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Gene: ENSG00000076864 |
Summary for RAP1GAP |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000076864 | Gene symbol | RAP1GAP |
| Gene name | RAP1 GTPase activating protein | |
| HGNC | 9858 | |
| Entrez ID | 5909 | |
| Gene type | protein_coding | |
| Synonyms | RAP1GAP|KIAA0474|RAP1GAP1|RAP1GAPII | |
| UniProtAcc | P47736 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for RAP1GAP |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| RAP1GAP | 8.32e+02 | -1.16e+00 | 2.36e-01 | -4.91e+00 | 8.98e-07 | 3.36e-06 | HNSC |
| RAP1GAP | 1.77e+03 | 1.70e+00 | 5.26e-01 | 3.24e+00 | 1.20e-03 | 3.87e-03 | BLCA |
| RAP1GAP | 4.04e+03 | -2.35e+00 | 5.22e-01 | -4.50e+00 | 6.74e-06 | 1.14e-04 | ESCA |
| RAP1GAP | 6.23e+03 | 2.26e+00 | 5.06e-01 | 4.46e+00 | 8.18e-06 | 4.70e-05 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| RAP1GAP | 2.95e+03 | 1.10e+00 | 2.92e-01 | 3.77e+00 | 1.64e-04 | 5.03e-04 | LIHC |
| RAP1GAP | 3.78e+04 | 1.06e+00 | 2.96e-01 | 3.59e+00 | 3.32e-04 | 8.01e-04 | KICH |
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Sex-biased somatic mutation for RAP1GAP |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for RAP1GAP |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| ACC | cg07138512 | chr1:21669824 | CGI:chr1:21669668-21669916 | promoter | 1.39e-01 | 2.94e-01 | -3.79e+00 | 1.54e-04 | 1.01e-03 | -1.55e-01 |
| ACC | cg17184245 | chr1:21670092 | CGI:chr1:21669668-21669916 | promoter | 3.11e-01 | 4.90e-01 | -2.93e+00 | 3.37e-03 | 1.32e-02 | -1.78e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| THCA | cg07138512 | chr1:21669824 | CGI:chr1:21669668-21669916 | promoter | 1.22e-01 | 2.23e-01 | -4.59e+00 | 4.48e-06 | 7.21e-05 | -1.01e-01 |
| HNSC | cg07138512 | chr1:21669824 | CGI:chr1:21669668-21669916 | promoter | 2.21e-01 | 1.17e-01 | 2.97e+00 | 3.01e-03 | 4.62e-03 | 1.04e-01 |
| LUSC | cg07138512 | chr1:21669824 | CGI:chr1:21669668-21669916 | promoter | 2.00e-01 | 9.68e-02 | 3.21e+00 | 1.32e-03 | 3.13e-03 | 1.03e-01 |
| BLCA | cg17184245 | chr1:21670092 | CGI:chr1:21669668-21669916 | promoter | 4.81e-01 | 6.79e-01 | -4.16e+00 | 3.14e-05 | 1.83e-04 | -1.99e-01 |
| KIRP | cg07138512 | chr1:21669824 | CGI:chr1:21669668-21669916 | promoter | 8.29e-02 | 1.97e-01 | -6.20e+00 | 5.68e-10 | 5.01e-08 | -1.14e-01 |
| CHOL | cg17184245 | chr1:21670092 | CGI:chr1:21669668-21669916 | promoter | 4.40e-01 | 5.44e-01 | -2.14e+00 | 3.25e-02 | 3.87e-02 | -1.04e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg07138512 | chr1:21669824 | CGI:chr1:21669668-21669916 | promoter | 2.41e-01 | 1.34e-01 | 4.57e+00 | 4.90e-06 | 8.48e-06 | 1.07e-01 |
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Exon skipping events with PSI in TCGA for RAP1GAP |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| KIRC | exon_skip_22877 | 4.57e-02 | 1.54e-01 | -8.26e+00 | 1.50e-16 | 1.17e-14 | -1.08e-01 |
| LUSC | exon_skip_22858 | 8.80e-01 | 9.89e-01 | -5.15e+00 | 2.63e-07 | 1.38e-06 | -1.09e-01 |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for RAP1GAP |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for RAP1GAP |
| TFs related to RAP1GAP. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| RAP1GAP related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for RAP1GAP |
| RBPs related to ES in RAP1GAP. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| STAD | HNRNPH2 | exon_skip_22883 | 8.40e+00 | 9.89e-01 | 7.95e+00 | 4.17e-03 | Male-biased |
| UVM | HNRNPH2 | exon_skip_22883 | 7.96e+00 | 5.50e-03 | 8.31e+00 | 9.87e-01 | Female-biased |
| COAD | G3BP2 | exon_skip_22887 | 9.10e+00 | 1.34e-02 | 9.40e+00 | 9.84e-01 | Female-biased |
| LUAD | HNRNPH2 | exon_skip_22883 | 8.01e+00 | 8.16e-04 | 8.62e+00 | 9.93e-01 | Female-biased |
| READ | FMR1 | exon_skip_22879 | 6.47e+00 | 4.03e-03 | 6.88e+00 | 9.81e-01 | Female-biased |
| LGG | HNRNPH2 | exon_skip_22883 | 8.14e+00 | 9.82e-01 | 7.81e+00 | 1.03e-02 | Male-biased |
| GBM | G3BP2 | exon_skip_22887 | 9.16e+00 | 9.87e-01 | 8.81e+00 | 8.85e-03 | Male-biased |
| PAAD | HNRNPH2 | exon_skip_22883 | 7.89e+00 | 4.70e-03 | 8.25e+00 | 9.88e-01 | Female-biased |
| KICH | HNRNPH2 | exon_skip_22883 | 8.33e+00 | 8.95e-03 | 8.66e+00 | 9.85e-01 | Female-biased |
| SKCM | HNRNPH2 | exon_skip_22883 | 8.10e+00 | 9.67e-03 | 8.46e+00 | 9.84e-01 | Female-biased |
| SKCM | SNRPA | exon_skip_22879 | 7.09e+00 | 9.82e-01 | 6.66e+00 | 4.83e-03 | Male-biased |
| RAP1GAP related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs10917263 | chr1:22590178:G:A | - | 0.227518198840562 | 0.0119407119396396 | KIRP | Female-baised eQTL |
| rs55777650 | chr1:14197019:A:G | - | 0.0995775039016541 | 0.0369724614515109 | KIRC | Female-baised eQTL |
| rs6693441 | chr1:15304936:C:T | - | 0.241093320073786 | 0.00707125456666271 | BLCA | Female-baised eQTL |
| rs6658018 | chr1:14574212:T:C | - | 0.149902954192331 | 0.0143068172468435 | BLCA | Female-baised eQTL |
| rs6703840 | chr1:14573923:A:G | - | 0.138886693047818 | 0.02140919317464 | BLCA | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs16829675 | chr1:24443649:C:T | - | 0.0541643650168557 | 0.0113506969448572 | LIHC | Male-baised eQTL |
| rs1818672 | chr1:18433364:T:C | - | -0.0530123378828412 | 0.0119132292132234 | KIRC | Male-baised eQTL |
| rs10907310 | chr1:18433458:T:C | - | -0.0530123378828412 | 0.0119132292132234 | KIRC | Male-baised eQTL |
| rs1336121 | chr1:18434704:C:T | - | -0.052630268037862 | 0.0120844600952462 | KIRC | Male-baised eQTL |
| rs11583897 | chr1:26361690:G:C | - | 0.0743575237096625 | 0.0278543812804251 | KIRC | Male-baised eQTL |
| rs11581153 | chr1:26362694:A:G | - | 0.0743575237096625 | 0.0278543812804251 | KIRC | Male-baised eQTL |
| rs77370022 | chr1:26360390:C:T | - | 0.0742942849397116 | 0.0282308922919189 | KIRC | Male-baised eQTL |
| rs12122817 | chr1:26363689:G:A | - | 0.0737158879172974 | 0.0312517201592997 | KIRC | Male-baised eQTL |
| rs3961710 | chr1:15986677:C:T | - | 0.0455988937513305 | 0.0415047343730665 | KIRC | Male-baised eQTL |
| rs4307563 | chr1:15987293:C:T | - | 0.0455988937513305 | 0.0415047343730665 | KIRC | Male-baised eQTL |
| rs6688245 | chr1:14740099:A:G | - | 0.0560106259057241 | 0.00872154669489134 | BLCA | Male-baised eQTL |
| rs1416831 | chr1:24295490:A:C | - | -0.0385193585193012 | 0.0471603081695162 | BLCA | Male-baised eQTL |
| rs2064378 | chr1:19318361:G:A | - | 0.0687799260930602 | 0.00176582625787972 | COAD | Male-baised eQTL |
| rs57215361 | chr1:26988323:A:G | - | 0.110185338548717 | 0.0151708450896986 | COAD | Male-baised eQTL |
| rs2073097 | chr1:19315998:G:A | - | 0.0531102714713088 | 0.0215195079546615 | COAD | Male-baised eQTL |
| rs12138571 | chr1:19316179:G:A | - | 0.0528045259965288 | 0.0227563290229111 | COAD | Male-baised eQTL |
| rs1003297 | chr1:19316574:G:A | - | 0.0525292064636253 | 0.0238980959749319 | COAD | Male-baised eQTL |
| rs1003296 | chr1:19316729:T:A | - | 0.0525292064636253 | 0.0238980959749319 | COAD | Male-baised eQTL |
| rs35271792 | chr1:26982465:T:C | - | 0.10424594983434 | 0.024272678327322 | COAD | Male-baised eQTL |
| rs34890754 | chr1:26985020:T:C | - | 0.10424594983434 | 0.024272678327322 | COAD | Male-baised eQTL |
| rs11802383 | chr1:13650493:C:A | - | 0.10032897793586 | 0.0246993436736968 | COAD | Male-baised eQTL |
| rs192236925 | chr1:13657732:G:A | - | 0.102439330827162 | 0.0250839494964821 | COAD | Male-baised eQTL |
| rs149744062 | chr1:13647750:A:G | - | 0.097600578354393 | 0.0290813275368232 | COAD | Male-baised eQTL |
| rs4912070 | chr1:19319315:A:C | - | 0.0513040083654636 | 0.0300303669626083 | COAD | Male-baised eQTL |
| rs12146076 | chr1:19318861:A:G | - | 0.0510357136651538 | 0.030277579154784 | COAD | Male-baised eQTL |
| rs79584300 | chr1:13653990:G:T | - | 0.0962302865333366 | 0.0333927125342664 | COAD | Male-baised eQTL |
| rs140621879 | chr1:13658166:C:T | - | 0.0958308863412096 | 0.0348054220955537 | COAD | Male-baised eQTL |
| rs11799368 | chr1:13646674:G:A | - | 0.0942692344153498 | 0.0358131883906765 | COAD | Male-baised eQTL |
| rs1061615 | chr1:13617229:T:C | - | 0.0541434797033691 | 0.0372746946257434 | COAD | Male-baised eQTL |
| rs11803252 | chr1:13657713:C:T | - | 0.0867941106378305 | 0.0373632554756618 | COAD | Male-baised eQTL |
| rs41275462 | chr1:11779915:G:A | - | 0.0775949023318553 | 0.0383505188398111 | COAD | Male-baised eQTL |
| rs12119092 | chr1:11781632:C:T | - | 0.0767990923774482 | 0.0435461845780727 | COAD | Male-baised eQTL |
| rs12141216 | chr1:11781852:G:A | - | 0.0767990923774482 | 0.0435461845780727 | COAD | Male-baised eQTL |
| rs61776071 | chr1:11782434:G:A | - | 0.0767990923774482 | 0.0435461845780727 | COAD | Male-baised eQTL |
| rs12132479 | chr1:11776393:A:G | - | 0.0767205863169527 | 0.0443556419240482 | COAD | Male-baised eQTL |
| rs12134663 | chr1:11778589:A:C | - | 0.076694515406947 | 0.0444806303445344 | COAD | Male-baised eQTL |
| rs4661300 | chr1:14712275:T:G | - | -0.0467437656522382 | 0.0476172832476079 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000076864 |
| CpG Site: cg06993467 | |
| Position to Gene: gene | |
| Male Effect: -0.387940056664035 | |
| Female Effect: - | |
 | Gene ID: ENSG00000076864 |
| CpG Site: cg10038867 | |
| Position to Gene: gene | |
| Male Effect: -0.387940056664035 | |
| Female Effect: - | |
 | Gene ID: ENSG00000076864 |
| CpG Site: cg24852446 | |
| Position to Gene: gene,exon,CDS | |
| Male Effect: -0.445848476399787 | |
| Female Effect: - | |
 | Gene ID: ENSG00000076864 |
| CpG Site: cg24001246 | |
| Position to Gene: gene | |
| Male Effect: -0.245151033444463 | |
| Female Effect: - | |
 | Gene ID: ENSG00000076864 |
| CpG Site: cg11072119 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.468436793391594 | |
 | Gene ID: ENSG00000076864 |
| CpG Site: cg11531272 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.468436793391594 | |
 | Gene ID: ENSG00000076864 |
| CpG Site: cg09118749 | |
| Position to Gene: gene | |
| Male Effect: -0.457292084057144 | |
| Female Effect: - | |
 | Gene ID: ENSG00000076864 |
| CpG Site: cg03727673 | |
| Position to Gene: gene | |
| Male Effect: -0.32912587032134 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg06993467 | chr1:21640007 | gene | -0.387940056664035 | 6.75410659379332e-25 | -0.853027208360752 | 7.290656773934647e-29 | PAAD |
| cg10038867 | chr1:21656018 | gene | -0.387940056664035 | 6.75410659379332e-25 | -0.853027208360752 | 7.290656773934647e-29 | PAAD |
| cg24852446 | chr1:21608233 | gene,exon,CDS | -0.445848476399787 | 1.71106546864143e-12 | -0.6958588626622794 | 1.8233284695104576e-15 | PAAD |
| cg24001246 | chr1:21622988 | gene | -0.245151033444463 | 1.59641140431022e-10 | -0.6546519226724008 | 2.643601389860067e-13 | PAAD |
| cg09118749 | chr1:21626073 | gene | -0.457292084057144 | 5.44860368717648e-07 | -0.4340861531917163 | 4.6106166350062795e-09 | COAD |
| cg03727673 | chr1:21639927 | gene | -0.32912587032134 | 7.48615523357153e-05 | -0.34147138371890423 | 1.7078994423755613e-07 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg11072119 | chr1:21607819 | gene | -0.468436793391594 | 2.14908229038631e-28 | -0.5548303385644997 | 4.278541335955389e-31 | THCA |
| cg11531272 | chr1:21608186 | gene | -0.468436793391594 | 2.14908229038631e-28 | -0.5548303385644997 | 4.278541335955389e-31 | THCA |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs2774026 | chr1:21320017:G:A | Distant downstream | -0.0397877908990622 | 0.0074411521119553 | LUAD | Female-baised sQTL |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs998978 | chr1:22522510:A:C | Distant upstream | 0.0177097214865564 | 0.0425883208351655 | LUAD | Female-baised sQTL |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs881646 | chr1:22526222:G:C | Distant upstream | 0.0177097214865564 | 0.0425883208351655 | LUAD | Female-baised sQTL |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs1062663 | chr1:22530108:T:C | Distant upstream | 0.0176323969501714 | 0.0429077087525241 | LUAD | Female-baised sQTL |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs1769819 | chr1:22483328:T:C | Distant upstream | 0.0172429002134825 | 0.0451794023663191 | LUAD | Female-baised sQTL |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs209753 | chr1:22495475:T:C | Distant upstream | 0.017233706341523 | 0.0487106023626801 | LUAD | Female-baised sQTL |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs1111878 | chr1:21318378:T:C | Distant downstream | -0.061456195429108 | 0.0414585928507059 | COAD | Female-baised sQTL |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs144616172 | chr1:21985163:G:T | Distant upstream | -0.0537535981768455 | 0.0449167393300753 | COAD | Female-baised sQTL |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs200354565 | chr1:21856983:A:G | Distant upstream | -0.13706437484124 | 0.0100270120561786 | GBM | Female-baised sQTL |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs12757277 | chr1:21856984:G:T | Distant upstream | -0.13706437484124 | 0.0100270120561786 | GBM | Female-baised sQTL |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs71636990 | chr1:21834161:T:C | Distant upstream | -0.136167838116776 | 0.0113322856290757 | GBM | Female-baised sQTL |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs35423650 | chr1:21836717:C:A | Distant upstream | -0.135648741799673 | 0.0121698722059559 | GBM | Female-baised sQTL |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs34470509 | chr1:21841783:G:T | Distant upstream | -0.135648741799673 | 0.0121698722059559 | GBM | Female-baised sQTL |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs2229489 | chr1:21842352:A:T | Distant upstream | -0.135648741799673 | 0.0121698722059559 | GBM | Female-baised sQTL |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs75779078 | chr1:21842693:A:G | Distant upstream | -0.135648741799673 | 0.0121698722059559 | GBM | Female-baised sQTL |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs34884591 | chr1:21843925:T:C | Distant upstream | -0.135648741799673 | 0.0121698722059559 | GBM | Female-baised sQTL |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs115963344 | chr1:21844973:C:T | Distant upstream | -0.135648741799673 | 0.0121698722059559 | GBM | Female-baised sQTL |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs34792235 | chr1:21846651:C:T | Distant upstream | -0.135648741799673 | 0.0121698722059559 | GBM | Female-baised sQTL |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs35286527 | chr1:21847061:G:A | Distant upstream | -0.135648741799673 | 0.0121698722059559 | GBM | Female-baised sQTL |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs12757119 | chr1:21847184:T:C | Distant upstream | -0.135648741799673 | 0.0121698722059559 | GBM | Female-baised sQTL |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs35921133 | chr1:21847243:C:T | Distant upstream | -0.135648741799673 | 0.0121698722059559 | GBM | Female-baised sQTL |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs35917892 | chr1:21847497:A:G | Distant upstream | -0.135648741799673 | 0.0121698722059559 | GBM | Female-baised sQTL |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs12737091 | chr1:21848025:G:T | Distant upstream | -0.135648741799673 | 0.0121698722059559 | GBM | Female-baised sQTL |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs12741617 | chr1:21848418:G:A | Distant upstream | -0.135648741799673 | 0.0121698722059559 | GBM | Female-baised sQTL |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs34726153 | chr1:21848603:T:C | Distant upstream | -0.135648741799673 | 0.0121698722059559 | GBM | Female-baised sQTL |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs71636992 | chr1:21849281:T:C | Distant upstream | -0.135648741799673 | 0.0121698722059559 | GBM | Female-baised sQTL |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs71636993 | chr1:21849969:C:T | Distant upstream | -0.135648741799673 | 0.0121698722059559 | GBM | Female-baised sQTL |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs34719083 | chr1:21850276:C:T | Distant upstream | -0.135648741799673 | 0.0121698722059559 | GBM | Female-baised sQTL |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs12724454 | chr1:21850815:G:A | Distant upstream | -0.135648741799673 | 0.0121698722059559 | GBM | Female-baised sQTL |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs12725566 | chr1:21850823:C:A | Distant upstream | -0.135648741799673 | 0.0121698722059559 | GBM | Female-baised sQTL |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs12749517 | chr1:21850873:T:C | Distant upstream | -0.135648741799673 | 0.0121698722059559 | GBM | Female-baised sQTL |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs12749847 | chr1:21851065:T:C | Distant upstream | -0.135648741799673 | 0.0121698722059559 | GBM | Female-baised sQTL |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs34019350 | chr1:21851262:C:T | Distant upstream | -0.135648741799673 | 0.0121698722059559 | GBM | Female-baised sQTL |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs12750012 | chr1:21851385:A:G | Distant upstream | -0.135648741799673 | 0.0121698722059559 | GBM | Female-baised sQTL |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs34346159 | chr1:21851976:A:G | Distant upstream | -0.135648741799673 | 0.0121698722059559 | GBM | Female-baised sQTL |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs35337242 | chr1:21852498:C:T | Distant upstream | -0.135648741799673 | 0.0121698722059559 | GBM | Female-baised sQTL |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs35999331 | chr1:21852543:G:A | Distant upstream | -0.135648741799673 | 0.0121698722059559 | GBM | Female-baised sQTL |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs35669711 | chr1:21852751:C:T | Distant upstream | -0.135648741799673 | 0.0121698722059559 | GBM | Female-baised sQTL |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs34443576 | chr1:21852958:C:T | Distant upstream | -0.135648741799673 | 0.0121698722059559 | GBM | Female-baised sQTL |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs56318008 | chr1:22143914:C:T | Distant upstream | -0.0388878592267398 | 0.0247055104726698 | COAD | Male-baised sQTL |
| exon_skip_22858 | chr1:21601683:21601797 | In-frame | rs55938609 | chr1:22143958:G:C | Distant upstream | -0.0388878592267398 | 0.0247055104726698 | COAD | Male-baised sQTL |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
 | EX ID: exon_skip_22858 |
| CpG Site: cg27585345 | |
| Position to EX: Distant upstream | |
| Male Effect: 0.232161562833435 | |
| Female Effect: - |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| exon_skip_22858 | chr1:21601683:21601797 | cg27585345 | chr1:21811888 | Distant upstream | 0.232161562833435 | 1.33284287041467e-05 | 0.37764300536865253 | 7.218872685906579e-08 | In-frame | LIHC |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of RAP1GAP |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000076864 | RAP1GAP | C0023487 | Acute Promyelocytic Leukemia | 1 | CTD_human |
| ENSG00000076864 | RAP1GAP | C0025202 | melanoma | 2 | CTD_human |
| ENSG00000076864 | RAP1GAP | C0030297 | Pancreatic Neoplasm | 1 | CTD_human |
| ENSG00000076864 | RAP1GAP | C0040136 | Thyroid Neoplasm | 1 | CTD_human |
| ENSG00000076864 | RAP1GAP | C0151468 | Thyroid Gland Follicular Adenoma | 1 | CTD_human |
| ENSG00000076864 | RAP1GAP | C0235874 | Disease Exacerbation | 1 | CTD_human |
| ENSG00000076864 | RAP1GAP | C0346647 | Malignant neoplasm of pancreas | 1 | CTD_human |
| ENSG00000076864 | RAP1GAP | C0549473 | Thyroid carcinoma | 1 | CTD_human |
