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Gene: ENSG00000085377 |
Summary for PREP |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000085377 | Gene symbol | PREP |
| Gene name | prolyl endopeptidase | |
| HGNC | 9358 | |
| Entrez ID | 5550 | |
| Gene type | protein_coding | |
| Synonyms | PREP| | |
| UniProtAcc | P48147 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| ENSG00000085377 | PREP | DB01684 | 1-Hydroxy-1-Thio-Glycerol | SmallMoleculeDrug |
| ENSG00000085377 | PREP | DB03382 | S-oxy-L-cysteine | SmallMoleculeDrug |
| ENSG00000085377 | PREP | DB03535 | Z-Pro-Prolinal | SmallMoleculeDrug |
| ENSG00000085377 | PREP | DB03864 | Monothioglycerol | SmallMoleculeDrug |
| ENSG00000085377 | PREP | DB07148 | (6S)-1-chloro-3-[(4-fluorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)pyrrolo[1,2-a]pyrazin-4(6H)-one | SmallMoleculeDrug |
| ENSG00000085377 | PREP | DB08738 | 1-{3-oxo-3-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propyl}-3-phenylquinoxalin-2(1H)-one | SmallMoleculeDrug |
| ENSG00000085377 | PREP | DB08739 | 2-{3-[(2S)-4,4-difluoro-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-3-oxopropyl}-isoindole-1,3(2H)-dione | SmallMoleculeDrug |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for PREP |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for PREP |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for PREP |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Top |
Exon skipping events with PSI in TCGA for PREP |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for PREP |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
 |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| COAD | PREP-001 | chr6_105307193_- | 4.88e-01 | 2.81e-01 | 3.36e+00 | 7.71e-04 | 1.45e-02 | 2.07e-01 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for PREP |
| TFs related to PREP. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BLCA | ZNF418 | PREP | 4.09e+00 | 9.82e-01 | 3.05e+00 | 4.08e-03 | Male-biased |
| DLBC | PRDM6 | PREP | 3.21e+00 | 1.62e-03 | 4.62e+00 | 9.93e-01 | Female-biased |
| DLBC | ZNF182 | PREP | 3.10e+00 | 2.32e-03 | 4.40e+00 | 9.90e-01 | Female-biased |
| DLBC | ZNF22 | PREP | 3.11e+00 | 2.11e-03 | 4.43e+00 | 9.91e-01 | Female-biased |
| DLBC | ZNF225 | PREP | 3.20e+00 | 1.45e-03 | 4.65e+00 | 9.93e-01 | Female-biased |
| DLBC | ZNF235 | PREP | 3.47e+00 | 1.25e-03 | 4.96e+00 | 9.96e-01 | Female-biased |
| DLBC | ZNF287 | PREP | 3.53e+00 | 1.53e-03 | 4.96e+00 | 9.95e-01 | Female-biased |
| DLBC | ZNF384 | PREP | 2.99e+00 | 3.42e-03 | 4.17e+00 | 9.85e-01 | Female-biased |
| DLBC | ZNF418 | PREP | 3.25e+00 | 1.01e-03 | 4.80e+00 | 9.95e-01 | Female-biased |
| DLBC | ZNF487 | PREP | 3.30e+00 | 1.71e-03 | 4.70e+00 | 9.94e-01 | Female-biased |
| DLBC | ZNF492 | PREP | 3.36e+00 | 4.49e-03 | 4.48e+00 | 9.89e-01 | Female-biased |
| DLBC | ZNF567 | PREP | 3.14e+00 | 7.21e-03 | 4.12e+00 | 9.80e-01 | Female-biased |
| DLBC | ZNF570 | PREP | 3.23e+00 | 5.92e-03 | 4.27e+00 | 9.84e-01 | Female-biased |
| DLBC | ZNF613 | PREP | 3.16e+00 | 3.54e-03 | 4.34e+00 | 9.88e-01 | Female-biased |
| DLBC | ZNF879 | PREP | 3.20e+00 | 1.28e-03 | 4.68e+00 | 9.94e-01 | Female-biased |
| MESO | ZNF25 | PREP | 3.07e+00 | 9.81e-03 | 4.34e+00 | 9.81e-01 | Female-biased |
| MESO | ZNF418 | PREP | 2.96e+00 | 6.82e-03 | 4.35e+00 | 9.84e-01 | Female-biased |
| PREP related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for PREP |
| RBPs related to ES in PREP. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| UVM | ENOX1 | exon_skip_461417 | 9.66e+00 | 9.95e-01 | 9.24e+00 | 2.29e-03 | Male-biased |
| KICH | ENOX1 | exon_skip_461417 | 9.13e+00 | 1.46e-02 | 9.42e+00 | 9.82e-01 | Female-biased |
| PREP related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs12192409 | chr6:106398142:G:A | - | 0.106409858726239 | 0.00919258379601649 | BLCA | Female-baised eQTL |
| rs56122958 | chr6:106399181:T:C | - | 0.106409858726239 | 0.00919258379601649 | BLCA | Female-baised eQTL |
| rs2792467 | chr6:106548800:A:T | - | 0.118171986708558 | 0.0118239120930924 | BLCA | Female-baised eQTL |
| rs847596 | chr6:108257774:G:A | - | 0.112572507356523 | 0.0169060633983802 | BLCA | Female-baised eQTL |
| rs55974983 | chr6:106397065:A:G | - | 0.0993556370877317 | 0.0206831285400806 | BLCA | Female-baised eQTL |
| rs4946797 | chr6:106821352:G:A | - | 0.0981590207141311 | 0.038135190351031 | BLCA | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs72931544 | chr6:105775952:C:T | - | 0.0510379040677239 | 1.97670915136609e-05 | LUSC | Male-baised eQTL |
| rs72931545 | chr6:105776377:G:A | - | 0.0510379040677239 | 1.97670915136609e-05 | LUSC | Male-baised eQTL |
| rs72931552 | chr6:105778897:C:T | - | 0.0510379040677239 | 1.97670915136609e-05 | LUSC | Male-baised eQTL |
| rs12663858 | chr6:105781687:C:T | - | 0.0510152983309902 | 2.01915234299923e-05 | LUSC | Male-baised eQTL |
| rs12664161 | chr6:105781698:G:A | - | 0.0510152983309902 | 2.01915234299923e-05 | LUSC | Male-baised eQTL |
| rs575141 | chr6:103176059:A:G | - | -0.0454157486227135 | 0.000506349495917516 | LUSC | Male-baised eQTL |
| rs12523767 | chr6:105122095:A:T | - | 0.0454954161381102 | 0.000518276723996279 | LUSC | Male-baised eQTL |
| rs35128336 | chr6:105185195:C:A | - | 0.0479317904965972 | 0.000633319524738112 | LUSC | Male-baised eQTL |
| rs2205681 | chr6:103111400:G:A | - | -0.0435727541013908 | 0.000756305090651871 | LUSC | Male-baised eQTL |
| rs531238 | chr6:103187986:T:C | - | -0.0446878305718504 | 0.000764489845413054 | LUSC | Male-baised eQTL |
| rs557167 | chr6:103179225:T:G | - | -0.0441958882596443 | 0.000799004955406503 | LUSC | Male-baised eQTL |
| rs495729 | chr6:103181617:C:G | - | -0.0441958882596443 | 0.000799004955406503 | LUSC | Male-baised eQTL |
| rs493338 | chr6:103184817:A:G | - | -0.0441386379818194 | 0.000834912344194316 | LUSC | Male-baised eQTL |
| rs73769950 | chr6:105191486:T:C | - | 0.0445376624351337 | 0.00144170464196493 | LUSC | Male-baised eQTL |
| rs503756 | chr6:103188712:G:A | - | -0.0427897207860374 | 0.00147662927179591 | LUSC | Male-baised eQTL |
| rs485898 | chr6:103192047:C:T | - | -0.0427897207860374 | 0.00147662927179591 | LUSC | Male-baised eQTL |
| rs550097 | chr6:103235865:T:C | - | -0.0417198727810483 | 0.00220271752266624 | LUSC | Male-baised eQTL |
| rs62429489 | chr6:103359490:A:T | - | 0.0420328778374852 | 0.00239533551990803 | LUSC | Male-baised eQTL |
| rs62429499 | chr6:103375487:T:A | - | 0.0417071669585978 | 0.00287652653500544 | LUSC | Male-baised eQTL |
| rs2223804 | chr6:103375548:A:C | - | 0.0417071669585978 | 0.00287652653500544 | LUSC | Male-baised eQTL |
| rs2207003 | chr6:103375790:T:A | - | 0.0417071669585978 | 0.00287652653500544 | LUSC | Male-baised eQTL |
| rs62429500 | chr6:103377445:G:T | - | 0.0417102723724137 | 0.00288316304367719 | LUSC | Male-baised eQTL |
| rs62429501 | chr6:103378521:T:C | - | 0.0417121009910724 | 0.00289235028001842 | LUSC | Male-baised eQTL |
| rs9373677 | chr6:103100818:C:T | - | -0.0396341725815795 | 0.00303794409264067 | LUSC | Male-baised eQTL |
| rs1012497 | chr6:103097940:A:T | - | -0.0396356547243387 | 0.00304845022633532 | LUSC | Male-baised eQTL |
| rs2205680 | chr6:103105377:T:G | - | -0.0396356547243387 | 0.00304845022633532 | LUSC | Male-baised eQTL |
| rs6914058 | chr6:103344514:T:C | - | -0.0412235854806749 | 0.00305267197938821 | LUSC | Male-baised eQTL |
| rs2223818 | chr6:103366958:C:A | - | 0.0412022356472631 | 0.00307802684416724 | LUSC | Male-baised eQTL |
| rs7753824 | chr6:103356942:T:C | - | -0.0412022356472631 | 0.00307802684416724 | LUSC | Male-baised eQTL |
| rs62429497 | chr6:103372137:T:A | - | 0.041157037006707 | 0.00316707078540014 | LUSC | Male-baised eQTL |
| rs9322699 | chr6:103092085:T:C | - | -0.0392824003351753 | 0.0037240251006828 | LUSC | Male-baised eQTL |
| rs2205678 | chr6:103099736:G:A | - | -0.038945140036198 | 0.00381024114368926 | LUSC | Male-baised eQTL |
| rs4946823 | chr6:103103339:C:A | - | -0.038945140036198 | 0.00381024114368926 | LUSC | Male-baised eQTL |
| rs760574 | chr6:103108251:C:T | - | -0.038945140036198 | 0.00381024114368926 | LUSC | Male-baised eQTL |
| rs7769040 | chr6:103348624:A:T | - | -0.0405056294448318 | 0.00381641226169263 | LUSC | Male-baised eQTL |
| rs2399931 | chr6:103346356:G:A | - | -0.0403612625375329 | 0.00402953576402002 | LUSC | Male-baised eQTL |
| rs2032569 | chr6:103347006:C:T | - | -0.0403612625375329 | 0.00402953576402002 | LUSC | Male-baised eQTL |
| rs62429145 | chr6:103066862:A:T | - | 0.0385311809032753 | 0.00413024139132499 | LUSC | Male-baised eQTL |
| rs2157554 | chr6:103330280:C:T | - | -0.0398051712195142 | 0.00461074780155873 | LUSC | Male-baised eQTL |
| rs2157553 | chr6:103330305:G:A | - | -0.0398051712195142 | 0.00461074780155873 | LUSC | Male-baised eQTL |
| rs2787112 | chr6:105180024:T:G | - | -0.0403522879028946 | 0.00480120817520006 | LUSC | Male-baised eQTL |
| rs62429144 | chr6:103066571:C:T | - | 0.0378846202347455 | 0.00505286614675176 | LUSC | Male-baised eQTL |
| rs62429143 | chr6:103065762:G:A | - | 0.0374999475931613 | 0.00537013113499651 | LUSC | Male-baised eQTL |
| rs17066212 | chr6:105701712:A:G | - | 0.0405747791119412 | 0.0054167328959932 | LUSC | Male-baised eQTL |
| rs176425 | chr6:103084485:C:T | - | -0.0376783786520319 | 0.00559891047220714 | LUSC | Male-baised eQTL |
| rs6934744 | chr6:103321766:C:T | - | -0.0381910783928406 | 0.00661311122199942 | LUSC | Male-baised eQTL |
| rs6571101 | chr6:103322464:A:C | - | -0.0381910783928406 | 0.00661311122199942 | LUSC | Male-baised eQTL |
| rs9404352 | chr6:103324632:G:C | - | -0.0381910783928406 | 0.00661311122199942 | LUSC | Male-baised eQTL |
| rs9404354 | chr6:103327001:A:G | - | -0.0381910783928406 | 0.00661311122199942 | LUSC | Male-baised eQTL |
| rs7768059 | chr6:103327431:G:T | - | -0.0381910783928406 | 0.00661311122199942 | LUSC | Male-baised eQTL |
| rs6901400 | chr6:103329045:G:A | - | -0.0381910783928406 | 0.00661311122199942 | LUSC | Male-baised eQTL |
| rs239243 | chr6:100644389:C:T | - | 0.0351143792125156 | 0.00662043968650347 | LUSC | Male-baised eQTL |
| rs62429146 | chr6:103069813:G:A | - | 0.0370978938071708 | 0.00666019586681368 | LUSC | Male-baised eQTL |
| rs62429147 | chr6:103070981:A:G | - | 0.0370978938071708 | 0.00666019586681368 | LUSC | Male-baised eQTL |
| rs176436 | chr6:103079868:A:G | - | -0.0370564725248563 | 0.00678732206069522 | LUSC | Male-baised eQTL |
| rs176429 | chr6:103083759:A:G | - | -0.0370564725248563 | 0.00678732206069522 | LUSC | Male-baised eQTL |
| rs4259285 | chr6:103089727:G:A | - | -0.0370564725248563 | 0.00678732206069522 | LUSC | Male-baised eQTL |
| rs9404357 | chr6:103338029:C:G | - | -0.0380670638032158 | 0.00710140290781182 | LUSC | Male-baised eQTL |
| rs9390990 | chr6:103340374:A:C | - | -0.0374894721608775 | 0.00819019998197789 | LUSC | Male-baised eQTL |
| rs61430404 | chr6:103340532:A:G | - | -0.0374894721608775 | 0.00819019998197789 | LUSC | Male-baised eQTL |
| rs9485801 | chr6:103340727:A:T | - | -0.0374894721608775 | 0.00819019998197789 | LUSC | Male-baised eQTL |
| rs1476054 | chr6:103339170:A:C | - | -0.0374364082567971 | 0.00837499265841127 | LUSC | Male-baised eQTL |
| rs9404358 | chr6:103339956:C:T | - | -0.0374364082567971 | 0.00837499265841127 | LUSC | Male-baised eQTL |
| rs9390988 | chr6:103340015:C:T | - | -0.0374364082567971 | 0.00837499265841127 | LUSC | Male-baised eQTL |
| rs9390989 | chr6:103340021:C:A | - | -0.0374364082567971 | 0.00837499265841127 | LUSC | Male-baised eQTL |
| rs9404359 | chr6:103340252:T:C | - | -0.0374364082567971 | 0.00837499265841127 | LUSC | Male-baised eQTL |
| rs9404360 | chr6:103340287:T:C | - | -0.0374364082567971 | 0.00837499265841127 | LUSC | Male-baised eQTL |
| rs62429123 | chr6:103045544:A:G | - | 0.0358781832189998 | 0.00972622794013152 | LUSC | Male-baised eQTL |
| rs62429121 | chr6:103042607:G:A | - | 0.0349977912150569 | 0.0120229820755354 | LUSC | Male-baised eQTL |
| rs2501181 | chr6:103625234:C:T | - | 0.0366435676798276 | 0.0126670670290955 | LUSC | Male-baised eQTL |
| rs9285558 | chr6:103350298:A:G | - | -0.0363538284852893 | 0.0140877488165269 | LUSC | Male-baised eQTL |
| rs7747690 | chr6:101096362:A:G | - | 0.0339657023609818 | 0.0148459479508702 | LUSC | Male-baised eQTL |
| rs176434 | chr6:103082297:C:T | - | -0.0319761847396647 | 0.0335570350592832 | LUSC | Male-baised eQTL |
| rs75191441 | chr6:105355032:T:C | gene | 0.0329856720686489 | 0.0477824571119797 | LUSC | Male-baised eQTL |
| rs115697506 | chr6:105355947:T:C | gene | 0.0329856720686489 | 0.0477824571119797 | LUSC | Male-baised eQTL |
| rs73516008 | chr6:105358075:T:C | gene | 0.0329384068191004 | 0.047830961901982 | LUSC | Male-baised eQTL |
| rs77520822 | chr6:105356832:A:G | gene | 0.0329344687814343 | 0.0485437756807264 | LUSC | Male-baised eQTL |
| rs9404133 | chr6:101729259:T:C | - | 0.0305208438443736 | 0.0488823917952289 | LUSC | Male-baised eQTL |
| rs11752450 | chr6:105359946:A:G | gene | 0.0328748524930125 | 0.0489422360639645 | LUSC | Male-baised eQTL |
| rs12111467 | chr6:110521982:C:T | - | 0.0723401423662802 | 0.0143335635674428 | STAD | Male-baised eQTL |
| rs58558730 | chr6:107450832:C:G | - | 0.0716506709004215 | 0.0480694874162521 | STAD | Male-baised eQTL |
| rs4945509 | chr6:113993492:G:A | - | 0.0569388053870382 | 0.0351853561133625 | LGG | Male-baised eQTL |
| rs78232430 | chr6:113994877:T:C | - | 0.0569388053870382 | 0.0351853561133625 | LGG | Male-baised eQTL |
| rs6916426 | chr6:114004265:C:T | - | 0.0569388053870382 | 0.0351853561133625 | LGG | Male-baised eQTL |
| rs75308109 | chr6:114006035:T:C | - | 0.0569388053870382 | 0.0351853561133625 | LGG | Male-baised eQTL |
| rs113738880 | chr6:105752085:C:T | - | 0.0726450911872774 | 0.00985816544946487 | BLCA | Male-baised eQTL |
| rs36005151 | chr6:113024691:T:C | - | 0.0367947911452656 | 0.0477019315339635 | BLCA | Male-baised eQTL |
| rs1481323 | chr6:113025104:G:T | - | 0.036756130599507 | 0.0485880019368622 | BLCA | Male-baised eQTL |
| rs9481415 | chr6:95568074:C:T | - | 0.113690245742618 | 0.0359528417732885 | LUAD | Male-baised eQTL |
| rs12530302 | chr6:95785340:C:T | - | 0.0683774300071279 | 0.0400866598555032 | LUAD | Male-baised eQTL |
| rs77723847 | chr6:101382537:T:C | - | 0.129802142984488 | 0.0439916474122572 | LUAD | Male-baised eQTL |
| rs4557564 | chr6:109910848:A:G | - | 0.102554564719094 | 0.00999448969728439 | COAD | Male-baised eQTL |
| rs4383853 | chr6:110743296:C:T | - | 0.0942861440758881 | 0.0109151323031742 | COAD | Male-baised eQTL |
| rs9374141 | chr6:109934071:T:C | - | 0.0594843138021625 | 0.0155240489658732 | COAD | Male-baised eQTL |
| rs35859360 | chr6:109892695:G:A | - | 0.115672644346593 | 0.0173118215560577 | COAD | Male-baised eQTL |
| rs4379330 | chr6:109886283:C:T | - | 0.115772460062462 | 0.0191770160592215 | COAD | Male-baised eQTL |
| rs6926020 | chr6:103787716:T:C | - | 0.0894601707903634 | 0.0209378673002053 | COAD | Male-baised eQTL |
| rs9399785 | chr6:103030947:G:T | - | 0.0681830839112696 | 0.0274771882217127 | COAD | Male-baised eQTL |
| rs9390938 | chr6:103036020:T:A | - | 0.0681830839112696 | 0.0274771882217127 | COAD | Male-baised eQTL |
| rs71558386 | chr6:109884082:A:G | - | 0.104331246917073 | 0.0406214168980268 | COAD | Male-baised eQTL |
| rs4947028 | chr6:109868541:T:A | - | 0.0528936680772977 | 0.0424814079072146 | COAD | Male-baised eQTL |
| rs9404303 | chr6:103036077:C:T | - | 0.0634274721706339 | 0.0467340831468293 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000085377 |
| CpG Site: cg26252958 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.39496848211473 | |
 | Gene ID: ENSG00000085377 |
| CpG Site: cg06471536 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.335853552929089 | |
 | Gene ID: ENSG00000085377 |
| CpG Site: cg12485556 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.226113688664946 | |
 | Gene ID: ENSG00000085377 |
| CpG Site: cg14309307 | |
| Position to Gene: gene | |
| Male Effect: -0.488490760166393 | |
| Female Effect: - | |
 | Gene ID: ENSG00000085377 |
| CpG Site: cg18338925 | |
| Position to Gene: gene | |
| Male Effect: -0.488465248504 | |
| Female Effect: - | |
 | Gene ID: ENSG00000085377 |
| CpG Site: cg12485556 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.35570109066233 | |
 | Gene ID: ENSG00000085377 |
| CpG Site: cg26252958 | |
| Position to Gene: gene | |
| Male Effect: -0.398876621737565 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg14309307 | chr6:105302648 | gene | -0.488490760166393 | 5.09375945180233e-143 | -0.9574655779027583 | 7.622625678412979e-149 | LUSC |
| cg18338925 | chr6:105304275 | gene | -0.488465248504 | 7.45479340397064e-143 | -0.9606634634024375 | 8.87018898806694e-143 | LUSC |
| cg26252958 | chr6:105399995 | gene | -0.398876621737565 | 7.35037785397078e-08 | -0.3735593895818967 | 4.214425943992557e-11 | SKCM |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg26252958 | chr6:105399995 | gene | -0.39496848211473 | 3.98972785020239e-05 | -0.5259580789026722 | 5.436913633810786e-07 | PAAD |
| cg06471536 | chr6:105301969 | gene | -0.335853552929089 | 6.33673221722908e-06 | -0.3304755132360488 | 6.51941739630624e-08 | LUAD |
| cg12485556 | chr6:105326742 | gene | -0.226113688664946 | 1.99680622507127e-05 | -0.32319796279396223 | 1.4635511516692175e-07 | LUAD |
| cg12485556 | chr6:105326742 | gene | -0.35570109066233 | 5.85862025660873e-09 | -0.6348577261199237 | 4.882370293517752e-12 | LUSC |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of PREP |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000085377 | PREP | C0002622 | Amnesia | 1 | CTD_human |
| ENSG00000085377 | PREP | C0002624 | Retrograde amnesia | 1 | CTD_human |
| ENSG00000085377 | PREP | C0024623 | Malignant neoplasm of stomach | 1 | CTD_human |
| ENSG00000085377 | PREP | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| ENSG00000085377 | PREP | C0233750 | Hysterical amnesia | 1 | CTD_human |
| ENSG00000085377 | PREP | C0233796 | Temporary Amnesia | 1 | CTD_human |
| ENSG00000085377 | PREP | C0235874 | Disease Exacerbation | 1 | CTD_human |
| ENSG00000085377 | PREP | C0236795 | Dissociative Amnesia | 1 | CTD_human |
| ENSG00000085377 | PREP | C0262497 | Global Amnesia | 1 | CTD_human |
| ENSG00000085377 | PREP | C0338831 | Manic | 1 | PSYGENET |
| ENSG00000085377 | PREP | C0750906 | Tactile Amnesia | 1 | CTD_human |
| ENSG00000085377 | PREP | C0750907 | Amnestic State | 1 | CTD_human |
| ENSG00000085377 | PREP | C0750908 | Pre-Ictal Amnesia | 1 | CTD_human |
| ENSG00000085377 | PREP | C0750909 | Retrograde Memory Loss | 1 | CTD_human |
| ENSG00000085377 | PREP | C0750910 | Pre-Ictal Memory Loss | 1 | CTD_human |
| ENSG00000085377 | PREP | C1708349 | Hereditary Diffuse Gastric Cancer | 1 | CTD_human |
