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Gene: ENSG00000074621 |
Summary for SLC24A1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000074621 | Gene symbol | SLC24A1 |
| Gene name | solute carrier family 24 member 1 | |
| HGNC | 10975 | |
| Entrez ID | 9187 | |
| Gene type | protein_coding | |
| Synonyms | SLC24A1|NCKX1|NCKX|RODX|KIAA0702|HsT17412|CSNB1D | |
| UniProtAcc | O60721 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for SLC24A1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for SLC24A1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for SLC24A1 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Top |
Exon skipping events with PSI in TCGA for SLC24A1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for SLC24A1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for SLC24A1 |
| TFs related to SLC24A1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ACC | ZNF418 | SLC24A1 | 4.46e+00 | 9.87e-01 | 3.58e+00 | 7.28e-03 | Male-biased |
| BLCA | FOXL1 | SLC24A1 | 3.24e+00 | 3.59e-03 | 4.34e+00 | 9.87e-01 | Female-biased |
| BLCA | FOXQ1 | SLC24A1 | 3.30e+00 | 5.95e-03 | 4.28e+00 | 9.83e-01 | Female-biased |
| BLCA | STAT2 | SLC24A1 | 2.84e+00 | 2.10e-03 | 4.07e+00 | 9.83e-01 | Female-biased |
| BLCA | ZFP82 | SLC24A1 | 3.02e+00 | 2.71e-03 | 4.19e+00 | 9.85e-01 | Female-biased |
| BLCA | ZKSCAN2 | SLC24A1 | 3.30e+00 | 6.55e-03 | 4.25e+00 | 9.82e-01 | Female-biased |
| BLCA | ZNF175 | SLC24A1 | 3.31e+00 | 7.80e-03 | 4.22e+00 | 9.80e-01 | Female-biased |
| BLCA | ZNF334 | SLC24A1 | 3.20e+00 | 5.96e-04 | 4.78e+00 | 9.95e-01 | Female-biased |
| BLCA | ZNF33B | SLC24A1 | 3.15e+00 | 3.37e-03 | 4.27e+00 | 9.86e-01 | Female-biased |
| BLCA | ZNF418 | SLC24A1 | 3.82e+00 | 1.59e-03 | 5.14e+00 | 9.96e-01 | Female-biased |
| BLCA | ZNF570 | SLC24A1 | 3.26e+00 | 3.63e-03 | 4.36e+00 | 9.87e-01 | Female-biased |
| MESO | ZNF334 | SLC24A1 | 3.27e+00 | 1.20e-02 | 4.49e+00 | 9.80e-01 | Female-biased |
| MESO | ZNF418 | SLC24A1 | 3.07e+00 | 5.06e-03 | 4.55e+00 | 9.88e-01 | Female-biased |
| SKCM | FOXL1 | SLC24A1 | 2.62e+00 | 9.84e-04 | 4.30e+00 | 9.82e-01 | Female-biased |
| SKCM | FOXQ1 | SLC24A1 | 3.05e+00 | 3.13e-03 | 4.39e+00 | 9.81e-01 | Female-biased |
| SKCM | ZNF334 | SLC24A1 | 2.76e+00 | 2.85e-04 | 4.80e+00 | 9.91e-01 | Female-biased |
| SKCM | ZNF418 | SLC24A1 | 2.43e+00 | 4.38e-05 | 5.00e+00 | 9.93e-01 | Female-biased |
| SLC24A1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for SLC24A1 |
| RBPs related to ES in SLC24A1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| SLC24A1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs920293 | chr15:67122087:A:G | - | 0.115862904133576 | 0.000321650585675045 | SARC | Female-baised eQTL |
| rs9944194 | chr15:70833570:A:G | - | 0.108280121222432 | 0.00052669777080656 | SARC | Female-baised eQTL |
| rs61592978 | chr15:67127519:A:G | - | 0.11027476436569 | 0.000657661238336458 | SARC | Female-baised eQTL |
| rs55993214 | chr15:67129702:A:C | - | 0.11027476436569 | 0.000657661238336458 | SARC | Female-baised eQTL |
| rs112053501 | chr15:66224510:G:A | - | 0.102498425362149 | 0.00252140750545841 | SARC | Female-baised eQTL |
| rs75950287 | chr15:61538124:G:T | - | 0.0983796133348043 | 0.00505864464539911 | SARC | Female-baised eQTL |
| rs79900850 | chr15:61567251:C:A | - | 0.093956982953739 | 0.00810716106879498 | SARC | Female-baised eQTL |
| rs16944371 | chr15:61596880:A:C | - | 0.0895819038643453 | 0.0132390337578284 | SARC | Female-baised eQTL |
| rs76654718 | chr15:66212352:G:T | - | 0.0867383926525734 | 0.01348600233204 | SARC | Female-baised eQTL |
| rs77385809 | chr15:61552263:C:T | - | 0.0866656526438837 | 0.0170720355924901 | SARC | Female-baised eQTL |
| rs2414721 | chr15:61584051:G:T | - | 0.0862666649708655 | 0.0184100849735784 | SARC | Female-baised eQTL |
| rs74395195 | chr15:61599386:T:C | - | 0.0861236366481514 | 0.0187999373198862 | SARC | Female-baised eQTL |
| rs139059398 | chr15:61609407:A:G | - | 0.0861236366481514 | 0.0187999373198862 | SARC | Female-baised eQTL |
| rs16944426 | chr15:61611404:G:A | - | 0.0861236366481514 | 0.0187999373198862 | SARC | Female-baised eQTL |
| rs76622675 | chr15:61611951:G:A | - | 0.0861236366481514 | 0.0187999373198862 | SARC | Female-baised eQTL |
| rs117675891 | chr15:61613406:C:T | - | 0.0861236366481514 | 0.0187999373198862 | SARC | Female-baised eQTL |
| rs16949697 | chr15:66211819:G:A | - | 0.0805620959315633 | 0.02514936122468 | SARC | Female-baised eQTL |
| rs77711754 | chr15:61564887:T:A | - | 0.0817578419971025 | 0.0256865143877379 | SARC | Female-baised eQTL |
| rs28363710 | chr15:61574243:G:A | - | 0.0789363988287262 | 0.0335231283939329 | SARC | Female-baised eQTL |
| rs28610370 | chr15:61576593:C:G | - | 0.0789363988287262 | 0.0335231283939329 | SARC | Female-baised eQTL |
| rs2642615 | chr15:58113200:G:A | - | 0.122495491719205 | 0.0303145305527865 | LGG | Female-baised eQTL |
| rs2704211 | chr15:58114873:T:A | - | 0.122495491719205 | 0.0303145305527865 | LGG | Female-baised eQTL |
| rs2704210 | chr15:58114997:G:A | - | 0.122495491719205 | 0.0303145305527865 | LGG | Female-baised eQTL |
| rs2642620 | chr15:58118197:T:C | - | 0.122495491719205 | 0.0303145305527865 | LGG | Female-baised eQTL |
| rs57469651 | chr15:69563566:A:G | - | 0.171107882349467 | 0.000273625701001419 | LUAD | Female-baised eQTL |
| rs16953470 | chr15:69565398:A:G | - | 0.171107882349467 | 0.000273625701001419 | LUAD | Female-baised eQTL |
| rs8027764 | chr15:69590050:G:A | - | 0.131542465854503 | 0.00892284782151151 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs4775324 | chr15:60937943:T:C | - | 0.121071526482244 | 0.0385451158402874 | KIRP | Male-baised eQTL |
| rs4775327 | chr15:60938211:T:C | - | 0.121071526482244 | 0.0385451158402874 | KIRP | Male-baised eQTL |
| rs6494234 | chr15:60938599:A:G | - | 0.120465083353018 | 0.0390504748893587 | KIRP | Male-baised eQTL |
| rs340006 | chr15:60586018:T:C | - | 0.137361542465214 | 0.0182712830728142 | LGG | Male-baised eQTL |
| rs12441973 | chr15:59057016:C:T | - | 0.049963106139177 | 0.0353336624986268 | KIRC | Male-baised eQTL |
| rs2289895 | chr15:59089570:A:T | - | 0.0500920428389144 | 0.0363309405715533 | KIRC | Male-baised eQTL |
| rs62004080 | chr15:59128044:G:A | - | 0.0499953521652057 | 0.0414223772536773 | KIRC | Male-baised eQTL |
| rs139431915 | chr15:55824817:C:T | - | 0.0684278353784135 | 0.0422251165273477 | KIRC | Male-baised eQTL |
| rs62046605 | chr15:55824991:G:T | - | 0.0684278353784135 | 0.0422251165273477 | KIRC | Male-baised eQTL |
| rs11853828 | chr15:59136031:G:A | - | 0.0488992877733284 | 0.0439517304538178 | KIRC | Male-baised eQTL |
| rs12442301 | chr15:59065968:T:C | - | 0.0489168874468054 | 0.0465278797868679 | KIRC | Male-baised eQTL |
| rs4359383 | chr15:61765637:T:C | - | 0.0560311793311887 | 0.0485436355226315 | KIRC | Male-baised eQTL |
| rs2036740 | chr15:55997822:T:A | - | 0.0854445710147881 | 0.010021012229427 | BLCA | Male-baised eQTL |
| rs12910319 | chr15:71393404:A:G | - | 0.0922670239917492 | 0.0218026734718208 | BLCA | Male-baised eQTL |
| rs12908717 | chr15:71390007:A:G | - | 0.0615115793669527 | 0.0399984737583573 | BLCA | Male-baised eQTL |
| rs17238329 | chr15:62095155:T:A | - | 0.14114476681136 | 0.015320488848223 | COAD | Male-baised eQTL |
| rs28690513 | chr15:62095247:A:G | - | 0.14114476681136 | 0.015320488848223 | COAD | Male-baised eQTL |
| rs4775461 | chr15:62095652:A:G | - | 0.14114476681136 | 0.015320488848223 | COAD | Male-baised eQTL |
| rs8025500 | chr15:62097852:T:A | - | 0.14114476681136 | 0.015320488848223 | COAD | Male-baised eQTL |
| rs8024531 | chr15:62098057:A:T | - | 0.14114476681136 | 0.015320488848223 | COAD | Male-baised eQTL |
| rs17238349 | chr15:62098354:A:G | - | 0.14114476681136 | 0.015320488848223 | COAD | Male-baised eQTL |
| rs59284760 | chr15:62487909:T:A | - | 0.0801728198953238 | 0.0194178924323934 | COAD | Male-baised eQTL |
| rs4775463 | chr15:62096585:G:A | - | 0.127464591319816 | 0.0285553616228774 | COAD | Male-baised eQTL |
| rs11630237 | chr15:62479251:A:G | - | 0.0757753601521135 | 0.0338729355369388 | COAD | Male-baised eQTL |
| rs17271758 | chr15:62479973:A:G | - | 0.0757753601521135 | 0.0338729355369388 | COAD | Male-baised eQTL |
| rs1372367 | chr15:57943783:C:T | - | 0.0824674616791226 | 0.0401663472726129 | COAD | Male-baised eQTL |
| rs35385267 | chr15:57943892:C:T | - | 0.0824674616791226 | 0.0401663472726129 | COAD | Male-baised eQTL |
| rs12592773 | chr15:57943991:G:C | - | 0.0824674616791226 | 0.0401663472726129 | COAD | Male-baised eQTL |
| rs8034864 | chr15:61154154:T:G | - | -0.0625449817135179 | 0.0425264714375763 | COAD | Male-baised eQTL |
| rs1995618 | chr15:62490067:A:G | - | 0.0712792538172473 | 0.0437664121215767 | COAD | Male-baised eQTL |
| rs4886604 | chr15:73786096:A:G | - | 0.0685030272629192 | 0.0482489648170352 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000074621 |
| CpG Site: cg01704999 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: 0.716062246798526 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg01704999 | chr15:65638854 | gene | 0.716062246798526 | 1.53910222627544e-07 | 0.3221462943087126 | 8.231418016214734e-05 | SARC |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_122855 | chr15:65645611:65645703 | Frame-shift | rs1477797 | chr15:66163204:G:A | Distant downstream | -0.0383888476225173 | 0.00990314226277769 | THCA | Male-baised sQTL |
| exon_skip_122855 | chr15:65645611:65645703 | Frame-shift | rs11635982 | chr15:66164432:C:T | Distant downstream | -0.0355406408836749 | 0.020233756735773 | THCA | Male-baised sQTL |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of SLC24A1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000074621 | SLC24A1 | C0339535 | Night blindness, congenital stationary | 1 | CTD_human |
| ENSG00000074621 | SLC24A1 | C1848172 | NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2A | 1 | CTD_human |
| ENSG00000074621 | SLC24A1 | C1850362 | NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 1B | 1 | CTD_human |
| ENSG00000074621 | SLC24A1 | C1864877 | NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2B (disorder) | 1 | CTD_human |
| ENSG00000074621 | SLC24A1 | C3495587 | Night Blindness, Congenital Stationary, Type 1A | 1 | CTD_human |
| ENSG00000074621 | SLC24A1 | C3501847 | Night blindness, congenital stationary, type 1 | 1 | CTD_human |
| ENSG00000074621 | SLC24A1 | C3711543 | X-Linked Csnb | 1 | CTD_human |
| ENSG00000074621 | SLC24A1 | C4041558 | Cone-rod synaptic disorder, congenital nonprogressive | 1 | CTD_human |
