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Gene: ENSG00000081277 |
Summary for PKP1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000081277 | Gene symbol | PKP1 |
| Gene name | plakophilin 1 | |
| HGNC | 9023 | |
| Entrez ID | 5317 | |
| Gene type | protein_coding | |
| Synonyms | PKP1|B6P | |
| UniProtAcc | Q13835 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for PKP1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| PKP1 | 2.75e+03 | -1.88e+00 | 6.58e-01 | -2.86e+00 | 4.25e-03 | 3.17e-02 | BRCA |
| PKP1 | 6.10e+02 | 1.30e+00 | 1.93e-01 | 6.76e+00 | 1.35e-11 | 1.19e-09 | KIRC |
| PKP1 | 3.82e+02 | 2.52e+00 | 6.57e-01 | 3.83e+00 | 1.30e-04 | 3.13e-02 | CHOL |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| PKP1 | 6.82e+02 | 2.67e+00 | 3.21e-01 | 8.31e+00 | 9.64e-17 | 3.87e-16 | KIRC |
| PKP1 | 9.20e+03 | 2.80e+00 | 6.73e-01 | 4.16e+00 | 3.14e-05 | 1.62e-04 | BLCA |
| PKP1 | 4.11e+02 | 5.23e+00 | 9.58e-01 | 5.46e+00 | 4.77e-08 | 4.67e-07 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| PKP1 | 3.79e+02 | 4.17e+00 | 7.95e-01 | 5.24e+00 | 1.57e-07 | 4.67e-06 | STAD |
| PKP1 | 4.09e+02 | 4.49e+00 | 5.12e-01 | 8.78e+00 | 1.71e-18 | 3.00e-16 | READ |
Top |
Sex-biased somatic mutation for PKP1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for PKP1 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg27571196 | chr1:201284131 | CGI:chr1:201283324-201284520 | promoter,gene body | 6.52e-01 | 7.93e-01 | -3.00e+00 | 2.74e-03 | 1.58e-02 | -1.41e-01 |
| BRCA | cg05184311 | chr1:201284409 | CGI:chr1:201283324-201284520 | promoter,gene body | 6.79e-01 | 7.83e-01 | -2.27e+00 | 2.33e-02 | 3.71e-02 | -1.04e-01 |
| SARC | cg20869257 | chr1:201283820 | CGI:chr1:201283324-201284520 | promoter,exon,CDS,gene body | 5.13e-01 | 4.11e-01 | 3.41e+00 | 6.41e-04 | 2.45e-03 | 1.02e-01 |
| SARC | cg05184311 | chr1:201284409 | CGI:chr1:201283324-201284520 | promoter,gene body | 7.27e-01 | 6.18e-01 | 5.33e+00 | 9.96e-08 | 7.67e-07 | 1.08e-01 |
| DLBC | cg12611449 | chr1:201283072 | CGI:chr1:201283324-201284520 | promoter | 6.69e-01 | 5.11e-01 | 2.96e+00 | 3.09e-03 | 9.28e-03 | 1.58e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| THCA | cg27571196 | chr1:201284131 | CGI:chr1:201283324-201284520 | promoter,gene body | 6.35e-01 | 5.14e-01 | 3.58e+00 | 3.42e-04 | 1.44e-03 | 1.21e-01 |
| LUSC | cg04904030 | chr1:201284843 | CGI:chr1:201283324-201284520 | promoter,gene body | 3.50e-01 | 5.36e-01 | -3.82e+00 | 1.31e-04 | 7.87e-04 | -1.85e-01 |
| LUSC | cg16819028 | chr1:201282854 | CGI:chr1:201283324-201284520 | promoter | 6.96e-01 | 9.02e-01 | -3.42e+00 | 6.16e-04 | 1.89e-03 | -2.06e-01 |
| LUSC | cg12611449 | chr1:201283072 | CGI:chr1:201283324-201284520 | promoter | 2.66e-01 | 3.69e-01 | -3.21e+00 | 1.32e-03 | 3.13e-03 | -1.02e-01 |
| LUSC | cg05184311 | chr1:201284409 | CGI:chr1:201283324-201284520 | promoter,gene body | 4.17e-01 | 5.97e-01 | -3.58e+00 | 3.44e-04 | 1.32e-03 | -1.81e-01 |
| BLCA | cg16819028 | chr1:201282854 | CGI:chr1:201283324-201284520 | promoter | 7.59e-01 | 8.91e-01 | -2.05e+00 | 4.03e-02 | 4.23e-02 | -1.32e-01 |
| LIHC | cg22606205 | chr1:201283606 | CGI:chr1:201283324-201284520 | UTR,promoter,exon,gene body | 2.57e-01 | 7.66e-02 | 2.06e+00 | 3.98e-02 | 4.10e-02 | 1.80e-01 |
| LIHC | cg16819028 | chr1:201282854 | CGI:chr1:201283324-201284520 | promoter | 6.15e-01 | 8.33e-01 | -3.73e+00 | 1.88e-04 | 3.62e-04 | -2.18e-01 |
| CHOL | cg20869257 | chr1:201283820 | CGI:chr1:201283324-201284520 | promoter,exon,CDS,gene body | 4.91e-01 | 2.66e-01 | 2.29e+00 | 2.23e-02 | 3.24e-02 | 2.25e-01 |
| CHOL | cg27571196 | chr1:201284131 | CGI:chr1:201283324-201284520 | promoter,gene body | 6.93e-01 | 4.38e-01 | 3.17e+00 | 1.52e-03 | 1.07e-02 | 2.56e-01 |
| CHOL | cg09009380 | chr1:201283846 | CGI:chr1:201283324-201284520 | promoter,exon,CDS,gene body | 5.85e-01 | 3.49e-01 | 3.10e+00 | 1.96e-03 | 1.07e-02 | 2.36e-01 |
| CHOL | cg05184311 | chr1:201284409 | CGI:chr1:201283324-201284520 | promoter,gene body | 6.96e-01 | 4.48e-01 | 3.32e+00 | 9.08e-04 | 1.01e-02 | 2.48e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg22606205 | chr1:201283606 | CGI:chr1:201283324-201284520 | UTR,promoter,exon,gene body | 1.42e-01 | 3.63e-02 | 4.53e+00 | 5.91e-06 | 1.01e-05 | 1.05e-01 |
| BRCA | cg20869257 | chr1:201283820 | CGI:chr1:201283324-201284520 | promoter,exon,CDS,gene body | 4.59e-01 | 2.59e-01 | 8.71e+00 | 2.99e-18 | 1.40e-17 | 2.00e-01 |
| BRCA | cg27571196 | chr1:201284131 | CGI:chr1:201283324-201284520 | promoter,gene body | 6.52e-01 | 4.31e-01 | 1.15e+01 | 1.03e-30 | 1.63e-29 | 2.21e-01 |
| BRCA | cg16819028 | chr1:201282854 | CGI:chr1:201283324-201284520 | promoter | 6.62e-01 | 8.82e-01 | -1.00e+01 | 1.25e-23 | 9.33e-23 | -2.20e-01 |
| BRCA | cg09009380 | chr1:201283846 | CGI:chr1:201283324-201284520 | promoter,exon,CDS,gene body | 4.98e-01 | 3.35e-01 | 9.06e+00 | 1.34e-19 | 7.01e-19 | 1.63e-01 |
| BRCA | cg05184311 | chr1:201284409 | CGI:chr1:201283324-201284520 | promoter,gene body | 6.79e-01 | 5.04e-01 | 1.06e+01 | 1.80e-26 | 1.77e-25 | 1.75e-01 |
| LIHC | cg20869257 | chr1:201283820 | CGI:chr1:201283324-201284520 | promoter,exon,CDS,gene body | 4.22e-01 | 2.91e-01 | 2.36e+00 | 1.83e-02 | 2.25e-02 | 1.31e-01 |
| KIRP | cg09009380 | chr1:201283846 | CGI:chr1:201283324-201284520 | promoter,exon,CDS,gene body | 4.98e-01 | 3.74e-01 | 2.47e+00 | 1.35e-02 | 2.06e-02 | 1.24e-01 |
Top |
Exon skipping events with PSI in TCGA for PKP1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for PKP1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for PKP1 |
| TFs related to PKP1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| DLBC | PRDM6 | PKP1 | 1.51e+00 | 8.84e-05 | 3.87e+00 | 9.82e-01 | Female-biased |
| DLBC | ZNF235 | PKP1 | 1.56e+00 | 6.59e-05 | 4.02e+00 | 9.86e-01 | Female-biased |
| DLBC | ZNF287 | PKP1 | 1.54e+00 | 6.06e-05 | 4.04e+00 | 9.86e-01 | Female-biased |
| PKP1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for PKP1 |
| RBPs related to ES in PKP1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| PKP1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000081277 | DARS-AS1,hsa-mir-372,PKP1 | Male-specific ceRNA | TCGA-BLCA |
| ENSG00000081277 | NPSR1-AS1,hsa-mir-483,PKP1 | Tumor-specific sex-biased ceRNA | TCGA-KIRC |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs3765849 | chr1:210440549:C:A | - | 0.0916109687098103 | 0.0145668264378728 | SARC | Female-baised eQTL |
| rs17343520 | chr1:204989514:C:T | - | 0.164604971750508 | 0.00304612189099494 | STAD | Female-baised eQTL |
| rs4501880 | chr1:204993222:C:T | - | 0.1644247715909 | 0.00307854037030212 | STAD | Female-baised eQTL |
| rs2249733 | chr1:195596834:T:A | - | -0.107510102311898 | 0.00817021398137449 | STAD | Female-baised eQTL |
| rs6674523 | chr1:208310766:C:A | - | 0.115599406237786 | 0.0160413480111086 | STAD | Female-baised eQTL |
| rs78430720 | chr1:202312633:C:A | - | 0.105700204351207 | 0.0249341824984582 | STAD | Female-baised eQTL |
| rs56234832 | chr1:202319165:C:T | - | 0.105700204351207 | 0.0249341824984582 | STAD | Female-baised eQTL |
| rs55930767 | chr1:202322655:G:A | - | 0.105668663700335 | 0.0252574371404885 | STAD | Female-baised eQTL |
| rs76114850 | chr1:208287435:C:T | - | 0.124514066060502 | 0.0296176750511165 | STAD | Female-baised eQTL |
| rs1562962 | chr1:202312225:G:C | - | 0.101967303468058 | 0.0342080753073304 | STAD | Female-baised eQTL |
| rs12126278 | chr1:202321175:C:T | - | 0.101908677948262 | 0.034508401439925 | STAD | Female-baised eQTL |
| rs694874 | chr1:207866240:T:C | - | -0.128703456815088 | 0.0412752174078775 | STAD | Female-baised eQTL |
| rs77906886 | chr1:202316599:T:G | - | 0.0987333802248691 | 0.0444457013648354 | STAD | Female-baised eQTL |
| rs12123010 | chr1:202318028:C:T | - | 0.0987333802248691 | 0.0444457013648354 | STAD | Female-baised eQTL |
| rs75658797 | chr1:202318626:G:A | - | 0.0987333802248691 | 0.0444457013648354 | STAD | Female-baised eQTL |
| rs55703256 | chr1:208313833:C:T | - | 0.117869694868016 | 0.0451113519238184 | STAD | Female-baised eQTL |
| rs6666999 | chr1:208313976:C:A | - | 0.117869694868016 | 0.0451113519238184 | STAD | Female-baised eQTL |
| rs6679557 | chr1:208313977:A:C | - | 0.117869694868016 | 0.0451113519238184 | STAD | Female-baised eQTL |
| rs12084679 | chr1:208322272:A:G | - | 0.117869694868016 | 0.0451113519238184 | STAD | Female-baised eQTL |
| rs56042747 | chr1:208319206:C:T | - | 0.117849911006086 | 0.045588646134954 | STAD | Female-baised eQTL |
| rs7515725 | chr1:208297363:T:C | - | 0.117831320394866 | 0.0456947425430425 | STAD | Female-baised eQTL |
| rs60330752 | chr1:208297811:C:G | - | 0.117831320394866 | 0.0456947425430425 | STAD | Female-baised eQTL |
| rs55902319 | chr1:208301465:T:G | - | 0.117831320394866 | 0.0456947425430425 | STAD | Female-baised eQTL |
| rs55991258 | chr1:202320637:A:G | - | 0.0984375958383869 | 0.0458424425127786 | STAD | Female-baised eQTL |
| rs10919636 | chr1:199208960:C:A | - | 0.145779716450612 | 0.00347193313589118 | BLCA | Female-baised eQTL |
| rs6427761 | chr1:199219779:A:G | - | 0.222385692238454 | 0.010021763878379 | BLCA | Female-baised eQTL |
| rs61470514 | chr1:199215226:C:T | - | 0.221949492013044 | 0.0104652031718465 | BLCA | Female-baised eQTL |
| rs11810195 | chr1:199218296:G:C | - | 0.221949492013044 | 0.0104652031718465 | BLCA | Female-baised eQTL |
| rs56822893 | chr1:209718561:C:A | - | 0.193639428466717 | 0.0113913910666266 | BLCA | Female-baised eQTL |
| rs10793756 | chr1:203658706:A:G | - | -0.131258969384086 | 0.0125600083818902 | BLCA | Female-baised eQTL |
| rs2999483 | chr1:204466292:C:G | - | -0.139185888929411 | 0.0168638945001068 | BLCA | Female-baised eQTL |
| rs11240747 | chr1:204473166:A:T | - | -0.137939354608311 | 0.0199752362233899 | BLCA | Female-baised eQTL |
| rs7532021 | chr1:209744384:G:A | - | 0.185901475217669 | 0.0212405677250921 | BLCA | Female-baised eQTL |
| rs10800895 | chr1:203000204:G:A | - | 0.120116686599217 | 0.0213265130811745 | BLCA | Female-baised eQTL |
| rs1590323 | chr1:193991687:A:G | - | 0.143712714452938 | 0.0310368160959218 | BLCA | Female-baised eQTL |
| rs16836064 | chr1:194000203:T:C | - | 0.143712714452938 | 0.0310368160959218 | BLCA | Female-baised eQTL |
| rs113173026 | chr1:202126403:C:T | - | 0.0765786753581138 | 0.000385310886399957 | LUAD | Female-baised eQTL |
| rs113989504 | chr1:202118412:C:T | - | 0.0749675265484931 | 0.000516570067601917 | LUAD | Female-baised eQTL |
| rs112893321 | chr1:202117814:G:A | - | 0.0747084742678135 | 0.000547681555350432 | LUAD | Female-baised eQTL |
| rs79438068 | chr1:202125567:A:G | - | 0.0713267367351739 | 0.00108427277079355 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs71635159 | chr1:207843629:G:A | - | 0.0882099671147712 | 0.0252744894146841 | STAD | Male-baised eQTL |
| rs4915182 | chr1:199653885:G:A | - | 0.0767735952743366 | 1.92468404472446e-06 | BLCA | Male-baised eQTL |
| rs7545206 | chr1:199649953:G:C | - | 0.0765604369782509 | 5.22826697323126e-06 | BLCA | Male-baised eQTL |
| rs148380723 | chr1:199651135:G:T | - | 0.0765604369782509 | 5.22826697323126e-06 | BLCA | Male-baised eQTL |
| rs114925025 | chr1:199651175:T:A | - | 0.0765604369782509 | 5.22826697323126e-06 | BLCA | Male-baised eQTL |
| rs137859843 | chr1:199651818:G:A | - | 0.0765604369782509 | 5.22826697323126e-06 | BLCA | Male-baised eQTL |
| rs150547497 | chr1:199651943:G:T | - | 0.0765604369782509 | 5.22826697323126e-06 | BLCA | Male-baised eQTL |
| rs144531380 | chr1:199652290:C:G | - | 0.0765604369782509 | 5.22826697323126e-06 | BLCA | Male-baised eQTL |
| rs116628230 | chr1:199653312:A:G | - | 0.0765604369782509 | 5.22826697323126e-06 | BLCA | Male-baised eQTL |
| rs4915376 | chr1:199653756:A:T | - | 0.0765019339539487 | 5.44475768433232e-06 | BLCA | Male-baised eQTL |
| rs17162614 | chr1:199682410:G:A | - | 0.083419369959356 | 1.05679344181551e-05 | BLCA | Male-baised eQTL |
| rs4623735 | chr1:199660310:G:T | - | 0.0687475471841444 | 0.000119089404094559 | BLCA | Male-baised eQTL |
| rs12691505 | chr1:199663360:C:T | - | 0.067588161286716 | 0.000284654872710429 | BLCA | Male-baised eQTL |
| rs9287104 | chr1:199662397:G:A | - | 0.0661130035022868 | 0.000431156735194504 | BLCA | Male-baised eQTL |
| rs9943087 | chr1:199667339:C:T | - | 0.0661130035022868 | 0.000431156735194504 | BLCA | Male-baised eQTL |
| rs16845394 | chr1:199667861:C:T | - | 0.0661130035022868 | 0.000431156735194504 | BLCA | Male-baised eQTL |
| rs4309008 | chr1:199660991:C:T | - | 0.0656274524079916 | 0.000455082974478896 | BLCA | Male-baised eQTL |
| rs7543872 | chr1:199661968:A:C | - | 0.0656274524079916 | 0.000455082974478896 | BLCA | Male-baised eQTL |
| rs9287103 | chr1:199662219:G:A | - | 0.0656274524079916 | 0.000455082974478896 | BLCA | Male-baised eQTL |
| rs4915373 | chr1:199645816:A:G | - | 0.0677529725737349 | 0.000616942582677819 | BLCA | Male-baised eQTL |
| rs7539332 | chr1:199648553:C:G | - | 0.0649752447314636 | 0.00111039153530753 | BLCA | Male-baised eQTL |
| rs7512900 | chr1:199654088:C:G | - | 0.0649752447314636 | 0.00111039153530753 | BLCA | Male-baised eQTL |
| rs16845327 | chr1:199655142:C:T | - | 0.0588432654154982 | 0.00323734366996772 | BLCA | Male-baised eQTL |
| rs12060823 | chr1:205018825:C:T | - | 0.0751035812292293 | 0.00368485440874401 | BLCA | Male-baised eQTL |
| rs16845322 | chr1:199646844:A:T | - | 0.0582519703343245 | 0.00382083454275568 | BLCA | Male-baised eQTL |
| rs4369252 | chr1:199641109:T:G | - | 0.0659401758489507 | 0.00448105905595202 | BLCA | Male-baised eQTL |
| rs75051897 | chr1:199640816:A:G | - | 0.0658679921503442 | 0.00461993689196843 | BLCA | Male-baised eQTL |
| rs7554701 | chr1:199643960:T:C | - | 0.0632996380172341 | 0.00523924476527052 | BLCA | Male-baised eQTL |
| rs4915377 | chr1:199658768:C:T | - | 0.0569405386278986 | 0.00974154060420735 | BLCA | Male-baised eQTL |
| rs5017022 | chr1:199660464:A:T | - | 0.0569405386278986 | 0.00974154060420735 | BLCA | Male-baised eQTL |
| rs79999205 | chr1:199624310:T:G | - | 0.0499358419466621 | 0.0132594100392459 | BLCA | Male-baised eQTL |
| rs16845332 | chr1:199655728:T:G | - | 0.0557133161658091 | 0.0159868246771035 | BLCA | Male-baised eQTL |
| rs10159025 | chr1:199663628:A:G | - | 0.0539099230706808 | 0.0226460581576423 | BLCA | Male-baised eQTL |
| rs9287105 | chr1:199664255:T:C | - | 0.0539099230706808 | 0.0226460581576423 | BLCA | Male-baised eQTL |
| rs16845381 | chr1:199664908:T:C | - | 0.0539099230706808 | 0.0226460581576423 | BLCA | Male-baised eQTL |
| rs7529572 | chr1:199666288:T:G | - | 0.0539099230706808 | 0.0226460581576423 | BLCA | Male-baised eQTL |
| rs77754510 | chr1:199667140:G:A | - | 0.0539099230706808 | 0.0226460581576423 | BLCA | Male-baised eQTL |
| rs16830028 | chr1:199667627:T:C | - | 0.0539099230706808 | 0.0226460581576423 | BLCA | Male-baised eQTL |
| rs74545525 | chr1:199667660:T:C | - | 0.0539099230706808 | 0.0226460581576423 | BLCA | Male-baised eQTL |
| rs4424540 | chr1:199661229:A:C | - | 0.0535196640104806 | 0.0231447052765384 | BLCA | Male-baised eQTL |
| rs75823344 | chr1:199661393:A:T | - | 0.0535196640104806 | 0.0231447052765384 | BLCA | Male-baised eQTL |
| rs16845393 | chr1:199667816:T:G | - | 0.0538295264709185 | 0.023276557676649 | BLCA | Male-baised eQTL |
| rs200776594 | chr1:199651465:A:G | - | 0.0530264984251839 | 0.028886452384536 | BLCA | Male-baised eQTL |
| rs2268147 | chr1:201283738:C:T | gene,CDS,exon,promoter | 0.0497540136272507 | 0.0331543985320161 | BLCA | Male-baised eQTL |
| rs12044365 | chr1:210258416:A:G | - | 0.0922497906867505 | 0.0474255552059362 | LUAD | Male-baised eQTL |
| rs12754753 | chr1:210536999:C:T | - | 0.0616430850334718 | 0.0106667817358641 | COAD | Male-baised eQTL |
| rs12122837 | chr1:210538316:T:C | - | 0.0608740621320786 | 0.0134415378054296 | COAD | Male-baised eQTL |
| rs34226838 | chr1:210539104:C:T | - | 0.0607488069495419 | 0.0139142687002725 | COAD | Male-baised eQTL |
| rs12139453 | chr1:210544615:C:A | - | 0.0598377787021122 | 0.0163143477489487 | COAD | Male-baised eQTL |
| rs17188344 | chr1:210547736:G:A | - | 0.0561678008538799 | 0.0234952214062668 | COAD | Male-baised eQTL |
| rs17188367 | chr1:210570945:A:C | - | 0.0544813524236479 | 0.0252144382740816 | COAD | Male-baised eQTL |
| rs10800651 | chr1:199813308:C:T | - | 0.0493104283746308 | 0.0360503575438669 | COAD | Male-baised eQTL |
| rs11488583 | chr1:199747846:G:A | - | 0.0472817863989821 | 0.0380832948690356 | COAD | Male-baised eQTL |
| rs6700109 | chr1:207491262:C:T | - | -0.0577176023347464 | 0.0383977693813854 | COAD | Male-baised eQTL |
| rs202104467 | chr1:194444899:G:T | - | 0.0989074643845264 | 0.0391016037517437 | COAD | Male-baised eQTL |
| rs17641369 | chr1:194515860:T:C | - | 0.100162878737682 | 0.0451075721137264 | COAD | Male-baised eQTL |
| rs6675873 | chr1:194516359:G:C | - | 0.0856751953931416 | 0.0498496695569799 | COAD | Male-baised eQTL |
| rs35936131 | chr1:199745177:A:C | - | 0.0473699321429328 | 0.0498617080249239 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000081277 |
| CpG Site: cg20869257 | |
| Position to Gene: gene,exon,CDS,promoter | |
| Male Effect: - | |
| Female Effect: -0.123943250541872 | |
 | Gene ID: ENSG00000081277 |
| CpG Site: cg04904030 | |
| Position to Gene: gene,promoter | |
| Male Effect: - | |
| Female Effect: -0.297588841049195 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg20869257 | chr1:201283820 | gene,exon,CDS,promoter | -0.123943250541872 | 3.03604920772853e-10 | -0.43443519218645654 | 3.6656138687392177e-13 | LUAD |
| cg04904030 | chr1:201284843 | gene,promoter | -0.297588841049195 | 3.29975702871743e-07 | -0.37893323119082367 | 3.9443409326377224e-10 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of PKP1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000081277 | PKP1 | C1858302 | Ectodermal dysplasia/ skin fragility syndrome | 1 | CTD_human |
| ENSG00000081277 | PKP1 | C2239176 | Liver carcinoma | 1 | CTD_human |
