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Gene: ENSG00000082497 |
Summary for SERTAD4 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000082497 | Gene symbol | SERTAD4 |
| Gene name | SERTA domain containing 4 | |
| HGNC | 25236 | |
| Entrez ID | 56256 | |
| Gene type | protein_coding | |
| Synonyms | SERTAD4|DJ667H12.2 | |
| UniProtAcc | Q9NUC0 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for SERTAD4 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for SERTAD4 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for SERTAD4 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| SARC | cg05723989 | chr1:210234332 | CGI:chr1:210234056-210234292 | promoter,gene body | 2.72e-01 | 3.90e-01 | -3.69e+00 | 2.22e-04 | 1.02e-03 | -1.17e-01 |
| CHOL | cg15926004 | chr1:210234628 | CGI:chr1:210234056-210234292 | promoter,gene body | 7.61e-01 | 6.08e-01 | 2.45e+00 | 1.42e-02 | 2.68e-02 | 1.53e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUAD | cg18234296 | chr1:210234551 | CGI:chr1:210234056-210234292 | promoter,gene body | 4.44e-01 | 5.48e-01 | -4.32e+00 | 1.59e-05 | 6.13e-05 | -1.04e-01 |
| LUAD | cg15926004 | chr1:210234628 | CGI:chr1:210234056-210234292 | promoter,gene body | 6.58e-01 | 7.66e-01 | -3.44e+00 | 5.80e-04 | 1.23e-03 | -1.08e-01 |
| LUSC | cg02743029 | chr1:210231867 | CGI:chr1:210232598-210233905 | promoter | 1.46e-01 | 3.23e-01 | -3.37e+00 | 7.45e-04 | 2.14e-03 | -1.77e-01 |
| BLCA | cg02743029 | chr1:210231867 | CGI:chr1:210232598-210233905 | promoter | 1.62e-01 | 2.82e-01 | -2.73e+00 | 6.36e-03 | 9.86e-03 | -1.19e-01 |
| LIHC | cg18234296 | chr1:210234551 | CGI:chr1:210234056-210234292 | promoter,gene body | 3.60e-01 | 4.80e-01 | -5.01e+00 | 5.34e-07 | 2.17e-06 | -1.20e-01 |
| KIRP | cg04282788 | chr1:210234128 | CGI:chr1:210234056-210234292 | promoter,gene body | 1.05e-01 | 2.15e-01 | -6.41e+00 | 1.46e-10 | 5.01e-08 | -1.11e-01 |
| ESCA | cg18234296 | chr1:210234551 | CGI:chr1:210234056-210234292 | promoter,gene body | 5.36e-01 | 4.04e-01 | 2.44e+00 | 1.46e-02 | 3.80e-02 | 1.31e-01 |
| ESCA | cg15926004 | chr1:210234628 | CGI:chr1:210234056-210234292 | promoter,gene body | 7.20e-01 | 5.62e-01 | 2.87e+00 | 4.12e-03 | 3.39e-02 | 1.58e-01 |
| CHOL | cg18265162 | chr1:210234243 | CGI:chr1:210234056-210234292 | promoter,gene body | 2.20e-01 | 3.43e-01 | -2.14e+00 | 3.25e-02 | 3.87e-02 | -1.23e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg05723989 | chr1:210234332 | CGI:chr1:210234056-210234292 | promoter,gene body | 9.88e-02 | 2.45e-01 | -1.27e+01 | 6.75e-37 | 2.75e-35 | -1.47e-01 |
| BRCA | cg02743029 | chr1:210231867 | CGI:chr1:210232598-210233905 | promoter | 1.49e-01 | 2.61e-01 | -9.11e+00 | 8.58e-20 | 4.56e-19 | -1.12e-01 |
| BRCA | cg04282788 | chr1:210234128 | CGI:chr1:210234056-210234292 | promoter,gene body | 1.17e-01 | 2.21e-01 | -1.37e+01 | 1.83e-42 | 2.80e-40 | -1.04e-01 |
| BRCA | cg25876656 | chr1:210234135 | CGI:chr1:210234056-210234292 | promoter,gene body | 9.07e-02 | 2.21e-01 | -1.39e+01 | 9.54e-44 | 2.31e-41 | -1.30e-01 |
| BRCA | cg18265162 | chr1:210234243 | CGI:chr1:210234056-210234292 | promoter,gene body | 1.04e-01 | 3.56e-01 | -1.45e+01 | 7.82e-48 | 2.84e-44 | -2.52e-01 |
| BRCA | cg16118387 | chr1:210234410 | CGI:chr1:210234056-210234292 | promoter,gene body | 2.26e-01 | 3.91e-01 | -1.36e+01 | 5.44e-42 | 7.17e-40 | -1.65e-01 |
| LIHC | cg06098761 | chr1:210232463 | CGI:chr1:210232598-210233905 | promoter | 1.97e-01 | 9.21e-02 | 3.70e+00 | 2.15e-04 | 6.87e-04 | 1.04e-01 |
| LIHC | cg22864433 | chr1:210232471 | CGI:chr1:210232598-210233905 | promoter | 1.52e-01 | 5.06e-02 | 4.21e+00 | 2.56e-05 | 1.38e-04 | 1.02e-01 |
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Exon skipping events with PSI in TCGA for SERTAD4 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for SERTAD4 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for SERTAD4 |
| TFs related to SERTAD4. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BRCA | PRDM6 | SERTAD4 | 4.70e+00 | 9.95e-01 | 1.78e+00 | 4.54e-05 | Male-biased |
| BRCA | ZNF182 | SERTAD4 | 4.60e+00 | 9.94e-01 | 2.00e+00 | 1.30e-04 | Male-biased |
| BRCA | ZNF22 | SERTAD4 | 4.68e+00 | 9.95e-01 | 1.95e+00 | 8.56e-05 | Male-biased |
| BRCA | ZNF225 | SERTAD4 | 4.74e+00 | 9.95e-01 | 2.09e+00 | 1.11e-04 | Male-biased |
| BRCA | ZNF235 | SERTAD4 | 5.17e+00 | 9.98e-01 | 1.67e+00 | 8.33e-06 | Male-biased |
| BRCA | ZNF287 | SERTAD4 | 4.95e+00 | 9.97e-01 | 1.83e+00 | 2.45e-05 | Male-biased |
| BRCA | ZNF334 | SERTAD4 | 4.61e+00 | 9.90e-01 | 3.02e+00 | 3.47e-03 | Male-biased |
| BRCA | ZNF384 | SERTAD4 | 4.34e+00 | 9.90e-01 | 2.07e+00 | 4.19e-04 | Male-biased |
| BRCA | ZNF487 | SERTAD4 | 4.85e+00 | 9.96e-01 | 1.87e+00 | 3.76e-05 | Male-biased |
| BRCA | ZNF492 | SERTAD4 | 4.39e+00 | 9.91e-01 | 2.15e+00 | 4.62e-04 | Male-biased |
| BRCA | ZNF613 | SERTAD4 | 4.44e+00 | 9.92e-01 | 2.18e+00 | 4.30e-04 | Male-biased |
| BRCA | ZNF879 | SERTAD4 | 4.83e+00 | 9.96e-01 | 2.18e+00 | 1.13e-04 | Male-biased |
| BRCA | ZNF98 | SERTAD4 | 4.45e+00 | 9.92e-01 | 2.12e+00 | 3.37e-04 | Male-biased |
| SKCM | ZNF334 | SERTAD4 | 4.24e+00 | 9.82e-01 | 2.32e+00 | 5.95e-04 | Male-biased |
| UVM | ZNF334 | SERTAD4 | 2.10e+00 | 7.73e-04 | 4.52e+00 | 9.85e-01 | Female-biased |
| UVM | ZNF879 | SERTAD4 | 1.63e+00 | 3.04e-04 | 4.38e+00 | 9.82e-01 | Female-biased |
| SERTAD4 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for SERTAD4 |
| RBPs related to ES in SERTAD4. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| SERTAD4 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs146618702 | chr1:214471080:T:A | - | 0.128702377233515 | 0.0253638104614847 | HNSC | Female-baised eQTL |
| rs61819624 | chr1:214471111:T:C | - | 0.128702377233515 | 0.0253638104614847 | HNSC | Female-baised eQTL |
| rs61819625 | chr1:214471211:T:C | - | 0.128702377233515 | 0.0253638104614847 | HNSC | Female-baised eQTL |
| rs74139887 | chr1:214471258:A:C | - | 0.128702377233515 | 0.0253638104614847 | HNSC | Female-baised eQTL |
| rs10159464 | chr1:214471646:G:A | - | 0.128702377233515 | 0.0253638104614847 | HNSC | Female-baised eQTL |
| rs10158378 | chr1:214471699:C:T | - | 0.128702377233515 | 0.0253638104614847 | HNSC | Female-baised eQTL |
| rs10159086 | chr1:214471787:A:C | - | 0.128702377233515 | 0.0253638104614847 | HNSC | Female-baised eQTL |
| rs4655353 | chr1:214472190:A:G | - | 0.128702377233515 | 0.0253638104614847 | HNSC | Female-baised eQTL |
| rs61819627 | chr1:214472306:C:T | - | 0.128702377233515 | 0.0253638104614847 | HNSC | Female-baised eQTL |
| rs74139888 | chr1:214472339:G:A | - | 0.128702377233515 | 0.0253638104614847 | HNSC | Female-baised eQTL |
| rs61819628 | chr1:214472405:G:A | - | 0.128702377233515 | 0.0253638104614847 | HNSC | Female-baised eQTL |
| rs17790515 | chr1:214473092:G:A | - | 0.128702377233515 | 0.0253638104614847 | HNSC | Female-baised eQTL |
| rs61819630 | chr1:214473847:C:A | - | 0.128702377233515 | 0.0253638104614847 | HNSC | Female-baised eQTL |
| rs61819631 | chr1:214473989:G:T | - | 0.128702377233515 | 0.0253638104614847 | HNSC | Female-baised eQTL |
| rs61819632 | chr1:214474733:A:G | - | 0.128702377233515 | 0.0253638104614847 | HNSC | Female-baised eQTL |
| rs74139889 | chr1:214472783:C:G | - | 0.128438450392495 | 0.0262171705553425 | HNSC | Female-baised eQTL |
| rs17790562 | chr1:214474285:G:A | - | 0.121380324227149 | 0.0334186451636905 | HNSC | Female-baised eQTL |
| rs75011796 | chr1:214471031:A:C | - | 0.13012381688838 | 0.0378894917166214 | HNSC | Female-baised eQTL |
| rs79842939 | chr1:214471043:A:C | - | 0.13012381688838 | 0.0378894917166214 | HNSC | Female-baised eQTL |
| rs146217406 | chr1:214468471:A:G | - | 0.126326352003417 | 0.0422096427426836 | HNSC | Female-baised eQTL |
| rs76065572 | chr1:214468656:G:C | - | 0.126326352003417 | 0.0422096427426836 | HNSC | Female-baised eQTL |
| rs74139884 | chr1:214468972:T:C | - | 0.126326352003417 | 0.0422096427426836 | HNSC | Female-baised eQTL |
| rs74139885 | chr1:214469056:A:G | - | 0.126326352003417 | 0.0422096427426836 | HNSC | Female-baised eQTL |
| rs61819616 | chr1:214470250:C:T | - | 0.126326352003417 | 0.0422096427426836 | HNSC | Female-baised eQTL |
| rs61819617 | chr1:214470263:A:G | - | 0.126326352003417 | 0.0422096427426836 | HNSC | Female-baised eQTL |
| rs61819618 | chr1:214470530:C:T | - | 0.126326352003417 | 0.0422096427426836 | HNSC | Female-baised eQTL |
| rs61819620 | chr1:214470661:G:A | - | 0.124950813703353 | 0.0429367507944842 | HNSC | Female-baised eQTL |
| rs61819621 | chr1:214470765:T:C | - | 0.124950813703353 | 0.0429367507944842 | HNSC | Female-baised eQTL |
| rs61819622 | chr1:214470882:G:A | - | 0.124950813703353 | 0.0429367507944842 | HNSC | Female-baised eQTL |
| rs61819623 | chr1:214470928:C:G | - | 0.124950813703353 | 0.0429367507944842 | HNSC | Female-baised eQTL |
| rs57880156 | chr1:214458135:A:G | - | 0.124930176498301 | 0.0499256034900128 | HNSC | Female-baised eQTL |
| rs2820456 | chr1:219434911:C:T | - | -0.0466257131171003 | 0.00291512329391897 | LUAD | Female-baised eQTL |
| rs5013629 | chr1:206660691:G:A | - | 0.059867243260083 | 0.00712617858223086 | LUAD | Female-baised eQTL |
| rs1660370 | chr1:214235623:T:C | - | -0.084831846290369 | 0.0131024879663932 | LUAD | Female-baised eQTL |
| rs2085261 | chr1:219431608:C:T | - | -0.0380015509757199 | 0.0323247499463231 | LUAD | Female-baised eQTL |
| rs12073237 | chr1:206639715:T:C | - | -0.0494374405586441 | 0.0419230685838186 | LUAD | Female-baised eQTL |
| rs6540512 | chr1:206640392:A:G | - | -0.0491650431000132 | 0.0456597842725727 | LUAD | Female-baised eQTL |
| rs10863755 | chr1:206638239:C:T | - | -0.0491100503096791 | 0.0467533789607655 | LUAD | Female-baised eQTL |
| rs12403837 | chr1:214985686:G:A | - | 0.0742316644146495 | 0.0495398142830653 | LUAD | Female-baised eQTL |
| rs4240841 | chr1:206633027:G:A | - | -0.0492205348712774 | 0.0499890079062596 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs510262 | chr1:208010884:A:T | - | -0.0775601343600898 | 0.0248007323660511 | LUAD | Male-baised eQTL |
| rs7530576 | chr1:200661690:C:A | - | 0.104800007354876 | 0.0335172649845831 | LUAD | Male-baised eQTL |
| rs586294 | chr1:208010964:A:T | - | -0.07322282441201 | 0.0401789903377802 | LUAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000082497 |
| CpG Site: cg18234296 | |
| Position to Gene: gene,promoter | |
| Male Effect: - | |
| Female Effect: -0.432853458962448 | |
 | Gene ID: ENSG00000082497 |
| CpG Site: cg15926004 | |
| Position to Gene: gene,promoter | |
| Male Effect: - | |
| Female Effect: -0.432853458962448 | |
 | Gene ID: ENSG00000082497 |
| CpG Site: cg04839207 | |
| Position to Gene: gene,enhancer | |
| Male Effect: - | |
| Female Effect: -0.432853458962448 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg18234296 | chr1:210234551 | gene,promoter | -0.432853458962448 | 6.28980674452897e-14 | -0.4955588353574402 | 3.29567948788614e-17 | LUAD |
| cg15926004 | chr1:210234628 | gene,promoter | -0.432853458962448 | 6.28980674452897e-14 | -0.4955588353574402 | 3.29567948788614e-17 | LUAD |
| cg04839207 | chr1:210236982 | gene,enhancer | -0.432853458962448 | 6.28980674452897e-14 | -0.4955588353574402 | 3.29567948788614e-17 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of SERTAD4 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
