|
||||||
|
 | |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
|
Gene: ENSG00000089159 |
Summary for PXN |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000089159 | Gene symbol | PXN |
| Gene name | paxillin | |
| HGNC | 9718 | |
| Entrez ID | 5829 | |
| Gene type | protein_coding | |
| Synonyms | PXN| | |
| UniProtAcc | P49023 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for PXN |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| PXN | 9.78e+03 | 1.07e+00 | 2.09e-01 | 5.14e+00 | 2.68e-07 | 3.50e-06 | HNSC |
Top |
Sex-biased somatic mutation for PXN |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for PXN |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| ESCA | cg11826475 | chr12:120266203 | CGI:chr12:120265173-120265738 | promoter | 3.26e-01 | 2.22e-01 | 2.61e+00 | 9.03e-03 | 3.58e-02 | 1.04e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| COAD | cg20153322 | chr12:120266174 | CGI:chr12:120265173-120265738 | promoter | 4.61e-01 | 3.61e-01 | 3.71e+00 | 2.05e-04 | 1.02e-03 | 1.00e-01 |
| KIRP | cg20153322 | chr12:120266174 | CGI:chr12:120265173-120265738 | promoter | 3.67e-01 | 2.42e-01 | 2.98e+00 | 2.92e-03 | 7.55e-03 | 1.25e-01 |
| KIRP | cg11826475 | chr12:120266203 | CGI:chr12:120265173-120265738 | promoter | 2.98e-01 | 1.94e-01 | 2.98e+00 | 2.92e-03 | 7.55e-03 | 1.03e-01 |
Top |
Exon skipping events with PSI in TCGA for PXN |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for PXN |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for PXN |
| TFs related to PXN. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| PXN related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for PXN |
| RBPs related to ES in PXN. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| UVM | RBM28 | exon_skip_97524 | 9.34e+00 | 3.74e-03 | 9.73e+00 | 9.94e-01 | Female-biased |
| THYM | HNRNPH2 | exon_skip_97499 | 8.11e+00 | 9.88e-01 | 7.69e+00 | 3.51e-03 | Male-biased |
| THYM | RBM28 | exon_skip_97524 | 9.36e+00 | 5.16e-03 | 9.73e+00 | 9.92e-01 | Female-biased |
| LUAD | HNRNPH2 | exon_skip_97499 | 8.16e+00 | 6.80e-03 | 8.53e+00 | 9.87e-01 | Female-biased |
| KIRP | QKI | exon_skip_97523 | 1.21e+01 | 9.90e-01 | 1.17e+01 | 9.72e-03 | Male-biased |
| KIRP | RBM28 | exon_skip_97524 | 9.26e+00 | 1.60e-03 | 9.75e+00 | 9.96e-01 | Female-biased |
| BRCA | RBM4 | exon_skip_97513 | 9.24e+00 | 8.17e-03 | 9.94e+00 | 9.90e-01 | Female-biased |
| READ | HNRNPH2 | exon_skip_97499 | 8.02e+00 | 7.49e-03 | 8.38e+00 | 9.86e-01 | Female-biased |
| READ | RBM28 | exon_skip_97524 | 9.56e+00 | 9.95e-01 | 9.08e+00 | 2.11e-03 | Male-biased |
| MESO | HNRNPH2 | exon_skip_97499 | 8.28e+00 | 9.81e-01 | 7.94e+00 | 1.19e-02 | Male-biased |
| MESO | RBM28 | exon_skip_97524 | 9.20e+00 | 2.63e-03 | 9.68e+00 | 9.95e-01 | Female-biased |
| LGG | ENOX1 | exon_skip_97524 | 6.45e+00 | 3.42e-03 | 6.88e+00 | 9.82e-01 | Female-biased |
| PAAD | RBM28 | exon_skip_97524 | 9.70e+00 | 9.87e-01 | 9.41e+00 | 1.07e-02 | Male-biased |
| PAAD | ZC3H10 | exon_skip_97524 | 6.56e+00 | 9.81e-01 | 6.13e+00 | 2.03e-03 | Male-biased |
| KIRC | HNRNPH2 | exon_skip_97499 | 7.98e+00 | 9.90e-03 | 8.30e+00 | 9.83e-01 | Female-biased |
| SARC | HNRNPH2 | exon_skip_97499 | 8.13e+00 | 1.38e-03 | 8.73e+00 | 9.93e-01 | Female-biased |
| PXN related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs11066823 | chr12:113934366:G:C | - | 0.180121161860057 | 0.0209812124871573 | HNSC | Female-baised eQTL |
| rs11066824 | chr12:113934501:A:G | - | 0.163238466853091 | 0.0413395675405936 | HNSC | Female-baised eQTL |
| rs11066834 | chr12:113938684:G:A | - | 0.162539356680164 | 0.0435586693255154 | HNSC | Female-baised eQTL |
| rs4129476 | chr12:128726003:A:G | - | 0.176708502347084 | 0.00553870197167366 | SARC | Female-baised eQTL |
| rs10847673 | chr12:128718817:A:G | - | 0.173442550568193 | 0.00778843945227376 | SARC | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs11068763 | chr12:117958857:A:T | - | 0.15791445301716 | 0.000496441533146398 | SARC | Male-baised eQTL |
| rs1726374 | chr12:124797274:C:T | - | 0.166583590181856 | 0.00148138169498888 | SARC | Male-baised eQTL |
| rs10219731 | chr12:116318599:G:A | - | -0.0902618674561063 | 0.0157737219900279 | SARC | Male-baised eQTL |
| rs10847824 | chr12:129277289:G:A | - | 0.123722636849506 | 0.0350162046320967 | SARC | Male-baised eQTL |
| rs73223549 | chr12:124293368:C:T | - | 0.0789826300092434 | 0.0440323938841847 | LUSC | Male-baised eQTL |
| rs10850595 | chr12:116110744:G:A | - | 0.0605316821514418 | 0.00767149652935542 | BLCA | Male-baised eQTL |
| rs11065341 | chr12:120932157:T:G | - | 0.0650035450161305 | 0.010987597125648 | BLCA | Male-baised eQTL |
| rs11067587 | chr12:115415919:T:C | - | 0.0423249862650996 | 0.0117207010244234 | BLCA | Male-baised eQTL |
| rs12426260 | chr12:116582947:G:A | - | 0.0771325317901042 | 0.0138016233968722 | BLCA | Male-baised eQTL |
| rs10431373 | chr12:120881816:C:A | - | 0.069641441518254 | 0.0250636474586788 | BLCA | Male-baised eQTL |
| rs16943162 | chr12:113736969:T:G | - | 0.055629051015428 | 0.0324164244108791 | BLCA | Male-baised eQTL |
| rs7960784 | chr12:120789379:G:A | - | 0.0448786847631998 | 0.0400297008803289 | BLCA | Male-baised eQTL |
| rs4766777 | chr12:116014558:A:C | - | 0.0644981365665581 | 0.0422085772632516 | BLCA | Male-baised eQTL |
| rs12425217 | chr12:129404068:G:A | - | 0.0520898216063903 | 0.0428755560678557 | BLCA | Male-baised eQTL |
| rs11067748 | chr12:115722466:G:T | - | 0.0382702345000443 | 0.0458981790158292 | BLCA | Male-baised eQTL |
| rs2393725 | chr12:120754816:A:G | - | 0.044021173905449 | 0.0473653313439715 | BLCA | Male-baised eQTL |
| rs10850559 | chr12:115722469:A:G | - | 0.0381572441920316 | 0.0476908483299232 | BLCA | Male-baised eQTL |
| rs7978886 | chr12:129429490:C:T | - | -0.0646369219747126 | 0.00103577685923614 | COAD | Male-baised eQTL |
| rs16942880 | chr12:113582684:C:G | - | -0.0697058558753129 | 0.0284697176330639 | COAD | Male-baised eQTL |
| rs73195205 | chr12:114175367:G:T | - | -0.0965993111827202 | 0.0361566513972821 | COAD | Male-baised eQTL |
| rs7954415 | chr12:125811635:C:T | - | -0.0486703986065335 | 0.0368812517045494 | COAD | Male-baised eQTL |
| rs56212914 | chr12:114171181:C:T | - | -0.097366474631634 | 0.037018707368649 | COAD | Male-baised eQTL |
| rs75651783 | chr12:114174716:C:T | - | -0.097330054191256 | 0.0372219267104287 | COAD | Male-baised eQTL |
| rs4448746 | chr12:125173806:C:G | - | -0.0515461946132372 | 0.0392871431843308 | COAD | Male-baised eQTL |
| rs17607395 | chr12:114182435:C:T | - | -0.0943460535994913 | 0.0404367175500834 | COAD | Male-baised eQTL |
| rs56272002 | chr12:114181711:G:A | - | -0.0937300500907428 | 0.0426001313878832 | COAD | Male-baised eQTL |
| rs17579603 | chr12:114181807:G:C | - | -0.0937300500907428 | 0.0426001313878832 | COAD | Male-baised eQTL |
| rs55822123 | chr12:114181898:C:T | - | -0.0937300500907428 | 0.0426001313878832 | COAD | Male-baised eQTL |
| rs55659238 | chr12:114182843:C:G | - | -0.0937300500907428 | 0.0426001313878832 | COAD | Male-baised eQTL |
| rs56153787 | chr12:114184167:T:C | - | -0.0937300500907428 | 0.0426001313878832 | COAD | Male-baised eQTL |
| rs56124011 | chr12:114185550:C:A | - | -0.0937300500907428 | 0.0426001313878832 | COAD | Male-baised eQTL |
| rs73195226 | chr12:114191906:C:T | - | -0.0937300500907428 | 0.0426001313878832 | COAD | Male-baised eQTL |
| rs838326 | chr12:114503746:A:C | - | 0.0874109971363067 | 0.0435482450946574 | COAD | Male-baised eQTL |
| rs56328692 | chr12:114183348:C:T | - | -0.0934069437287408 | 0.0439586010097996 | COAD | Male-baised eQTL |
| rs11060314 | chr12:129394884:C:G | - | 0.047494131750424 | 0.0448568471645941 | COAD | Male-baised eQTL |
| rs61953428 | chr12:121241525:G:A | - | -0.0680791065955513 | 0.045390099377243 | COAD | Male-baised eQTL |
| rs4140703 | chr12:114181198:A:G | - | -0.0936097851050309 | 0.0472583730103392 | COAD | Male-baised eQTL |
| rs55870434 | chr12:114187532:A:G | - | -0.0936097851050309 | 0.0472583730103392 | COAD | Male-baised eQTL |
| rs56044493 | chr12:114190895:C:T | - | -0.0936097851050309 | 0.0472583730103392 | COAD | Male-baised eQTL |
| rs56327154 | chr12:114193664:C:A | - | -0.0936097851050309 | 0.0472583730103392 | COAD | Male-baised eQTL |
| rs55939057 | chr12:114193735:C:G | - | -0.0936097851050309 | 0.0472583730103392 | COAD | Male-baised eQTL |
| rs73197335 | chr12:114193940:T:C | - | -0.0936097851050309 | 0.0472583730103392 | COAD | Male-baised eQTL |
| rs55980442 | chr12:114183270:C:T | - | -0.0932882017327405 | 0.0487141200508797 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000089159 |
| CpG Site: cg15893360 | |
| Position to Gene: gene | |
| Male Effect: -0.43425716022054 | |
| Female Effect: - | |
 | Gene ID: ENSG00000089159 |
| CpG Site: cg27168573 | |
| Position to Gene: gene | |
| Male Effect: -0.43425716022054 | |
| Female Effect: - | |
 | Gene ID: ENSG00000089159 |
| CpG Site: cg15893360 | |
| Position to Gene: gene | |
| Male Effect: -0.449823973317577 | |
| Female Effect: - | |
 | Gene ID: ENSG00000089159 |
| CpG Site: cg27168573 | |
| Position to Gene: gene | |
| Male Effect: -0.449823973317577 | |
| Female Effect: - | |
 | Gene ID: ENSG00000089159 |
| CpG Site: cg07470634 | |
| Position to Gene: gene | |
| Male Effect: -0.341289757966477 | |
| Female Effect: - | |
 | Gene ID: ENSG00000089159 |
| CpG Site: cg27168573 | |
| Position to Gene: gene | |
| Male Effect: -0.341289757966477 | |
| Female Effect: - | |
 | Gene ID: ENSG00000089159 |
| CpG Site: cg11307565 | |
| Position to Gene: gene | |
| Male Effect: -0.341289757966477 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg15893360 | chr12:120262558 | gene | -0.43425716022054 | 3.53517668979089e-15 | -0.5426316700133683 | 1.788873602616175e-18 | LUAD |
| cg27168573 | chr12:120263126 | gene | -0.43425716022054 | 3.53517668979089e-15 | -0.5426316700133683 | 1.788873602616175e-18 | LUAD |
| cg15893360 | chr12:120262558 | gene | -0.449823973317577 | 6.02958298331467e-34 | -0.7291827790661216 | 8.995558464116465e-38 | STAD |
| cg27168573 | chr12:120263126 | gene | -0.449823973317577 | 6.02958298331467e-34 | -0.7291827790661216 | 8.995558464116465e-38 | STAD |
| cg07470634 | chr12:120229121 | gene | -0.341289757966477 | 1.36708508070934e-06 | -0.3216345242371829 | 2.2264542092047554e-08 | LGG |
| cg27168573 | chr12:120263126 | gene | -0.341289757966477 | 1.36708508070934e-06 | -0.3216345242371829 | 2.2264542092047554e-08 | LGG |
| cg11307565 | chr12:120263362 | gene | -0.341289757966477 | 1.36708508070934e-06 | -0.3216345242371829 | 2.2264542092047554e-08 | LGG |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_97425 | chr12:120215559:120215661 | In-frame | rs1179434 | chr12:120348280:C:A | Distant upstream | 0.0326873894991597 | 0.040943237620448 | LUSC | Female-baised sQTL |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of PXN |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000089159 | PXN | C0004565 | Melanoma, B16 | 1 | CTD_human |
| ENSG00000089159 | PXN | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
| ENSG00000089159 | PXN | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
| ENSG00000089159 | PXN | C0009075 | Melanoma, Cloudman S91 | 1 | CTD_human |
| ENSG00000089159 | PXN | C0018598 | Melanoma, Harding-Passey | 1 | CTD_human |
| ENSG00000089159 | PXN | C0025205 | Melanoma, Experimental | 1 | CTD_human |
| ENSG00000089159 | PXN | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
