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Gene: ENSG00000078081 |
Summary for LAMP3 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000078081 | Gene symbol | LAMP3 |
| Gene name | lysosomal associated membrane protein 3 | |
| HGNC | 14582 | |
| Entrez ID | 27074 | |
| Gene type | protein_coding | |
| Synonyms | LAMP3|LAMP|TSC403|DC-LAMP|DCLAMP|CD208 | |
| UniProtAcc | Q9UQV4 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for LAMP3 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| LAMP3 | 8.88e+02 | -2.75e+00 | 5.16e-01 | -5.34e+00 | 9.51e-08 | 9.88e-06 | BRCA |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| LAMP3 | 3.63e+02 | 1.51e+00 | 1.41e-01 | 1.07e+01 | 8.52e-27 | 6.01e-26 | KIRC |
| LAMP3 | 1.01e+03 | 1.98e+00 | 3.62e-01 | 5.47e+00 | 4.42e-08 | 3.44e-07 | THCA |
| LAMP3 | 1.03e+03 | 2.08e+00 | 4.76e-01 | 4.36e+00 | 1.30e-05 | 7.43e-05 | BLCA |
| LAMP3 | 2.80e+03 | 3.00e+00 | 4.45e-01 | 6.74e+00 | 1.59e-11 | 2.37e-09 | ESCA |
| LAMP3 | 1.75e+02 | 2.25e+00 | 4.62e-01 | 4.86e+00 | 1.16e-06 | 8.24e-06 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| LAMP3 | 8.35e+02 | 1.90e+00 | 1.72e-01 | 1.10e+01 | 2.80e-28 | 1.34e-27 | BRCA |
Top |
Sex-biased somatic mutation for LAMP3 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for LAMP3 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg19825758 | chr3:183162904 | CGI:chr3:183162489-183162934 | UTR,promoter,exon,gene body | 3.29e-01 | 5.15e-01 | -3.25e+00 | 1.16e-03 | 1.03e-02 | -1.86e-01 |
| BRCA | cg24615528 | chr3:183162906 | CGI:chr3:183162489-183162934 | UTR,promoter,exon,gene body | 2.31e-01 | 5.31e-01 | -3.27e+00 | 1.09e-03 | 9.89e-03 | -3.00e-01 |
| BRCA | cg01698108 | chr3:183162682 | CGI:chr3:183162489-183162934 | UTR,promoter,exon,gene body | 1.72e-01 | 3.76e-01 | -2.77e+00 | 5.55e-03 | 2.13e-02 | -2.04e-01 |
| BRCA | cg02072885 | chr3:183162689 | CGI:chr3:183162489-183162934 | UTR,promoter,exon,gene body | 2.06e-01 | 4.35e-01 | -2.59e+00 | 9.71e-03 | 2.64e-02 | -2.29e-01 |
| BRCA | cg00119079 | chr3:183162490 | CGI:chr3:183162489-183162934 | promoter,gene body | 1.55e-01 | 2.65e-01 | -2.52e+00 | 1.18e-02 | 2.84e-02 | -1.10e-01 |
| BRCA | cg07334977 | chr3:183162980 | CGI:chr3:183162489-183162934 | promoter,gene body | 3.10e-01 | 4.74e-01 | -2.34e+00 | 1.94e-02 | 3.45e-02 | -1.63e-01 |
| ACC | cg20742009 | chr3:183162029 | CGI:chr3:183162489-183162934 | promoter,gene body | 4.69e-01 | 6.60e-01 | -2.86e+00 | 4.22e-03 | 1.54e-02 | -1.91e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg02345747 | chr3:183161966 | CGI:chr3:183162489-183162934 | UTR,promoter,exon,gene body | 3.22e-01 | 2.04e-01 | 2.09e+00 | 3.65e-02 | 3.87e-02 | 1.18e-01 |
| COAD | cg22356117 | chr3:183163639 | CGI:chr3:183162489-183162934 | UTR,promoter,exon,gene body | 7.39e-01 | 8.57e-01 | -2.01e+00 | 4.39e-02 | 4.53e-02 | -1.17e-01 |
| KIRP | cg20742009 | chr3:183162029 | CGI:chr3:183162489-183162934 | promoter,gene body | 2.44e-01 | 1.24e-01 | 2.07e+00 | 3.80e-02 | 3.96e-02 | 1.20e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg19825758 | chr3:183162904 | CGI:chr3:183162489-183162934 | UTR,promoter,exon,gene body | 3.29e-01 | 2.17e-01 | 6.54e+00 | 6.29e-11 | 1.68e-10 | 1.12e-01 |
| BRCA | cg24615528 | chr3:183162906 | CGI:chr3:183162489-183162934 | UTR,promoter,exon,gene body | 2.31e-01 | 2.85e-02 | 7.46e+00 | 8.57e-14 | 2.85e-13 | 2.02e-01 |
| BRCA | cg01698108 | chr3:183162682 | CGI:chr3:183162489-183162934 | UTR,promoter,exon,gene body | 1.72e-01 | 1.56e-02 | 7.77e+00 | 7.63e-15 | 2.75e-14 | 1.56e-01 |
| BRCA | cg02072885 | chr3:183162689 | CGI:chr3:183162489-183162934 | UTR,promoter,exon,gene body | 2.06e-01 | 1.82e-02 | 7.82e+00 | 5.27e-15 | 1.92e-14 | 1.88e-01 |
| BRCA | cg02345747 | chr3:183161966 | CGI:chr3:183162489-183162934 | UTR,promoter,exon,gene body | 4.81e-01 | 2.82e-01 | 9.91e+00 | 3.81e-23 | 2.72e-22 | 1.99e-01 |
| BRCA | cg20742009 | chr3:183162029 | CGI:chr3:183162489-183162934 | promoter,gene body | 3.50e-01 | 1.41e-01 | 2.22e+00 | 2.63e-02 | 2.77e-02 | 2.08e-01 |
| BRCA | cg07334977 | chr3:183162980 | CGI:chr3:183162489-183162934 | promoter,gene body | 3.10e-01 | 1.24e-01 | 7.16e+00 | 8.02e-13 | 2.48e-12 | 1.86e-01 |
| KIRP | cg02345747 | chr3:183161966 | CGI:chr3:183162489-183162934 | UTR,promoter,exon,gene body | 3.38e-01 | 2.01e-01 | 1.96e+00 | 4.97e-02 | 4.97e-02 | 1.38e-01 |
Top |
Exon skipping events with PSI in TCGA for LAMP3 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for LAMP3 |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
 |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| LUAD | LAMP3-002 | chr3_183127354_- | 2.15e-01 | 1.79e-01 | 2.00e+00 | 4.53e-02 | 4.83e-02 | 3.59e-02 |
| LUAD | LAMP3-002 | chr3_183128680_- | 1.22e-01 | 1.65e-01 | -2.01e+00 | 4.46e-02 | 4.83e-02 | -4.34e-02 |
| LUAD | LAMP3-002 | chr3_183128817_- | 6.05e-01 | 5.03e-01 | 2.97e+00 | 3.02e-03 | 2.14e-02 | 1.02e-01 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| LUAD | LAMP3-002 | chr3_183128745_- | 2.58e-01 | 1.65e-01 | 3.01e+00 | 2.59e-03 | 7.46e-03 | 9.29e-02 |
| LUSC | LAMP3-002 | chr3_183127165_- | 2.93e-01 | 1.93e-01 | 4.16e+00 | 3.23e-05 | 4.89e-04 | 1.00e-01 |
| LUSC | LAMP3-002 | chr3_183127207_- | 2.12e-01 | 1.31e-01 | 2.52e+00 | 1.16e-02 | 2.12e-02 | 8.12e-02 |
| LUSC | LAMP3-002 | chr3_183127406_- | 2.01e-01 | 1.15e-01 | 2.87e+00 | 4.10e-03 | 1.14e-02 | 8.62e-02 |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| LUAD | LAMP3-002 | chr3_183127967_- | 3.33e-01 | 1.95e-01 | 2.26e+00 | 2.39e-02 | 3.16e-02 | 1.37e-01 |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for LAMP3 |
| TFs related to LAMP3. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| LAMP3 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for LAMP3 |
| RBPs related to ES in LAMP3. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| LAMP3 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000078081 | LINC02723,hsa-mir-424,LAMP3 | Male-specific ceRNA | TCGA-THCA |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs4686698 | chr3:185813909:G:A | - | 0.244988771595162 | 0.0274704979483145 | READ | Female-baised eQTL |
| rs16862763 | chr3:187955201:C:T | - | 0.17224370883516 | 0.00643672637986463 | STAD | Female-baised eQTL |
| rs79879183 | chr3:187936551:A:C | - | 0.15613589584208 | 0.0107743898186977 | STAD | Female-baised eQTL |
| rs78772278 | chr3:187940655:G:C | - | 0.15613589584208 | 0.0107743898186977 | STAD | Female-baised eQTL |
| rs16862738 | chr3:187943365:C:T | - | 0.15613589584208 | 0.0107743898186977 | STAD | Female-baised eQTL |
| rs75908211 | chr3:187944559:C:G | - | 0.15613589584208 | 0.0107743898186977 | STAD | Female-baised eQTL |
| rs74369881 | chr3:187945057:C:T | - | 0.15613589584208 | 0.0107743898186977 | STAD | Female-baised eQTL |
| rs55917093 | chr3:187946337:C:T | - | 0.15613589584208 | 0.0107743898186977 | STAD | Female-baised eQTL |
| rs78775129 | chr3:187947204:C:T | - | 0.15613589584208 | 0.0107743898186977 | STAD | Female-baised eQTL |
| rs77689312 | chr3:187949715:G:C | - | 0.15613589584208 | 0.0107743898186977 | STAD | Female-baised eQTL |
| rs76273372 | chr3:187949863:C:T | - | 0.15613589584208 | 0.0107743898186977 | STAD | Female-baised eQTL |
| rs73889247 | chr3:187949876:C:T | - | 0.15613589584208 | 0.0107743898186977 | STAD | Female-baised eQTL |
| rs75556421 | chr3:187950609:T:G | - | 0.15613589584208 | 0.0107743898186977 | STAD | Female-baised eQTL |
| rs16862759 | chr3:187953362:T:C | - | 0.15613589584208 | 0.0107743898186977 | STAD | Female-baised eQTL |
| rs79089290 | chr3:187953598:C:T | - | 0.15613589584208 | 0.0107743898186977 | STAD | Female-baised eQTL |
| rs73051536 | chr3:187954938:T:C | - | 0.155736657469215 | 0.011434513082459 | STAD | Female-baised eQTL |
| rs16862729 | chr3:187934936:A:T | - | 0.155201195661864 | 0.0118785279847872 | STAD | Female-baised eQTL |
| rs9829804 | chr3:185409663:A:G | - | 0.12370933005026 | 0.0135420812584209 | STAD | Female-baised eQTL |
| rs34246060 | chr3:187953388:C:T | - | 0.146826659706742 | 0.018103883181948 | STAD | Female-baised eQTL |
| rs73051532 | chr3:187954127:C:T | - | 0.146826659706742 | 0.018103883181948 | STAD | Female-baised eQTL |
| rs73051534 | chr3:187954526:T:C | - | 0.146826659706742 | 0.018103883181948 | STAD | Female-baised eQTL |
| rs4687292 | chr3:185388358:C:T | - | 0.121319407673643 | 0.0182740394163947 | STAD | Female-baised eQTL |
| rs55854300 | chr3:185407544:C:T | - | 0.118661631290177 | 0.0198978717689646 | STAD | Female-baised eQTL |
| rs7427542 | chr3:185379158:G:A | - | 0.113895261436398 | 0.0269243347822999 | STAD | Female-baised eQTL |
| rs76506022 | chr3:185377167:G:A | - | 0.11363665118627 | 0.028071246967666 | STAD | Female-baised eQTL |
| rs148484291 | chr3:185377452:A:G | - | 0.11363665118627 | 0.028071246967666 | STAD | Female-baised eQTL |
| rs77944662 | chr3:185379102:T:G | - | 0.11363665118627 | 0.028071246967666 | STAD | Female-baised eQTL |
| rs56796831 | chr3:185383375:C:A | - | 0.112012713127847 | 0.0359184195614107 | STAD | Female-baised eQTL |
| rs57175457 | chr3:185383385:G:A | - | 0.112012713127847 | 0.0359184195614107 | STAD | Female-baised eQTL |
| rs74286925 | chr3:187917492:T:C | - | 0.124811126176345 | 0.0480091456684161 | STAD | Female-baised eQTL |
| rs78859589 | chr3:187924621:T:C | - | 0.124811126176345 | 0.0480091456684161 | STAD | Female-baised eQTL |
| rs2679531 | chr3:187927342:G:A | - | 0.124811126176345 | 0.0480091456684161 | STAD | Female-baised eQTL |
| rs12631112 | chr3:187928025:G:T | - | 0.124811126176345 | 0.0480091456684161 | STAD | Female-baised eQTL |
| rs12632303 | chr3:187929257:C:T | - | 0.124811126176345 | 0.0480091456684161 | STAD | Female-baised eQTL |
| rs76348980 | chr3:187929373:A:G | - | 0.124811126176345 | 0.0480091456684161 | STAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs9814367 | chr3:190874697:T:C | - | 0.0894112376691334 | 0.0307895266308893 | THCA | Male-baised eQTL |
| rs2901924 | chr3:173702558:G:T | - | 0.0673322975083161 | 0.0164750792506046 | COAD | Male-baised eQTL |
| rs953329 | chr3:173704832:T:G | - | 0.0626879137679151 | 0.0291462423166316 | COAD | Male-baised eQTL |
| rs1021807 | chr3:173705164:T:A | - | 0.0626879137679151 | 0.0291462423166316 | COAD | Male-baised eQTL |
| rs62289915 | chr3:173716552:A:T | - | 0.0649525442258644 | 0.0308161687065754 | COAD | Male-baised eQTL |
| rs12488449 | chr3:173717438:T:A | - | 0.0639923022375182 | 0.0342162666595189 | COAD | Male-baised eQTL |
| rs13098487 | chr3:173706972:A:G | - | 0.0573960202648187 | 0.0397761044651311 | COAD | Male-baised eQTL |
| rs71310556 | chr3:173709391:A:G | - | 0.063544140166536 | 0.041889994698123 | COAD | Male-baised eQTL |
| rs35816547 | chr3:173709579:A:T | - | 0.063544140166536 | 0.041889994698123 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000078081 |
| CpG Site: cg18030943 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.389018910773354 | |
 | Gene ID: ENSG00000078081 |
| CpG Site: cg18030943 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.354868648676667 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg18030943 | chr3:183158768 | gene | -0.389018910773354 | 3.60222368318222e-16 | -0.5217813284344793 | 3.2986626753289587e-19 | LUAD |
| cg18030943 | chr3:183158768 | gene | -0.354868648676667 | 2.42671664858725e-07 | -0.5386226933274527 | 3.146498743588271e-10 | STAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of LAMP3 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000078081 | LAMP3 | C0021400 | Influenza | 1 | CTD_human |
