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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000091136

Summary for LAMB1

check button Gene summary

Gene informationEnsembl ID

ENSG00000091136

Gene symbol

LAMB1

Gene namelaminin subunit beta 1
HGNC

6486

Entrez ID

3912

Gene typeprotein_coding
SynonymsLAMB1|
UniProtAcc

P07942


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type
ENSG00000091136LAMB1DB06245LanoteplaseBiotechDrug

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

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Structure and expression level for LAMB1

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
LAMB19.48e+031.63e+003.88e-014.20e+002.69e-051.37e-04CHOL

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
LAMB14.09e+031.02e+002.52e-014.04e+005.44e-051.86e-04LIHC

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Sex-biased somatic mutation for LAMB1

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for LAMB1

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg02561733chr7:108003495CGI:chr7:108001350-108003613promoter3.73e-021.44e-01-2.09e+003.64e-024.42e-02-1.06e-01
BRCAcg26087411chr7:108003503CGI:chr7:108001350-108003613promoter5.38e-022.28e-01-2.40e+001.62e-023.22e-02-1.74e-01
BRCAcg17657268chr7:108003511CGI:chr7:108001350-108003613promoter6.11e-022.05e-01-2.24e+002.50e-023.81e-02-1.44e-01
ACCcg00471159chr7:108001351CGI:chr7:108001350-108003613promoter,gene body3.41e-014.95e-01-2.59e+009.59e-032.50e-02-1.54e-01
ACCcg04744624chr7:108001325CGI:chr7:108001350-108003613promoter,gene body4.25e-015.91e-01-2.90e+003.71e-031.41e-02-1.66e-01

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
KIRCcg04744624chr7:108001325CGI:chr7:108001350-108003613promoter,gene body3.80e-012.27e-013.73e+001.94e-043.66e-041.53e-01
KIRCcg00471159chr7:108001351CGI:chr7:108001350-108003613promoter,gene body3.87e-011.98e-013.98e+006.75e-051.45e-041.89e-01
LUSCcg22338567chr7:108001999CGI:chr7:108001350-108003613UTR,promoter,exon,gene body2.51e-011.41e-023.87e+001.08e-047.20e-042.37e-01
LUSCcg06248480chr7:108002008CGI:chr7:108001350-108003613UTR,promoter,exon,gene body2.98e-016.63e-022.84e+004.51e-037.55e-032.32e-01
LUSCcg18181496chr7:108002094CGI:chr7:108001350-108003613promoter,gene body2.98e-011.42e-012.98e+002.91e-035.47e-031.56e-01
BLCAcg00471159chr7:108001351CGI:chr7:108001350-108003613promoter,gene body3.94e-012.32e-011.96e+004.98e-024.98e-021.62e-01
BLCAcg10064162chr7:108003804CGI:chr7:108001350-108003613promoter2.57e-013.81e-01-3.15e+001.65e-033.38e-03-1.23e-01
LIHCcg00471159chr7:108001351CGI:chr7:108001350-108003613promoter,gene body5.37e-014.32e-012.77e+005.64e-037.34e-031.06e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg22338567chr7:108001999CGI:chr7:108001350-108003613UTR,promoter,exon,gene body1.97e-012.54e-028.42e+003.82e-171.64e-161.71e-01
BRCAcg00471159chr7:108001351CGI:chr7:108001350-108003613promoter,gene body6.04e-015.03e-015.97e+002.30e-095.43e-091.01e-01
BRCAcg06248480chr7:108002008CGI:chr7:108001350-108003613UTR,promoter,exon,gene body2.53e-019.80e-026.44e+001.23e-103.20e-101.55e-01
BRCAcg18181496chr7:108002094CGI:chr7:108001350-108003613promoter,gene body3.31e-011.46e-011.04e+012.44e-252.14e-241.85e-01
LUADcg00471159chr7:108001351CGI:chr7:108001350-108003613promoter,gene body5.51e-014.07e-012.92e+003.48e-037.46e-031.44e-01
HNSCcg00471159chr7:108001351CGI:chr7:108001350-108003613promoter,gene body6.17e-014.69e-012.65e+008.13e-031.67e-021.48e-01

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Exon skipping events with PSI in TCGA for LAMB1

∗Please access ExonSkipDB for exon skipping annotation.
check buttonLandscape of exon skipping events across multiple cancer types.
AS event heatmap

check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

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RNA A-to-I editing events in TCGA for LAMB1

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for LAMB1

check buttonTFs related to LAMB1.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
TF Gene
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
DLBCDMRTA1LAMB12.82e+003.45e-033.99e+009.81e-01Female-biased
DLBCFOXO1LAMB13.39e+008.61e-034.33e+009.83e-01Female-biased
DLBCNKX3-1LAMB12.94e+002.02e-034.27e+009.88e-01Female-biased

check buttonLAMB1 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for LAMB1

check buttonRBPs related to ES in LAMB1.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
RBP ES
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
THYMhnRNPKexon_skip_4789379.15e+009.88e-018.81e+007.65e-03Male-biased
COADEIF4Bexon_skip_4789399.97e+001.65e-021.03e+019.82e-01Female-biased
DLBCKHDRBS1exon_skip_4789307.21e+009.80e-016.84e+007.05e-03Male-biased
CHOLEIF4Bexon_skip_4789391.02e+018.29e-031.06e+019.90e-01Female-biased
CHOLSRSF1exon_skip_4789409.08e+009.86e-018.67e+009.12e-03Male-biased
ESCABRUNOL6exon_skip_4789218.14e+003.10e-038.73e+009.92e-01Female-biased
ESCAhnRNPKexon_skip_4789378.68e+001.24e-029.10e+009.84e-01Female-biased
READEIF4Bexon_skip_4789399.94e+001.37e-031.05e+019.97e-01Female-biased
READhnRNPKexon_skip_4789378.73e+005.98e-039.11e+009.90e-01Female-biased
THCAEIF4Bexon_skip_4789391.05e+019.97e-011.00e+011.72e-03Male-biased
MESOBRUNOL6exon_skip_4789218.90e+009.83e-018.56e+001.24e-02Male-biased
MESOEIF4Bexon_skip_4789391.00e+011.49e-031.05e+019.97e-01Female-biased
GBMEIF4Bexon_skip_4789391.00e+012.33e-031.05e+019.96e-01Female-biased
KIRCBRUNOL6exon_skip_4789218.48e+001.06e-028.79e+009.84e-01Female-biased
KICHEIF4Bexon_skip_4789391.04e+019.90e-011.01e+018.29e-03Male-biased
BLCABRUNOL6exon_skip_4789238.80e+009.84e-018.44e+001.02e-02Male-biased
HNSCEIF4Bexon_skip_4789391.01e+011.06e-021.05e+019.88e-01Female-biased

check buttonLAMB1 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs66556278chr7:99290877:A:G-0.2678669171761540.0042955703846611GBMFemale-baised eQTL
rs144663042chr7:99294626:C:T-0.2405504408367210.0184542625693635GBMFemale-baised eQTL
rs10261635chr7:99378863:G:A-0.2222138665711280.0228907958111628GBMFemale-baised eQTL
rs10236240chr7:99379905:A:G-0.2222138665711280.0228907958111628GBMFemale-baised eQTL
rs10268984chr7:99365717:C:T-0.2217393593900350.0242072884001171GBMFemale-baised eQTL
rs4765chr7:99386776:C:T-0.2131701887211060.0433473071971123GBMFemale-baised eQTL
rs11971640chr7:99390430:G:A-0.2131701887211060.0433473071971123GBMFemale-baised eQTL
rs62479802chr7:98170691:A:G-0.1327377125443820.0110897776166187LGGFemale-baised eQTL
rs62479818chr7:98188934:C:G-0.132586670135660.0112228181356923LGGFemale-baised eQTL
rs62479765chr7:98079051:C:G-0.1245479183106040.0192651152690164LGGFemale-baised eQTL
rs75563976chr7:117354262:C:G-0.09611370633040970.0211554310638765LGGFemale-baised eQTL
rs62479799chr7:98152632:A:G-0.1252674076809940.0218768721361668LGGFemale-baised eQTL
rs34343837chr7:101635083:G:A-0.1185546829712590.0282266769185381BLCAFemale-baised eQTL
rs6965163chr7:117830639:C:G--0.1264510693350610.0292083491136734BLCAFemale-baised eQTL
rs2014985chr7:98659630:G:A-0.1135521141649360.0199177850818523COADFemale-baised eQTL
rs113126106chr7:98663051:C:G-0.1132264466144610.0231428609418015COADFemale-baised eQTL
rs41268chr7:105979119:G:A--0.07012533497471240.0423861946832591COADFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs10240841chr7:113550005:G:A-0.3301278320300050.0398344424893558PCPGMale-baised eQTL
rs6949164chr7:112252586:C:T-0.1183343132727270.0240381644280372GBMMale-baised eQTL
rs4730516chr7:112240115:T:A-0.1181316949714060.025341208758979GBMMale-baised eQTL
rs4730517chr7:112240121:T:A-0.1181316949714060.025341208758979GBMMale-baised eQTL
rs3823515chr7:112318284:T:A-0.1110540725232580.0356644393977062GBMMale-baised eQTL
rs60445595chr7:112310711:A:C-0.107880030749460.0452101902946376GBMMale-baised eQTL
rs77574575chr7:102975904:C:T-0.03944580331901220.0492121064272116LGGMale-baised eQTL
rs2396570chr7:112803486:G:T--0.05184852607373060.0440904164937897KIRCMale-baised eQTL
rs12705034chr7:99202349:G:A-0.1061711056470810.00902301067995851COADMale-baised eQTL
rs1404583chr7:109164941:A:T--0.1282561230604880.0103302386904641COADMale-baised eQTL
rs79282338chr7:109180337:C:A--0.1137235587402670.0254327180084204COADMale-baised eQTL
rs10243061chr7:109210912:T:C--0.1079974760827130.0287064847422227COADMale-baised eQTL
rs74606627chr7:109211629:A:C--0.1079974760827130.0287064847422227COADMale-baised eQTL
rs28883916chr7:109213445:T:G--0.1079974760827130.0287064847422227COADMale-baised eQTL
rs28582559chr7:109156938:A:G--0.1177690952495990.0299218356934047COADMale-baised eQTL
rs10231177chr7:109158803:G:T--0.1177690952495990.0299218356934047COADMale-baised eQTL
rs10268318chr7:109160535:A:G--0.1177690952495990.0299218356934047COADMale-baised eQTL
rs1799052chr7:98045889:A:C--0.0926466678403130.0306640335807585COADMale-baised eQTL
rs77970094chr7:109196637:G:C--0.1121186892377020.0316721499622078COADMale-baised eQTL
rs10278149chr7:109199791:T:C--0.1121186892377020.0316721499622078COADMale-baised eQTL
rs9656154chr7:109164560:A:G--0.1163607072984820.0336639952853289COADMale-baised eQTL
rs2030740chr7:109207498:T:C--0.1113247969143520.033775095285467COADMale-baised eQTL
rs10236576chr7:109230512:A:C--0.1122183519490110.0343346735924427COADMale-baised eQTL
rs7802387chr7:109235464:A:G--0.1122183519490110.0343346735924427COADMale-baised eQTL
rs10254806chr7:109169713:G:C--0.113981422048550.0404051407660476COADMale-baised eQTL
rs74665061chr7:109174555:C:G--0.1119280113228160.0406045949859106COADMale-baised eQTL
rs10249919chr7:109175596:A:G--0.1119280113228160.0406045949859106COADMale-baised eQTL
rs28846699chr7:109226182:T:C--0.1092228053689940.0432326718703669COADMale-baised eQTL
rs28850421chr7:109225778:A:G--0.1089758889663290.0443373669096124COADMale-baised eQTL
rs76288722chr7:109241582:T:C--0.109910709616780.0446274404210917COADMale-baised eQTL
rs2188435chr7:109246223:C:T--0.109910709616780.0446274404210917COADMale-baised eQTL
rs10232116chr7:109153760:C:T--0.1125312940187530.0455013226594882COADMale-baised eQTL
rs847564chr7:98053759:T:C--0.08977671746429960.0459114493960802COADMale-baised eQTL
rs10263638chr7:109224747:G:T--0.1084582845200360.0460263765186409COADMale-baised eQTL
rs1405063chr7:109615844:C:G-0.06316106755227450.0488164949456053COADMale-baised eQTL
rs10225255chr7:109222412:A:T--0.1075189394123110.0496075475549845COADMale-baised eQTL
rs1525028chr7:109219566:T:C--0.1075158937926960.0496169848763248COADMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000091136
CpG Site: cg00471159
Position to Gene: gene,promoter
Male Effect: -
Female Effect: -0.145859441975052
eQTM boxplot analysisGene ID: ENSG00000091136
CpG Site: cg09480446
Position to Gene: gene
Male Effect: -0.48583374336803
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000091136
CpG Site: cg04744624
Position to Gene: gene,promoter
Male Effect: -0.48583374336803
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000091136
CpG Site: cg00471159
Position to Gene: gene,promoter
Male Effect: -0.48583374336803
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000091136
CpG Site: cg09803764
Position to Gene: gene,exon,CDS
Male Effect: -0.385945829219951
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000091136
CpG Site: cg13661703
Position to Gene: gene
Male Effect: -0.385945829219951
Female Effect: -

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg09480446chr7:108000490gene-0.485833743368032.92956859945025e-35-0.66424273255586193.7813870102556686e-38LGG
cg04744624chr7:108001325gene,promoter-0.485833743368032.92956859945025e-35-0.66424273255586193.7813870102556686e-38LGG
cg00471159chr7:108001351gene,promoter-0.485833743368032.92956859945025e-35-0.66424273255586193.7813870102556686e-38LGG
cg09803764chr7:107932308gene,exon,CDS-0.3859458292199511.5560711280474e-05-0.30374509912304076.257520869298741e-08BLCA
cg13661703chr7:107995074gene-0.3859458292199511.5560711280474e-05-0.30374509912304076.257520869298741e-08BLCA

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg00471159chr7:108001351gene,promoter-0.1458594419750529.77830709688113e-05-0.322450947837221341.4008567970302242e-07LUAD

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of LAMB1

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource
ENSG00000091136LAMB1C0004352Autistic Disorder1CTD_human
ENSG00000091136LAMB1C0009324Ulcerative Colitis1CTD_human
ENSG00000091136LAMB1C0009363Congenital ocular coloboma (disorder)1CTD_human
ENSG00000091136LAMB1C0014175Endometriosis1CTD_human
ENSG00000091136LAMB1C0034069Pulmonary Fibrosis1CTD_human
ENSG00000091136LAMB1C0266463Lissencephaly1CTD_human
ENSG00000091136LAMB1C0266483Pachygyria1CTD_human
ENSG00000091136LAMB1C0269102Endometrioma1CTD_human
ENSG00000091136LAMB1C1879312Agyria1CTD_human
ENSG00000091136LAMB1C4554007Uveoretinal Coloboma1CTD_human
ENSG00000091136LAMB1C4721507Alveolitis, Fibrosing1CTD_human