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Gene: ENSG00000076944

Summary for STXBP2

Gene summary

Gene information	Ensembl ID	ENSG00000076944
	Gene symbol	STXBP2
	Gene name	syntaxin binding protein 2
	HGNC	11445
	Entrez ID	6813
	Gene type	protein_coding
	Synonyms	STXBP2\|UNC18B\|Hunc18b\|Unc18-2\|MUNC18-2
	UniProtAcc	Q15833

Drugs associated with this gene(DrugBank).

Gene ID

Gene Symbol

Drug ID

Drug Name

Drug Type

Cancer therapeutic drugs associated with this gene(NCI).

Gene ID

Gene Name

Drug ID

Drug Name

Drug Type

Cancer

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Structure and expression level for STXBP2

AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.

Landscape of gene expressions across multiple cancer types.

Differentially expressed gene analysis between tumor male and tumor female samples.

Coding Name

Base Mean

log2FoldChange

lfcSE

Stat

P value

P.adjust Value

Cancer Type

Differentially expressed gene analysis between tumor male and normal male samples.

Coding Name	Base Mean	log2FoldChange	lfcSE	Stat	P value	P.adjust Value	Cancer Type
STXBP2	4.34e+03	1.52e+00	2.48e-01	6.11e+00	9.73e-10	1.61e-08	BLCA

Differentially expressed gene analysis between tumor female and normal female samples.

Coding Name	Base Mean	log2FoldChange	lfcSE	Stat	P value	P.adjust Value	Cancer Type
STXBP2	3.22e+03	1.42e+00	8.17e-02	1.74e+01	1.43e-67	2.33e-66	BRCA

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Sex-biased somatic mutation for STXBP2

∗For more information on exon skipping events please check the ExonskipDB database.

Gene ID

Cancer Type

Hugo Symbol

Male

Female

pval

ci.up

ci.low

adjPval

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DNA methylation with beta values for STXBP2

Landscape of DNA methylation across multiple cancer types.

Differentially expressed CpG sites between male tumor and female tumor patients.

Cancer Type	CpG Site	Position	CpG Island	Position to Gene	ave1	ave2	wilcoxon.w	wilcoxon.p	padj	dBeta
BRCA	cg21541083	chr19:7636326	CGI:chr19:7636775-7637450	promoter	5.35e-01	3.53e-01	3.04e+00	2.33e-03	1.47e-02	1.82e-01

Differentially expressed CpG sites between male tumor and male normal patients.

Cancer Type	CpG Site	Position	CpG Island	Position to Gene	ave1	ave2	wilcoxon.w	wilcoxon.p	padj	dBeta
KIRP	cg24759919	chr19:7637608	CGI:chr19:7636775-7637450	promoter,gene body	7.55e-02	1.96e-01	-5.69e+00	1.24e-08	1.75e-07	-1.20e-01
ESCA	cg04770751	chr19:7636776	CGI:chr19:7636775-7637450	promoter	4.87e-01	6.37e-01	-2.11e+00	3.45e-02	4.51e-02	-1.50e-01
CHOL	cg24759919	chr19:7637608	CGI:chr19:7636775-7637450	promoter,gene body	9.31e-02	3.36e-01	-3.54e+00	4.02e-04	8.32e-03	-2.43e-01

Differentially expressed CpG sites between female tumor and female normal patients.

Cancer Type	CpG Site	Position	CpG Island	Position to Gene	ave1	ave2	wilcoxon.w	wilcoxon.p	padj	dBeta
BRCA	cg21541083	chr19:7636326	CGI:chr19:7636775-7637450	promoter	5.35e-01	6.63e-01	-7.89e+00	3.05e-15	1.13e-14	-1.28e-01
LIHC	cg04770751	chr19:7636776	CGI:chr19:7636775-7637450	promoter	4.40e-01	5.57e-01	-2.87e+00	4.06e-03	6.82e-03	-1.17e-01
LIHC	cg24759919	chr19:7637608	CGI:chr19:7636775-7637450	promoter,gene body	3.17e-01	4.33e-01	-2.43e+00	1.49e-02	1.91e-02	-1.17e-01

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Exon skipping events with PSI in TCGA for STXBP2

∗Please access ExonSkipDB for exon skipping annotation.

Landscape of exon skipping events across multiple cancer types.

Differentially expressed exon skipping events between male tumor and female tumor patients.

Cancer Type

Exon Skipping

ave.female_T

ave.female_N

wilcoxon.w

wilcoxon.p

padj

dPSI

Differentially expressed exon skipping events between male tumor and male normal patients.

Cancer Type

Exon Skipping

ave.female_T

ave.female_N

wilcoxon.w

wilcoxon.p

padj

dPSI

Differentially expressed exon skipping events between female tumor and female normal patients.

Cancer Type

Exon Skipping

ave.female_T

ave.female_N

wilcoxon.w

wilcoxon.p

padj

dPSI

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RNA A-to-I editing events in TCGA for STXBP2

∗Please access CAeditome for RNA editing annotation.

Differentially expressed RNA editing events between male tumor and female tumor patients.

Cancer Type

Transcript

Editing

ave.male_T

ave.female_T

wilcoxon.w

wilcoxon.p

p_adj

dFre

Differentially expressed RNA editing events between male tumor and male normal patients.

Cancer Type

Transcript

Editing

ave.male_T

ave.female_T

wilcoxon.w

wilcoxon.p

p_adj

dFre

Differentially expressed RNA editing events between female tumor and female normal patients.

Cancer Type

Transcript

Editing

ave.male_T

ave.female_T

wilcoxon.w

wilcoxon.p

p_adj

dFre

Protein coding RNA editing(s).

Editing Position

Variant Type

Gene Symbol

Transcript ID

NTchange

AAchange

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Sex-biased TF-Gene network for STXBP2

TFs related to STXBP2.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.

Cancer Type

Target Gene

Male Edge Score

Male Edge Threshold

Female Edge Score

Female Edge Threshold

Type

STXBP2 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for STXBP2

RBPs related to ES in STXBP2.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.

Cancer Type	RBP	Target ES	Male Edge Score	Male Edge Threshold	Female Edge Score	Female Edge Threshold	Type
DLBC	SAMD4A	exon_skip_301352	8.67e+00	9.89e-01	8.28e+00	5.34e-03	Male-biased
KIRP	SAMD4A	exon_skip_301352	8.48e+00	9.82e-01	8.16e+00	1.14e-02	Male-biased
ESCA	SAMD4A	exon_skip_301352	8.36e+00	9.90e-01	7.78e+00	3.65e-03	Male-biased
LGG	ESRP2	exon_skip_301348	8.57e+00	9.92e-01	8.07e+00	1.78e-03	Male-biased
LGG	SFPQ	exon_skip_301347	1.24e+01	6.29e-03	1.28e+01	9.93e-01	Female-biased
KIRC	ESRP2	exon_skip_301348	8.23e+00	1.18e-02	8.53e+00	9.82e-01	Female-biased

STXBP2 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

Sex-biased CeRNA regulation of gene.

Gene ID

ceRNA(lncRNA-miRNA-mRNA)

Group

Cancer Type

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Sex-biased eQTL regulation of gene

Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).

eQTL

Description

Male-specific eQTL regulation.

SNP ID

SNP Info

Position to Gene

Effect Score

FDR

Cancer Type

Biased Type

Female-specific eQTL regulation.

SNP ID	SNP Info	Position to Gene	Effect Score	FDR	Cancer Type	Biased Type
rs78420735	chr19:6289394:C:G	-	0.0754810340174388	0.00201510001963844	COAD	Male-baised eQTL
rs61433643	chr19:6281244:A:C	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs59674226	chr19:6281352:C:T	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs75906229	chr19:6281537:G:T	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs76937622	chr19:6281552:C:A	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs77896245	chr19:6281744:G:A	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs58389022	chr19:6282024:A:G	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs60740603	chr19:6282039:G:A	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs57673269	chr19:6282164:A:G	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs60510180	chr19:6282291:G:A	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs57051856	chr19:6282315:G:A	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs60672655	chr19:6282320:C:T	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs78306771	chr19:6282338:C:T	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs74480537	chr19:6282457:G:A	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs145958414	chr19:6282509:G:A	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs149284797	chr19:6282532:A:G	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs148465822	chr19:6282566:A:G	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs61315207	chr19:6282613:A:G	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs58791570	chr19:6282727:A:C	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs57554985	chr19:6282792:A:G	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs78285147	chr19:6282911:A:G	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs75623738	chr19:6282981:C:T	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs76574478	chr19:6283191:A:G	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs75365495	chr19:6283308:T:G	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs79876197	chr19:6283460:T:C	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs8107391	chr19:6283636:C:T	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs8107518	chr19:6283739:C:T	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs8107615	chr19:6283827:C:T	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs76793200	chr19:6284191:C:G	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs8182602	chr19:6284204:G:T	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs8182605	chr19:6284268:C:A	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs8182603	chr19:6284331:G:A	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs8182458	chr19:6284407:T:G	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs8182608	chr19:6284652:A:G	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs8100859	chr19:6285005:A:G	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs8182466	chr19:6285131:A:G	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs77378202	chr19:6285738:T:C	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs78923521	chr19:6285891:G:A	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs79117896	chr19:6286021:G:A	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs79809146	chr19:6286151:T:C	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs77048734	chr19:6286316:C:T	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs75873778	chr19:6286339:G:T	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs75518248	chr19:6286664:A:C	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs76369673	chr19:6286968:T:C	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs74761806	chr19:6287191:C:T	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs8108233	chr19:6287508:G:A	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs8109041	chr19:6287512:C:T	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs8109289	chr19:6287746:C:T	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs8109671	chr19:6287747:A:G	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs8113160	chr19:6288346:A:G	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs8113097	chr19:6288637:C:T	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs8112505	chr19:6288850:G:C	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs61350505	chr19:6289651:C:T	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs60693247	chr19:6289723:T:C	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs75522212	chr19:6290120:T:C	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs143677015	chr19:6290237:T:A	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs8100560	chr19:6290715:A:G	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs8113335	chr19:6290718:G:A	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs8102464	chr19:6291139:G:T	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs74770610	chr19:6291343:T:C	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs7249515	chr19:6291368:C:A	-	0.0749846369783492	0.00224695031995518	COAD	Male-baised eQTL
rs140043517	chr19:6290168:C:T	-	0.0749897937895594	0.00225395535531559	COAD	Male-baised eQTL
rs59685037	chr19:6282223:G:A	-	0.0739191269338083	0.00239892953659374	COAD	Male-baised eQTL
rs80199148	chr19:6283019:C:T	-	0.0721638054743093	0.00358097740745201	COAD	Male-baised eQTL
rs286270	chr19:11709702:C:A	-	0.0348046452613061	0.0121654688941155	COAD	Male-baised eQTL
rs12710084	chr19:6232160:C:T	-	0.0367159094460536	0.0122319294414771	COAD	Male-baised eQTL
rs10414026	chr19:6246468:G:A	-	0.0359215926490783	0.0134927131690894	COAD	Male-baised eQTL
rs3787058	chr19:6233420:T:C	-	0.035873990444314	0.0149064092126819	COAD	Male-baised eQTL
rs8111706	chr19:6235321:A:G	-	0.035800098889146	0.0152232137144973	COAD	Male-baised eQTL
rs12979828	chr19:6266767:G:T	-	0.0347257399880692	0.0155818552512027	COAD	Male-baised eQTL
rs16980187	chr19:15004945:C:T	-	0.036696998283004	0.0224612088951407	COAD	Male-baised eQTL
rs773896	chr19:16883149:A:G	-	0.0434652375646738	0.0246333550639593	COAD	Male-baised eQTL
rs8113439	chr19:1778040:C:G	-	-0.0395325441606395	0.0335318575309312	COAD	Male-baised eQTL

Opposite sex-biased eQTL regulation.

SNP ID

SNP Info

Position to Gene

Male Effect

Male FDR

Female Effect

Female FDR

Sex-biased Gene in Cancer

Cancer Type

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Sex-biased eQTM regulation of gene

Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).

eQTM

Description

Male-specific eQTM regulation.

CpG Site

CpG Postion

Position to Gene

Effect Score

FDR

Cor.r

Cor.Pvalue

Cancer Type

Female-specific eQTM regulation.

CpG Site

CpG Postion

Position to Gene

Effect Score

FDR

Cor.r

Cor.Pvalue

Cancer Type

Opposite sex-biased eQTM regulation.

CpG Site

CpG Postion

CpG Island

Position to Gene

Male Effect

Male FDR

Female Effect

Female FDR

Male Cor

Male P-value

Female Cor

Female P-value

Sex-biased Coding Gene

Cancer Type

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Sex-biased sQTL regulation of gene

Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).

sQTL	Description
	EX ID: exon_skip_301347
	SNP ID: rs2161568
	SNP Position to ES: Distant upstream
	Male Effect: -0.0839733534835546
	Female Effect: -

Male-specific sQTL regulation.

ES ID	Skipped Exon	ORF Anno	SNP ID	SNP Info	SNP Position to ES	Effect Score	FDR	Cancer Type	Biased Type
exon_skip_301347	chr19:7643164:7643245	In-frame	rs7253567	chr19:8323526:G:A	Distant downstream	-0.0348083859308839	0.0495924850614666	LUSC	Female-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs10416635	chr19:8324280:C:T	Distant downstream	-0.0348083859308839	0.0495924850614666	LUSC	Female-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs60006507	chr19:8330053:G:A	Distant downstream	-0.0348083859308839	0.0495924850614666	LUSC	Female-baised sQTL

Female-specific sQTL regulation.

ES ID	Skipped Exon	ORF Anno	SNP ID	SNP Info	SNP Position to ES	Effect Score	FDR	Cancer Type	Biased Type
exon_skip_301347	chr19:7643164:7643245	In-frame	rs2161568	chr19:7510032:G:A	Distant upstream	-0.0839733534835546	5.74263139774958e-05	LUAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs184628	chr19:6747383:A:C	Distant upstream	-0.0408348859446909	0.00060639409294203	LUAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs376620	chr19:6945850:C:T	Distant upstream	0.0430235961160123	0.00258581590364736	LUAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs12610223	chr19:6808645:G:A	Distant upstream	0.0346701169599472	0.0151740092325159	LUAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs12710098	chr19:6808536:T:G	Distant upstream	0.0341456459447462	0.0173833151385214	LUAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs55972112	chr19:7115046:C:T	Distant upstream	-0.036279501755979	0.0452393553601956	LUAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs2012175	chr19:8309982:T:A	Distant downstream	-0.0825428695196775	1.623401181394e-09	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs183811906	chr19:8301386:A:G	Distant downstream	-0.0801645273403447	4.15149937706591e-09	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs7247033	chr19:8301523:C:T	Distant downstream	-0.0801645273403447	4.15149937706591e-09	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs9426	chr19:8302274:C:T	Distant downstream	-0.0799643763319349	4.70270765172195e-09	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs2227289	chr19:8302475:G:C	Distant downstream	-0.0799643763319349	4.70270765172195e-09	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs2336573	chr19:8302825:C:T	Distant downstream	-0.0799643763319349	4.70270765172195e-09	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs2878740	chr19:8303104:G:A	Distant downstream	-0.0799643763319349	4.70270765172195e-09	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs6603163	chr19:8303135:G:A	Distant downstream	-0.0799643763319349	4.70270765172195e-09	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs7245991	chr19:8303224:A:C	Distant downstream	-0.0799643763319349	4.70270765172195e-09	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs10418490	chr19:8303473:C:T	Distant downstream	-0.0799643763319349	4.70270765172195e-09	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs2232785	chr19:8303737:C:T	Distant downstream	-0.0799643763319349	4.70270765172195e-09	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs2232784	chr19:8303874:G:A	Distant downstream	-0.0799643763319349	4.70270765172195e-09	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs8104777	chr19:8304630:A:C	Distant downstream	-0.0799643763319349	4.70270765172195e-09	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs148523270	chr19:8304846:C:T	Distant downstream	-0.0799643763319349	4.70270765172195e-09	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs2232780	chr19:8305012:A:C	Distant downstream	-0.0799643763319349	4.70270765172195e-09	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs10417680	chr19:8305572:A:G	Distant downstream	-0.0799643763319349	4.70270765172195e-09	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs60613220	chr19:8305622:C:T	Distant downstream	-0.0799643763319349	4.70270765172195e-09	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs17160390	chr19:8305925:A:G	Distant downstream	-0.0799643763319349	4.70270765172195e-09	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs58403183	chr19:8306134:C:T	Distant downstream	-0.0799643763319349	4.70270765172195e-09	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs10425703	chr19:8306901:A:G	Distant downstream	-0.0799643763319349	4.70270765172195e-09	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs73925315	chr19:8307382:G:A	Distant downstream	-0.0799643763319349	4.70270765172195e-09	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs2232776	chr19:8308139:C:G	Distant downstream	-0.0799643763319349	4.70270765172195e-09	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs2232773	chr19:8308292:C:T	Distant downstream	-0.0799643763319349	4.70270765172195e-09	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs2232767	chr19:8308649:A:C	Distant downstream	-0.0799643763319349	4.70270765172195e-09	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs10409627	chr19:8308894:G:A	Distant downstream	-0.0799643763319349	4.70270765172195e-09	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs116072763	chr19:8309031:G:A	Distant downstream	-0.0799643763319349	4.70270765172195e-09	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs4147645	chr19:8321778:T:C	Distant downstream	-0.0799643763319349	4.70270765172195e-09	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs7250792	chr19:8319741:T:C	Distant downstream	-0.0800949091320463	5.15905283276656e-09	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs75958896	chr19:8304669:T:C	Distant downstream	-0.0803433853087458	6.88391120769484e-09	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs4147650	chr19:8311892:T:C	Distant downstream	-0.0783390725822474	7.52663944906149e-09	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs4147649	chr19:8312293:A:C	Distant downstream	-0.0783390725822474	7.52663944906149e-09	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs8109720	chr19:8314856:A:G	Distant downstream	-0.0783390725822474	7.52663944906149e-09	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs8108103	chr19:8315759:C:T	Distant downstream	-0.0783390725822474	7.52663944906149e-09	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs10403563	chr19:8318961:T:G	Distant downstream	-0.0783390725822474	7.52663944906149e-09	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs73925316	chr19:8320609:A:G	Distant downstream	-0.0783390725822474	7.52663944906149e-09	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs2288414	chr19:8320768:C:G	Distant downstream	-0.0783390725822474	7.52663944906149e-09	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs8106855	chr19:8314603:G:A	Distant downstream	-0.0662893354942627	3.12123619367962e-07	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs8101842	chr19:8304337:G:C	Distant downstream	-0.0764055982844594	5.88723321226955e-07	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs2232783	chr19:8303910:C:A	Distant downstream	-0.0719564341080563	6.00158421127628e-07	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs8100119	chr19:8309704:T:C	Distant downstream	-0.0704381388313946	8.86548924943283e-07	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs465961	chr19:6919322:G:A	Distant upstream	0.0322847991829121	0.0105846493427607	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs461645	chr19:6919742:A:G	Distant upstream	0.0322847991829121	0.0105846493427607	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs372077	chr19:6919123:C:A	Distant upstream	0.0323680136971788	0.0109176332739388	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs373533	chr19:6919613:A:C	Distant upstream	0.0314124072688011	0.0125048950771558	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs55972112	chr19:7115046:C:T	Distant upstream	-0.043353159219674	0.0146815210756805	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs1864193	chr19:7114202:C:A	Distant upstream	-0.0414828312239388	0.0215210567839912	COAD	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs164017	chr19:6820401:T:C	Distant upstream	-0.143548878505942	0.00521646399854609	SARC	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs2967773	chr19:8533193:A:T	Distant downstream	-0.0842650328451798	0.020533190845155	SARC	Male-baised sQTL
exon_skip_301347	chr19:7643164:7643245	In-frame	rs113576178	chr19:8531128:G:T	Distant downstream	-0.0837699323017488	0.0233981219155746	SARC	Male-baised sQTL

Opposite sex-biased sQTL regulation.

ES ID

Skipped Exon

ORF Anno

SNP ID

SNP Info

SNP Position to ES

Male Effect

Male FDR

Female Effect

Female FDR

Cancer Type

Top

Sex-biased sQTM regulation of gene

Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).

sQTM

Description

Male-specific sQTM regulation.

EX ID

Skipped Exon

CPG Site

CPG Position

Position to EX Events

Effect Score

FDR

Cor.r

Cor.Pvalue

ORF_anno

Cancer Type

Female-specific sQTM regulation.

EX ID

Skipped Exon

CPG Site

CPG Position

Position to EX Events

Effect Score

FDR

Cor.r

Cor.Pvalue

ORF_anno

Cancer Type

Opposite sex-biased sQTM regulation.

EX ID

EX Info

Skipped Exon

CPG Site

CPG Position

CPG Island

Position to EX Events

Male Effect

Male FDR

Female Effect

Female FDR

Male Correlation

Male P-value

Female Correlation

Female P-value

ORF_anno

Cancer Type

Top

Related disease information of STXBP2

Diseases associated with this gene (DisGeNET).

Gene ID	Gene Symbol	Disease ID	Disease Name	Number of PMID	Source
ENSG00000076944	STXBP2	C2751293	HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS, FAMILIAL, 5	1	CTD_human

	Gene summary
	Gene structure and Gene expression level
	Sex-biased somatic mutation
	DNA methylation with beta values in gene
	Exon skipping events with PSI in TCGA
	RNA A-to-I editing events in TCGA
	Sex-biased TF-Gene network of gene
	Sex-biased RBP-ES network of gene
	Sex-biased CeRNA regulation of gene
	Sex-biased eQTL regulation of gene
	Sex-biased eQTM regulation of gene
	Sex-biased sQTL regulation of gene
	Sex-biased sQTM regulation of gene
	Related disease information of gene