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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000091831

Summary for ESR1

check button Gene summary

Gene informationEnsembl ID

ENSG00000091831

Gene symbol

ESR1

Gene nameestrogen receptor 1
HGNC

3467

Entrez ID

2099

Gene typeprotein_coding
SynonymsESR1|NR3A1|Era|ER-alpha
UniProtAcc

P03372


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type
ENSG00000091831ESR1DB00255DiethylstilbestrolSmallMoleculeDrug
ENSG00000091831ESR1DB00269ChlorotrianiseneSmallMoleculeDrug
ENSG00000091831ESR1DB00286Conjugated estrogensSmallMoleculeDrug
ENSG00000091831ESR1DB00304DesogestrelSmallMoleculeDrug
ENSG00000091831ESR1DB00367LevonorgestrelSmallMoleculeDrug
ENSG00000091831ESR1DB00396ProgesteroneSmallMoleculeDrug
ENSG00000091831ESR1DB00431LindaneSmallMoleculeDrug
ENSG00000091831ESR1DB00481RaloxifeneSmallMoleculeDrug
ENSG00000091831ESR1DB00539ToremifeneSmallMoleculeDrug
ENSG00000091831ESR1DB00603Medroxyprogesterone acetateSmallMoleculeDrug
ENSG00000091831ESR1DB00624TestosteroneSmallMoleculeDrug
ENSG00000091831ESR1DB00648MitotaneSmallMoleculeDrug
ENSG00000091831ESR1DB00655EstroneSmallMoleculeDrug
ENSG00000091831ESR1DB00675TamoxifenSmallMoleculeDrug
ENSG00000091831ESR1DB00756HexachloropheneSmallMoleculeDrug
ENSG00000091831ESR1DB00783EstradiolSmallMoleculeDrug
ENSG00000091831ESR1DB00823Ethynodiol diacetateSmallMoleculeDrug
ENSG00000091831ESR1DB00841DobutamineSmallMoleculeDrug
ENSG00000091831ESR1DB00882ClomifeneSmallMoleculeDrug
ENSG00000091831ESR1DB00890DienestrolSmallMoleculeDrug
ENSG00000091831ESR1DB00947FulvestrantSmallMoleculeDrug
ENSG00000091831ESR1DB00957NorgestimateSmallMoleculeDrug
ENSG00000091831ESR1DB00977EthinylestradiolSmallMoleculeDrug
ENSG00000091831ESR1DB01065MelatoninSmallMoleculeDrug
ENSG00000091831ESR1DB01108TrilostaneSmallMoleculeDrug
ENSG00000091831ESR1DB01183NaloxoneSmallMoleculeDrug
ENSG00000091831ESR1DB01185FluoxymesteroneSmallMoleculeDrug
ENSG00000091831ESR1DB01196EstramustineSmallMoleculeDrug
ENSG00000091831ESR1DB01357MestranolSmallMoleculeDrug
ENSG00000091831ESR1DB01406DanazolSmallMoleculeDrug
ENSG00000091831ESR1DB01428OxybenzoneSmallMoleculeDrug
ENSG00000091831ESR1DB01431AllylestrenolSmallMoleculeDrug
ENSG00000091831ESR1DB01593ZincSmallMoleculeDrug
ENSG00000091831ESR1DB01645GenisteinSmallMoleculeDrug
ENSG00000091831ESR1DB01708PrasteroneSmallMoleculeDrug
ENSG00000091831ESR1DB01878BenzophenoneSmallMoleculeDrug
ENSG00000091831ESR1DB02187EquilinSmallMoleculeDrug
ENSG00000091831ESR1DB02615Compound 19SmallMoleculeDrug
ENSG00000091831ESR1DB02709ResveratrolSmallMoleculeDrug
ENSG00000091831ESR1DB02715Compound 18SmallMoleculeDrug
ENSG00000091831ESR1DB02746Phthalic AcidSmallMoleculeDrug
ENSG00000091831ESR1DB02757PyrazoleSmallMoleculeDrug
ENSG00000091831ESR1DB02901StanoloneSmallMoleculeDrug
ENSG00000091831ESR1DB03467NaringeninSmallMoleculeDrug
ENSG00000091831ESR1DB03742Compound 4-DSmallMoleculeDrug
ENSG00000091831ESR1DB038021-[4-(Octahydro-Pyrido[1,2-a]Pyrazin-2-Yl)-Phenyl]-2-Phenyl-1,2,3,4-Tetrahydro-Isoquinolin-6-OlSmallMoleculeDrug
ENSG00000091831ESR1DB04216QuercetinSmallMoleculeDrug
ENSG00000091831ESR1DB04468AfimoxifeneSmallMoleculeDrug
ENSG00000091831ESR1DB044712-Phenyl-1-[4-(2-Piperidin-1-Yl-Ethoxy)-Phenyl]-1,2,3,4-Tetrahydro-Isoquinolin-6-OlSmallMoleculeDrug
ENSG00000091831ESR1DB04573EstriolSmallMoleculeDrug
ENSG00000091831ESR1DB04574Estrone sulfateSmallMoleculeDrug
ENSG00000091831ESR1DB04575QuinestrolSmallMoleculeDrug
ENSG00000091831ESR1DB04824PhenolphthaleinSmallMoleculeDrug
ENSG00000091831ESR1DB04930PermethrinSmallMoleculeDrug
ENSG00000091831ESR1DB04938OspemifeneSmallMoleculeDrug
ENSG00000091831ESR1DB05233AP1081SmallMoleculeDrug
ENSG00000091831ESR1DB05487CustirsenSmallMoleculeDrug
ENSG00000091831ESR1DB05662NP-50301SmallMoleculeDrug
ENSG00000091831ESR1DB05882CHF 4227SmallMoleculeDrug
ENSG00000091831ESR1DB05966TAS-108SmallMoleculeDrug
ENSG00000091831ESR1DB06202LasofoxifeneSmallMoleculeDrug
ENSG00000091831ESR1DB06249ArzoxifeneSmallMoleculeDrug
ENSG00000091831ESR1DB06374ElacestrantSmallMoleculeDrug
ENSG00000091831ESR1DB06401BazedoxifeneSmallMoleculeDrug
ENSG00000091831ESR1DB06710MethyltestosteroneSmallMoleculeDrug
ENSG00000091831ESR1DB06732beta-NaphthoflavoneSmallMoleculeDrug
ENSG00000091831ESR1DB0687117-METHYL-17-ALPHA-DIHYDROEQUILENINSmallMoleculeDrug
ENSG00000091831ESR1DB068984-(2-amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenolSmallMoleculeDrug
ENSG00000091831ESR1DB06927[5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILESmallMoleculeDrug
ENSG00000091831ESR1DB070864-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOLSmallMoleculeDrug
ENSG00000091831ESR1DB070874-[(1S,2S,5S,9R)-5-(HYDROXYMETHYL)-8,9-DIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOLSmallMoleculeDrug
ENSG00000091831ESR1DB071954-[(1S,2S,5S)-5-(HYDROXYMETHYL)-6,8,9-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOLSmallMoleculeDrug
ENSG00000091831ESR1DB07567(2R,3R,4S)-3-(4-HYDROXYPHENYL)-4-METHYL-2-[4-(2-PYRROLIDIN-1-YLETHOXY)PHENYL]CHROMAN-6-OLSmallMoleculeDrug
ENSG00000091831ESR1DB07638(3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OLSmallMoleculeDrug
ENSG00000091831ESR1DB07678(9ALPHA,13BETA,17BETA)-2-[(1Z)-BUT-1-EN-1-YL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOLSmallMoleculeDrug
ENSG00000091831ESR1DB07707(9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOLSmallMoleculeDrug
ENSG00000091831ESR1DB077083-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OLSmallMoleculeDrug
ENSG00000091831ESR1DB077123-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OLSmallMoleculeDrug
ENSG00000091831ESR1DB07931HexestrolSmallMoleculeDrug
ENSG00000091831ESR1DB07932dimethyl (1R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylateSmallMoleculeDrug
ENSG00000091831ESR1DB07933ErteberelSmallMoleculeDrug
ENSG00000091831ESR1DB07991N-[(1R)-3-(4-HYDROXYPHENYL)-1-METHYLPROPYL]-2-(2-PHENYL-1H-INDOL-3-YL)ACETAMIDESmallMoleculeDrug
ENSG00000091831ESR1DB08020(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OLSmallMoleculeDrug
ENSG00000091831ESR1DB080474-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diolSmallMoleculeDrug
ENSG00000091831ESR1DB080484-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOLSmallMoleculeDrug
ENSG00000091831ESR1DB08320DIETHYL (1R,2S,3R,4S)-5,6-BIS(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLATESmallMoleculeDrug
ENSG00000091831ESR1DB083982-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridineSmallMoleculeDrug
ENSG00000091831ESR1DB085954-[(1S,2R,5S)-4,4,8-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOLSmallMoleculeDrug
ENSG00000091831ESR1DB08737(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-9-OLSmallMoleculeDrug
ENSG00000091831ESR1DB087732-(4-hydroxyphenyl)benzo[b]thiophen-6-olSmallMoleculeDrug
ENSG00000091831ESR1DB09070TiboloneSmallMoleculeDrug
ENSG00000091831ESR1DB09086EugenolSmallMoleculeDrug
ENSG00000091831ESR1DB09317Synthetic Conjugated Estrogens, ASmallMoleculeDrug
ENSG00000091831ESR1DB09318Synthetic Conjugated Estrogens, BSmallMoleculeDrug
ENSG00000091831ESR1DB09369Polyestradiol phosphateSmallMoleculeDrug
ENSG00000091831ESR1DB09371NorethynodrelSmallMoleculeDrug
ENSG00000091831ESR1DB09535OctocryleneSmallMoleculeDrug
ENSG00000091831ESR1DB11064HomosalateSmallMoleculeDrug
ENSG00000091831ESR1DB11219EnzacameneSmallMoleculeDrug
ENSG00000091831ESR1DB11478ZeranolSmallMoleculeDrug
ENSG00000091831ESR1DB11541RactopamineSmallMoleculeDrug
ENSG00000091831ESR1DB11619GestrinoneSmallMoleculeDrug
ENSG00000091831ESR1DB12235EstetrolSmallMoleculeDrug
ENSG00000091831ESR1DB12450Propyl GallateSmallMoleculeDrug
ENSG00000091831ESR1DB138692-Methoxy-6-{(E)-[(4-methylphenyl)imino]methyl}phenolSmallMoleculeDrug
ENSG00000091831ESR1DB13943Testosterone cypionateSmallMoleculeDrug
ENSG00000091831ESR1DB13944Testosterone enanthateSmallMoleculeDrug
ENSG00000091831ESR1DB13946Testosterone undecanoateSmallMoleculeDrug
ENSG00000091831ESR1DB13951Stanolone acetateSmallMoleculeDrug
ENSG00000091831ESR1DB13952Estradiol acetateSmallMoleculeDrug
ENSG00000091831ESR1DB13953Estradiol benzoateSmallMoleculeDrug
ENSG00000091831ESR1DB13954Estradiol cypionateSmallMoleculeDrug
ENSG00000091831ESR1DB13955Estradiol dienanthateSmallMoleculeDrug
ENSG00000091831ESR1DB13956Estradiol valerateSmallMoleculeDrug
ENSG00000091831ESR1DB14487Zinc acetateSmallMoleculeDrug
ENSG00000091831ESR1DB14533Zinc chlorideSmallMoleculeDrug
ENSG00000091831ESR1DB14548Zinc sulfate, unspecified formSmallMoleculeDrug
ENSG00000091831ESR1DB14641Estriol tripropionateSmallMoleculeDrug
ENSG00000091831ESR1DB15690Fluoroestradiol F-18SmallMoleculeDrug

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer
ENSG00000091831ESR1DB00481RaloxifeneSmallMoleculeDrugPrevent Breast Cancer
ENSG00000091831ESR1DB00539ToremifeneSmallMoleculeDrugTreat Breast Cancer
ENSG00000091831ESR1DB00675TamoxifenSmallMoleculeDrugPrevent Breast Cancer,Treat Breast Cancer
ENSG00000091831ESR1DB00947FulvestrantSmallMoleculeDrugTreat Breast Cancer

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Structure and expression level for ESR1

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
ESR11.62e+03-3.13e+002.61e-01-1.20e+015.38e-337.98e-30SARC

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
ESR11.84e+031.37e+004.28e-013.20e+001.39e-033.67e-03THCA

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
ESR17.20e+021.03e+002.78e-013.69e+002.25e-044.82e-04LUAD
ESR12.91e+041.66e+001.89e-018.79e+001.46e-184.66e-18BRCA

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Sex-biased somatic mutation for ESR1

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for ESR1

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta

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Exon skipping events with PSI in TCGA for ESR1

∗Please access ExonSkipDB for exon skipping annotation.
check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

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RNA A-to-I editing events in TCGA for ESR1

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for ESR1

check buttonTFs related to ESR1.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
TF Gene
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
DLBCZNF235ESR14.22e+009.86e-013.07e+003.14e-03Male-biased
DLBCZNF287ESR14.17e+009.85e-013.01e+003.02e-03Male-biased

check buttonESR1 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.
related_gene

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Sex-biased RBP-ES network for ESR1

check buttonRBPs related to ES in ESR1.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType

check buttonESR1 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type
ENSG00000091831CCDC18-AS1,hsa-mir-301a,ESR1Female-specific ceRNATCGA-KICH
ENSG00000091831AC025569.1,hsa-mir-301a,ESR1Female-specific ceRNATCGA-KICH
ENSG00000091831PCAT19,hsa-mir-372,ESR1Female-specific ceRNATCGA-KICH
ENSG00000091831AL357140.2,hsa-mir-372,ESR1Female-specific ceRNATCGA-KICH
ENSG00000091831CCDC18-AS1,hsa-mir-372,ESR1Female-specific ceRNATCGA-KICH
ENSG00000091831AGAP11,hsa-mir-372,ESR1Female-specific ceRNATCGA-KICH
ENSG00000091831HAND2-AS1,hsa-mir-206,ESR1Tumor sex-biased ceRNATCGA-SARC
ENSG00000091831AL162584.1,hsa-mir-211,ESR1Tumor sex-biased ceRNATCGA-SARC
ENSG00000091831LINC02728,hsa-mir-211,ESR1Tumor sex-biased ceRNATCGA-SARC
ENSG00000091831AC103925.1,hsa-mir-211,ESR1Tumor sex-biased ceRNATCGA-SARC
ENSG00000091831LINC00298,hsa-mir-211,ESR1Tumor sex-biased ceRNATCGA-SARC
ENSG00000091831XIST,hsa-mir-211,ESR1Tumor sex-biased ceRNATCGA-SARC

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of ESR1

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource
ENSG00000091831ESR1C0001418Adenocarcinoma2CTD_human
ENSG00000091831ESR1C0002395Alzheimer's Disease1CTD_human
ENSG00000091831ESR1C0004114Astrocytoma1CTD_human
ENSG00000091831ESR1C0004153Atherosclerosis1CTD_human
ENSG00000091831ESR1C0005586Bipolar Disorder5PSYGENET
ENSG00000091831ESR1C0005684Malignant neoplasm of urinary bladder1CTD_human
ENSG00000091831ESR1C0005695Bladder Neoplasm1CTD_human
ENSG00000091831ESR1C0005940Bone Diseases1CTD_human
ENSG00000091831ESR1C0005944Metabolic Bone Disorder1CTD_human
ENSG00000091831ESR1C0006142Malignant neoplasm of breast14CTD_human
ENSG00000091831ESR1C0007097Carcinoma2CTD_human
ENSG00000091831ESR1C0007621Neoplastic Cell Transformation2CTD_human
ENSG00000091831ESR1C0007852Cervical Migraine Syndrome1CTD_human
ENSG00000091831ESR1C0010054Coronary Arteriosclerosis2CTD_human
ENSG00000091831ESR1C0011265Presenile dementia1CTD_human
ENSG00000091831ESR1C0011570Mental Depression5PSYGENET
ENSG00000091831ESR1C0011581Depressive disorder5PSYGENET
ENSG00000091831ESR1C0014170Endometrial Neoplasms1CTD_human
ENSG00000091831ESR1C0017658Glomerulonephritis1CTD_human
ENSG00000091831ESR1C0018984Hemicrania migraine1CTD_human
ENSG00000091831ESR1C0021361Female infertility1CTD_human
ENSG00000091831ESR1C0021364Male infertility2CTD_human
ENSG00000091831ESR1C0023267Fibroid Tumor1CTD_human
ENSG00000091831ESR1C0023418leukemia1CTD_human
ENSG00000091831ESR1C0023903Liver neoplasms1CTD_human
ENSG00000091831ESR1C0024121Lung Neoplasms2CTD_human
ENSG00000091831ESR1C0024667Animal Mammary Neoplasms2CTD_human
ENSG00000091831ESR1C0024668Mammary Neoplasms, Experimental1CTD_human
ENSG00000091831ESR1C0024809Marijuana Abuse1PSYGENET
ENSG00000091831ESR1C0025500Mesothelioma2CTD_human
ENSG00000091831ESR1C0026858Musculoskeletal Pain1CTD_human
ENSG00000091831ESR1C0027051Myocardial Infarction1CTD_human
ENSG00000091831ESR1C0027626Neoplasm Invasiveness2CTD_human
ENSG00000091831ESR1C0027627Neoplasm Metastasis1CTD_human
ENSG00000091831ESR1C0027643Neoplasm Recurrence, Local1CTD_human
ENSG00000091831ESR1C0027819Neuroblastoma1CTD_human
ENSG00000091831ESR1C0028754Obesity1CTD_human
ENSG00000091831ESR1C0028960Oligospermia1CTD_human
ENSG00000091831ESR1C0029453Osteopenia1CTD_human
ENSG00000091831ESR1C0033578Prostatic Neoplasms2CTD_human
ENSG00000091831ESR1C0033937Psychoses, Drug1CTD_human
ENSG00000091831ESR1C0033941Psychoses, Substance-Induced1CTD_human
ENSG00000091831ESR1C0036341Schizophrenia5PSYGENET
ENSG00000091831ESR1C0036939Shared Paranoid Disorder1PSYGENET
ENSG00000091831ESR1C0038279Sterility, Postpartum1CTD_human
ENSG00000091831ESR1C0042133Uterine Fibroids1CTD_human
ENSG00000091831ESR1C0149931Migraine Disorders1CTD_human
ENSG00000091831ESR1C0205641Adenocarcinoma, Basal Cell2CTD_human
ENSG00000091831ESR1C0205642Adenocarcinoma, Oxyphilic2CTD_human
ENSG00000091831ESR1C0205643Carcinoma, Cribriform2CTD_human
ENSG00000091831ESR1C0205644Carcinoma, Granular Cell2CTD_human
ENSG00000091831ESR1C0205645Adenocarcinoma, Tubular2CTD_human
ENSG00000091831ESR1C0205696Anaplastic carcinoma2CTD_human
ENSG00000091831ESR1C0205697Carcinoma, Spindle-Cell2CTD_human
ENSG00000091831ESR1C0205698Undifferentiated carcinoma2CTD_human
ENSG00000091831ESR1C0205699Carcinomatosis2CTD_human
ENSG00000091831ESR1C0205768Subependymal Giant Cell Astrocytoma1CTD_human
ENSG00000091831ESR1C0235874Disease Exacerbation1CTD_human
ENSG00000091831ESR1C0242379Malignant neoplasm of lung2CTD_human
ENSG00000091831ESR1C0270858Abdominal Migraine1CTD_human
ENSG00000091831ESR1C0276496Familial Alzheimer Disease (FAD)1CTD_human
ENSG00000091831ESR1C0280783Juvenile Pilocytic Astrocytoma1CTD_human
ENSG00000091831ESR1C0280785Diffuse Astrocytoma1CTD_human
ENSG00000091831ESR1C0282612Prostatic Intraepithelial Neoplasias1CTD_human
ENSG00000091831ESR1C0334579Anaplastic astrocytoma1CTD_human
ENSG00000091831ESR1C0334580Protoplasmic astrocytoma1CTD_human
ENSG00000091831ESR1C0334581Gemistocytic astrocytoma1CTD_human
ENSG00000091831ESR1C0334582Fibrillary Astrocytoma1CTD_human
ENSG00000091831ESR1C0334583Pilocytic Astrocytoma1CTD_human
ENSG00000091831ESR1C0338070Childhood Cerebral Astrocytoma1CTD_human
ENSG00000091831ESR1C0338489Status Migrainosus1CTD_human
ENSG00000091831ESR1C0341869Subfertility, Female1CTD_human
ENSG00000091831ESR1C0345904Malignant neoplasm of liver1CTD_human
ENSG00000091831ESR1C0376358Malignant neoplasm of prostate2CTD_human
ENSG00000091831ESR1C0476089Endometrial Carcinoma1CTD_human
ENSG00000091831ESR1C0494463Alzheimer Disease, Late Onset1CTD_human
ENSG00000091831ESR1C0521664Acute Confusional Migraine1CTD_human
ENSG00000091831ESR1C0525045Mood Disorders4PSYGENET
ENSG00000091831ESR1C0546126Acute Confusional Senile Dementia1CTD_human
ENSG00000091831ESR1C0547065Mixed oligoastrocytoma1CTD_human
ENSG00000091831ESR1C0678222Breast Carcinoma14CTD_human
ENSG00000091831ESR1C0700438Sick Headaches1CTD_human
ENSG00000091831ESR1C0750900Alzheimer's Disease, Focal Onset1CTD_human
ENSG00000091831ESR1C0750901Alzheimer Disease, Early Onset1CTD_human
ENSG00000091831ESR1C0750935Cerebral Astrocytoma1CTD_human
ENSG00000091831ESR1C0750936Intracranial Astrocytoma1CTD_human
ENSG00000091831ESR1C0848676Subfertility, Male2CTD_human
ENSG00000091831ESR1C0917730Female sterility1CTD_human
ENSG00000091831ESR1C0917731Male sterility2CTD_human
ENSG00000091831ESR1C1257925Mammary Carcinoma, Animal2CTD_human
ENSG00000091831ESR1C1257931Mammary Neoplasms, Human14CTD_human
ENSG00000091831ESR1C1458155Mammary Neoplasms14CTD_human
ENSG00000091831ESR1C1563937Atherogenesis1CTD_human
ENSG00000091831ESR1C1704230Grade I Astrocytoma1CTD_human
ENSG00000091831ESR1C1704377Bright Disease1CTD_human
ENSG00000091831ESR1C1720887Female Urogenital Diseases1CTD_human
ENSG00000091831ESR1C1800706Idiopathic Pulmonary Fibrosis1CTD_human
ENSG00000091831ESR1C1956346Coronary Artery Disease2CTD_human
ENSG00000091831ESR1C2239176Liver carcinoma2CTD_human
ENSG00000091831ESR1C3887485MIGRAINE WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 11CTD_human
ENSG00000091831ESR1C4704874Mammary Carcinoma, Human14CTD_human
ENSG00000091831ESR1C4721508Hamman-Rich Disease1CTD_human
ENSG00000091831ESR1C4721509Usual Interstitial Pneumonia1CTD_human
ENSG00000091831ESR1C4721952Familial Idiopathic Pulmonary Fibrosis1CTD_human