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Gene: ENSG00000089820

Summary for ARHGAP4

Gene summary

Gene information	Ensembl ID	ENSG00000089820
	Gene symbol	ARHGAP4
	Gene name	Rho GTPase activating protein 4
	HGNC	674
	Entrez ID	393
	Gene type	protein_coding
	Synonyms	ARHGAP4\|KIAA0131\|C1\|p115\|RhoGAP4\|SrGAP4
	UniProtAcc	P98171

Drugs associated with this gene(DrugBank).

Gene ID

Gene Symbol

Drug ID

Drug Name

Drug Type

Cancer therapeutic drugs associated with this gene(NCI).

Gene ID

Gene Name

Drug ID

Drug Name

Drug Type

Cancer

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Structure and expression level for ARHGAP4

AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.

Landscape of gene expressions across multiple cancer types.

Differentially expressed gene analysis between tumor male and tumor female samples.

Coding Name

Base Mean

log2FoldChange

lfcSE

Stat

P value

P.adjust Value

Cancer Type

Differentially expressed gene analysis between tumor male and normal male samples.

Coding Name	Base Mean	log2FoldChange	lfcSE	Stat	P value	P.adjust Value	Cancer Type
ARHGAP4	1.66e+03	1.10e+00	4.00e-01	2.74e+00	6.13e-03	1.57e-02	BLCA
ARHGAP4	2.28e+03	1.27e+00	4.14e-01	3.07e+00	2.14e-03	6.59e-03	CHOL

Differentially expressed gene analysis between tumor female and normal female samples.

Coding Name	Base Mean	log2FoldChange	lfcSE	Stat	P value	P.adjust Value	Cancer Type
ARHGAP4	1.30e+03	1.46e+00	2.59e-01	5.61e+00	1.99e-08	1.46e-07	LIHC

Top

Sex-biased somatic mutation for ARHGAP4

∗For more information on exon skipping events please check the ExonskipDB database.

Gene ID

Cancer Type

Hugo Symbol

Male

Female

pval

ci.up

ci.low

adjPval

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DNA methylation with beta values for ARHGAP4

Landscape of DNA methylation across multiple cancer types.

Differentially expressed CpG sites between male tumor and female tumor patients.

Cancer Type	CpG Site	Position	CpG Island	Position to Gene	ave1	ave2	wilcoxon.w	wilcoxon.p	padj	dBeta
BRCA	cg23175583	chrX:153934856	CGI:chrX:153934499-153935471	promoter,gene body	3.92e-01	1.84e-02	5.15e+00	2.56e-07	1.16e-05	3.74e-01
BRCA	cg00072288	chrX:153935039	CGI:chrX:153934499-153935471	promoter	4.32e-01	2.22e-02	5.11e+00	3.21e-07	1.20e-05	4.10e-01
BRCA	cg12727431	chrX:153935453	CGI:chrX:153934499-153935471	promoter	3.78e-01	2.68e-02	5.14e+00	2.75e-07	1.16e-05	3.51e-01
BRCA	cg26791257	chrX:153934656	CGI:chrX:153934499-153935471	promoter,gene body	3.11e-01	1.37e-02	5.16e+00	2.52e-07	1.16e-05	2.97e-01
BRCA	cg02602300	chrX:153934260	CGI:chrX:153934499-153935471	promoter,gene body	4.19e-01	9.99e-02	3.98e+00	6.95e-05	1.24e-03	3.19e-01
BRCA	cg07635888	chrX:153934736	CGI:chrX:153934499-153935471	promoter,gene body	3.20e-01	5.79e-02	5.15e+00	2.66e-07	1.16e-05	2.62e-01
BRCA	cg02232536	chrX:153935446	CGI:chrX:153934499-153935471	promoter	4.42e-01	6.03e-02	5.15e+00	2.56e-07	1.16e-05	3.82e-01
BRCA	cg25758314	chrX:153935572	CGI:chrX:153934499-153935471	promoter	4.30e-01	1.06e-01	5.09e+00	3.61e-07	1.26e-05	3.25e-01
LGG	cg23175583	chrX:153934856	CGI:chrX:153934499-153935471	promoter,gene body	4.28e-01	1.87e-02	1.98e+01	3.64e-87	2.64e-85	4.09e-01
LGG	cg00072288	chrX:153935039	CGI:chrX:153934499-153935471	promoter	4.18e-01	2.36e-02	1.97e+01	1.16e-86	5.33e-85	3.94e-01
LGG	cg12727431	chrX:153935453	CGI:chrX:153934499-153935471	promoter	4.30e-01	2.53e-02	1.98e+01	3.56e-87	2.64e-85	4.05e-01
LGG	cg26791257	chrX:153934656	CGI:chrX:153934499-153935471	promoter,gene body	3.51e-01	1.60e-02	1.98e+01	6.07e-87	3.17e-85	3.35e-01
LGG	cg02602300	chrX:153934260	CGI:chrX:153934499-153935471	promoter,gene body	4.55e-01	1.50e-01	1.78e+01	1.04e-70	1.66e-69	3.05e-01
LGG	cg07635888	chrX:153934736	CGI:chrX:153934499-153935471	promoter,gene body	3.07e-01	5.55e-02	1.97e+01	2.53e-86	1.06e-84	2.52e-01
LGG	cg02232536	chrX:153935446	CGI:chrX:153934499-153935471	promoter	4.79e-01	5.32e-02	1.98e+01	3.72e-87	2.64e-85	4.26e-01
LGG	cg25758314	chrX:153935572	CGI:chrX:153934499-153935471	promoter	6.93e-01	5.90e-01	4.74e+00	2.18e-06	1.11e-05	1.03e-01
LUSC	cg23175583	chrX:153934856	CGI:chrX:153934499-153935471	promoter,gene body	3.93e-01	2.17e-02	1.45e+01	2.10e-47	1.26e-45	3.72e-01
LUSC	cg00072288	chrX:153935039	CGI:chrX:153934499-153935471	promoter	3.96e-01	2.75e-02	1.44e+01	4.47e-47	1.48e-45	3.68e-01
LUSC	cg12727431	chrX:153935453	CGI:chrX:153934499-153935471	promoter	3.33e-01	2.79e-02	1.44e+01	2.85e-47	1.26e-45	3.05e-01
LUSC	cg26791257	chrX:153934656	CGI:chrX:153934499-153935471	promoter,gene body	3.06e-01	1.75e-02	1.45e+01	2.17e-47	1.26e-45	2.88e-01
LUSC	cg02602300	chrX:153934260	CGI:chrX:153934499-153935471	promoter,gene body	3.97e-01	2.12e-01	1.16e+01	4.74e-31	6.23e-30	1.85e-01
LUSC	cg07635888	chrX:153934736	CGI:chrX:153934499-153935471	promoter,gene body	2.68e-01	6.05e-02	1.44e+01	4.54e-47	1.50e-45	2.07e-01
LUSC	cg02232536	chrX:153935446	CGI:chrX:153934499-153935471	promoter	3.99e-01	5.50e-02	1.44e+01	2.63e-47	1.26e-45	3.44e-01
LUSC	cg25758314	chrX:153935572	CGI:chrX:153934499-153935471	promoter	3.95e-01	2.21e-01	1.14e+01	4.54e-30	5.85e-29	1.74e-01
SKCM	cg23175583	chrX:153934856	CGI:chrX:153934499-153935471	promoter,gene body	3.66e-01	1.92e-02	1.82e+01	5.92e-74	4.10e-72	3.47e-01
SKCM	cg00072288	chrX:153935039	CGI:chrX:153934499-153935471	promoter	3.71e-01	2.32e-02	1.80e+01	1.59e-72	5.92e-71	3.47e-01
SKCM	cg12727431	chrX:153935453	CGI:chrX:153934499-153935471	promoter	3.27e-01	2.59e-02	1.80e+01	1.19e-72	4.60e-71	3.02e-01
SKCM	cg26791257	chrX:153934656	CGI:chrX:153934499-153935471	promoter,gene body	2.64e-01	1.54e-02	1.81e+01	7.10e-73	2.90e-71	2.48e-01
SKCM	cg02602300	chrX:153934260	CGI:chrX:153934499-153935471	promoter,gene body	3.54e-01	1.59e-01	1.36e+01	2.07e-42	2.65e-41	1.95e-01
SKCM	cg07635888	chrX:153934736	CGI:chrX:153934499-153935471	promoter,gene body	2.67e-01	5.67e-02	1.79e+01	5.33e-72	1.81e-70	2.10e-01
SKCM	cg02232536	chrX:153935446	CGI:chrX:153934499-153935471	promoter	3.80e-01	5.52e-02	1.82e+01	9.00e-74	5.41e-72	3.25e-01
SKCM	cg25758314	chrX:153935572	CGI:chrX:153934499-153935471	promoter	4.39e-01	2.68e-01	1.06e+01	3.69e-26	3.29e-25	1.71e-01
STAD	cg23175583	chrX:153934856	CGI:chrX:153934499-153935471	promoter,gene body	4.05e-01	1.83e-02	1.52e+01	6.81e-52	4.96e-50	3.87e-01
STAD	cg00072288	chrX:153935039	CGI:chrX:153934499-153935471	promoter	4.60e-01	2.56e-02	1.51e+01	1.22e-51	6.10e-50	4.34e-01
STAD	cg12727431	chrX:153935453	CGI:chrX:153934499-153935471	promoter	3.82e-01	3.20e-02	1.51e+01	8.89e-52	5.09e-50	3.50e-01
STAD	cg26791257	chrX:153934656	CGI:chrX:153934499-153935471	promoter,gene body	3.64e-01	1.60e-02	1.51e+01	7.58e-52	4.96e-50	3.48e-01
STAD	cg02602300	chrX:153934260	CGI:chrX:153934499-153935471	promoter,gene body	4.32e-01	1.79e-01	1.27e+01	9.80e-37	1.79e-35	2.53e-01
STAD	cg07635888	chrX:153934736	CGI:chrX:153934499-153935471	promoter,gene body	3.08e-01	5.43e-02	1.51e+01	2.40e-51	1.03e-49	2.54e-01
STAD	cg02232536	chrX:153935446	CGI:chrX:153934499-153935471	promoter	4.42e-01	5.42e-02	1.51e+01	1.41e-51	6.74e-50	3.88e-01
STAD	cg25758314	chrX:153935572	CGI:chrX:153934499-153935471	promoter	4.53e-01	2.47e-01	1.09e+01	1.02e-27	1.48e-26	2.07e-01
SARC	cg23175583	chrX:153934856	CGI:chrX:153934499-153935471	promoter,gene body	3.03e-01	1.84e-02	1.34e+01	4.81e-41	2.96e-39	2.85e-01
SARC	cg00072288	chrX:153935039	CGI:chrX:153934499-153935471	promoter	2.87e-01	2.25e-02	1.29e+01	6.66e-38	2.73e-36	2.65e-01
SARC	cg12727431	chrX:153935453	CGI:chrX:153934499-153935471	promoter	2.79e-01	2.45e-02	1.33e+01	2.37e-40	1.29e-38	2.54e-01
SARC	cg26791257	chrX:153934656	CGI:chrX:153934499-153935471	promoter,gene body	2.17e-01	1.48e-02	1.30e+01	7.48e-39	3.35e-37	2.02e-01
SARC	cg02602300	chrX:153934260	CGI:chrX:153934499-153935471	promoter,gene body	3.62e-01	1.76e-01	8.46e+00	2.62e-17	3.23e-16	1.87e-01
SARC	cg07635888	chrX:153934736	CGI:chrX:153934499-153935471	promoter,gene body	2.26e-01	5.49e-02	1.30e+01	1.99e-38	8.60e-37	1.71e-01
SARC	cg02232536	chrX:153935446	CGI:chrX:153934499-153935471	promoter	3.43e-01	4.83e-02	1.37e+01	6.59e-43	8.74e-41	2.95e-01
SARC	cg25758314	chrX:153935572	CGI:chrX:153934499-153935471	promoter	4.96e-01	3.07e-01	7.18e+00	7.10e-13	7.20e-12	1.89e-01
PCPG	cg23175583	chrX:153934856	CGI:chrX:153934499-153935471	promoter,gene body	2.56e-01	1.96e-02	1.16e+01	3.83e-31	1.92e-29	2.36e-01
PCPG	cg00072288	chrX:153935039	CGI:chrX:153934499-153935471	promoter	1.87e-01	2.34e-02	1.10e+01	3.19e-28	5.06e-27	1.63e-01
PCPG	cg12727431	chrX:153935453	CGI:chrX:153934499-153935471	promoter	3.00e-01	2.19e-02	1.16e+01	3.83e-31	1.92e-29	2.78e-01
PCPG	cg26791257	chrX:153934656	CGI:chrX:153934499-153935471	promoter,gene body	1.41e-01	1.73e-02	1.10e+01	5.76e-28	8.88e-27	1.24e-01
PCPG	cg02602300	chrX:153934260	CGI:chrX:153934499-153935471	promoter,gene body	3.72e-01	1.36e-01	9.76e+00	1.71e-22	1.90e-21	2.36e-01
PCPG	cg07635888	chrX:153934736	CGI:chrX:153934499-153935471	promoter,gene body	1.93e-01	6.23e-02	1.10e+01	3.97e-28	6.24e-27	1.30e-01
PCPG	cg02232536	chrX:153935446	CGI:chrX:153934499-153935471	promoter	3.81e-01	5.00e-02	1.16e+01	4.66e-31	1.94e-29	3.31e-01
PCPG	cg25758314	chrX:153935572	CGI:chrX:153934499-153935471	promoter	4.45e-01	1.90e-01	9.00e+00	2.28e-19	2.07e-18	2.54e-01
PAAD	cg23175583	chrX:153934856	CGI:chrX:153934499-153935471	promoter,gene body	3.93e-01	1.84e-02	1.14e+01	4.70e-30	1.60e-28	3.75e-01
PAAD	cg00072288	chrX:153935039	CGI:chrX:153934499-153935471	promoter	4.23e-01	2.45e-02	1.14e+01	2.75e-30	1.08e-28	3.98e-01
PAAD	cg12727431	chrX:153935453	CGI:chrX:153934499-153935471	promoter	3.93e-01	2.61e-02	1.14e+01	6.15e-30	2.02e-28	3.67e-01
PAAD	cg26791257	chrX:153934656	CGI:chrX:153934499-153935471	promoter,gene body	3.55e-01	1.86e-02	1.11e+01	1.79e-28	4.36e-27	3.36e-01
PAAD	cg02602300	chrX:153934260	CGI:chrX:153934499-153935471	promoter,gene body	4.80e-01	1.91e-01	1.10e+01	2.33e-28	5.59e-27	2.89e-01
PAAD	cg07635888	chrX:153934736	CGI:chrX:153934499-153935471	promoter,gene body	2.82e-01	5.58e-02	1.14e+01	4.11e-30	1.44e-28	2.26e-01
PAAD	cg02232536	chrX:153935446	CGI:chrX:153934499-153935471	promoter	4.45e-01	4.72e-02	1.15e+01	2.03e-30	1.01e-28	3.98e-01
PAAD	cg25758314	chrX:153935572	CGI:chrX:153934499-153935471	promoter	4.63e-01	1.93e-01	1.07e+01	5.97e-27	1.26e-25	2.69e-01
READ	cg23175583	chrX:153934856	CGI:chrX:153934499-153935471	promoter,gene body	3.60e-01	1.70e-02	8.49e+00	2.15e-17	4.34e-16	3.43e-01
READ	cg00072288	chrX:153935039	CGI:chrX:153934499-153935471	promoter	4.07e-01	2.03e-02	8.48e+00	2.29e-17	4.34e-16	3.87e-01
READ	cg12727431	chrX:153935453	CGI:chrX:153934499-153935471	promoter	3.30e-01	2.39e-02	8.46e+00	2.59e-17	4.56e-16	3.06e-01
READ	cg26791257	chrX:153934656	CGI:chrX:153934499-153935471	promoter,gene body	3.20e-01	1.41e-02	8.46e+00	2.59e-17	4.56e-16	3.06e-01
READ	cg02602300	chrX:153934260	CGI:chrX:153934499-153935471	promoter,gene body	3.77e-01	1.42e-01	7.87e+00	3.52e-15	4.10e-14	2.35e-01
READ	cg07635888	chrX:153934736	CGI:chrX:153934499-153935471	promoter,gene body	3.14e-01	5.58e-02	8.45e+00	2.92e-17	4.94e-16	2.58e-01
READ	cg02232536	chrX:153935446	CGI:chrX:153934499-153935471	promoter	3.95e-01	4.57e-02	8.49e+00	2.15e-17	4.34e-16	3.49e-01
READ	cg25758314	chrX:153935572	CGI:chrX:153934499-153935471	promoter	3.49e-01	1.36e-01	7.30e+00	2.89e-13	2.92e-12	2.13e-01
GBM	cg23175583	chrX:153934856	CGI:chrX:153934499-153935471	promoter,gene body	4.55e-01	1.83e-02	6.75e+00	1.48e-11	2.64e-10	4.36e-01
GBM	cg00072288	chrX:153935039	CGI:chrX:153934499-153935471	promoter	4.99e-01	2.25e-02	6.75e+00	1.48e-11	2.64e-10	4.77e-01
GBM	cg12727431	chrX:153935453	CGI:chrX:153934499-153935471	promoter	4.53e-01	2.45e-02	6.75e+00	1.48e-11	2.64e-10	4.28e-01
GBM	cg26791257	chrX:153934656	CGI:chrX:153934499-153935471	promoter,gene body	3.90e-01	1.32e-02	6.75e+00	1.48e-11	2.64e-10	3.77e-01
GBM	cg02602300	chrX:153934260	CGI:chrX:153934499-153935471	promoter,gene body	4.96e-01	1.88e-01	6.18e+00	6.39e-10	6.59e-09	3.07e-01
GBM	cg07635888	chrX:153934736	CGI:chrX:153934499-153935471	promoter,gene body	3.52e-01	5.35e-02	6.74e+00	1.63e-11	2.71e-10	2.98e-01
GBM	cg02232536	chrX:153935446	CGI:chrX:153934499-153935471	promoter	5.10e-01	4.96e-02	6.75e+00	1.48e-11	2.64e-10	4.60e-01
GBM	cg25758314	chrX:153935572	CGI:chrX:153934499-153935471	promoter	6.37e-01	4.28e-01	3.83e+00	1.26e-04	6.13e-04	2.09e-01
ESCA	cg23175583	chrX:153934856	CGI:chrX:153934499-153935471	promoter,gene body	3.87e-01	2.08e-02	7.58e+00	3.47e-14	6.84e-13	3.66e-01
ESCA	cg00072288	chrX:153935039	CGI:chrX:153934499-153935471	promoter	4.51e-01	2.75e-02	7.59e+00	3.10e-14	6.84e-13	4.23e-01
ESCA	cg12727431	chrX:153935453	CGI:chrX:153934499-153935471	promoter	3.61e-01	2.95e-02	7.57e+00	3.60e-14	6.84e-13	3.32e-01
ESCA	cg26791257	chrX:153934656	CGI:chrX:153934499-153935471	promoter,gene body	3.22e-01	1.89e-02	7.58e+00	3.47e-14	6.84e-13	3.03e-01
ESCA	cg02602300	chrX:153934260	CGI:chrX:153934499-153935471	promoter,gene body	3.75e-01	1.68e-01	6.66e+00	2.68e-11	2.60e-10	2.07e-01
ESCA	cg07635888	chrX:153934736	CGI:chrX:153934499-153935471	promoter,gene body	2.90e-01	5.72e-02	7.57e+00	3.73e-14	6.84e-13	2.33e-01
ESCA	cg02232536	chrX:153935446	CGI:chrX:153934499-153935471	promoter	4.15e-01	4.92e-02	7.58e+00	3.47e-14	6.84e-13	3.66e-01
ESCA	cg25758314	chrX:153935572	CGI:chrX:153934499-153935471	promoter	4.25e-01	1.58e-01	7.31e+00	2.75e-13	3.41e-12	2.67e-01
LAML	cg23175583	chrX:153934856	CGI:chrX:153934499-153935471	promoter,gene body	4.25e-01	2.64e-02	1.01e+01	4.19e-24	2.70e-22	3.99e-01
LAML	cg00072288	chrX:153935039	CGI:chrX:153934499-153935471	promoter	4.28e-01	3.70e-02	1.00e+01	1.03e-23	3.07e-22	3.91e-01
LAML	cg12727431	chrX:153935453	CGI:chrX:153934499-153935471	promoter	4.74e-01	6.98e-02	9.58e+00	1.00e-21	9.73e-21	4.04e-01
LAML	cg26791257	chrX:153934656	CGI:chrX:153934499-153935471	promoter,gene body	4.12e-01	2.42e-02	1.01e+01	4.90e-24	2.72e-22	3.88e-01
LAML	cg02602300	chrX:153934260	CGI:chrX:153934499-153935471	promoter,gene body	5.57e-01	3.63e-01	4.70e+00	2.58e-06	9.45e-06	1.93e-01
LAML	cg07635888	chrX:153934736	CGI:chrX:153934499-153935471	promoter,gene body	3.37e-01	5.49e-02	1.00e+01	9.92e-24	3.04e-22	2.82e-01
LAML	cg02232536	chrX:153935446	CGI:chrX:153934499-153935471	promoter	4.86e-01	8.61e-02	9.79e+00	1.21e-22	1.48e-21	4.00e-01
LAML	cg25758314	chrX:153935572	CGI:chrX:153934499-153935471	promoter	7.22e-01	5.83e-01	1.98e+00	4.80e-02	4.91e-02	1.39e-01
THYM	cg23175583	chrX:153934856	CGI:chrX:153934499-153935471	promoter,gene body	3.52e-01	1.63e-02	9.40e+00	5.48e-21	1.00e-19	3.36e-01
THYM	cg00072288	chrX:153935039	CGI:chrX:153934499-153935471	promoter	3.33e-01	2.13e-02	9.25e+00	2.23e-20	2.76e-19	3.12e-01
THYM	cg12727431	chrX:153935453	CGI:chrX:153934499-153935471	promoter	3.52e-01	2.14e-02	9.39e+00	5.77e-21	1.00e-19	3.31e-01
THYM	cg26791257	chrX:153934656	CGI:chrX:153934499-153935471	promoter,gene body	3.23e-01	1.65e-02	9.40e+00	5.48e-21	1.00e-19	3.07e-01
THYM	cg07635888	chrX:153934736	CGI:chrX:153934499-153935471	promoter,gene body	2.46e-01	5.95e-02	9.39e+00	5.77e-21	1.00e-19	1.87e-01
THYM	cg02232536	chrX:153935446	CGI:chrX:153934499-153935471	promoter	4.12e-01	4.26e-02	9.40e+00	5.48e-21	1.00e-19	3.70e-01
THYM	cg25758314	chrX:153935572	CGI:chrX:153934499-153935471	promoter	5.05e-01	3.95e-01	3.26e+00	1.13e-03	3.02e-03	1.10e-01
MESO	cg23175583	chrX:153934856	CGI:chrX:153934499-153935471	promoter,gene body	3.18e-01	1.74e-02	6.06e+00	1.36e-09	2.54e-08	3.01e-01
MESO	cg00072288	chrX:153935039	CGI:chrX:153934499-153935471	promoter	3.47e-01	2.37e-02	6.06e+00	1.36e-09	2.54e-08	3.23e-01
MESO	cg12727431	chrX:153935453	CGI:chrX:153934499-153935471	promoter	3.10e-01	2.22e-02	6.06e+00	1.36e-09	2.54e-08	2.87e-01
MESO	cg26791257	chrX:153934656	CGI:chrX:153934499-153935471	promoter,gene body	2.63e-01	1.71e-02	6.06e+00	1.36e-09	2.54e-08	2.46e-01
MESO	cg02602300	chrX:153934260	CGI:chrX:153934499-153935471	promoter,gene body	4.31e-01	2.26e-01	4.83e+00	1.36e-06	1.07e-05	2.04e-01
MESO	cg07635888	chrX:153934736	CGI:chrX:153934499-153935471	promoter,gene body	2.36e-01	5.70e-02	6.05e+00	1.46e-09	2.54e-08	1.79e-01
MESO	cg02232536	chrX:153935446	CGI:chrX:153934499-153935471	promoter	3.70e-01	4.86e-02	6.06e+00	1.36e-09	2.54e-08	3.22e-01
MESO	cg25758314	chrX:153935572	CGI:chrX:153934499-153935471	promoter	4.81e-01	3.30e-01	3.17e+00	1.53e-03	7.28e-03	1.50e-01
UVM	cg23175583	chrX:153934856	CGI:chrX:153934499-153935471	promoter,gene body	1.90e-01	1.59e-02	7.59e+00	3.22e-14	1.00e-12	1.74e-01
UVM	cg00072288	chrX:153935039	CGI:chrX:153934499-153935471	promoter	2.03e-01	2.09e-02	6.18e+00	6.30e-10	4.62e-09	1.82e-01
UVM	cg12727431	chrX:153935453	CGI:chrX:153934499-153935471	promoter	2.15e-01	2.03e-02	7.42e+00	1.13e-13	1.87e-12	1.94e-01
UVM	cg26791257	chrX:153934656	CGI:chrX:153934499-153935471	promoter,gene body	1.75e-01	1.52e-02	7.37e+00	1.76e-13	2.59e-12	1.60e-01
UVM	cg02602300	chrX:153934260	CGI:chrX:153934499-153935471	promoter,gene body	3.47e-01	8.48e-02	6.70e+00	2.13e-11	1.84e-10	2.62e-01
UVM	cg07635888	chrX:153934736	CGI:chrX:153934499-153935471	promoter,gene body	1.55e-01	5.33e-02	7.02e+00	2.27e-12	2.29e-11	1.02e-01
UVM	cg02232536	chrX:153935446	CGI:chrX:153934499-153935471	promoter	2.64e-01	4.10e-02	7.60e+00	2.99e-14	9.97e-13	2.23e-01
UVM	cg25758314	chrX:153935572	CGI:chrX:153934499-153935471	promoter	3.30e-01	2.00e-01	4.20e+00	2.62e-05	1.01e-04	1.30e-01
ACC	cg00072288	chrX:153935039	CGI:chrX:153934499-153935471	promoter	3.00e-01	2.45e-02	7.17e+00	7.57e-13	1.36e-11	2.75e-01
ACC	cg02232536	chrX:153935446	CGI:chrX:153934499-153935471	promoter	3.85e-01	5.58e-02	7.45e+00	9.34e-14	2.69e-12	3.29e-01
ACC	cg02602300	chrX:153934260	CGI:chrX:153934499-153935471	promoter,gene body	4.00e-01	2.24e-01	4.34e+00	1.44e-05	1.08e-04	1.75e-01
ACC	cg07635888	chrX:153934736	CGI:chrX:153934499-153935471	promoter,gene body	2.34e-01	5.68e-02	7.12e+00	1.09e-12	1.88e-11	1.77e-01
ACC	cg12727431	chrX:153935453	CGI:chrX:153934499-153935471	promoter	3.30e-01	2.43e-02	7.47e+00	8.02e-14	2.68e-12	3.05e-01
ACC	cg23175583	chrX:153934856	CGI:chrX:153934499-153935471	promoter,gene body	3.18e-01	1.88e-02	7.46e+00	8.66e-14	2.68e-12	2.99e-01
ACC	cg25758314	chrX:153935572	CGI:chrX:153934499-153935471	promoter	4.24e-01	2.69e-01	4.03e+00	5.67e-05	3.96e-04	1.55e-01
ACC	cg26791257	chrX:153934656	CGI:chrX:153934499-153935471	promoter,gene body	2.27e-01	1.49e-02	7.37e+00	1.71e-13	3.92e-12	2.12e-01
KICH	cg23175583	chrX:153934856	CGI:chrX:153934499-153935471	promoter,gene body	2.53e-01	2.35e-02	6.61e+00	3.72e-11	1.88e-09	2.29e-01
KICH	cg00072288	chrX:153935039	CGI:chrX:153934499-153935471	promoter	2.23e-01	2.71e-02	6.61e+00	3.72e-11	1.88e-09	1.96e-01
KICH	cg12727431	chrX:153935453	CGI:chrX:153934499-153935471	promoter	2.28e-01	2.83e-02	6.63e+00	3.39e-11	1.88e-09	2.00e-01
KICH	cg26791257	chrX:153934656	CGI:chrX:153934499-153935471	promoter,gene body	1.72e-01	1.70e-02	6.41e+00	1.42e-10	2.83e-09	1.55e-01
KICH	cg02602300	chrX:153934260	CGI:chrX:153934499-153935471	promoter,gene body	2.88e-01	1.78e-01	3.64e+00	2.70e-04	1.74e-03	1.10e-01
KICH	cg07635888	chrX:153934736	CGI:chrX:153934499-153935471	promoter,gene body	1.68e-01	6.76e-02	6.31e+00	2.85e-10	4.89e-09	1.01e-01
KICH	cg02232536	chrX:153935446	CGI:chrX:153934499-153935471	promoter	2.90e-01	6.31e-02	6.51e+00	7.62e-11	1.94e-09	2.27e-01
KICH	cg25758314	chrX:153935572	CGI:chrX:153934499-153935471	promoter	2.92e-01	1.64e-01	4.35e+00	1.35e-05	1.08e-04	1.28e-01
DLBC	cg23175583	chrX:153934856	CGI:chrX:153934499-153935471	promoter,gene body	3.73e-01	1.79e-02	5.92e+00	3.26e-09	5.31e-08	3.55e-01
DLBC	cg00072288	chrX:153935039	CGI:chrX:153934499-153935471	promoter	4.20e-01	2.33e-02	5.92e+00	3.26e-09	5.31e-08	3.97e-01
DLBC	cg12727431	chrX:153935453	CGI:chrX:153934499-153935471	promoter	3.42e-01	6.39e-02	5.38e+00	7.46e-08	7.44e-07	2.78e-01
DLBC	cg26791257	chrX:153934656	CGI:chrX:153934499-153935471	promoter,gene body	3.19e-01	1.55e-02	5.92e+00	3.26e-09	5.31e-08	3.03e-01
DLBC	cg02602300	chrX:153934260	CGI:chrX:153934499-153935471	promoter,gene body	3.87e-01	1.79e-01	4.32e+00	1.53e-05	1.04e-04	2.08e-01
DLBC	cg07635888	chrX:153934736	CGI:chrX:153934499-153935471	promoter,gene body	2.89e-01	5.37e-02	5.92e+00	3.26e-09	5.31e-08	2.35e-01
DLBC	cg02232536	chrX:153935446	CGI:chrX:153934499-153935471	promoter	3.98e-01	7.86e-02	5.38e+00	7.46e-08	7.44e-07	3.19e-01
DLBC	cg25758314	chrX:153935572	CGI:chrX:153934499-153935471	promoter	4.50e-01	2.74e-01	3.33e+00	8.64e-04	3.14e-03	1.76e-01
CHOL	cg23175583	chrX:153934856	CGI:chrX:153934499-153935471	promoter,gene body	3.70e-01	1.93e-02	5.09e+00	3.51e-07	4.92e-06	3.51e-01
CHOL	cg00072288	chrX:153935039	CGI:chrX:153934499-153935471	promoter	4.15e-01	2.39e-02	5.09e+00	3.51e-07	4.92e-06	3.91e-01
CHOL	cg12727431	chrX:153935453	CGI:chrX:153934499-153935471	promoter	3.74e-01	2.59e-02	4.90e+00	9.45e-07	9.05e-06	3.48e-01
CHOL	cg26791257	chrX:153934656	CGI:chrX:153934499-153935471	promoter,gene body	3.31e-01	2.12e-02	4.97e+00	6.82e-07	7.03e-06	3.10e-01
CHOL	cg02602300	chrX:153934260	CGI:chrX:153934499-153935471	promoter,gene body	4.98e-01	1.86e-01	4.33e+00	1.49e-05	9.53e-05	3.12e-01
CHOL	cg07635888	chrX:153934736	CGI:chrX:153934499-153935471	promoter,gene body	2.99e-01	5.27e-02	4.97e+00	6.82e-07	7.03e-06	2.47e-01
CHOL	cg02232536	chrX:153935446	CGI:chrX:153934499-153935471	promoter	4.26e-01	4.99e-02	5.09e+00	3.51e-07	4.92e-06	3.76e-01
CHOL	cg25758314	chrX:153935572	CGI:chrX:153934499-153935471	promoter	4.59e-01	1.74e-01	4.52e+00	6.16e-06	4.47e-05	2.86e-01

Differentially expressed CpG sites between male tumor and male normal patients.

Cancer Type	CpG Site	Position	CpG Island	Position to Gene	ave1	ave2	wilcoxon.w	wilcoxon.p	padj	dBeta
LUAD	cg02602300	chrX:153934260	CGI:chrX:153934499-153935471	promoter,gene body	2.03e-01	3.24e-01	-4.55e+00	5.31e-06	2.52e-05	-1.20e-01
LUSC	cg00434413	chrX:153936200	CGI:chrX:153934499-153935471	promoter	7.96e-01	9.59e-01	-2.98e+00	2.91e-03	5.47e-03	-1.63e-01
KIRP	cg02602300	chrX:153934260	CGI:chrX:153934499-153935471	promoter,gene body	3.42e-01	1.82e-01	3.89e+00	1.02e-04	2.63e-04	1.60e-01
CHOL	cg02602300	chrX:153934260	CGI:chrX:153934499-153935471	promoter,gene body	1.86e-01	2.87e-01	-2.21e+00	2.70e-02	3.50e-02	-1.01e-01

Differentially expressed CpG sites between female tumor and female normal patients.

Cancer Type	CpG Site	Position	CpG Island	Position to Gene	ave1	ave2	wilcoxon.w	wilcoxon.p	padj	dBeta
BLCA	cg02602300	chrX:153934260	CGI:chrX:153934499-153935471	promoter,gene body	4.22e-01	5.41e-01	-3.75e+00	1.79e-04	2.90e-03	-1.20e-01
LIHC	cg26791257	chrX:153934656	CGI:chrX:153934499-153935471	promoter,gene body	2.28e-01	3.32e-01	-3.29e+00	9.90e-04	2.24e-03	-1.04e-01
LIHC	cg02232536	chrX:153935446	CGI:chrX:153934499-153935471	promoter	3.77e-01	4.80e-01	-2.33e+00	1.96e-02	2.37e-02	-1.02e-01

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Exon skipping events with PSI in TCGA for ARHGAP4

∗Please access ExonSkipDB for exon skipping annotation.

Landscape of exon skipping events across multiple cancer types.

Differentially expressed exon skipping events between male tumor and female tumor patients.

Cancer Type

Exon Skipping

ave.female_T

ave.female_N

wilcoxon.w

wilcoxon.p

padj

dPSI

Differentially expressed exon skipping events between male tumor and male normal patients.

Cancer Type

Exon Skipping

ave.female_T

ave.female_N

wilcoxon.w

wilcoxon.p

padj

dPSI

Differentially expressed exon skipping events between female tumor and female normal patients.

Cancer Type

Exon Skipping

ave.female_T

ave.female_N

wilcoxon.w

wilcoxon.p

padj

dPSI

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RNA A-to-I editing events in TCGA for ARHGAP4

∗Please access CAeditome for RNA editing annotation.

Differentially expressed RNA editing events between male tumor and female tumor patients.

Cancer Type

Transcript

Editing

ave.male_T

ave.female_T

wilcoxon.w

wilcoxon.p

p_adj

dFre

Differentially expressed RNA editing events between male tumor and male normal patients.

Cancer Type

Transcript

Editing

ave.male_T

ave.female_T

wilcoxon.w

wilcoxon.p

p_adj

dFre

Differentially expressed RNA editing events between female tumor and female normal patients.

Cancer Type

Transcript

Editing

ave.male_T

ave.female_T

wilcoxon.w

wilcoxon.p

p_adj

dFre

Protein coding RNA editing(s).

Editing Position

Variant Type

Gene Symbol

Transcript ID

NTchange

AAchange

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Sex-biased TF-Gene network for ARHGAP4

TFs related to ARHGAP4.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.

Cancer Type

Target Gene

Male Edge Score

Male Edge Threshold

Female Edge Score

Female Edge Threshold

Type

ARHGAP4 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for ARHGAP4

RBPs related to ES in ARHGAP4.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.

Cancer Type	RBP	Target ES	Male Edge Score	Male Edge Threshold	Female Edge Score	Female Edge Threshold	Type
STAD	SAMD4A	exon_skip_517383	8.80e+00	9.95e-01	8.06e+00	5.77e-04	Male-biased
STAD	ZC3H10	exon_skip_517376	9.75e+00	9.93e-01	9.33e+00	5.18e-03	Male-biased
THYM	RBM4	exon_skip_517377	8.14e+00	4.87e-03	8.52e+00	9.89e-01	Female-biased
LUSC	FXR2	exon_skip_517399	1.00e+01	9.96e-01	9.50e+00	2.20e-03	Male-biased
COAD	SAMD4A	exon_skip_517383	8.81e+00	9.94e-01	8.22e+00	9.64e-04	Male-biased
DLBC	ZC3H10	exon_skip_517414	6.44e+00	2.32e-03	6.90e+00	9.83e-01	Female-biased
LUAD	FXR2	exon_skip_517399	9.78e+00	1.50e-02	1.01e+01	9.83e-01	Female-biased
LUAD	SAMD4A	exon_skip_517383	8.45e+00	1.58e-03	8.99e+00	9.94e-01	Female-biased
LUAD	ZC3H10	exon_skip_517376	9.40e+00	1.68e-02	9.69e+00	9.81e-01	Female-biased
BRCA	ZC3H10	exon_skip_517376	9.27e+00	1.31e-02	9.85e+00	9.85e-01	Female-biased
THCA	SAMD4A	exon_skip_517383	8.11e+00	3.79e-03	8.48e+00	9.90e-01	Female-biased
THCA	ZC3H10	exon_skip_517376	9.06e+00	4.41e-03	9.42e+00	9.93e-01	Female-biased
PCPG	FXR2	exon_skip_517399	9.49e+00	1.73e-02	9.77e+00	9.80e-01	Female-biased
PCPG	SAMD4A	exon_skip_517383	8.62e+00	9.89e-01	8.24e+00	4.79e-03	Male-biased
LGG	BRUNOL6	exon_skip_517371	8.47e+00	1.02e-02	8.80e+00	9.85e-01	Female-biased
KIRC	BRUNOL6	exon_skip_517371	8.82e+00	9.91e-01	8.44e+00	4.10e-03	Male-biased
KIRC	ZC3H10	exon_skip_517377	6.69e+00	9.31e-04	7.25e+00	9.87e-01	Female-biased
KICH	RBM4	exon_skip_517377	8.29e+00	3.72e-03	8.70e+00	9.91e-01	Female-biased
KICH	SAMD4A	exon_skip_517383	8.54e+00	9.86e-01	8.19e+00	7.50e-03	Male-biased
KICH	SRSF1	exon_skip_517392	8.75e+00	1.12e-02	9.06e+00	9.85e-01	Female-biased
KICH	ZC3H10	exon_skip_517376	9.44e+00	9.87e-01	9.12e+00	1.04e-02	Male-biased
SKCM	ZC3H10	exon_skip_517377	6.42e+00	3.74e-03	6.88e+00	9.82e-01	Female-biased

ARHGAP4 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

Sex-biased CeRNA regulation of gene.

Gene ID

ceRNA(lncRNA-miRNA-mRNA)

Group

Cancer Type

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Sex-biased eQTL regulation of gene

Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).

eQTL

Description

Male-specific eQTL regulation.

SNP ID

SNP Info

Position to Gene

Effect Score

FDR

Cancer Type

Biased Type

Female-specific eQTL regulation.

SNP ID

SNP Info

Position to Gene

Effect Score

FDR

Cancer Type

Biased Type

Opposite sex-biased eQTL regulation.

SNP ID

SNP Info

Position to Gene

Male Effect

Male FDR

Female Effect

Female FDR

Sex-biased Gene in Cancer

Cancer Type

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Sex-biased eQTM regulation of gene

Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).

eQTM	Description
	Gene ID: ENSG00000089820
	CpG Site: cg06791102
	Position to Gene: gene,exon,CDS
	Male Effect: -0.0708180616288738
	Female Effect: -
	Gene ID: ENSG00000089820
	CpG Site: cg26918720
	Position to Gene: gene
	Male Effect: -0.0690379915277842
	Female Effect: -
	Gene ID: ENSG00000089820
	CpG Site: cg06791102
	Position to Gene: gene,exon,CDS
	Male Effect: -0.0364509473270971
	Female Effect: -
	Gene ID: ENSG00000089820
	CpG Site: cg06921456
	Position to Gene: gene
	Male Effect: -0.0800316501193911
	Female Effect: -
	Gene ID: ENSG00000089820
	CpG Site: cg06791102
	Position to Gene: gene,exon,CDS
	Male Effect: -0.0990505778332176
	Female Effect: -

Male-specific eQTM regulation.

CpG Site	CpG Postion	Position to Gene	Effect Score	FDR	Cor.r	Cor.Pvalue	Cancer Type
cg06791102	chrX:153926146	gene,exon,CDS	-0.0708180616288738	1.84306826462064e-08	-0.4193470037895689	6.554882771722132e-11	LUAD
cg26918720	chrX:153926430	gene	-0.0690379915277842	5.72852382011112e-09	-0.4210595847778996	2.710736063770392e-12	LIHC
cg06791102	chrX:153926146	gene,exon,CDS	-0.0364509473270971	1.03748913196827e-10	-0.4284648612771314	9.462972648542246e-14	LUSC
cg06921456	chrX:153924316	gene	-0.0800316501193911	9.5965114695929e-17	-0.5037157088696865	3.418766438295715e-20	SKCM
cg06791102	chrX:153926146	gene,exon,CDS	-0.0990505778332176	5.64536208795362e-38	-0.6317751885105283	2.1533212807825e-42	HNSC

Female-specific eQTM regulation.

CpG Site

CpG Postion

Position to Gene

Effect Score

FDR

Cor.r

Cor.Pvalue

Cancer Type

Opposite sex-biased eQTM regulation.

CpG Site

CpG Postion

CpG Island

Position to Gene

Male Effect

Male FDR

Female Effect

Female FDR

Male Cor

Male P-value

Female Cor

Female P-value

Sex-biased Coding Gene

Cancer Type

Top

Sex-biased sQTL regulation of gene

Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).

sQTL

Description

Male-specific sQTL regulation.

ES ID

Skipped Exon

ORF Anno

SNP ID

SNP Info

SNP Position to ES

Effect Score

FDR

Cancer Type

Biased Type

Female-specific sQTL regulation.

ES ID

Skipped Exon

ORF Anno

SNP ID

SNP Info

SNP Position to ES

Effect Score

FDR

Cancer Type

Biased Type

Opposite sex-biased sQTL regulation.

ES ID

Skipped Exon

ORF Anno

SNP ID

SNP Info

SNP Position to ES

Male Effect

Male FDR

Female Effect

Female FDR

Cancer Type

Top

Sex-biased sQTM regulation of gene

Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).

sQTM

Description

Male-specific sQTM regulation.

EX ID

Skipped Exon

CPG Site

CPG Position

Position to EX Events

Effect Score

FDR

Cor.r

Cor.Pvalue

ORF_anno

Cancer Type

Female-specific sQTM regulation.

EX ID

Skipped Exon

CPG Site

CPG Position

Position to EX Events

Effect Score

FDR

Cor.r

Cor.Pvalue

ORF_anno

Cancer Type

Opposite sex-biased sQTM regulation.

EX ID

EX Info

Skipped Exon

CPG Site

CPG Position

CPG Island

Position to EX Events

Male Effect

Male FDR

Female Effect

Female FDR

Male Correlation

Male P-value

Female Correlation

Female P-value

ORF_anno

Cancer Type

Top

Related disease information of ARHGAP4

Diseases associated with this gene (DisGeNET).

Gene ID	Gene Symbol	Disease ID	Disease Name	Number of PMID	Source
ENSG00000089820	ARHGAP4	C0019693	HIV Infections	1	CTD_human
ENSG00000089820	ARHGAP4	C4505456	HIV Coinfection	1	CTD_human

	Gene summary
	Gene structure and Gene expression level
	Sex-biased somatic mutation
	DNA methylation with beta values in gene
	Exon skipping events with PSI in TCGA
	RNA A-to-I editing events in TCGA
	Sex-biased TF-Gene network of gene
	Sex-biased RBP-ES network of gene
	Sex-biased CeRNA regulation of gene
	Sex-biased eQTL regulation of gene
	Sex-biased eQTM regulation of gene
	Sex-biased sQTL regulation of gene
	Sex-biased sQTM regulation of gene
	Related disease information of gene