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Gene: ENSG00000091129 |
Summary for NRCAM |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000091129 | Gene symbol | NRCAM |
| Gene name | neuronal cell adhesion molecule | |
| HGNC | 7994 | |
| Entrez ID | 4897 | |
| Gene type | protein_coding | |
| Synonyms | NRCAM|KIAA0343|Bravo | |
| UniProtAcc | Q92823 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for NRCAM |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| NRCAM | 5.74e+02 | 1.29e+00 | 2.73e-01 | 4.74e+00 | 2.10e-06 | 4.91e-05 | LIHC |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| NRCAM | 6.18e+02 | 3.34e+00 | 4.93e-01 | 6.76e+00 | 1.39e-11 | 1.72e-10 | LIHC |
| NRCAM | 1.82e+03 | 1.94e+00 | 6.53e-01 | 2.98e+00 | 2.91e-03 | 1.44e-02 | ESCA |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| NRCAM | 3.53e+03 | 1.10e+00 | 4.61e-01 | 2.38e+00 | 1.71e-02 | 2.91e-02 | KICH |
| NRCAM | 8.46e+02 | 1.12e+00 | 1.74e-01 | 6.46e+00 | 1.06e-10 | 2.33e-10 | BRCA |
Top |
Sex-biased somatic mutation for NRCAM |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for NRCAM |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg17583077 | chr7:108456992 | CGI:chr7:108454957-108456714 | promoter | 2.66e-01 | 6.34e-02 | 3.59e+00 | 3.32e-04 | 1.29e-03 | 2.02e-01 |
| LUSC | cg09561125 | chr7:108457033 | CGI:chr7:108454957-108456714 | promoter | 5.78e-01 | 2.83e-01 | 3.95e+00 | 7.75e-05 | 6.33e-04 | 2.95e-01 |
| LUSC | cg15531930 | chr7:108457162 | CGI:chr7:108454957-108456714 | promoter | 3.30e-01 | 1.10e-01 | 3.68e+00 | 2.34e-04 | 1.06e-03 | 2.20e-01 |
| COAD | cg15531930 | chr7:108457162 | CGI:chr7:108454957-108456714 | promoter | 2.42e-01 | 1.12e-01 | 3.89e+00 | 9.88e-05 | 3.47e-04 | 1.30e-01 |
| BLCA | cg17583077 | chr7:108456992 | CGI:chr7:108454957-108456714 | promoter | 1.72e-01 | 6.13e-02 | 2.37e+00 | 1.76e-02 | 2.21e-02 | 1.11e-01 |
| LIHC | cg06292947 | chr7:108455597 | CGI:chr7:108454957-108456714 | promoter,gene body | 1.40e-01 | 2.79e-02 | 3.07e+00 | 2.17e-03 | 3.15e-03 | 1.12e-01 |
| ESCA | cg24188919 | chr7:108456761 | CGI:chr7:108454957-108456714 | promoter | 1.96e-01 | 6.64e-02 | 2.40e+00 | 1.63e-02 | 3.88e-02 | 1.30e-01 |
| ESCA | cg09561125 | chr7:108457033 | CGI:chr7:108454957-108456714 | promoter | 6.69e-01 | 4.74e-01 | 2.20e+00 | 2.75e-02 | 4.30e-02 | 1.96e-01 |
| CHOL | cg09561125 | chr7:108457033 | CGI:chr7:108454957-108456714 | promoter | 6.80e-01 | 4.11e-01 | 2.80e+00 | 5.09e-03 | 1.63e-02 | 2.68e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUAD | cg06570167 | chr7:108455275 | CGI:chr7:108454957-108456714 | promoter,gene body | 1.90e-01 | 2.64e-02 | 2.32e+00 | 2.03e-02 | 2.61e-02 | 1.64e-01 |
| LIHC | cg09561125 | chr7:108457033 | CGI:chr7:108454957-108456714 | promoter | 5.37e-01 | 3.96e-01 | 2.80e+00 | 5.04e-03 | 8.09e-03 | 1.41e-01 |
Top |
Exon skipping events with PSI in TCGA for NRCAM |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for NRCAM |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for NRCAM |
| TFs related to NRCAM. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ACC | ALX1 | NRCAM | 3.20e+00 | 8.78e-03 | 4.06e+00 | 9.80e-01 | Female-biased |
| ACC | ALX3 | NRCAM | 3.82e+00 | 1.23e-02 | 4.61e+00 | 9.83e-01 | Female-biased |
| ACC | ALX4 | NRCAM | 3.81e+00 | 1.38e-02 | 4.57e+00 | 9.81e-01 | Female-biased |
| ACC | DMRT2 | NRCAM | 3.29e+00 | 6.93e-03 | 4.21e+00 | 9.85e-01 | Female-biased |
| ACC | FOXP3 | NRCAM | 3.43e+00 | 1.09e-02 | 4.24e+00 | 9.81e-01 | Female-biased |
| ACC | IRX3 | NRCAM | 3.76e+00 | 1.39e-02 | 4.52e+00 | 9.81e-01 | Female-biased |
| ACC | LHX2 | NRCAM | 3.56e+00 | 9.88e-03 | 4.39e+00 | 9.84e-01 | Female-biased |
| ACC | POU4F3 | NRCAM | 3.01e+00 | 6.64e-03 | 3.94e+00 | 9.80e-01 | Female-biased |
| ACC | PROP1 | NRCAM | 3.81e+00 | 1.36e-02 | 4.57e+00 | 9.82e-01 | Female-biased |
| ACC | SOX5 | NRCAM | 3.55e+00 | 1.09e-02 | 4.36e+00 | 9.83e-01 | Female-biased |
| MESO | ARGFX | NRCAM | 4.58e+00 | 9.81e-01 | 3.45e+00 | 1.27e-02 | Male-biased |
| MESO | DMRT2 | NRCAM | 4.18e+00 | 9.82e-01 | 2.86e+00 | 6.65e-03 | Male-biased |
| MESO | LHX2 | NRCAM | 4.54e+00 | 9.83e-01 | 3.35e+00 | 1.06e-02 | Male-biased |
| NRCAM related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for NRCAM |
| RBPs related to ES in NRCAM. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| NRCAM related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000091129 | HEXD-IT1,hsa-mir-150,NRCAM | Female-specific ceRNA | TCGA-KICH |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs10277164 | chr7:109339142:G:A | - | 0.212732418052328 | 0.0122765173754507 | PAAD | Female-baised eQTL |
| rs12113350 | chr7:109346524:T:C | - | 0.213862681183698 | 0.0152320039511624 | PAAD | Female-baised eQTL |
| rs45498702 | chr7:116525179:C:T | - | 0.224415010609955 | 0.0304482176156331 | HNSC | Female-baised eQTL |
| rs10953671 | chr7:110945251:A:C | - | 0.373599848599522 | 0.0397956610012489 | GBM | Female-baised eQTL |
| rs10249084 | chr7:110941109:T:A | - | 0.412672820151075 | 0.0425204417877962 | GBM | Female-baised eQTL |
| rs10252294 | chr7:110950509:C:G | - | 0.412672820151075 | 0.0425204417877962 | GBM | Female-baised eQTL |
| rs9656179 | chr7:110957082:C:A | - | 0.412672820151075 | 0.0425204417877962 | GBM | Female-baised eQTL |
| rs1069358 | chr7:109690026:G:T | - | -0.195454191377261 | 0.0476792618836135 | GBM | Female-baised eQTL |
| rs1069366 | chr7:109691561:T:A | - | -0.195454191377261 | 0.0476792618836135 | GBM | Female-baised eQTL |
| rs11972123 | chr7:106193228:T:C | - | 0.13112240362264 | 0.0241075630584137 | BLCA | Female-baised eQTL |
| rs176528 | chr7:106158130:C:T | - | 0.131596852954867 | 0.025810772040845 | BLCA | Female-baised eQTL |
| rs28718141 | chr7:113661878:C:T | - | 0.230021942324917 | 0.0282242177460903 | BLCA | Female-baised eQTL |
| rs12668146 | chr7:113684595:G:A | - | 0.143507419954114 | 0.0290525026234676 | BLCA | Female-baised eQTL |
| rs75093721 | chr7:113667731:A:T | - | 0.143333722968253 | 0.0301340492994854 | BLCA | Female-baised eQTL |
| rs76066346 | chr7:113667830:C:A | - | 0.143333722968253 | 0.0301340492994854 | BLCA | Female-baised eQTL |
| rs55684545 | chr7:106152020:A:T | - | 0.128437316334935 | 0.0343608903279745 | BLCA | Female-baised eQTL |
| rs176520 | chr7:106152681:C:T | - | 0.127675539462169 | 0.0392879885907255 | BLCA | Female-baised eQTL |
| rs176521 | chr7:106153411:G:A | - | 0.127675539462169 | 0.0392879885907255 | BLCA | Female-baised eQTL |
| rs176522 | chr7:106154317:A:G | - | 0.127675539462169 | 0.0392879885907255 | BLCA | Female-baised eQTL |
| rs993262 | chr7:104515703:C:T | - | 0.210604688377583 | 0.0459783564307735 | BLCA | Female-baised eQTL |
| rs17152734 | chr7:106190315:G:A | - | 0.121541987292 | 0.047224702915752 | BLCA | Female-baised eQTL |
| rs11768663 | chr7:106167708:G:A | - | 0.124093552144288 | 0.0477937709717303 | BLCA | Female-baised eQTL |
| rs11973208 | chr7:106168173:A:G | - | 0.124093552144288 | 0.0477937709717303 | BLCA | Female-baised eQTL |
| rs73186454 | chr7:106169596:T:A | - | 0.12401906786917 | 0.049442241108307 | BLCA | Female-baised eQTL |
| rs17152694 | chr7:106170407:G:A | - | 0.12401906786917 | 0.049442241108307 | BLCA | Female-baised eQTL |
| rs995310 | chr7:108449706:T:C | gene | 0.0372343302777093 | 0.020177616284872 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs151178749 | chr7:113370744:C:T | - | 0.0719168883723277 | 0.0183700535481735 | LUAD | Male-baised eQTL |
| rs74662364 | chr7:113372083:T:G | - | 0.0718250513629314 | 0.0187610517005901 | LUAD | Male-baised eQTL |
| rs182492418 | chr7:113336914:T:A | - | 0.0701370315188311 | 0.0220754321117282 | LUAD | Male-baised eQTL |
| rs76227020 | chr7:113339195:C:T | - | 0.0701370315188311 | 0.0220754321117282 | LUAD | Male-baised eQTL |
| rs7789778 | chr7:113341530:T:C | - | 0.0701370315188311 | 0.0220754321117282 | LUAD | Male-baised eQTL |
| rs183337329 | chr7:113342182:C:A | - | 0.0701370315188311 | 0.0220754321117282 | LUAD | Male-baised eQTL |
| rs77320634 | chr7:113343873:C:A | - | 0.0701370315188311 | 0.0220754321117282 | LUAD | Male-baised eQTL |
| rs76937908 | chr7:113348854:A:G | - | 0.0701370315188311 | 0.0220754321117282 | LUAD | Male-baised eQTL |
| rs77875048 | chr7:113349287:C:A | - | 0.0701370315188311 | 0.0220754321117282 | LUAD | Male-baised eQTL |
| rs76686680 | chr7:113361792:A:G | - | 0.0693605873618346 | 0.0251411013638427 | LUAD | Male-baised eQTL |
| rs78470496 | chr7:113363494:A:G | - | 0.0693605873618346 | 0.0251411013638427 | LUAD | Male-baised eQTL |
| rs76802510 | chr7:113367269:C:T | - | 0.0693605873618346 | 0.0251411013638427 | LUAD | Male-baised eQTL |
| rs7786731 | chr7:113345049:C:T | - | 0.0682178574527096 | 0.0273045164160521 | LUAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000091129 |
| CpG Site: cg19055872 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.245978264141829 | |
 | Gene ID: ENSG00000091129 |
| CpG Site: cg19055872 | |
| Position to Gene: gene | |
| Male Effect: -0.46422789229756 | |
| Female Effect: - | |
 | Gene ID: ENSG00000091129 |
| CpG Site: cg25994871 | |
| Position to Gene: gene | |
| Male Effect: -0.464111102002673 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg19055872 | chr7:108193802 | gene | -0.46422789229756 | 2.96875823663448e-09 | -0.4503204215956372 | 2.201743028061326e-12 | STAD |
| cg25994871 | chr7:108327170 | gene | -0.464111102002673 | 3.01385353086342e-09 | -0.4503965671437497 | 2.448041686709337e-12 | STAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg19055872 | chr7:108193802 | gene | -0.245978264141829 | 1.14567701032463e-20 | -0.5811762001004326 | 1.9513496798384677e-24 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of NRCAM |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000091129 | NRCAM | C0004352 | Autistic Disorder | 2 | CTD_human |
| ENSG00000091129 | NRCAM | C0006142 | Malignant neoplasm of breast | 1 | CTD_human |
| ENSG00000091129 | NRCAM | C0009402 | Colorectal Carcinoma | 2 | CTD_human |
| ENSG00000091129 | NRCAM | C0009404 | Colorectal Neoplasms | 2 | CTD_human |
| ENSG00000091129 | NRCAM | C0013146 | Drug abuse | 1 | CTD_human |
| ENSG00000091129 | NRCAM | C0013170 | Drug habituation | 1 | CTD_human |
| ENSG00000091129 | NRCAM | C0013222 | Drug Use Disorders | 1 | CTD_human |
| ENSG00000091129 | NRCAM | C0029231 | Organic Mental Disorders, Substance-Induced | 1 | CTD_human |
| ENSG00000091129 | NRCAM | C0038580 | Substance Dependence | 1 | CTD_human |
| ENSG00000091129 | NRCAM | C0038586 | Substance Use Disorders | 1 | CTD_human |
| ENSG00000091129 | NRCAM | C0236969 | Substance-Related Disorders | 1 | CTD_human |
| ENSG00000091129 | NRCAM | C0678222 | Breast Carcinoma | 1 | CTD_human |
| ENSG00000091129 | NRCAM | C0740858 | Substance abuse problem | 1 | CTD_human |
| ENSG00000091129 | NRCAM | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human |
| ENSG00000091129 | NRCAM | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| ENSG00000091129 | NRCAM | C1510472 | Drug Dependence | 1 | CTD_human |
| ENSG00000091129 | NRCAM | C4316881 | Prescription Drug Abuse | 1 | CTD_human |
| ENSG00000091129 | NRCAM | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |
