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Gene: ENSG00000090273 |
Summary for NUDC |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000090273 | Gene symbol | NUDC |
| Gene name | nuclear distribution C, dynein complex regulator | |
| HGNC | 8045 | |
| Entrez ID | 10726 | |
| Gene type | protein_coding | |
| Synonyms | NUDC| | |
| UniProtAcc | Q9Y266 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| ENSG00000090273 | NUDC | DB12695 | Phenethyl Isothiocyanate | SmallMoleculeDrug |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for NUDC |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for NUDC |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for NUDC |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| ESCA | cg03952248 | chr1:26900849 | CGI:chr1:26900001-26900518 | promoter,gene body | 5.38e-01 | 3.66e-01 | 3.46e+00 | 5.45e-04 | 2.60e-03 | 1.72e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BLCA | cg16991868 | chr1:26900892 | CGI:chr1:26900001-26900518 | promoter,gene body | 3.34e-01 | 5.18e-01 | -2.73e+00 | 6.43e-03 | 9.95e-03 | -1.84e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg03952248 | chr1:26900849 | CGI:chr1:26900001-26900518 | promoter,gene body | 4.84e-01 | 3.47e-01 | 3.59e+00 | 3.27e-04 | 4.58e-04 | 1.37e-01 |
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Exon skipping events with PSI in TCGA for NUDC |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for NUDC |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
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| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| LUAD | NUDC-001 | chr1_26945002_+ | 2.12e-01 | 3.00e-01 | -2.07e+00 | 3.88e-02 | 4.61e-02 | -8.84e-02 |
| STAD | NUDC-002 | chr1_26925419_+ | 4.95e-01 | 3.27e-01 | 2.04e+00 | 4.16e-02 | 4.96e-02 | 1.68e-01 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for NUDC |
| TFs related to NUDC. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BRCA | PLAGL2 | NUDC | 3.75e+00 | 5.90e-03 | 5.13e+00 | 9.91e-01 | Female-biased |
| BRCA | ZNF28 | NUDC | 3.40e+00 | 9.81e-03 | 4.62e+00 | 9.82e-01 | Female-biased |
| NUDC related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for NUDC |
| RBPs related to ES in NUDC. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ACC | ESRP2 | exon_skip_3025 | 8.30e+00 | 2.16e-03 | 8.89e+00 | 9.93e-01 | Female-biased |
| ACC | ZNF638 | exon_skip_3041 | 1.51e+01 | 9.99e-01 | 1.44e+01 | 1.33e-03 | Male-biased |
| DLBC | ZNF638 | exon_skip_3041 | 1.46e+01 | 6.81e-04 | 1.52e+01 | 9.99e-01 | Female-biased |
| KIRP | ZNF638 | exon_skip_3041 | 1.47e+01 | 6.63e-04 | 1.53e+01 | 9.99e-01 | Female-biased |
| BRCA | ZNF638 | exon_skip_3041 | 1.50e+01 | 9.90e-01 | 1.44e+01 | 9.52e-03 | Male-biased |
| READ | ESRP2 | exon_skip_3025 | 8.31e+00 | 5.91e-03 | 8.69e+00 | 9.89e-01 | Female-biased |
| THCA | ZNF638 | exon_skip_3041 | 1.50e+01 | 9.99e-01 | 1.45e+01 | 4.86e-04 | Male-biased |
| MESO | ESRP2 | exon_skip_3025 | 8.36e+00 | 1.22e-02 | 8.70e+00 | 9.82e-01 | Female-biased |
| MESO | SAMD4A | exon_skip_3035 | 7.94e+00 | 8.64e-04 | 8.55e+00 | 9.93e-01 | Female-biased |
| MESO | ZNF638 | exon_skip_3041 | 1.45e+01 | 6.08e-04 | 1.52e+01 | 9.99e-01 | Female-biased |
| LGG | ZNF638 | exon_skip_3041 | 1.51e+01 | 9.99e-01 | 1.45e+01 | 9.78e-04 | Male-biased |
| GBM | ZNF638 | exon_skip_3041 | 1.45e+01 | 4.89e-04 | 1.52e+01 | 9.99e-01 | Female-biased |
| KIRC | ESRP2 | exon_skip_3025 | 8.54e+00 | 9.85e-01 | 8.22e+00 | 8.53e-03 | Male-biased |
| KIRC | ZNF638 | exon_skip_3041 | 1.44e+01 | 8.63e-04 | 1.50e+01 | 9.99e-01 | Female-biased |
| BLCA | ZNF638 | exon_skip_3041 | 1.47e+01 | 1.06e-03 | 1.53e+01 | 9.99e-01 | Female-biased |
| SARC | ZNF638 | exon_skip_3041 | 1.52e+01 | 9.98e-01 | 1.46e+01 | 1.75e-03 | Male-biased |
| NUDC related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs6698957 | chr1:36569987:G:A | - | -0.0518495417178868 | 0.0329693511927036 | LUAD | Female-baised eQTL |
| rs4652917 | chr1:36572410:A:G | - | -0.0517277341681324 | 0.0352144751024049 | LUAD | Female-baised eQTL |
| rs72665836 | chr1:36568172:G:A | - | -0.0513600495197107 | 0.0352309370885593 | LUAD | Female-baised eQTL |
| rs10916662 | chr1:19877141:T:A | - | -0.0615389094742463 | 0.0390841015071074 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs2296470 | chr1:35894068:A:G | - | 0.306321146210818 | 0.00544089372542571 | SARC | Male-baised eQTL |
| rs72902972 | chr1:35900915:T:A | - | 0.306321146210818 | 0.00544089372542571 | SARC | Male-baised eQTL |
| rs274743 | chr1:36070315:A:G | - | 0.306321146210818 | 0.00544089372542571 | SARC | Male-baised eQTL |
| rs10914180 | chr1:30663301:G:A | - | -0.0763165375554453 | 0.0430761895668619 | LUSC | Male-baised eQTL |
| rs12407778 | chr1:20610235:C:T | - | 0.113536190774173 | 0.00343516826552856 | LGG | Male-baised eQTL |
| rs12091854 | chr1:31611032:C:T | - | 0.0521263948795636 | 0.0182052345551458 | KIRC | Male-baised eQTL |
| rs785200 | chr1:21371522:A:C | - | -0.0595220239706804 | 0.0387356383601824 | LUAD | Male-baised eQTL |
| rs785204 | chr1:21372747:T:A | - | -0.0595220239706804 | 0.0387356383601824 | LUAD | Male-baised eQTL |
| rs11260965 | chr1:18238907:C:G | - | 0.107543248472985 | 0.0470308445369109 | LUAD | Male-baised eQTL |
| rs10914745 | chr1:33566298:A:G | - | 0.0614029807105699 | 0.00605457538474742 | COAD | Male-baised eQTL |
| rs12034846 | chr1:24373099:G:A | - | 0.0664386414845903 | 0.0104457022750825 | COAD | Male-baised eQTL |
| rs2884926 | chr1:24378604:C:A | - | 0.0659451427447571 | 0.0117644981149135 | COAD | Male-baised eQTL |
| rs3765427 | chr1:24379077:G:A | - | 0.0659451427447571 | 0.0117644981149135 | COAD | Male-baised eQTL |
| rs3765425 | chr1:24373382:G:C | - | 0.0648332739260068 | 0.0132993811151001 | COAD | Male-baised eQTL |
| rs7546748 | chr1:24377031:T:C | - | 0.0644132570469415 | 0.014392388579673 | COAD | Male-baised eQTL |
| rs7546875 | chr1:24377177:T:C | - | 0.0644132570469415 | 0.014392388579673 | COAD | Male-baised eQTL |
| rs1064842 | chr1:24379779:A:G | - | 0.0619258429085277 | 0.0195190664878141 | COAD | Male-baised eQTL |
| rs3765431 | chr1:24379920:T:C | - | 0.0619258429085277 | 0.0195190664878141 | COAD | Male-baised eQTL |
| rs3765428 | chr1:24379623:G:A | - | 0.0617573456698655 | 0.0205474465805831 | COAD | Male-baised eQTL |
| rs10916799 | chr1:20441031:C:T | - | -0.0560579395342627 | 0.027926436579162 | COAD | Male-baised eQTL |
| rs1142057 | chr1:24379802:T:C | - | 0.058226926521026 | 0.0305057209855333 | COAD | Male-baised eQTL |
| rs4653377 | chr1:34026870:G:A | - | -0.081904637192743 | 0.0387280233809514 | COAD | Male-baised eQTL |
| rs6693247 | chr1:33565241:G:T | - | 0.0520865856833025 | 0.0429299773753821 | COAD | Male-baised eQTL |
| rs2274168 | chr1:24380721:G:T | - | 0.0570797989201481 | 0.0465734821095479 | COAD | Male-baised eQTL |
| rs2274167 | chr1:24380806:C:T | - | 0.0570797989201481 | 0.0465734821095479 | COAD | Male-baised eQTL |
| rs6692646 | chr1:24381139:C:T | - | 0.0567519904821705 | 0.0478770016617355 | COAD | Male-baised eQTL |
| rs6667695 | chr1:24381179:G:A | - | 0.0567519904821705 | 0.0478770016617355 | COAD | Male-baised eQTL |
| rs6656485 | chr1:24381195:A:G | - | 0.0567519904821705 | 0.0478770016617355 | COAD | Male-baised eQTL |
| rs3765432 | chr1:24379971:A:G | - | 0.0566541888844751 | 0.0491465085037569 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of NUDC |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
