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Gene: ENSG00000079277 |
Summary for MKNK1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000079277 | Gene symbol | MKNK1 |
| Gene name | MAPK interacting serine/threonine kinase 1 | |
| HGNC | 7110 | |
| Entrez ID | 8569 | |
| Gene type | protein_coding | |
| Synonyms | MKNK1|MNK1 | |
| UniProtAcc | Q9BUB5 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| ENSG00000079277 | MKNK1 | DB12010 | Fostamatinib | SmallMoleculeDrug |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for MKNK1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for MKNK1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for MKNK1 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg05376185 | chr1:46617197 | CGI:chr1:46616344-46616905 | promoter | 1.36e-01 | 2.98e-02 | 9.56e+00 | 1.23e-21 | 7.65e-21 | 1.06e-01 |
Top |
Exon skipping events with PSI in TCGA for MKNK1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| LUSC | exon_skip_26372 | 5.77e-01 | 6.93e-01 | -6.32e+00 | 2.64e-10 | 2.40e-09 | -1.16e-01 |
| BLCA | exon_skip_26372 | 5.92e-01 | 6.95e-01 | -2.69e+00 | 7.10e-03 | 1.75e-02 | -1.03e-01 |
| CHOL | exon_skip_26372 | 6.24e-01 | 7.71e-01 | -2.18e+00 | 2.93e-02 | 3.54e-02 | -1.47e-01 |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for MKNK1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
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| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| LAML | MKNK1-019 | chr1_46593327_- | 2.85e-01 | 4.04e-01 | -2.35e+00 | 1.85e-02 | 4.94e-02 | -1.19e-01 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for MKNK1 |
| TFs related to MKNK1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| MKNK1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for MKNK1 |
| RBPs related to ES in MKNK1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| UVM | Fusip1 | exon_skip_26397 | 9.29e+00 | 9.85e-01 | 9.00e+00 | 1.13e-02 | Male-biased |
| UVM | HNRNPH2 | exon_skip_26377 | 6.25e+00 | 1.93e-03 | 6.70e+00 | 9.82e-01 | Female-biased |
| LIHC | HNRNPH2 | exon_skip_26377 | 6.90e+00 | 9.84e-01 | 6.13e+00 | 7.69e-04 | Male-biased |
| LUSC | ESRP2 | exon_skip_26372 | 7.20e+00 | 9.80e-01 | 6.80e+00 | 7.42e-03 | Male-biased |
| ESCA | HNRNPH2 | exon_skip_26377 | 6.93e+00 | 9.82e-01 | 6.35e+00 | 3.89e-03 | Male-biased |
| PCPG | Fusip1 | exon_skip_26398 | 9.14e+00 | 9.87e-01 | 8.81e+00 | 9.42e-03 | Male-biased |
| PCPG | HNRNPH2 | exon_skip_26377 | 6.67e+00 | 9.81e-01 | 6.22e+00 | 2.27e-03 | Male-biased |
| MESO | Fusip1 | exon_skip_26397 | 8.73e+00 | 9.62e-03 | 9.08e+00 | 9.86e-01 | Female-biased |
| BLCA | HNRNPH2 | exon_skip_26377 | 6.97e+00 | 9.85e-01 | 6.24e+00 | 5.61e-04 | Male-biased |
| MKNK1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs2245468 | chr1:48469215:A:G | - | 0.217541264229931 | 0.000129232569948621 | BLCA | Female-baised eQTL |
| rs2245681 | chr1:48471679:G:C | - | 0.217541264229931 | 0.000129232569948621 | BLCA | Female-baised eQTL |
| rs10788890 | chr1:48503295:T:C | - | -0.236666781260126 | 0.000161888038527622 | BLCA | Female-baised eQTL |
| rs4926733 | chr1:48503918:A:G | - | -0.232931349690647 | 0.000384181309882424 | BLCA | Female-baised eQTL |
| rs7524129 | chr1:48504281:T:C | - | -0.232931349690647 | 0.000384181309882424 | BLCA | Female-baised eQTL |
| rs79415770 | chr1:48508278:C:G | - | 0.239227418044156 | 0.000390117731738991 | BLCA | Female-baised eQTL |
| rs2803282 | chr1:48467100:C:G | - | 0.199619646430116 | 0.000459075981086564 | BLCA | Female-baised eQTL |
| rs2252984 | chr1:48402313:C:T | - | 0.210092576772221 | 0.000485735331694729 | BLCA | Female-baised eQTL |
| rs2803281 | chr1:48409156:C:T | - | 0.210092576772221 | 0.000485735331694729 | BLCA | Female-baised eQTL |
| rs2803280 | chr1:48414608:G:A | - | 0.210092576772221 | 0.000485735331694729 | BLCA | Female-baised eQTL |
| rs1416048 | chr1:48417254:A:G | - | 0.210092576772221 | 0.000485735331694729 | BLCA | Female-baised eQTL |
| rs1416046 | chr1:48421439:A:G | - | 0.210092576772221 | 0.000485735331694729 | BLCA | Female-baised eQTL |
| rs2265770 | chr1:48430020:C:T | - | 0.210092576772221 | 0.000485735331694729 | BLCA | Female-baised eQTL |
| rs2251338 | chr1:48436629:T:C | - | 0.210092576772221 | 0.000485735331694729 | BLCA | Female-baised eQTL |
| rs2265771 | chr1:48440184:G:A | - | 0.210092576772221 | 0.000485735331694729 | BLCA | Female-baised eQTL |
| rs2485910 | chr1:48442358:G:A | - | 0.210092576772221 | 0.000485735331694729 | BLCA | Female-baised eQTL |
| rs2255264 | chr1:48445758:C:T | - | 0.210092576772221 | 0.000485735331694729 | BLCA | Female-baised eQTL |
| rs2255525 | chr1:48459905:T:G | - | 0.210092576772221 | 0.000485735331694729 | BLCA | Female-baised eQTL |
| rs2787871 | chr1:48460196:G:T | - | 0.210092576772221 | 0.000485735331694729 | BLCA | Female-baised eQTL |
| rs143706472 | chr1:48313838:G:A | - | 0.205425933745406 | 0.000849780663746126 | BLCA | Female-baised eQTL |
| rs12085605 | chr1:48318737:C:G | - | 0.205425933745406 | 0.000849780663746126 | BLCA | Female-baised eQTL |
| rs1418105 | chr1:48319993:C:T | - | 0.205425933745406 | 0.000849780663746126 | BLCA | Female-baised eQTL |
| rs1418104 | chr1:48320211:C:G | - | 0.205425933745406 | 0.000849780663746126 | BLCA | Female-baised eQTL |
| rs10399798 | chr1:48327052:G:A | - | 0.205425933745406 | 0.000849780663746126 | BLCA | Female-baised eQTL |
| rs2067692 | chr1:48330448:C:A | - | 0.205425933745406 | 0.000849780663746126 | BLCA | Female-baised eQTL |
| rs11205475 | chr1:48337068:C:A | - | 0.205425933745406 | 0.000849780663746126 | BLCA | Female-baised eQTL |
| rs3767614 | chr1:48338771:G:C | - | 0.205425933745406 | 0.000849780663746126 | BLCA | Female-baised eQTL |
| rs12097126 | chr1:48342370:C:T | - | 0.205425933745406 | 0.000849780663746126 | BLCA | Female-baised eQTL |
| rs72893254 | chr1:48363716:T:A | - | 0.205425933745406 | 0.000849780663746126 | BLCA | Female-baised eQTL |
| rs6587873 | chr1:48369905:A:G | - | 0.205425933745406 | 0.000849780663746126 | BLCA | Female-baised eQTL |
| rs11205480 | chr1:48373610:A:T | - | 0.205425933745406 | 0.000849780663746126 | BLCA | Female-baised eQTL |
| rs11205481 | chr1:48377499:C:G | - | 0.205425933745406 | 0.000849780663746126 | BLCA | Female-baised eQTL |
| rs2265767 | chr1:48396378:A:G | - | 0.205425933745406 | 0.000849780663746126 | BLCA | Female-baised eQTL |
| rs926978 | chr1:48267108:T:C | - | 0.184968290760515 | 0.00117567449528709 | BLCA | Female-baised eQTL |
| rs17470284 | chr1:48493905:G:A | - | 0.223907107196856 | 0.0014402091789631 | BLCA | Female-baised eQTL |
| rs12070926 | chr1:48257489:G:A | - | 0.181483398922241 | 0.00146455523844418 | BLCA | Female-baised eQTL |
| rs72694388 | chr1:48177271:C:T | - | 0.174884192341965 | 0.00196789668765183 | BLCA | Female-baised eQTL |
| rs72694390 | chr1:48187473:T:C | - | 0.194505998800102 | 0.00209927678229974 | BLCA | Female-baised eQTL |
| rs11806440 | chr1:48276171:T:A | - | 0.198059743734546 | 0.00253831185312298 | BLCA | Female-baised eQTL |
| rs6687661 | chr1:48279210:T:C | - | 0.198059743734546 | 0.00253831185312298 | BLCA | Female-baised eQTL |
| rs140581887 | chr1:48281447:C:T | - | 0.198059743734546 | 0.00253831185312298 | BLCA | Female-baised eQTL |
| rs151261344 | chr1:48282619:T:C | - | 0.198059743734546 | 0.00253831185312298 | BLCA | Female-baised eQTL |
| rs113859272 | chr1:48283307:C:A | - | 0.198059743734546 | 0.00253831185312298 | BLCA | Female-baised eQTL |
| rs6694372 | chr1:48235895:C:T | - | 0.18032371542627 | 0.002539278515235 | BLCA | Female-baised eQTL |
| rs6704171 | chr1:48259759:A:T | - | 0.173243271944054 | 0.00339930756642312 | BLCA | Female-baised eQTL |
| rs72694375 | chr1:48148241:G:A | - | 0.18636646807635 | 0.00430286156981346 | BLCA | Female-baised eQTL |
| rs72694385 | chr1:48167346:T:C | - | 0.18636646807635 | 0.00430286156981346 | BLCA | Female-baised eQTL |
| rs1180350 | chr1:39541341:T:C | - | 0.21829456074078 | 0.00923990187435204 | BLCA | Female-baised eQTL |
| rs58642822 | chr1:48187135:G:A | - | 0.168860310212011 | 0.00959266038422906 | BLCA | Female-baised eQTL |
| rs58085319 | chr1:48194031:G:A | - | 0.168860310212011 | 0.00959266038422906 | BLCA | Female-baised eQTL |
| rs55875335 | chr1:48194220:A:C | - | 0.168860310212011 | 0.00959266038422906 | BLCA | Female-baised eQTL |
| rs11587740 | chr1:48196151:C:G | - | 0.168860310212011 | 0.00959266038422906 | BLCA | Female-baised eQTL |
| rs535295 | chr1:48208019:A:G | - | 0.164739717346896 | 0.0111242213985177 | BLCA | Female-baised eQTL |
| rs12074395 | chr1:48120759:T:C | - | 0.168383038044019 | 0.0146628082819366 | BLCA | Female-baised eQTL |
| rs533598 | chr1:48207849:C:A | - | 0.168093376408493 | 0.0178318901678094 | BLCA | Female-baised eQTL |
| rs540944 | chr1:48240207:T:C | - | 0.14911502549097 | 0.0235683193626479 | BLCA | Female-baised eQTL |
| rs212986 | chr1:48221320:A:T | - | 0.146958446942163 | 0.0236635927629515 | BLCA | Female-baised eQTL |
| rs542281 | chr1:48219530:C:T | - | 0.148938090876667 | 0.0245574731662852 | BLCA | Female-baised eQTL |
| rs212985 | chr1:48221194:C:T | - | 0.148938090876667 | 0.0245574731662852 | BLCA | Female-baised eQTL |
| rs212989 | chr1:48229409:G:A | - | 0.148938090876667 | 0.0245574731662852 | BLCA | Female-baised eQTL |
| rs850785 | chr1:48214096:G:A | - | 0.14890440978008 | 0.0252385994619597 | BLCA | Female-baised eQTL |
| rs490631 | chr1:48217733:A:T | - | 0.14890440978008 | 0.0252385994619597 | BLCA | Female-baised eQTL |
| rs6685450 | chr1:48243325:T:C | - | -0.127167218787293 | 0.0372425739802824 | BLCA | Female-baised eQTL |
| rs61783060 | chr1:46488269:C:T | - | 0.281798959138401 | 0.0382464049345625 | BLCA | Female-baised eQTL |
| rs212958 | chr1:48212696:T:C | - | 0.142188940374284 | 0.0499552383961265 | BLCA | Female-baised eQTL |
| rs72679828 | chr1:46471301:A:T | - | 0.124149479558569 | 0.0330146185145502 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs652451 | chr1:38638597:G:C | - | 0.153758708050955 | 0.00351907419695584 | READ | Male-baised eQTL |
| rs11211377 | chr1:46843277:C:A | - | 0.0953881779508831 | 0.0238947005951288 | LGG | Male-baised eQTL |
| rs6658037 | chr1:46844927:A:C | - | 0.0953881779508831 | 0.0238947005951288 | LGG | Male-baised eQTL |
| rs116130927 | chr1:46849607:T:A | - | 0.0953881779508831 | 0.0238947005951288 | LGG | Male-baised eQTL |
| rs146129207 | chr1:46852170:A:G | - | 0.0944641531946131 | 0.0276889342280019 | LGG | Male-baised eQTL |
| rs2653924 | chr1:46857995:A:G | - | 0.0928641867904925 | 0.0418659463927456 | LGG | Male-baised eQTL |
| rs3766194 | chr1:46819478:G:A | - | 0.0888779714256933 | 0.0465353926996738 | LGG | Male-baised eQTL |
| rs12733133 | chr1:46822134:G:A | - | 0.0888779714256933 | 0.0465353926996738 | LGG | Male-baised eQTL |
| rs35191195 | chr1:46822193:G:A | - | 0.0888779714256933 | 0.0465353926996738 | LGG | Male-baised eQTL |
| rs7535312 | chr1:46823279:G:T | - | 0.0888779714256933 | 0.0465353926996738 | LGG | Male-baised eQTL |
| rs143145493 | chr1:46826230:G:C | - | 0.0888779714256933 | 0.0465353926996738 | LGG | Male-baised eQTL |
| rs2065995 | chr1:46858437:T:C | - | 0.0938425405745377 | 0.0499408787480648 | LGG | Male-baised eQTL |
| rs11205976 | chr1:39389416:G:A | - | 0.0968681257218792 | 0.013571956183411 | KIRC | Male-baised eQTL |
| rs10888936 | chr1:55598756:A:G | - | 0.0509417263797069 | 0.0468199877712307 | BLCA | Male-baised eQTL |
| rs17424028 | chr1:47752297:G:C | - | -0.103834716883475 | 0.0128383754487612 | COAD | Male-baised eQTL |
| rs150542278 | chr1:52625622:A:G | - | -0.112833088985057 | 0.0238905517618294 | COAD | Male-baised eQTL |
| rs59209359 | chr1:55667805:C:G | - | 0.085991803321845 | 0.0426973821022439 | COAD | Male-baised eQTL |
| rs6672470 | chr1:52619665:C:T | - | -0.106385662369944 | 0.0463585807142646 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000079277 |
| CpG Site: cg16039867 | |
| Position to Gene: gene,exon,UTR | |
| Male Effect: -0.344519244807318 | |
| Female Effect: - | |
 | Gene ID: ENSG00000079277 |
| CpG Site: cg16039867 | |
| Position to Gene: gene,exon,UTR | |
| Male Effect: -0.410048822843552 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg16039867 | chr1:46557462 | gene,exon,UTR | -0.344519244807318 | 2.19892920323774e-05 | -0.35926077191697486 | 1.6272141284922997e-07 | KIRP |
| cg16039867 | chr1:46557462 | gene,exon,UTR | -0.410048822843552 | 1.90692890225762e-10 | -0.47326705044651757 | 7.559488705596498e-14 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_26372 | chr1:46560233:46560277 | Frame-shift | rs1267304 | chr1:46524754:C:T | Distant downstream | -0.0381502878762856 | 0.0442939012543398 | LGG | Female-baised sQTL |
| exon_skip_26372 | chr1:46560233:46560277 | Frame-shift | rs952947 | chr1:46537217:C:T | Distant downstream | 0.0702610905883234 | 0.0127494526588084 | BLCA | Female-baised sQTL |
| exon_skip_26372 | chr1:46560233:46560277 | Frame-shift | rs956527 | chr1:46590320:T:C | Distant upstream | 0.067764929478029 | 0.0274997774385564 | BLCA | Female-baised sQTL |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_26372 | chr1:46560233:46560277 | Frame-shift | rs2622909 | chr1:47419156:G:A | Distant upstream | -0.0464465759552052 | 0.0132851881176082 | COAD | Male-baised sQTL |
| exon_skip_26372 | chr1:46560233:46560277 | Frame-shift | rs524158 | chr1:47467422:G:T | Distant upstream | 0.0421514109575702 | 0.0159910526920865 | COAD | Male-baised sQTL |
| exon_skip_26372 | chr1:46560233:46560277 | Frame-shift | rs7526434 | chr1:47454832:A:G | Distant upstream | 0.0442009800267387 | 0.0257962543459889 | COAD | Male-baised sQTL |
| exon_skip_26372 | chr1:46560233:46560277 | Frame-shift | rs3125629 | chr1:47456423:G:A | Distant upstream | 0.0442009800267387 | 0.0257962543459889 | COAD | Male-baised sQTL |
| exon_skip_26372 | chr1:46560233:46560277 | Frame-shift | rs4660962 | chr1:46859418:T:C | Distant upstream | 0.0449739724128718 | 0.0267118001488594 | COAD | Male-baised sQTL |
| exon_skip_26372 | chr1:46560233:46560277 | Frame-shift | rs557851 | chr1:47453170:A:G | Distant upstream | 0.0431623412127131 | 0.0270983872833979 | COAD | Male-baised sQTL |
| exon_skip_26372 | chr1:46560233:46560277 | Frame-shift | rs1680020 | chr1:47453748:T:C | Distant upstream | 0.0443998935651188 | 0.0275483616410796 | COAD | Male-baised sQTL |
| exon_skip_26372 | chr1:46560233:46560277 | Frame-shift | rs497606 | chr1:47458603:C:T | Distant upstream | 0.0458830278580888 | 0.0298321164892254 | COAD | Male-baised sQTL |
| exon_skip_26372 | chr1:46560233:46560277 | Frame-shift | rs571281 | chr1:47448899:T:C | Distant upstream | 0.0445894173088542 | 0.0305336810237431 | COAD | Male-baised sQTL |
| exon_skip_26372 | chr1:46560233:46560277 | Frame-shift | rs7552140 | chr1:47445039:C:T | Distant upstream | -0.0442065872453485 | 0.0329528262633418 | COAD | Male-baised sQTL |
| exon_skip_26372 | chr1:46560233:46560277 | Frame-shift | rs1680018 | chr1:47464947:A:G | Distant upstream | 0.0408400294374666 | 0.036211941887781 | COAD | Male-baised sQTL |
| exon_skip_26372 | chr1:46560233:46560277 | Frame-shift | rs148075195 | chr1:46794172:A:C | Distant upstream | 0.065039355945487 | 0.0479895786648633 | COAD | Male-baised sQTL |
| exon_skip_26372 | chr1:46560233:46560277 | Frame-shift | rs3738315 | chr1:47437391:G:C | Distant upstream | -0.0418496641097748 | 0.0489680014950863 | COAD | Male-baised sQTL |
| exon_skip_26388 | chr1:46574946:46575020 | Frame-shift | rs1890247 | chr1:46839482:A:G | Distant upstream | -0.02572221636486 | 0.0302136679755497 | BLCA | Male-baised sQTL |
| exon_skip_26388 | chr1:46574946:46575020 | Frame-shift | rs9725948 | chr1:46851098:A:G | Distant upstream | -0.02572221636486 | 0.0302136679755497 | BLCA | Male-baised sQTL |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of MKNK1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000079277 | MKNK1 | C0013146 | Drug abuse | 1 | CTD_human |
| ENSG00000079277 | MKNK1 | C0013170 | Drug habituation | 1 | CTD_human |
| ENSG00000079277 | MKNK1 | C0013222 | Drug Use Disorders | 1 | CTD_human |
| ENSG00000079277 | MKNK1 | C0029231 | Organic Mental Disorders, Substance-Induced | 1 | CTD_human |
| ENSG00000079277 | MKNK1 | C0038580 | Substance Dependence | 1 | CTD_human |
| ENSG00000079277 | MKNK1 | C0038586 | Substance Use Disorders | 1 | CTD_human |
| ENSG00000079277 | MKNK1 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
| ENSG00000079277 | MKNK1 | C0740858 | Substance abuse problem | 1 | CTD_human |
| ENSG00000079277 | MKNK1 | C1510472 | Drug Dependence | 1 | CTD_human |
| ENSG00000079277 | MKNK1 | C4316881 | Prescription Drug Abuse | 1 | CTD_human |
