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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000076716

Summary for GPC4

check button Gene summary

Gene informationEnsembl ID

ENSG00000076716

Gene symbol

GPC4

Gene nameglypican 4
HGNC

4452

Entrez ID

2239

Gene typeprotein_coding
SynonymsGPC4|K-glypican
UniProtAcc

O75487


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

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Structure and expression level for GPC4

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
GPC41.19e+032.32e+005.70e-014.07e+004.70e-052.25e-04CHOL

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
GPC44.90e+021.56e+004.27e-013.66e+002.52e-047.42e-04LIHC
GPC43.73e+031.12e+001.21e-019.28e+001.73e-205.93e-20BRCA

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Sex-biased somatic mutation for GPC4

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for GPC4

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg07312966chrX:133415177CGI:chrX:133413539-133416256UTR,promoter,exon,gene body2.82e-012.22e-025.13e+002.90e-071.16e-052.60e-01
BRCAcg08798116chrX:133414854CGI:chrX:133413539-133416256promoter,exon,CDS,gene body4.32e-011.27e-025.16e+002.43e-071.16e-054.20e-01
BRCAcg06558166chrX:133414975CGI:chrX:133413539-133416256UTR,promoter,exon,gene body4.46e-011.83e-025.16e+002.43e-071.16e-054.28e-01
BRCAcg17223593chrX:133415269CGI:chrX:133413539-133416256UTR,promoter,exon,gene body3.95e-012.35e-025.15e+002.56e-071.16e-053.71e-01
BRCAcg05347431chrX:133413540CGI:chrX:133413539-133416256promoter,gene body3.85e-012.77e-012.82e+004.84e-032.01e-021.08e-01
BRCAcg27382931chrX:133415662CGI:chrX:133413539-133416256promoter4.31e-014.54e-025.16e+002.43e-071.16e-053.86e-01
BRCAcg14600040chrX:133415736CGI:chrX:133413539-133416256promoter3.25e-019.77e-022.83e+004.69e-031.98e-022.28e-01
BRCAcg12600766chrX:133416103CGI:chrX:133413539-133416256promoter3.56e-015.75e-024.00e+006.34e-051.15e-032.99e-01
LGGcg07312966chrX:133415177CGI:chrX:133413539-133416256UTR,promoter,exon,gene body2.74e-012.24e-021.98e+015.93e-873.12e-852.51e-01
LGGcg08798116chrX:133414854CGI:chrX:133413539-133416256promoter,exon,CDS,gene body4.44e-011.38e-021.98e+013.52e-872.64e-854.31e-01
LGGcg06558166chrX:133414975CGI:chrX:133413539-133416256UTR,promoter,exon,gene body4.81e-011.85e-021.98e+013.52e-872.64e-854.63e-01
LGGcg17223593chrX:133415269CGI:chrX:133413539-133416256UTR,promoter,exon,gene body4.12e-012.32e-021.98e+014.67e-872.73e-853.89e-01
LGGcg27382931chrX:133415662CGI:chrX:133413539-133416256promoter4.12e-015.28e-021.98e+013.52e-872.64e-853.59e-01
LGGcg14600040chrX:133415736CGI:chrX:133413539-133416256promoter2.95e-018.79e-021.88e+011.55e-783.13e-772.07e-01
LGGcg12600766chrX:133416103CGI:chrX:133413539-133416256promoter3.72e-011.11e-011.67e+019.76e-631.31e-612.61e-01
LGGcg23647832chrX:133416802CGI:chrX:133413539-133416256promoter7.47e-018.75e-01-1.23e+011.60e-341.36e-33-1.28e-01
LUSCcg07312966chrX:133415177CGI:chrX:133413539-133416256UTR,promoter,exon,gene body2.78e-012.57e-021.44e+014.76e-471.56e-452.53e-01
LUSCcg08798116chrX:133414854CGI:chrX:133413539-133416256promoter,exon,CDS,gene body4.17e-011.96e-021.45e+011.81e-471.26e-453.97e-01
LUSCcg06558166chrX:133414975CGI:chrX:133413539-133416256UTR,promoter,exon,gene body4.55e-012.38e-021.45e+011.73e-471.26e-454.31e-01
LUSCcg17223593chrX:133415269CGI:chrX:133413539-133416256UTR,promoter,exon,gene body3.67e-012.59e-021.45e+011.52e-471.26e-453.41e-01
LUSCcg10418630chrX:133413663CGI:chrX:133413539-133416256promoter,gene body2.75e-011.55e-018.37e+005.71e-175.54e-161.20e-01
LUSCcg13536141chrX:133414250CGI:chrX:133413539-133416256promoter,gene body4.27e-011.96e-011.03e+019.02e-251.04e-232.30e-01
LUSCcg27382931chrX:133415662CGI:chrX:133413539-133416256promoter4.13e-017.78e-021.44e+012.67e-471.26e-453.35e-01
LUSCcg14600040chrX:133415736CGI:chrX:133413539-133416256promoter3.83e-018.77e-021.45e+011.84e-471.26e-452.96e-01
LUSCcg12600766chrX:133416103CGI:chrX:133413539-133416256promoter3.66e-016.26e-021.42e+018.80e-462.00e-443.04e-01
SKCMcg07312966chrX:133415177CGI:chrX:133413539-133416256UTR,promoter,exon,gene body2.58e-012.31e-021.79e+012.85e-718.78e-702.35e-01
SKCMcg08798116chrX:133414854CGI:chrX:133413539-133416256promoter,exon,CDS,gene body3.91e-012.51e-021.78e+011.57e-704.42e-693.66e-01
SKCMcg06558166chrX:133414975CGI:chrX:133413539-133416256UTR,promoter,exon,gene body4.06e-012.38e-021.80e+019.49e-733.75e-713.82e-01
SKCMcg17223593chrX:133415269CGI:chrX:133413539-133416256UTR,promoter,exon,gene body3.62e-012.78e-021.77e+012.96e-708.18e-693.34e-01
SKCMcg13536141chrX:133414250CGI:chrX:133413539-133416256promoter,gene body5.55e-014.38e-013.88e+001.05e-044.99e-041.17e-01
SKCMcg27382931chrX:133415662CGI:chrX:133413539-133416256promoter3.92e-016.64e-021.80e+018.26e-733.33e-713.26e-01
SKCMcg14600040chrX:133415736CGI:chrX:133413539-133416256promoter3.17e-011.01e-011.68e+012.92e-635.77e-622.16e-01
SKCMcg12600766chrX:133416103CGI:chrX:133413539-133416256promoter3.05e-011.58e-011.17e+018.86e-328.88e-311.47e-01
STADcg07312966chrX:133415177CGI:chrX:133413539-133416256UTR,promoter,exon,gene body3.01e-012.55e-021.50e+018.69e-513.06e-492.75e-01
STADcg08798116chrX:133414854CGI:chrX:133413539-133416256promoter,exon,CDS,gene body4.33e-012.09e-021.51e+018.89e-525.09e-504.12e-01
STADcg06558166chrX:133414975CGI:chrX:133413539-133416256UTR,promoter,exon,gene body4.69e-012.64e-021.51e+012.20e-519.52e-504.42e-01
STADcg17223593chrX:133415269CGI:chrX:133413539-133416256UTR,promoter,exon,gene body3.93e-012.50e-021.51e+012.48e-511.06e-493.68e-01
STADcg05347431chrX:133413540CGI:chrX:133413539-133416256promoter,gene body4.03e-012.41e-019.22e+002.99e-203.49e-191.62e-01
STADcg10418630chrX:133413663CGI:chrX:133413539-133416256promoter,gene body2.65e-011.05e-011.17e+018.04e-321.29e-301.60e-01
STADcg13536141chrX:133414250CGI:chrX:133413539-133416256promoter,gene body4.00e-011.35e-011.14e+014.51e-306.97e-292.65e-01
STADcg27382931chrX:133415662CGI:chrX:133413539-133416256promoter4.22e-017.82e-021.51e+019.72e-525.31e-503.43e-01
STADcg14600040chrX:133415736CGI:chrX:133413539-133416256promoter4.20e-019.68e-021.26e+011.14e-362.07e-353.23e-01
STADcg12600766chrX:133416103CGI:chrX:133413539-133416256promoter3.91e-011.04e-011.32e+016.24e-401.23e-382.87e-01
SARCcg07312966chrX:133415177CGI:chrX:133413539-133416256UTR,promoter,exon,gene body2.17e-013.65e-021.21e+019.44e-343.02e-321.81e-01
SARCcg08798116chrX:133414854CGI:chrX:133413539-133416256promoter,exon,CDS,gene body3.47e-012.77e-021.33e+013.75e-401.98e-383.20e-01
SARCcg06558166chrX:133414975CGI:chrX:133413539-133416256UTR,promoter,exon,gene body3.92e-013.61e-021.31e+014.38e-392.02e-373.56e-01
SARCcg17223593chrX:133415269CGI:chrX:133413539-133416256UTR,promoter,exon,gene body3.22e-014.77e-021.20e+015.26e-331.62e-312.74e-01
SARCcg05347431chrX:133413540CGI:chrX:133413539-133416256promoter,gene body3.48e-011.57e-019.17e+004.61e-206.36e-191.90e-01
SARCcg10418630chrX:133413663CGI:chrX:133413539-133416256promoter,gene body2.02e-016.52e-021.06e+011.97e-264.02e-251.37e-01
SARCcg13536141chrX:133414250CGI:chrX:133413539-133416256promoter,gene body3.72e-011.15e-017.90e+002.85e-153.22e-142.58e-01
SARCcg27382931chrX:133415662CGI:chrX:133413539-133416256promoter3.63e-017.28e-021.33e+013.02e-401.62e-382.91e-01
SARCcg14600040chrX:133415736CGI:chrX:133413539-133416256promoter3.41e-019.84e-028.77e+001.75e-182.27e-172.43e-01
SARCcg12600766chrX:133416103CGI:chrX:133413539-133416256promoter3.60e-011.20e-019.53e+001.63e-212.42e-202.40e-01
PCPGcg07312966chrX:133415177CGI:chrX:133413539-133416256UTR,promoter,exon,gene body1.36e-012.41e-021.13e+011.75e-293.22e-281.12e-01
PCPGcg08798116chrX:133414854CGI:chrX:133413539-133416256promoter,exon,CDS,gene body2.53e-011.61e-021.15e+019.89e-312.93e-292.36e-01
PCPGcg06558166chrX:133414975CGI:chrX:133413539-133416256UTR,promoter,exon,gene body3.97e-011.91e-021.16e+013.83e-311.92e-293.78e-01
PCPGcg17223593chrX:133415269CGI:chrX:133413539-133416256UTR,promoter,exon,gene body2.47e-012.34e-021.16e+014.09e-311.92e-292.23e-01
PCPGcg13536141chrX:133414250CGI:chrX:133413539-133416256promoter,gene body4.76e-012.07e-018.26e+001.42e-161.09e-152.68e-01
PCPGcg27382931chrX:133415662CGI:chrX:133413539-133416256promoter3.69e-015.47e-021.16e+013.83e-311.92e-293.15e-01
PCPGcg12600766chrX:133416103CGI:chrX:133413539-133416256promoter2.37e-016.22e-021.02e+011.34e-241.66e-231.75e-01
PAADcg07312966chrX:133415177CGI:chrX:133413539-133416256UTR,promoter,exon,gene body2.63e-012.54e-021.14e+016.15e-302.02e-282.37e-01
PAADcg08798116chrX:133414854CGI:chrX:133413539-133416256promoter,exon,CDS,gene body4.19e-011.58e-021.15e+012.03e-301.01e-284.03e-01
PAADcg06558166chrX:133414975CGI:chrX:133413539-133416256UTR,promoter,exon,gene body4.81e-012.09e-021.15e+012.03e-301.01e-284.60e-01
PAADcg17223593chrX:133415269CGI:chrX:133413539-133416256UTR,promoter,exon,gene body3.83e-012.35e-021.15e+012.03e-301.01e-283.60e-01
PAADcg05347431chrX:133413540CGI:chrX:133413539-133416256promoter,gene body3.91e-011.92e-019.45e+003.55e-215.59e-201.99e-01
PAADcg10418630chrX:133413663CGI:chrX:133413539-133416256promoter,gene body2.45e-016.98e-021.01e+014.34e-247.88e-231.75e-01
PAADcg13536141chrX:133414250CGI:chrX:133413539-133416256promoter,gene body4.20e-011.18e-011.06e+012.71e-265.53e-253.02e-01
PAADcg27382931chrX:133415662CGI:chrX:133413539-133416256promoter4.12e-016.39e-021.15e+012.03e-301.01e-283.48e-01
PAADcg14600040chrX:133415736CGI:chrX:133413539-133416256promoter4.05e-019.37e-021.13e+011.24e-293.78e-283.11e-01
PAADcg12600766chrX:133416103CGI:chrX:133413539-133416256promoter3.87e-015.98e-021.14e+013.72e-301.33e-283.27e-01
READcg07312966chrX:133415177CGI:chrX:133413539-133416256UTR,promoter,exon,gene body3.15e-011.89e-028.49e+002.15e-174.34e-162.96e-01
READcg08798116chrX:133414854CGI:chrX:133413539-133416256promoter,exon,CDS,gene body4.23e-011.29e-028.49e+002.15e-174.34e-164.11e-01
READcg06558166chrX:133414975CGI:chrX:133413539-133416256UTR,promoter,exon,gene body4.34e-011.79e-028.49e+002.15e-174.34e-164.16e-01
READcg17223593chrX:133415269CGI:chrX:133413539-133416256UTR,promoter,exon,gene body3.36e-011.89e-028.48e+002.29e-174.34e-163.17e-01
READcg05347431chrX:133413540CGI:chrX:133413539-133416256promoter,gene body4.32e-012.85e-014.55e+005.37e-062.95e-051.47e-01
READcg10418630chrX:133413663CGI:chrX:133413539-133416256promoter,gene body2.49e-011.19e-015.57e+002.53e-081.73e-071.30e-01
READcg13536141chrX:133414250CGI:chrX:133413539-133416256promoter,gene body3.44e-011.18e-017.26e+003.96e-133.99e-122.26e-01
READcg27382931chrX:133415662CGI:chrX:133413539-133416256promoter4.31e-015.58e-028.49e+002.15e-174.34e-163.75e-01
READcg14600040chrX:133415736CGI:chrX:133413539-133416256promoter3.86e-017.14e-028.49e+002.15e-174.34e-163.15e-01
READcg12600766chrX:133416103CGI:chrX:133413539-133416256promoter3.83e-014.58e-028.44e+003.30e-175.42e-163.37e-01
READcg23647832chrX:133416802CGI:chrX:133413539-133416256promoter4.15e-015.35e-01-2.99e+002.77e-039.63e-03-1.20e-01
GBMcg07312966chrX:133415177CGI:chrX:133413539-133416256UTR,promoter,exon,gene body3.63e-012.16e-026.71e+001.97e-113.03e-103.42e-01
GBMcg08798116chrX:133414854CGI:chrX:133413539-133416256promoter,exon,CDS,gene body4.68e-011.30e-026.75e+001.48e-112.64e-104.55e-01
GBMcg06558166chrX:133414975CGI:chrX:133413539-133416256UTR,promoter,exon,gene body4.69e-011.79e-026.75e+001.48e-112.64e-104.51e-01
GBMcg17223593chrX:133415269CGI:chrX:133413539-133416256UTR,promoter,exon,gene body4.48e-012.29e-026.75e+001.48e-112.64e-104.25e-01
GBMcg05347431chrX:133413540CGI:chrX:133413539-133416256promoter,gene body3.69e-011.56e-015.24e+001.64e-071.22e-062.13e-01
GBMcg10418630chrX:133413663CGI:chrX:133413539-133416256promoter,gene body2.36e-015.33e-026.22e+004.90e-105.14e-091.83e-01
GBMcg13536141chrX:133414250CGI:chrX:133413539-133416256promoter,gene body4.60e-011.69e-014.82e+001.44e-069.59e-062.90e-01
GBMcg27382931chrX:133415662CGI:chrX:133413539-133416256promoter4.60e-014.27e-026.75e+001.48e-112.64e-104.17e-01
GBMcg14600040chrX:133415736CGI:chrX:133413539-133416256promoter3.99e-019.28e-025.89e+003.89e-093.52e-083.06e-01
GBMcg12600766chrX:133416103CGI:chrX:133413539-133416256promoter3.97e-019.45e-025.89e+003.89e-093.52e-083.02e-01
GBMcg23647832chrX:133416802CGI:chrX:133413539-133416256promoter7.09e-018.35e-01-3.18e+001.47e-035.63e-03-1.26e-01
ESCAcg07312966chrX:133415177CGI:chrX:133413539-133416256UTR,promoter,exon,gene body2.99e-012.82e-027.48e+007.50e-141.08e-122.71e-01
ESCAcg08798116chrX:133414854CGI:chrX:133413539-133416256promoter,exon,CDS,gene body4.32e-012.31e-027.48e+007.23e-141.05e-124.09e-01
ESCAcg06558166chrX:133414975CGI:chrX:133413539-133416256UTR,promoter,exon,gene body4.53e-012.77e-027.47e+007.78e-141.11e-124.25e-01
ESCAcg17223593chrX:133415269CGI:chrX:133413539-133416256UTR,promoter,exon,gene body3.88e-012.81e-027.51e+005.81e-148.95e-133.60e-01
ESCAcg10418630chrX:133413663CGI:chrX:133413539-133416256promoter,gene body2.58e-011.33e-014.82e+001.47e-069.87e-061.26e-01
ESCAcg13536141chrX:133414250CGI:chrX:133413539-133416256promoter,gene body4.24e-011.91e-014.59e+004.33e-062.78e-052.33e-01
ESCAcg27382931chrX:133415662CGI:chrX:133413539-133416256promoter4.28e-016.80e-027.60e+002.88e-146.84e-133.60e-01
ESCAcg14600040chrX:133415736CGI:chrX:133413539-133416256promoter3.88e-011.04e-016.03e+001.60e-091.37e-082.84e-01
ESCAcg12600766chrX:133416103CGI:chrX:133413539-133416256promoter3.56e-016.67e-027.41e+001.25e-131.67e-122.89e-01
LAMLcg07312966chrX:133415177CGI:chrX:133413539-133416256UTR,promoter,exon,gene body3.77e-017.69e-029.09e+009.72e-207.77e-193.00e-01
LAMLcg08798116chrX:133414854CGI:chrX:133413539-133416256promoter,exon,CDS,gene body4.69e-017.26e-029.13e+007.06e-205.72e-193.97e-01
LAMLcg06558166chrX:133414975CGI:chrX:133413539-133416256UTR,promoter,exon,gene body5.22e-019.79e-028.41e+004.20e-172.82e-164.24e-01
LAMLcg17223593chrX:133415269CGI:chrX:133413539-133416256UTR,promoter,exon,gene body4.87e-011.14e-018.41e+004.06e-172.73e-163.73e-01
LAMLcg05347431chrX:133413540CGI:chrX:133413539-133416256promoter,gene body4.01e-012.17e-016.32e+002.65e-101.20e-091.84e-01
LAMLcg10418630chrX:133413663CGI:chrX:133413539-133416256promoter,gene body4.13e-012.15e-016.58e+004.72e-112.22e-101.98e-01
LAMLcg13536141chrX:133414250CGI:chrX:133413539-133416256promoter,gene body6.36e-014.31e-014.68e+002.89e-061.06e-052.05e-01
LAMLcg27382931chrX:133415662CGI:chrX:133413539-133416256promoter4.86e-011.22e-019.28e+001.69e-201.44e-193.64e-01
LAMLcg14600040chrX:133415736CGI:chrX:133413539-133416256promoter4.68e-011.42e-019.05e+001.43e-191.13e-183.26e-01
LAMLcg12600766chrX:133416103CGI:chrX:133413539-133416256promoter4.17e-011.36e-018.17e+003.02e-161.92e-152.81e-01
THYMcg07312966chrX:133415177CGI:chrX:133413539-133416256UTR,promoter,exon,gene body2.22e-012.56e-029.40e+005.48e-211.00e-191.97e-01
THYMcg08798116chrX:133414854CGI:chrX:133413539-133416256promoter,exon,CDS,gene body3.96e-011.40e-029.40e+005.48e-211.00e-193.82e-01
THYMcg06558166chrX:133414975CGI:chrX:133413539-133416256UTR,promoter,exon,gene body4.52e-011.91e-029.39e+005.77e-211.00e-194.33e-01
THYMcg17223593chrX:133415269CGI:chrX:133413539-133416256UTR,promoter,exon,gene body3.49e-012.36e-029.40e+005.48e-211.00e-193.25e-01
THYMcg05347431chrX:133413540CGI:chrX:133413539-133416256promoter,gene body3.24e-011.23e-018.40e+004.29e-173.30e-162.01e-01
THYMcg10418630chrX:133413663CGI:chrX:133413539-133416256promoter,gene body2.53e-017.27e-028.54e+001.31e-171.06e-161.80e-01
THYMcg13536141chrX:133414250CGI:chrX:133413539-133416256promoter,gene body4.17e-011.94e-018.04e+009.15e-166.03e-152.23e-01
THYMcg27382931chrX:133415662CGI:chrX:133413539-133416256promoter3.58e-015.89e-029.40e+005.48e-211.00e-192.99e-01
THYMcg14600040chrX:133415736CGI:chrX:133413539-133416256promoter3.58e-017.85e-029.38e+006.71e-211.04e-192.79e-01
THYMcg12600766chrX:133416103CGI:chrX:133413539-133416256promoter3.52e-015.43e-029.27e+001.92e-202.42e-192.98e-01
MESOcg07312966chrX:133415177CGI:chrX:133413539-133416256UTR,promoter,exon,gene body2.19e-012.78e-026.06e+001.36e-092.54e-081.91e-01
MESOcg08798116chrX:133414854CGI:chrX:133413539-133416256promoter,exon,CDS,gene body3.87e-011.60e-026.06e+001.36e-092.54e-083.71e-01
MESOcg06558166chrX:133414975CGI:chrX:133413539-133416256UTR,promoter,exon,gene body3.74e-012.13e-026.06e+001.36e-092.54e-083.53e-01
MESOcg17223593chrX:133415269CGI:chrX:133413539-133416256UTR,promoter,exon,gene body3.08e-012.60e-026.04e+001.57e-092.60e-082.82e-01
MESOcg05347431chrX:133413540CGI:chrX:133413539-133416256promoter,gene body3.17e-011.83e-013.59e+003.30e-041.86e-031.34e-01
MESOcg10418630chrX:133413663CGI:chrX:133413539-133416256promoter,gene body1.72e-016.51e-025.22e+001.81e-071.61e-061.07e-01
MESOcg13536141chrX:133414250CGI:chrX:133413539-133416256promoter,gene body3.99e-011.43e-015.57e+002.54e-082.56e-072.56e-01
MESOcg27382931chrX:133415662CGI:chrX:133413539-133416256promoter3.53e-016.68e-026.06e+001.36e-092.54e-082.86e-01
MESOcg14600040chrX:133415736CGI:chrX:133413539-133416256promoter2.91e-019.59e-025.99e+002.08e-093.08e-081.95e-01
MESOcg12600766chrX:133416103CGI:chrX:133413539-133416256promoter3.58e-018.72e-025.70e+001.23e-081.32e-072.71e-01
UVMcg07312966chrX:133415177CGI:chrX:133413539-133416256UTR,promoter,exon,gene body1.48e-012.38e-026.82e+008.92e-128.13e-111.24e-01
UVMcg08798116chrX:133414854CGI:chrX:133413539-133416256promoter,exon,CDS,gene body3.15e-011.37e-027.55e+004.34e-141.08e-123.01e-01
UVMcg06558166chrX:133414975CGI:chrX:133413539-133416256UTR,promoter,exon,gene body3.21e-011.74e-027.64e+002.21e-149.97e-133.04e-01
UVMcg17223593chrX:133415269CGI:chrX:133413539-133416256UTR,promoter,exon,gene body2.28e-012.25e-027.20e+005.97e-136.97e-122.06e-01
UVMcg13536141chrX:133414250CGI:chrX:133413539-133416256promoter,gene body3.18e-011.18e-015.65e+001.61e-089.54e-082.00e-01
UVMcg27382931chrX:133415662CGI:chrX:133413539-133416256promoter3.41e-015.40e-027.58e+003.47e-141.01e-122.87e-01
UVMcg14600040chrX:133415736CGI:chrX:133413539-133416256promoter2.96e-018.11e-026.55e+005.70e-114.64e-102.15e-01
UVMcg12600766chrX:133416103CGI:chrX:133413539-133416256promoter2.07e-014.72e-026.31e+002.81e-102.13e-091.60e-01
ACCcg06558166chrX:133414975CGI:chrX:133413539-133416256UTR,promoter,exon,gene body4.58e-011.67e-027.47e+008.02e-142.68e-124.41e-01
ACCcg07312966chrX:133415177CGI:chrX:133413539-133416256UTR,promoter,exon,gene body2.67e-011.94e-027.15e+008.76e-131.54e-112.48e-01
ACCcg08798116chrX:133414854CGI:chrX:133413539-133416256promoter,exon,CDS,gene body4.01e-011.22e-027.47e+008.02e-142.68e-123.89e-01
ACCcg12600766chrX:133416103CGI:chrX:133413539-133416256promoter3.16e-018.93e-026.12e+009.09e-101.01e-082.27e-01
ACCcg13536141chrX:133414250CGI:chrX:133413539-133416256promoter,gene body4.31e-012.49e-013.87e+001.11e-047.43e-041.83e-01
ACCcg14600040chrX:133415736CGI:chrX:133413539-133416256promoter2.67e-017.11e-027.22e+005.24e-139.88e-121.96e-01
ACCcg17223593chrX:133415269CGI:chrX:133413539-133416256UTR,promoter,exon,gene body3.81e-011.96e-027.47e+008.02e-142.68e-123.61e-01
ACCcg23647832chrX:133416802CGI:chrX:133413539-133416256promoter6.83e-018.30e-01-2.70e+006.92e-032.08e-02-1.47e-01
ACCcg27382931chrX:133415662CGI:chrX:133413539-133416256promoter3.99e-016.32e-027.43e+001.09e-132.87e-123.36e-01
KICHcg08798116chrX:133414854CGI:chrX:133413539-133416256promoter,exon,CDS,gene body2.48e-012.04e-026.53e+006.38e-111.88e-092.28e-01
KICHcg06558166chrX:133414975CGI:chrX:133413539-133416256UTR,promoter,exon,gene body2.59e-012.51e-026.55e+005.83e-111.88e-092.34e-01
KICHcg17223593chrX:133415269CGI:chrX:133413539-133416256UTR,promoter,exon,gene body1.55e-012.41e-026.52e+006.97e-111.88e-091.31e-01
KICHcg05347431chrX:133413540CGI:chrX:133413539-133416256promoter,gene body2.69e-011.64e-014.07e+004.69e-053.47e-041.05e-01
KICHcg10418630chrX:133413663CGI:chrX:133413539-133416256promoter,gene body1.53e-014.65e-025.99e+002.16e-092.84e-081.07e-01
KICHcg13536141chrX:133414250CGI:chrX:133413539-133416256promoter,gene body2.34e-011.24e-014.74e+002.13e-061.88e-051.10e-01
KICHcg27382931chrX:133415662CGI:chrX:133413539-133416256promoter2.69e-017.29e-026.25e+004.02e-106.52e-091.96e-01
KICHcg14600040chrX:133415736CGI:chrX:133413539-133416256promoter1.82e-017.89e-025.76e+008.51e-099.94e-081.03e-01
KICHcg12600766chrX:133416103CGI:chrX:133413539-133416256promoter1.91e-017.67e-025.17e+002.36e-072.28e-061.15e-01
KICHcg23647832chrX:133416802CGI:chrX:133413539-133416256promoter5.13e-013.76e-012.26e+002.36e-023.96e-021.36e-01
DLBCcg08798116chrX:133414854CGI:chrX:133413539-133416256promoter,exon,CDS,gene body5.98e-014.78e-012.19e+002.83e-024.11e-021.20e-01
DLBCcg06558166chrX:133414975CGI:chrX:133413539-133416256UTR,promoter,exon,gene body6.30e-014.93e-012.23e+002.54e-023.93e-021.38e-01
DLBCcg17223593chrX:133415269CGI:chrX:133413539-133416256UTR,promoter,exon,gene body6.08e-014.65e-012.13e+003.31e-024.38e-021.43e-01
CHOLcg07312966chrX:133415177CGI:chrX:133413539-133416256UTR,promoter,exon,gene body2.97e-012.86e-024.81e+001.53e-061.32e-052.69e-01
CHOLcg08798116chrX:133414854CGI:chrX:133413539-133416256promoter,exon,CDS,gene body4.26e-011.92e-025.09e+003.51e-074.92e-064.07e-01
CHOLcg06558166chrX:133414975CGI:chrX:133413539-133416256UTR,promoter,exon,gene body4.61e-013.23e-025.09e+003.51e-074.92e-064.29e-01
CHOLcg17223593chrX:133415269CGI:chrX:133413539-133416256UTR,promoter,exon,gene body4.09e-012.86e-025.03e+004.90e-075.60e-063.80e-01
CHOLcg05347431chrX:133413540CGI:chrX:133413539-133416256promoter,gene body4.05e-012.46e-012.67e+007.49e-031.76e-021.59e-01
CHOLcg10418630chrX:133413663CGI:chrX:133413539-133416256promoter,gene body2.49e-019.58e-023.76e+001.72e-048.33e-041.53e-01
CHOLcg27382931chrX:133415662CGI:chrX:133413539-133416256promoter4.45e-017.85e-024.93e+008.03e-077.97e-063.67e-01
CHOLcg14600040chrX:133415736CGI:chrX:133413539-133416256promoter4.41e-011.61e-012.67e+007.49e-031.76e-022.80e-01
CHOLcg12600766chrX:133416103CGI:chrX:133413539-133416256promoter4.14e-011.08e-014.17e+003.04e-051.78e-043.06e-01

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
LUADcg05347431chrX:133413540CGI:chrX:133413539-133416256promoter,gene body2.31e-011.10e-014.06e+004.92e-051.56e-041.21e-01
HNSCcg05347431chrX:133413540CGI:chrX:133413539-133416256promoter,gene body3.26e-011.31e-014.56e+005.14e-062.20e-051.95e-01
HNSCcg10418630chrX:133413663CGI:chrX:133413539-133416256promoter,gene body1.45e-013.99e-024.99e+006.13e-073.93e-061.05e-01
HNSCcg13536141chrX:133414250CGI:chrX:133413539-133416256promoter,gene body2.22e-018.63e-024.20e+002.62e-058.44e-051.36e-01
LUSCcg05347431chrX:133413540CGI:chrX:133413539-133416256promoter,gene body3.26e-011.17e-013.90e+009.62e-056.87e-042.09e-01
LUSCcg10418630chrX:133413663CGI:chrX:133413539-133416256promoter,gene body1.55e-014.36e-023.06e+002.24e-034.52e-031.11e-01
COADcg05347431chrX:133413540CGI:chrX:133413539-133416256promoter,gene body3.23e-011.03e-014.49e+007.07e-064.55e-052.20e-01
COADcg23647832chrX:133416802CGI:chrX:133413539-133416256promoter5.13e-013.59e-012.56e+001.05e-021.49e-021.54e-01
BLCAcg23647832chrX:133416802CGI:chrX:133413539-133416256promoter4.99e-016.69e-01-2.18e+002.92e-023.29e-02-1.70e-01
LIHCcg17223593chrX:133415269CGI:chrX:133413539-133416256UTR,promoter,exon,gene body1.46e-012.34e-022.06e+003.90e-024.02e-021.23e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
KIRCcg07312966chrX:133415177CGI:chrX:133413539-133416256UTR,promoter,exon,gene body2.83e-011.73e-012.56e+001.05e-021.76e-021.10e-01
KIRCcg17223593chrX:133415269CGI:chrX:133413539-133416256UTR,promoter,exon,gene body4.10e-013.09e-012.99e+002.80e-037.79e-031.01e-01
KIRCcg23647832chrX:133416802CGI:chrX:133413539-133416256promoter6.69e-018.14e-01-2.69e+007.04e-031.36e-02-1.45e-01
THCAcg23647832chrX:133416802CGI:chrX:133413539-133416256promoter6.59e-017.79e-01-4.88e+001.04e-066.37e-06-1.20e-01
COADcg14600040chrX:133415736CGI:chrX:133413539-133416256promoter4.19e-015.30e-01-2.30e+002.16e-022.75e-02-1.11e-01
LIHCcg06558166chrX:133414975CGI:chrX:133413539-133416256UTR,promoter,exon,gene body4.07e-015.20e-01-3.78e+001.55e-045.36e-04-1.13e-01
KIRPcg14600040chrX:133415736CGI:chrX:133413539-133416256promoter2.93e-013.98e-01-2.50e+001.24e-021.94e-02-1.05e-01

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Exon skipping events with PSI in TCGA for GPC4

∗Please access ExonSkipDB for exon skipping annotation.
check buttonLandscape of exon skipping events across multiple cancer types.
AS event heatmap

check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

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RNA A-to-I editing events in TCGA for GPC4

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for GPC4

check buttonTFs related to GPC4.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType

check buttonGPC4 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for GPC4

check buttonRBPs related to ES in GPC4.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType

check buttonGPC4 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type
ENSG00000076716AC068790.5,hsa-mir-330,GPC4Female-specific ceRNATCGA-LIHC

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000076716
CpG Site: cg05347431
Position to Gene: gene,promoter
Male Effect: -0.057893238708406
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000076716
CpG Site: cg26953234
Position to Gene: gene
Male Effect: -0.412935465419558
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000076716
CpG Site: cg09773769
Position to Gene: gene
Male Effect: -0.203359411631188
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000076716
CpG Site: cg02784144
Position to Gene: gene
Male Effect: -0.203446189248135
Female Effect: -

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg05347431chrX:133413540gene,promoter-0.0578932387084062.09069802446637e-05-0.38250298296217353.8014648585478575e-09LUAD
cg26953234chrX:133413114gene-0.4129354654195589.25657346579455e-21-0.623923066440194.999124916105491e-25STAD
cg09773769chrX:133413359gene-0.2033594116311882.25450272226939e-08-0.43539014425389591.3663899161777733e-11STAD
cg02784144chrX:133413207gene-0.2034461892481353.06234362708139e-08-0.435591159243697851.4852646964106855e-11STAD

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of GPC4

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource
ENSG00000076716GPC4C0027708Nephroblastoma1CTD_human
ENSG00000076716GPC4C0376634Craniofacial Abnormalities1CTD_human
ENSG00000076716GPC4C0796154SIMPSON-GOLABI-BEHMEL SYNDROME, TYPE 11CTD_human
ENSG00000076716GPC4C2930471Bilateral Wilms Tumor1CTD_human