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Gene: ENSG00000081760 |
Summary for AACS |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000081760 | Gene symbol | AACS |
| Gene name | acetoacetyl-CoA synthetase | |
| HGNC | 21298 | |
| Entrez ID | 65985 | |
| Gene type | protein_coding | |
| Synonyms | AACS|FLJ12389|SUR-5|ACSF1 | |
| UniProtAcc | Q86V21 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for AACS |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| AACS | 1.39e+03 | 1.90e+00 | 2.73e-01 | 6.98e+00 | 2.96e-12 | 6.99e-11 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| AACS | 2.78e+03 | 1.01e+00 | 1.73e-01 | 5.83e+00 | 5.54e-09 | 3.16e-08 | LUSC |
| AACS | 7.31e+02 | 1.42e+00 | 2.03e-01 | 7.01e+00 | 2.44e-12 | 3.75e-11 | LIHC |
Top |
Sex-biased somatic mutation for AACS |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for AACS |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| SKCM | cg05303448 | chr12:125064989 | CGI:chr12:125065126-125065765 | promoter | 1.94e-01 | 3.05e-01 | 5.88e+00 | 4.07e-09 | 2.34e-08 | -1.11e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg16118089 | chr12:125065996 | CGI:chr12:125065126-125065765 | promoter,gene body | 1.73e-01 | 2.99e-01 | -4.16e+00 | 3.13e-05 | 5.26e-04 | -1.25e-01 |
| CHOL | cg03013422 | chr12:125065804 | CGI:chr12:125065126-125065765 | promoter,gene body | 6.01e-02 | 1.78e-01 | -3.54e+00 | 4.02e-04 | 8.32e-03 | -1.18e-01 |
| CHOL | cg16118089 | chr12:125065996 | CGI:chr12:125065126-125065765 | promoter,gene body | 1.71e-01 | 2.82e-01 | -2.95e+00 | 3.19e-03 | 1.32e-02 | -1.11e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LIHC | cg16118089 | chr12:125065996 | CGI:chr12:125065126-125065765 | promoter,gene body | 2.20e-01 | 3.29e-01 | -4.65e+00 | 3.24e-06 | 3.04e-05 | -1.08e-01 |
Top |
Exon skipping events with PSI in TCGA for AACS |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for AACS |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for AACS |
| TFs related to AACS. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| AACS related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for AACS |
| RBPs related to ES in AACS. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| STAD | SAMD4A | exon_skip_88443 | 7.30e+00 | 9.87e-01 | 6.74e+00 | 1.88e-03 | Male-biased |
| ACC | ESRP2 | exon_skip_88474 | 6.24e+00 | 3.60e-03 | 6.77e+00 | 9.80e-01 | Female-biased |
| LUSC | SAMD4A | exon_skip_88443 | 7.23e+00 | 9.87e-01 | 6.61e+00 | 1.18e-03 | Male-biased |
| COAD | PABPN1 | exon_skip_88437 | 9.03e+00 | 6.84e-03 | 9.40e+00 | 9.90e-01 | Female-biased |
| LUAD | SAMD4A | exon_skip_88443 | 6.37e+00 | 1.05e-03 | 6.95e+00 | 9.85e-01 | Female-biased |
| BRCA | SAMD4A | exon_skip_88443 | 6.26e+00 | 1.64e-03 | 7.49e+00 | 9.88e-01 | Female-biased |
| ESCA | PABPN1 | exon_skip_88437 | 8.92e+00 | 1.17e-02 | 9.35e+00 | 9.85e-01 | Female-biased |
| ESCA | SAMD4A | exon_skip_88443 | 7.26e+00 | 9.83e-01 | 6.73e+00 | 5.31e-03 | Male-biased |
| MESO | PABPN1 | exon_skip_88437 | 9.08e+00 | 8.38e-03 | 9.45e+00 | 9.89e-01 | Female-biased |
| MESO | SART3 | exon_skip_88477 | 6.86e+00 | 6.98e-03 | 7.24e+00 | 9.81e-01 | Female-biased |
| SARC | SAMD4A | exon_skip_88443 | 7.20e+00 | 9.85e-01 | 6.66e+00 | 2.20e-03 | Male-biased |
| AACS related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs10744216 | chr12:125556880:A:G | - | -0.111725009775222 | 0.00220350971373858 | STAD | Female-baised eQTL |
| rs903771 | chr12:116853786:C:A | - | -0.0905215930403489 | 0.0356982373534462 | LGG | Female-baised eQTL |
| rs545343 | chr12:117332768:G:A | - | -0.0801005294087914 | 0.0135653968254245 | KIRC | Female-baised eQTL |
| rs10850995 | chr12:118584415:T:A | - | 0.130833211949636 | 0.0158048100594769 | KIRC | Female-baised eQTL |
| rs471871 | chr12:117327713:T:A | - | -0.0773799096955598 | 0.0164557400144628 | KIRC | Female-baised eQTL |
| rs7295846 | chr12:127913932:G:T | - | -0.0888285508364314 | 0.0376045027789733 | KIRC | Female-baised eQTL |
| rs1716454 | chr12:119543191:G:A | - | 0.0954300436144687 | 0.00897380923669506 | BLCA | Female-baised eQTL |
| rs814161 | chr12:119532327:A:T | - | 0.0949047788067968 | 0.00975730697173994 | BLCA | Female-baised eQTL |
| rs784843 | chr12:119532968:C:T | - | 0.0949047788067968 | 0.00975730697173994 | BLCA | Female-baised eQTL |
| rs1085094 | chr12:119533805:A:G | - | 0.0949047788067968 | 0.00975730697173994 | BLCA | Female-baised eQTL |
| rs146581767 | chr12:119534730:A:G | - | 0.0949047788067968 | 0.00975730697173994 | BLCA | Female-baised eQTL |
| rs1090246 | chr12:119538239:T:C | - | 0.0949047788067968 | 0.00975730697173994 | BLCA | Female-baised eQTL |
| rs1090247 | chr12:119538863:C:A | - | 0.0949047788067968 | 0.00975730697173994 | BLCA | Female-baised eQTL |
| rs2695509 | chr12:119540130:G:A | - | 0.0949047788067968 | 0.00975730697173994 | BLCA | Female-baised eQTL |
| rs708889 | chr12:119540599:A:G | - | 0.0949047788067968 | 0.00975730697173994 | BLCA | Female-baised eQTL |
| rs784847 | chr12:119541015:G:A | - | 0.0949047788067968 | 0.00975730697173994 | BLCA | Female-baised eQTL |
| rs708890 | chr12:119541674:G:A | - | 0.0949047788067968 | 0.00975730697173994 | BLCA | Female-baised eQTL |
| rs1716458 | chr12:119524280:G:A | - | 0.0937820988028257 | 0.011385989873731 | BLCA | Female-baised eQTL |
| rs2711744 | chr12:119524489:A:G | - | 0.0937820988028257 | 0.011385989873731 | BLCA | Female-baised eQTL |
| rs1727433 | chr12:119527956:T:G | - | 0.0937820988028257 | 0.011385989873731 | BLCA | Female-baised eQTL |
| rs708884 | chr12:119520056:T:C | - | 0.0913528952133336 | 0.0164780356995927 | BLCA | Female-baised eQTL |
| rs2695511 | chr12:119537782:T:C | - | 0.0934256309935354 | 0.0198167030710195 | BLCA | Female-baised eQTL |
| rs264508 | chr12:129680202:C:T | - | 0.0606206786995615 | 0.0221729701165019 | LUAD | Female-baised eQTL |
| rs264516 | chr12:129683917:G:A | - | 0.0582457452491596 | 0.0329494483517343 | LUAD | Female-baised eQTL |
| rs264518 | chr12:129685129:G:A | - | 0.0582457452491596 | 0.0329494483517343 | LUAD | Female-baised eQTL |
| rs591194 | chr12:129688665:C:T | - | 0.0584470350447297 | 0.0345600271174125 | LUAD | Female-baised eQTL |
| rs590292 | chr12:129688861:C:A | - | 0.0584470350447297 | 0.0345600271174125 | LUAD | Female-baised eQTL |
| rs264515 | chr12:129683735:T:C | - | 0.057249076570444 | 0.0381076143049916 | LUAD | Female-baised eQTL |
| rs1451906 | chr12:129688441:T:C | - | 0.0578731637885908 | 0.0386933344794434 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs4759384 | chr12:122872464:T:C | - | -0.148134338267462 | 0.0326927113744258 | KIRP | Male-baised eQTL |
| rs7967309 | chr12:115110568:A:G | - | 0.0926762324744938 | 0.0445381019795788 | KIRC | Male-baised eQTL |
| rs6421995 | chr12:131548976:G:T | - | 0.0624921894878297 | 0.00994146541046566 | COAD | Male-baised eQTL |
| rs12810544 | chr12:131548149:C:G | - | 0.0608409789896468 | 0.0143130184820205 | COAD | Male-baised eQTL |
| rs11246898 | chr12:131550384:C:A | - | 0.0577188461339242 | 0.0178590584865962 | COAD | Male-baised eQTL |
| rs35465949 | chr12:131563804:T:C | - | 0.0643568535412419 | 0.0230705217526437 | COAD | Male-baised eQTL |
| rs61934636 | chr12:131544095:T:C | - | 0.0571751188597721 | 0.0320873078158687 | COAD | Male-baised eQTL |
| rs16919429 | chr12:125711643:C:T | - | -0.0951940192747627 | 0.0373735577743708 | COAD | Male-baised eQTL |
| rs2398486 | chr12:129793857:T:C | - | 0.0697005645937653 | 0.0381256593832995 | COAD | Male-baised eQTL |
| rs12370900 | chr12:131547668:T:C | - | 0.0555967377737404 | 0.0388119901285355 | COAD | Male-baised eQTL |
| rs9888360 | chr12:124161278:G:C | - | 0.0525897723649834 | 0.0395262646484564 | COAD | Male-baised eQTL |
| rs12826295 | chr12:131553821:C:G | - | 0.0620872888184508 | 0.0407830349733393 | COAD | Male-baised eQTL |
| rs7300403 | chr12:129396207:G:A | - | -0.0869944749782632 | 0.0446326429329873 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000081760 |
| CpG Site: cg00417147 | |
| Position to Gene: gene | |
| Male Effect: -0.264493254440935 | |
| Female Effect: - | |
 | Gene ID: ENSG00000081760 |
| CpG Site: cg00417147 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.365486979803315 | |
 | Gene ID: ENSG00000081760 |
| CpG Site: cg17297045 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.365486979803315 | |
 | Gene ID: ENSG00000081760 |
| CpG Site: cg21881338 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.365351936770198 | |
 | Gene ID: ENSG00000081760 |
| CpG Site: cg17297045 | |
| Position to Gene: gene | |
| Male Effect: -0.43689521112814 | |
| Female Effect: - | |
 | Gene ID: ENSG00000081760 |
| CpG Site: cg08572757 | |
| Position to Gene: gene | |
| Male Effect: -0.43689521112814 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg00417147 | chr12:125093999 | gene | -0.264493254440935 | 1.10764533348123e-09 | -0.6378649583190359 | 1.6212082637303523e-12 | PAAD |
| cg17297045 | chr12:125096797 | gene | -0.43689521112814 | 3.57557657240227e-19 | -0.5456267365926954 | 8.222784732378574e-23 | LUSC |
| cg08572757 | chr12:125097919 | gene | -0.43689521112814 | 3.57557657240227e-19 | -0.5456267365926954 | 8.222784732378574e-23 | LUSC |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg00417147 | chr12:125093999 | gene | -0.365486979803315 | 4.86040532779395e-05 | -0.32470337951140676 | 1.1327110909839963e-07 | LUAD |
| cg17297045 | chr12:125096797 | gene | -0.365486979803315 | 4.86040532779395e-05 | -0.32470337951140676 | 1.1327110909839963e-07 | LUAD |
| cg21881338 | chr12:125081643 | gene | -0.365351936770198 | 4.91428576659621e-05 | -0.32473240968023126 | 1.1965530439002557e-07 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
 | EX ID: exon_skip_88482 |
| SNP ID: rs12578446 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: -0.0296678928322722 | |
| Female Effect: - | |
 | EX ID: exon_skip_88482 |
| SNP ID: rs7398636 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: -0.0264667655546377 | |
| Female Effect: - | |
 | EX ID: exon_skip_88482 |
| SNP ID: rs58624919 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: -0.0266739572733511 | |
| Female Effect: - | |
 | EX ID: exon_skip_88482 |
| SNP ID: rs57491100 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: -0.0265156144082302 | |
| Female Effect: - | |
 | EX ID: exon_skip_88482 |
| SNP ID: rs57031290 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: -0.0265156144082302 | |
| Female Effect: - | |
 | EX ID: exon_skip_88482 |
| SNP ID: rs2297478 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: -0.0264031268239748 | |
| Female Effect: - | |
 | EX ID: exon_skip_88482 |
| SNP ID: rs12316499 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: -0.0255116915988705 | |
| Female Effect: - | |
 | EX ID: exon_skip_88482 |
| SNP ID: rs35941060 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: -0.0260797047325561 | |
| Female Effect: - | |
 | EX ID: exon_skip_88482 |
| SNP ID: rs4765217 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: -0.0251515436695316 | |
| Female Effect: - | |
 | EX ID: exon_skip_88482 |
| SNP ID: rs34624329 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: -0.0244903946536854 | |
| Female Effect: - | |
 | EX ID: exon_skip_88482 |
| SNP ID: rs7138557 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: -0.0250394842298275 | |
| Female Effect: - | |
 | EX ID: exon_skip_88482 |
| SNP ID: rs12303416 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: -0.0254705657828045 | |
| Female Effect: - | |
 | EX ID: exon_skip_88482 |
| SNP ID: rs10846824 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: -0.0241593230797356 | |
| Female Effect: - | |
 | EX ID: exon_skip_88482 |
| SNP ID: rs12305181 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: -0.0251349283974086 | |
| Female Effect: - | |
 | EX ID: exon_skip_88482 |
| SNP ID: rs55999005 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: -0.0241721502101926 | |
| Female Effect: - | |
 | EX ID: exon_skip_88482 |
| SNP ID: rs56394386 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: -0.0241915730826826 | |
| Female Effect: - | |
 | EX ID: exon_skip_88482 |
| SNP ID: rs7135489 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: -0.0239112632956309 | |
| Female Effect: - | |
 | EX ID: exon_skip_88482 |
| SNP ID: rs4765218 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: -0.023702900236913 | |
| Female Effect: - | |
 | EX ID: exon_skip_88482 |
| SNP ID: rs7953077 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: -0.0231694283886881 | |
| Female Effect: - | |
 | EX ID: exon_skip_88482 |
| SNP ID: rs12302714 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: -0.022946467310557 | |
| Female Effect: - | |
 | EX ID: exon_skip_88482 |
| SNP ID: rs7970937 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: -0.0239225568211436 | |
| Female Effect: - | |
 | EX ID: exon_skip_88482 |
| SNP ID: rs7307700 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: -0.0232441027444931 | |
| Female Effect: - |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs7976029 | chr12:124241874:C:T | Distant upstream | -0.0712662298740364 | 0.0127736040380842 | STAD | Female-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs11057505 | chr12:124199235:G:C | Distant upstream | -0.0383328702410006 | 0.0199574501845525 | STAD | Female-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs11057506 | chr12:124199272:C:T | Distant upstream | -0.0383328702410006 | 0.0199574501845525 | STAD | Female-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs12426519 | chr12:124267207:G:A | Distant upstream | -0.060144867204337 | 0.0448094082581047 | STAD | Female-baised sQTL |
| exon_skip_88474 | chr12:125124901:125125024 | In-frame | rs10846621 | chr12:124183041:C:A | Distant upstream | -0.0509798344219467 | 0.0435152728222037 | GBM | Female-baised sQTL |
| exon_skip_88474 | chr12:125124901:125125024 | In-frame | rs11057512 | chr12:124203825:A:C | Distant upstream | -0.05554225083454 | 0.0465298473800121 | GBM | Female-baised sQTL |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_88474 | chr12:125124901:125125024 | In-frame | rs730280 | chr12:124758416:A:G | Distant upstream | -0.0278577320065966 | 0.0133713522145249 | KIRC | Male-baised sQTL |
| exon_skip_88474 | chr12:125124901:125125024 | In-frame | rs11057777 | chr12:124718223:T:C | Distant upstream | -0.0278700990328442 | 0.0443661081394241 | KIRC | Male-baised sQTL |
| exon_skip_88474 | chr12:125124901:125125024 | In-frame | rs61933399 | chr12:124716953:G:A | Distant upstream | -0.02704156667546 | 0.0484512047397916 | KIRC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs10846836 | chr12:125164063:G:A | Distant downstream | -0.0263612357993943 | 0.000161451010047756 | LUAD | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs2062149 | chr12:125163018:T:C | Distant downstream | -0.0229263751547473 | 0.000295946958341801 | LUAD | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs12818489 | chr12:125163613:T:C | Distant downstream | -0.0229263751547473 | 0.000295946958341801 | LUAD | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs11058059 | chr12:125164093:C:T | Distant downstream | -0.0229787571101475 | 0.000305809003145901 | LUAD | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs7301269 | chr12:125168545:A:G | Distant downstream | -0.0226409056141916 | 0.000439393479703619 | LUAD | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs7296088 | chr12:125166653:T:C | Distant downstream | -0.0223016156687039 | 0.000506399279033165 | LUAD | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs12369173 | chr12:125167151:T:C | Distant downstream | -0.0214281625381301 | 0.00108408200048631 | LUAD | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs4448746 | chr12:125173806:C:G | Distant downstream | -0.0197551247094791 | 0.0050864953552844 | LUAD | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs12813120 | chr12:125163413:A:T | Distant downstream | -0.0183770321315704 | 0.0125826715963547 | LUAD | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs10846838 | chr12:125167680:A:G | Distant downstream | -0.0183557686007375 | 0.0147456372049886 | LUAD | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs10846837 | chr12:125164376:T:A | Distant downstream | -0.0179834741517731 | 0.0245199634487464 | LUAD | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs1021131 | chr12:125039688:G:A | Distant upstream | -0.0310829656241593 | 0.0459821715030519 | LGG | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs12578446 | chr12:125121341:A:G | Distant upstream | -0.0296678928322722 | 1.55965819076866e-09 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs7398636 | chr12:125114058:G:C | Distant upstream | -0.0264667655546377 | 1.8468151641375e-07 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs58624919 | chr12:125111912:G:A | Distant upstream | -0.0266739572733511 | 3.06621091001511e-07 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs57491100 | chr12:125108464:C:T | Distant upstream | -0.0265156144082302 | 3.80854264212744e-07 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs57031290 | chr12:125108507:A:G | Distant upstream | -0.0265156144082302 | 3.80854264212744e-07 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs2297478 | chr12:125107298:C:T | Distant upstream | -0.0264031268239748 | 4.56120366228726e-07 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs12316499 | chr12:125108772:G:A | Distant upstream | -0.0255116915988705 | 4.88586110306819e-07 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs35941060 | chr12:125109699:G:A | Distant upstream | -0.0260797047325561 | 6.14657370985086e-07 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs4765217 | chr12:125104032:T:G | Distant upstream | -0.0251515436695316 | 7.0664741885818e-07 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs34624329 | chr12:125123482:T:G | Distant upstream | -0.0244903946536854 | 7.33500037133656e-07 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs7138557 | chr12:125103160:T:C | Distant upstream | -0.0250394842298275 | 8.923066587254e-07 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs12303416 | chr12:125108812:C:T | Distant upstream | -0.0254705657828045 | 1.48140645296784e-06 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs10846824 | chr12:125088825:C:T | Distant upstream | -0.0241593230797356 | 1.83205225273764e-06 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs12305181 | chr12:125109610:C:A | Distant upstream | -0.0251349283974086 | 2.09194824916556e-06 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs55999005 | chr12:125087333:C:T | Distant upstream | -0.0241721502101926 | 2.46577707859961e-06 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs56394386 | chr12:125104174:A:G | Distant upstream | -0.0241915730826826 | 3.25675246230787e-06 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs73233307 | chr12:125191327:G:C | Distant downstream | -0.0265946401726975 | 4.21281083049706e-06 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs7135489 | chr12:125103293:A:G | Distant upstream | -0.0239112632956309 | 4.32658071158845e-06 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs4765218 | chr12:125104445:A:G | Distant upstream | -0.023702900236913 | 4.35172984900942e-06 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs7953077 | chr12:125105716:C:T | Distant upstream | -0.0231694283886881 | 4.62468222195879e-06 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs12302714 | chr12:125093188:C:T | Distant upstream | -0.022946467310557 | 4.81347391733901e-06 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs12580033 | chr12:125191537:A:T | Distant downstream | -0.0264824071358301 | 4.88217580909976e-06 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs7970937 | chr12:125105871:T:C | Distant upstream | -0.0239225568211436 | 5.36623683647155e-06 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs7307700 | chr12:125103651:G:A | Distant upstream | -0.0232441027444931 | 5.79724638028193e-06 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs12582808 | chr12:125176913:G:T | Distant downstream | -0.0256233428928167 | 1.47798130087934e-05 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs6488992 | chr12:125196576:G:A | Distant downstream | -0.0256073339875755 | 1.64892056891226e-05 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs12578774 | chr12:125197215:C:T | Distant downstream | -0.0251125783388239 | 1.83012255337584e-05 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs6488993 | chr12:125196680:C:T | Distant downstream | -0.0250868255528082 | 1.84061371714317e-05 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs12811438 | chr12:125168944:C:T | Distant downstream | -0.0275476399913003 | 2.34071137811526e-05 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs12822191 | chr12:125167277:C:T | Distant downstream | -0.0274241819343761 | 2.58580343261027e-05 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs4073534 | chr12:125187254:C:T | Distant downstream | -0.0253662499992325 | 2.62277462819923e-05 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs7132026 | chr12:125193550:C:T | Distant downstream | -0.0244701229934901 | 3.71065342096755e-05 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs12815578 | chr12:125191054:G:A | Distant downstream | -0.0228023759280929 | 4.42564272441717e-05 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs12826658 | chr12:125195691:A:G | Distant downstream | -0.0241666906618987 | 5.23841082079878e-05 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs12832525 | chr12:125195820:T:C | Distant downstream | -0.0241666906618987 | 5.23841082079878e-05 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs7295689 | chr12:125196376:T:G | Distant downstream | -0.0241666906618987 | 5.23841082079878e-05 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs36097456 | chr12:125166896:A:G | Distant downstream | -0.0264635464765811 | 6.5061799445926e-05 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs7302475 | chr12:125193340:T:C | Distant downstream | -0.0223027090757678 | 0.000108683841666379 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs883315 | chr12:125192343:T:C | Distant downstream | -0.0222543560057535 | 0.000113678846192351 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs2343638 | chr12:125192576:G:C | Distant downstream | -0.0222543560057535 | 0.000113678846192351 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs12579211 | chr12:125163206:C:T | Distant downstream | -0.0261903770745748 | 0.000116004823963351 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs10846836 | chr12:125164063:G:A | Distant downstream | -0.0261903770745748 | 0.000116004823963351 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs4412800 | chr12:125190196:T:C | Distant downstream | -0.0215162647256479 | 0.00014045522163037 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs34764657 | chr12:125195093:A:G | Distant downstream | -0.0220953715566653 | 0.000140679656911054 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs117431213 | chr12:125190725:C:G | Distant downstream | -0.0216191214339073 | 0.000162013231729289 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs2062150 | chr12:125162910:C:T | Distant downstream | -0.0256507268598952 | 0.000189039028974752 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs35508749 | chr12:125163651:G:A | Distant downstream | -0.0256507268598952 | 0.000189039028974752 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs3751178 | chr12:125179811:T:C | Distant downstream | -0.0209464438990701 | 0.000461112777257525 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs73233315 | chr12:125204165:A:G | Distant downstream | -0.0212538390000923 | 0.000515461696008637 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs67041765 | chr12:125188367:T:G | Distant downstream | -0.0208623920181549 | 0.000517661374150586 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs67385590 | chr12:125206978:C:T | Distant downstream | -0.0210428720690337 | 0.000614877980405909 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs35111534 | chr12:125203580:T:C | Distant downstream | -0.0210214222402086 | 0.000642200638818983 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs35050183 | chr12:125200750:T:C | Distant downstream | -0.0203083307091021 | 0.00065132797443711 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs11058066 | chr12:125205686:C:A | Distant downstream | -0.0204181678720594 | 0.00098747310435121 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs12580291 | chr12:125167547:A:G | Distant downstream | -0.0216913915227782 | 0.00112756792122046 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs11058065 | chr12:125199357:G:A | Distant downstream | -0.0201731179156714 | 0.00125783501546066 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs12581813 | chr12:125171856:A:G | Distant downstream | -0.0234644960359506 | 0.00168311900113948 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs12831151 | chr12:125171717:C:T | Distant downstream | -0.0231547950257276 | 0.00206731757302366 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs35698828 | chr12:125174057:C:T | Distant downstream | -0.0225067641524088 | 0.00338370401310328 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs11057971 | chr12:125002251:G:C | Distant upstream | -0.0189904648806383 | 0.00689250495999085 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs962598 | chr12:125216538:T:A | Distant downstream | -0.0169882539293856 | 0.00913386575039083 | LUSC | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs11057570 | chr12:124296380:C:T | Distant upstream | -0.0431073272578804 | 0.0181982558755359 | BLCA | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs11836438 | chr12:124299651:A:G | Distant upstream | -0.0412574104198231 | 0.0277686069609759 | BLCA | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs7963351 | chr12:126088216:T:C | Distant downstream | -0.0281343006946748 | 0.0349446994992357 | BLCA | Male-baised sQTL |
| exon_skip_88482 | chr12:125136661:125136864 | Frame-shift | rs10847084 | chr12:126105977:T:C | Distant downstream | -0.0278716302615491 | 0.0494456963076383 | BLCA | Male-baised sQTL |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of AACS |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
