035169 | chr14:23183889 | CGI:chr14:23094769-23095515 | promoter | 3.16e-01 | 1.46e-01 | 6.27e+00 | 3.64e-10 | 5.91e-09 | 1.70e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Top |
Exon skipping events with PSI in TCGA for SLC7A8 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for SLC7A8 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for SLC7A8 |
| TFs related to SLC7A8. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| SLC7A8 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for SLC7A8 |
| RBPs related to ES in SLC7A8. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| LUAD | CNOT4 | exon_skip_111677 | 8.52e+00 | 9.92e-01 | 8.00e+00 | 1.43e-03 | Male-biased |
| LUAD | PCBP2 | exon_skip_111678 | 6.20e+00 | 2.31e-03 | 6.68e+00 | 9.81e-01 | Female-biased |
| LUAD | SAMD4A | exon_skip_111677 | 6.08e+00 | 3.63e-05 | 7.12e+00 | 9.87e-01 | Female-biased |
| ESCA | ZC3H10 | exon_skip_111678 | 7.08e+00 | 1.91e-03 | 7.74e+00 | 9.89e-01 | Female-biased |
| THCA | PCBP2 | exon_skip_111678 | 6.02e+00 | 1.18e-03 | 6.50e+00 | 9.81e-01 | Female-biased |
| THCA | PCBP2 | exon_skip_111687 | 5.94e+00 | 7.80e-04 | 6.47e+00 | 9.81e-01 | Female-biased |
| MESO | CNOT4 | exon_skip_111677 | 8.33e+00 | 1.09e-02 | 8.67e+00 | 9.83e-01 | Female-biased |
| MESO | FMR1 | exon_skip_111683 | 8.23e+00 | 3.29e-03 | 8.68e+00 | 9.91e-01 | Female-biased |
| MESO | NOVA2 | exon_skip_111687 | 7.40e+00 | 1.01e-02 | 7.75e+00 | 9.80e-01 | Female-biased |
| MESO | ZC3H10 | exon_skip_111678 | 7.15e+00 | 8.11e-03 | 7.52e+00 | 9.81e-01 | Female-biased |
| LGG | CNOT4 | exon_skip_111677 | 8.27e+00 | 1.20e-02 | 8.58e+00 | 9.82e-01 | Female-biased |
| KIRC | SAMD4A | exon_skip_111677 | 6.59e+00 | 9.81e-01 | 6.14e+00 | 1.66e-03 | Male-biased |
| SKCM | SAMD4A | exon_skip_111677 | 6.10e+00 | 2.37e-03 | 6.61e+00 | 9.81e-01 | Female-biased |
| SLC7A8 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs17257822 | chr14:25076120:G:A | - | 0.164486706840497 | 0.0194640752560676 | READ | Female-baised eQTL |
| rs61254962 | chr14:25079642:A:G | - | 0.164486706840497 | 0.0194640752560676 | READ | Female-baised eQTL |
| rs74414391 | chr14:25079732:A:T | - | 0.164486706840497 | 0.0194640752560676 | READ | Female-baised eQTL |
| rs17257836 | chr14:25079935:A:G | - | 0.164486706840497 | 0.0194640752560676 | READ | Female-baised eQTL |
| rs74726335 | chr14:25082199:C:T | - | 0.164199667741858 | 0.0196415048405917 | READ | Female-baised eQTL |
| rs7159074 | chr14:25089115:T:G | - | 0.164199667741858 | 0.0196415048405917 | READ | Female-baised eQTL |
| rs77672864 | chr14:25052570:A:G | - | 0.163766814350379 | 0.0217398874901604 | READ | Female-baised eQTL |
| rs77189372 | chr14:25056461:A:G | - | 0.157752244676079 | 0.029057520768783 | READ | Female-baised eQTL |
| rs17185593 | chr14:25057103:A:G | - | 0.157752244676079 | 0.029057520768783 | READ | Female-baised eQTL |
| rs17257808 | chr14:25062399:G:A | - | 0.157752244676079 | 0.029057520768783 | READ | Female-baised eQTL |
| rs77285092 | chr14:25064000:A:C | - | 0.157752244676079 | 0.029057520768783 | READ | Female-baised eQTL |
| rs80217454 | chr14:25070328:C:G | - | 0.157752244676079 | 0.029057520768783 | READ | Female-baised eQTL |
| rs77362971 | chr14:25072276:C:G | - | 0.157752244676079 | 0.029057520768783 | READ | Female-baised eQTL |
| rs1952504 | chr14:25090982:G:T | - | 0.180110607841306 | 0.0296934187939036 | READ | Female-baised eQTL |
| rs112934577 | chr14:25091466:A:G | - | 0.180110607841306 | 0.0296934187939036 | READ | Female-baised eQTL |
| rs78954888 | chr14:25091496:G:A | - | 0.180110607841306 | 0.0296934187939036 | READ | Female-baised eQTL |
| rs80020731 | chr14:25091503:A:T | - | 0.180110607841306 | 0.0296934187939036 | READ | Female-baised eQTL |
| rs77040052 | chr14:25091650:T:C | - | 0.180110607841306 | 0.0296934187939036 | READ | Female-baised eQTL |
| rs1958389 | chr14:25092439:A:G | - | 0.180110607841306 | 0.0296934187939036 | READ | Female-baised eQTL |
| rs113922971 | chr14:22243893:C:T | - | 0.136791101247666 | 0.0347399382068042 | STAD | Female-baised eQTL |
| rs113054511 | chr14:20613481:G:A | - | 0.112697667889092 | 0.00358322851772605 | KIRC | Female-baised eQTL |
| rs112692801 | chr14:20613484:A:G | - | 0.109507813604096 | 0.00533312959973917 | KIRC | Female-baised eQTL |
| rs1270808 | chr14:20613473:G:A | - | 0.10728053204755 | 0.00673933485343358 | KIRC | Female-baised eQTL |
| rs7157450 | chr14:30379946:T:C | - | 0.0966499780074557 | 0.0140976447244007 | KIRC | Female-baised eQTL |
| rs10148093 | chr14:30381596:T:C | - | 0.0746671563758787 | 0.036489978147604 | KIRC | Female-baised eQTL |
| rs10136085 | chr14:30381645:G:A | - | 0.0746671563758787 | 0.036489978147604 | KIRC | Female-baised eQTL |
| rs73600941 | chr14:24659197:C:G | - | 0.103688085751033 | 0.0366740400149287 | KIRC | Female-baised eQTL |
| rs17560052 | chr14:29158612:A:T | - | 0.0545421317015817 | 0.043508264808767 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs78981500 | chr14:26070397:A:T | - | 0.126569862289205 | 0.0269485392392886 | SARC | Male-baised eQTL |
| rs28693910 | chr14:26069418:A:G | - | 0.121987500566969 | 0.0395540757853467 | SARC | Male-baised eQTL |
| rs10140182 | chr14:26069304:G:A | - | 0.121543720177464 | 0.0407316323690883 | SARC | Male-baised eQTL |
| rs12432888 | chr14:26069712:T:C | - | 0.121543720177464 | 0.0407316323690883 | SARC | Male-baised eQTL |
| rs72688481 | chr14:22254136:G:C | - | 0.061577888406339 | 0.000380657282897374 | LGG | Male-baised eQTL |
| rs72688480 | chr14:22250356:T:C | - | 0.0536147485197561 | 0.0011693133460835 | LGG | Male-baised eQTL |
| rs17115771 | chr14:22251836:G:C | - | 0.053098560057406 | 0.00147983716225433 | LGG | Male-baised eQTL |
| rs55886817 | chr14:22251371:C:T | - | 0.0520150815600376 | 0.00193457652229864 | LGG | Male-baised eQTL |
| rs56083522 | chr14:22251442:G:A | - | 0.0520150815600376 | 0.00193457652229864 | LGG | Male-baised eQTL |
| rs7148749 | chr14:22248267:G:A | - | 0.0481791753344837 | 0.00307536318205988 | LGG | Male-baised eQTL |
| rs10135281 | chr14:22248721:A:G | - | 0.0481318178431178 | 0.00311581157588737 | LGG | Male-baised eQTL |
| rs10135499 | chr14:22248907:A:G | - | 0.0481318178431178 | 0.00311581157588737 | LGG | Male-baised eQTL |
| rs6572331 | chr14:22246958:G:A | - | 0.0467568285550212 | 0.00478524746014817 | LGG | Male-baised eQTL |
| rs17115728 | chr14:22247467:C:G | - | 0.0457355138200134 | 0.0055905320618949 | LGG | Male-baised eQTL |
| rs6572330 | chr14:22246943:C:T | - | 0.0459551782712289 | 0.00581676690800353 | LGG | Male-baised eQTL |
| rs6572336 | chr14:22247834:T:C | - | 0.0459551782712289 | 0.00581676690800353 | LGG | Male-baised eQTL |
| rs72688484 | chr14:22267108:T:C | - | 0.0473627952448849 | 0.0124902948077509 | LGG | Male-baised eQTL |
| rs142909881 | chr14:22259208:C:T | - | 0.0470990885415062 | 0.0135601968047748 | LGG | Male-baised eQTL |
| rs1951184 | chr14:32391562:G:A | - | -0.0718058972460989 | 0.000597839010985783 | BLCA | Male-baised eQTL |
| rs1951182 | chr14:32391477:T:C | - | -0.070758490425505 | 0.00068994466085264 | BLCA | Male-baised eQTL |
| rs2031106 | chr14:32392503:A:G | - | -0.0697016388839202 | 0.000901539619281347 | BLCA | Male-baised eQTL |
| rs2025261 | chr14:32392891:C:T | - | -0.0636724485448094 | 0.00281819873262468 | BLCA | Male-baised eQTL |
| rs1805261 | chr14:32397948:T:A | - | -0.0593257262069561 | 0.0119087334557129 | BLCA | Male-baised eQTL |
| rs6572346 | chr14:22266389:G:A | - | 0.0871688667120122 | 0.0222042074969038 | COAD | Male-baised eQTL |
| rs4982597 | chr14:22267065:C:T | - | 0.0924190690975489 | 0.0321632179841022 | COAD | Male-baised eQTL |
| rs61974560 | chr14:22267406:C:A | - | 0.0882956636777968 | 0.0354419228752043 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000092068 |
| CpG Site: cg23168192 | |
| Position to Gene: gene | |
| Male Effect: -0.226178020877793 | |
| Female Effect: - | |
 | Gene ID: ENSG00000092068 |
| CpG Site: cg15527515 | |
| Position to Gene: gene | |
| Male Effect: -0.32374278041754 | |
| Female Effect: - | |
 | Gene ID: ENSG00000092068 |
| CpG Site: cg05357695 | |
| Position to Gene: gene,exon,UTR | |
| Male Effect: -0.482356918221457 | |
| Female Effect: - | |
 | Gene ID: ENSG00000092068 |
| CpG Site: cg19473656 | |
| Position to Gene: gene | |
| Male Effect: -0.131306503932869 | |
| Female Effect: - | |
 | Gene ID: ENSG00000092068 |
| CpG Site: cg23543481 | |
| Position to Gene: gene | |
| Male Effect: -0.131306503932869 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg23168192 | chr14:23155579 | gene | -0.226178020877793 | 6.75709566791572e-13 | -0.708607393219278 | 3.286822341717987e-16 | PAAD |
| cg15527515 | chr14:23161500 | gene | -0.32374278041754 | 1.74307753219824e-11 | -0.48538377386223824 | 1.3936674324506628e-14 | LUAD |
| cg05357695 | chr14:23154271 | gene,exon,UTR | -0.482356918221457 | 8.1993004990096e-84 | -0.8591973207567297 | 1.6288104277286335e-85 | LGG |
| cg19473656 | chr14:23154454 | gene | -0.131306503932869 | 1.31801090348338e-14 | -0.46975561360714296 | 2.868050863459598e-17 | LGG |
| cg23543481 | chr14:23154475 | gene | -0.131306503932869 | 1.31801090348338e-14 | -0.46975561360714296 | 2.868050863459598e-17 | LGG |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of SLC7A8 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000092068 | SLC7A8 | C0014175 | Endometriosis | 1 | CTD_human |
| ENSG00000092068 | SLC7A8 | C0269102 | Endometrioma | 1 | CTD_human |
