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Gene: ENSG00000074410

Summary for CA12

Gene summary

Gene information	Ensembl ID	ENSG00000074410
	Gene symbol	CA12
	Gene name	carbonic anhydrase 12
	HGNC	1371
	Entrez ID	771
	Gene type	protein_coding
	Synonyms	CA12\|HsT18816
	UniProtAcc	O43570

Drugs associated with this gene(DrugBank).

Gene ID	Gene Symbol	Drug ID	Drug Name	Drug Type
ENSG00000074410	CA12	DB00562	Benzthiazide	SmallMoleculeDrug
ENSG00000074410	CA12	DB00774	Hydroflumethiazide	SmallMoleculeDrug
ENSG00000074410	CA12	DB00819	Acetazolamide	SmallMoleculeDrug
ENSG00000074410	CA12	DB00909	Zonisamide	SmallMoleculeDrug
ENSG00000074410	CA12	DB08846	Ellagic acid	SmallMoleculeDrug

Cancer therapeutic drugs associated with this gene(NCI).

Gene ID

Gene Name

Drug ID

Drug Name

Drug Type

Cancer

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Structure and expression level for CA12

AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.

Landscape of gene expressions across multiple cancer types.

Differentially expressed gene analysis between tumor male and tumor female samples.

Coding Name	Base Mean	log2FoldChange	lfcSE	Stat	P value	P.adjust Value	Cancer Type
CA12	8.96e+02	3.45e+00	5.28e-01	6.54e+00	6.11e-11	9.42e-08	UVM

Differentially expressed gene analysis between tumor male and normal male samples.

Coding Name

Base Mean

log2FoldChange

lfcSE

Stat

P value

P.adjust Value

Cancer Type

Differentially expressed gene analysis between tumor female and normal female samples.

Coding Name	Base Mean	log2FoldChange	lfcSE	Stat	P value	P.adjust Value	Cancer Type
CA12	2.99e+03	1.72e+00	5.07e-01	3.40e+00	6.83e-04	4.12e-03	STAD
CA12	2.55e+04	1.70e+00	1.59e-01	1.07e+01	7.87e-27	3.52e-26	BRCA
CA12	4.26e+03	-1.98e+00	4.31e-01	-4.60e+00	4.28e-06	3.10e-05	READ

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Sex-biased somatic mutation for CA12

∗For more information on exon skipping events please check the ExonskipDB database.

Gene ID

Cancer Type

Hugo Symbol

Male

Female

pval

ci.up

ci.low

adjPval

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DNA methylation with beta values for CA12

Landscape of DNA methylation across multiple cancer types.

Differentially expressed CpG sites between male tumor and female tumor patients.

Cancer Type	CpG Site	Position	CpG Island	Position to Gene	ave1	ave2	wilcoxon.w	wilcoxon.p	padj	dBeta
BRCA	cg23931734	chr15:63380814	CGI:chr15:63381689-63381961	promoter,gene body	3.15e-01	1.76e-01	2.73e+00	6.26e-03	2.23e-02	1.39e-01
BRCA	cg10091775	chr15:63382724	CGI:chr15:63381689-63381961	promoter	6.06e-01	4.62e-01	2.64e+00	8.32e-03	2.49e-02	1.44e-01
SARC	cg04192393	chr15:63381087	CGI:chr15:63381689-63381961	promoter,gene body	3.96e-01	5.26e-01	-2.09e+00	3.64e-02	4.14e-02	-1.30e-01
CHOL	cg15755265	chr15:63381303	CGI:chr15:63381689-63381961	promoter,gene body	3.89e-01	2.39e-01	2.61e+00	9.04e-03	2.00e-02	1.50e-01
CHOL	cg11178920	chr15:63382077	CGI:chr15:63381689-63381961	UTR,promoter,exon,gene body	3.31e-01	1.79e-01	2.23e+00	2.58e-02	3.76e-02	1.53e-01

Differentially expressed CpG sites between male tumor and male normal patients.

Cancer Type	CpG Site	Position	CpG Island	Position to Gene	ave1	ave2	wilcoxon.w	wilcoxon.p	padj	dBeta
LUSC	cg23931734	chr15:63380814	CGI:chr15:63381689-63381961	promoter,gene body	4.56e-01	6.62e-01	-3.02e+00	2.49e-03	4.89e-03	-2.06e-01
COAD	cg10091775	chr15:63382724	CGI:chr15:63381689-63381961	promoter	6.15e-01	7.23e-01	-3.12e+00	1.81e-03	3.63e-03	-1.08e-01
LIHC	cg10091775	chr15:63382724	CGI:chr15:63381689-63381961	promoter	6.75e-01	8.41e-01	-5.47e+00	4.59e-08	2.75e-07	-1.66e-01
ESCA	cg04192393	chr15:63381087	CGI:chr15:63381689-63381961	promoter,gene body	5.59e-01	4.50e-01	2.08e+00	3.71e-02	4.58e-02	1.09e-01

Differentially expressed CpG sites between female tumor and female normal patients.

Cancer Type	CpG Site	Position	CpG Island	Position to Gene	ave1	ave2	wilcoxon.w	wilcoxon.p	padj	dBeta
BRCA	cg10091775	chr15:63382724	CGI:chr15:63381689-63381961	promoter	6.06e-01	8.19e-01	-1.22e+01	2.77e-34	7.26e-33	-2.13e-01
HNSC	cg23931734	chr15:63380814	CGI:chr15:63381689-63381961	promoter,gene body	3.73e-01	2.71e-01	2.23e+00	2.59e-02	3.23e-02	1.02e-01
HNSC	cg04192393	chr15:63381087	CGI:chr15:63381689-63381961	promoter,gene body	4.82e-01	3.41e-01	2.05e+00	4.06e-02	4.32e-02	1.42e-01

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Exon skipping events with PSI in TCGA for CA12

∗Please access ExonSkipDB for exon skipping annotation.

Landscape of exon skipping events across multiple cancer types.

Differentially expressed exon skipping events between male tumor and female tumor patients.

Cancer Type

Exon Skipping

ave.female_T

ave.female_N

wilcoxon.w

wilcoxon.p

padj

dPSI

Differentially expressed exon skipping events between male tumor and male normal patients.

Cancer Type

Exon Skipping

ave.female_T

ave.female_N

wilcoxon.w

wilcoxon.p

padj

dPSI

Differentially expressed exon skipping events between female tumor and female normal patients.

Cancer Type

Exon Skipping

ave.female_T

ave.female_N

wilcoxon.w

wilcoxon.p

padj

dPSI

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RNA A-to-I editing events in TCGA for CA12

∗Please access CAeditome for RNA editing annotation.

Differentially expressed RNA editing events between male tumor and female tumor patients.

Cancer Type

Transcript

Editing

ave.male_T

ave.female_T

wilcoxon.w

wilcoxon.p

p_adj

dFre

Differentially expressed RNA editing events between male tumor and male normal patients.

Cancer Type

Transcript

Editing

ave.male_T

ave.female_T

wilcoxon.w

wilcoxon.p

p_adj

dFre

Differentially expressed RNA editing events between female tumor and female normal patients.

Cancer Type

Transcript

Editing

ave.male_T

ave.female_T

wilcoxon.w

wilcoxon.p

p_adj

dFre

Protein coding RNA editing(s).

Editing Position

Variant Type

Gene Symbol

Transcript ID

NTchange

AAchange

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Sex-biased TF-Gene network for CA12

TFs related to CA12.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.

Cancer Type	TF	Target Gene	Male Edge Score	Male Edge Threshold	Female Edge Score	Female Edge Threshold	Type
CHOL	DMRT3	CA12	3.07e+00	3.44e-03	4.27e+00	9.88e-01	Female-biased
CHOL	DMRTA1	CA12	2.84e+00	1.84e-03	4.18e+00	9.89e-01	Female-biased
CHOL	HOXB7	CA12	3.04e+00	6.98e-03	4.05e+00	9.81e-01	Female-biased

CA12 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for CA12

RBPs related to ES in CA12.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.

Cancer Type	RBP	Target ES	Male Edge Score	Male Edge Threshold	Female Edge Score	Female Edge Threshold	Type
COAD	KHDRBS3	exon_skip_128135	1.07e+01	4.12e-03	1.11e+01	9.95e-01	Female-biased
KIRP	KHDRBS3	exon_skip_128135	1.14e+01	9.87e-01	1.10e+01	1.21e-02	Male-biased

CA12 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

Sex-biased CeRNA regulation of gene.

Gene ID

ceRNA(lncRNA-miRNA-mRNA)

Group

Cancer Type

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Sex-biased eQTL regulation of gene

Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).

eQTL

Description

Male-specific eQTL regulation.

SNP ID	SNP Info	Position to Gene	Effect Score	FDR	Cancer Type	Biased Type
rs12438157	chr15:63400698:C:T	-	0.0615764360631611	0.00209787373975322	THCA	Female-baised eQTL
rs75643571	chr15:61442438:C:T	-	0.0974940627465471	0.0421938288755679	KIRC	Female-baised eQTL
rs35391470	chr15:61442552:C:T	-	0.0974940627465471	0.0421938288755679	KIRC	Female-baised eQTL
rs76293750	chr15:61419045:T:C	-	0.102465121630027	0.049469350165332	KIRC	Female-baised eQTL
rs2917831	chr15:59882685:A:G	-	0.101430627524748	0.000128631116585078	LUAD	Female-baised eQTL
rs12899283	chr15:59859347:A:G	-	0.0748684878468031	0.016722313418905	LUAD	Female-baised eQTL
rs12911927	chr15:59870706:C:T	-	0.069883604068603	0.0298329641318615	LUAD	Female-baised eQTL
rs12908727	chr15:59873699:A:T	-	0.069883604068603	0.0298329641318615	LUAD	Female-baised eQTL
rs2912117	chr15:59917593:C:T	-	0.0711344615424835	0.037030565910867	LUAD	Female-baised eQTL
rs12916540	chr15:59862546:G:T	-	0.0666223137159733	0.0401716550354538	LUAD	Female-baised eQTL
rs335777	chr15:60053668:A:G	-	0.0829920982077004	0.0291379183095454	COAD	Female-baised eQTL

Female-specific eQTL regulation.

SNP ID	SNP Info	Position to Gene	Effect Score	FDR	Cancer Type	Biased Type
rs8031959	chr15:69310385:T:C	-	0.104273571553185	0.000268281669554709	STAD	Male-baised eQTL
rs6494793	chr15:69330932:C:G	-	-0.118611042420691	0.000369481340321179	STAD	Male-baised eQTL
rs8031053	chr15:69310616:A:G	-	0.0993961976738306	0.000692194280847481	STAD	Male-baised eQTL
rs12442102	chr15:69310810:G:A	-	0.0993961976738306	0.000692194280847481	STAD	Male-baised eQTL
rs77053864	chr15:69328878:A:T	-	0.101361919945666	0.00368320197674807	STAD	Male-baised eQTL
rs199659789	chr15:69323106:G:A	-	0.0972063258957999	0.0057478721826564	STAD	Male-baised eQTL
rs12907455	chr15:69321280:A:G	-	-0.0927227580790783	0.0100981535712757	STAD	Male-baised eQTL
rs12443423	chr15:69319146:T:C	-	0.0927227580790782	0.0100981535712757	STAD	Male-baised eQTL
rs75966151	chr15:69320059:C:G	-	0.0927227580790782	0.0100981535712757	STAD	Male-baised eQTL
rs12907455	chr15:69321280:A:C	-	0.0927227580790782	0.0100981535712757	STAD	Male-baised eQTL
rs12439741	chr15:69321608:T:A	-	0.0927227580790782	0.0100981535712757	STAD	Male-baised eQTL
rs78062638	chr15:69324196:G:A	-	0.0925918168431822	0.0103107008662857	STAD	Male-baised eQTL
rs76334050	chr15:69324471:A:G	-	0.0925918168431822	0.0103107008662857	STAD	Male-baised eQTL
rs80183440	chr15:69324828:A:G	-	0.0925918168431822	0.0103107008662857	STAD	Male-baised eQTL
rs113454341	chr15:69324948:G:C	-	0.0925918168431822	0.0103107008662857	STAD	Male-baised eQTL
rs112354514	chr15:69325118:T:C	-	0.0925918168431822	0.0103107008662857	STAD	Male-baised eQTL
rs74579781	chr15:69325339:A:G	-	0.0925918168431822	0.0103107008662857	STAD	Male-baised eQTL
rs16953134	chr15:69325822:G:T	-	0.0925918168431822	0.0103107008662857	STAD	Male-baised eQTL
rs16953139	chr15:69325980:C:T	-	0.0925918168431822	0.0103107008662857	STAD	Male-baised eQTL
rs78962241	chr15:69326337:T:G	-	0.0925918168431822	0.0103107008662857	STAD	Male-baised eQTL
rs78579993	chr15:69326461:G:A	-	0.0925918168431822	0.0103107008662857	STAD	Male-baised eQTL
rs76735676	chr15:69327015:T:G	-	0.0925918168431822	0.0103107008662857	STAD	Male-baised eQTL
rs80189285	chr15:69323108:A:C	-	0.0924480249210561	0.0106473817908341	STAD	Male-baised eQTL
rs76582533	chr15:69323403:T:A	-	0.0924480249210561	0.0106473817908341	STAD	Male-baised eQTL
rs11072082	chr15:69323762:C:T	-	-0.0924480249210561	0.0106473817908341	STAD	Male-baised eQTL
rs11072083	chr15:69323775:A:G	-	-0.0924480249210561	0.0106473817908341	STAD	Male-baised eQTL
rs7170755	chr15:69317323:T:C	-	-0.0834174843410484	0.0308927914746291	STAD	Male-baised eQTL
rs76116632	chr15:67058305:G:T	-	0.0733989326504939	0.0215558796765458	KIRC	Male-baised eQTL
rs907552	chr15:70378349:G:A	-	0.0438550410567977	0.0229158680739204	KIRC	Male-baised eQTL
rs62017627	chr15:72809972:A:C	-	0.074231090191786	0.0475112588724638	KIRC	Male-baised eQTL
rs4447365	chr15:61452833:C:G	-	-0.0671345271821465	0.0225207441466738	BLCA	Male-baised eQTL
rs7182693	chr15:61452255:T:C	-	-0.0662239885151474	0.0225633574716488	BLCA	Male-baised eQTL
rs7181267	chr15:61452262:A:G	-	-0.0662239885151474	0.0225633574716488	BLCA	Male-baised eQTL
rs7177619	chr15:61451795:T:C	-	-0.066019549022038	0.0237736959367633	BLCA	Male-baised eQTL
rs36034625	chr15:59544675:C:T	-	0.0621613270769832	0.0199880172533054	LUAD	Male-baised eQTL

Opposite sex-biased eQTL regulation.

SNP ID

SNP Info

Position to Gene

Male Effect

Male FDR

Female Effect

Female FDR

Sex-biased Gene in Cancer

Cancer Type

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Sex-biased eQTM regulation of gene

Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).

eQTM	Description
	Gene ID: ENSG00000074410
	CpG Site: cg04192393
	Position to Gene: gene,promoter
	Male Effect: -
	Female Effect: -0.4768340959982

Male-specific eQTM regulation.

CpG Site

CpG Postion

Position to Gene

Effect Score

FDR

Cor.r

Cor.Pvalue

Cancer Type

Female-specific eQTM regulation.

CpG Site	CpG Postion	Position to Gene	Effect Score	FDR	Cor.r	Cor.Pvalue	Cancer Type
cg04192393	chr15:63381087	gene,promoter	-0.4768340959982	6.14171161350162e-09	-0.4760582080531138	5.1510113458455834e-14	LUAD

Opposite sex-biased eQTM regulation.

CpG Site

CpG Postion

CpG Island

Position to Gene

Male Effect

Male FDR

Female Effect

Female FDR

Male Cor

Male P-value

Female Cor

Female P-value

Sex-biased Coding Gene

Cancer Type

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Sex-biased sQTL regulation of gene

Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).

sQTL

Description

Male-specific sQTL regulation.

ES ID	Skipped Exon	ORF Anno	SNP ID	SNP Info	SNP Position to ES	Effect Score	FDR	Cancer Type	Biased Type
exon_skip_128127	chr15:63328097:63328130	In-frame	rs72750988	chr15:63708850:C:T	Distant upstream	0.369079372958783	0.0456321461364482	GBM	Female-baised sQTL
exon_skip_128127	chr15:63328097:63328130	In-frame	rs56113145	chr15:63829157:G:A	Distant upstream	0.369079372958783	0.0456321461364482	GBM	Female-baised sQTL

Female-specific sQTL regulation.

ES ID	Skipped Exon	ORF Anno	SNP ID	SNP Info	SNP Position to ES	Effect Score	FDR	Cancer Type	Biased Type
exon_skip_128127	chr15:63328097:63328130	In-frame	rs34980406	chr15:63459099:G:C	Distant upstream	-0.0933276215115008	0.00652425347995937	LUSC	Male-baised sQTL
exon_skip_128127	chr15:63328097:63328130	In-frame	rs35527136	chr15:63459168:G:A	Distant upstream	-0.0933276215115008	0.00652425347995937	LUSC	Male-baised sQTL
exon_skip_128127	chr15:63328097:63328130	In-frame	rs8035085	chr15:63455423:C:G	Distant upstream	-0.0919426760921718	0.00804499401767634	LUSC	Male-baised sQTL
exon_skip_128127	chr15:63328097:63328130	In-frame	rs35974024	chr15:63459144:G:A	Distant upstream	-0.0812654210726636	0.016439702707959	LUSC	Male-baised sQTL
exon_skip_128127	chr15:63328097:63328130	In-frame	rs4984310	chr15:63667130:T:C	Distant upstream	0.0894884193781652	0.0232034166967942	LUSC	Male-baised sQTL
exon_skip_128127	chr15:63328097:63328130	In-frame	rs4556742	chr15:63572234:C:T	Distant upstream	0.0696182478407451	0.0271488979081013	LUSC	Male-baised sQTL
exon_skip_128127	chr15:63328097:63328130	In-frame	rs7168903	chr15:63581069:A:G	Distant upstream	0.0696182478407451	0.0271488979081013	LUSC	Male-baised sQTL
exon_skip_128127	chr15:63328097:63328130	In-frame	rs12907106	chr15:63581459:C:G	Distant upstream	0.0696182478407451	0.0271488979081013	LUSC	Male-baised sQTL
exon_skip_128127	chr15:63328097:63328130	In-frame	rs28531781	chr15:63587036:T:C	Distant upstream	0.0696182478407451	0.0271488979081013	LUSC	Male-baised sQTL
exon_skip_128127	chr15:63328097:63328130	In-frame	rs6494419	chr15:63651707:T:G	Distant upstream	0.0880048176320863	0.0289395269952668	LUSC	Male-baised sQTL
exon_skip_128127	chr15:63328097:63328130	In-frame	rs2272209	chr15:63660954:A:G	Distant upstream	0.0874128928271426	0.0302530648268327	LUSC	Male-baised sQTL
exon_skip_128127	chr15:63328097:63328130	In-frame	rs2414828	chr15:63663377:A:C	Distant upstream	0.0874128928271426	0.0302530648268327	LUSC	Male-baised sQTL
exon_skip_128127	chr15:63328097:63328130	In-frame	rs2414827	chr15:63663872:T:C	Distant upstream	0.0874128928271426	0.0302530648268327	LUSC	Male-baised sQTL
exon_skip_128127	chr15:63328097:63328130	In-frame	rs1815130	chr15:63666563:T:C	Distant upstream	0.0874128928271426	0.0302530648268327	LUSC	Male-baised sQTL
exon_skip_128127	chr15:63328097:63328130	In-frame	rs58860501	chr15:63450530:A:G	Distant upstream	-0.0839604056926904	0.0324612697495126	LUSC	Male-baised sQTL
exon_skip_128127	chr15:63328097:63328130	In-frame	rs2228511	chr15:63661830:C:T	Distant upstream	0.0854629546760584	0.0341771446733461	LUSC	Male-baised sQTL
exon_skip_128127	chr15:63328097:63328130	In-frame	rs34999961	chr15:63451037:G:A	Distant upstream	-0.0831703843063782	0.0356067108624871	LUSC	Male-baised sQTL
exon_skip_128127	chr15:63328097:63328130	In-frame	rs12441236	chr15:63450002:G:A	Distant upstream	-0.0815283152659509	0.0459474435517311	LUSC	Male-baised sQTL
exon_skip_128127	chr15:63328097:63328130	In-frame	rs8023506	chr15:63592263:T:C	Distant upstream	0.0659307003893576	0.0471569336145813	LUSC	Male-baised sQTL
exon_skip_128127	chr15:63328097:63328130	In-frame	rs17185483	chr15:63555028:C:T	Distant upstream	-0.148583296946344	0.00789939744475692	COAD	Male-baised sQTL
exon_skip_128127	chr15:63328097:63328130	In-frame	rs290299	chr15:62403515:G:T	Distant downstream	-0.0718734102693754	0.0142615353853501	COAD	Male-baised sQTL
exon_skip_128127	chr15:63328097:63328130	In-frame	rs290298	chr15:62403525:G:A	Distant downstream	-0.0716914702737145	0.0147206472203334	COAD	Male-baised sQTL
exon_skip_128127	chr15:63328097:63328130	In-frame	rs78905544	chr15:63500267:T:A	Distant upstream	-0.137288872808367	0.0164439398677084	COAD	Male-baised sQTL
exon_skip_128127	chr15:63328097:63328130	In-frame	rs11631220	chr15:62977204:C:G	Distant downstream	-0.085489380751896	0.0169915793047324	COAD	Male-baised sQTL
exon_skip_128127	chr15:63328097:63328130	In-frame	rs80029078	chr15:63740265:C:A	Distant upstream	-0.15523774429789	0.020646092053542	COAD	Male-baised sQTL
exon_skip_128127	chr15:63328097:63328130	In-frame	rs79488359	chr15:63525806:T:G	Distant upstream	-0.13053786938703	0.0218495831117865	COAD	Male-baised sQTL
exon_skip_128127	chr15:63328097:63328130	In-frame	rs146741740	chr15:62975149:G:T	Distant downstream	-0.0838474188924228	0.0222068980418224	COAD	Male-baised sQTL
exon_skip_128127	chr15:63328097:63328130	In-frame	rs144335858	chr15:63621620:G:A	Distant upstream	-0.137818639468627	0.0290358722225938	COAD	Male-baised sQTL
exon_skip_128127	chr15:63328097:63328130	In-frame	rs76285931	chr15:63642831:G:A	Distant upstream	-0.135551950170013	0.0347732922515914	COAD	Male-baised sQTL
exon_skip_128127	chr15:63328097:63328130	In-frame	rs78738389	chr15:63526453:A:G	Distant upstream	-0.124588287286373	0.036694456887982	COAD	Male-baised sQTL
exon_skip_128127	chr15:63328097:63328130	In-frame	rs17185055	chr15:63527785:C:T	Distant upstream	-0.124588287286373	0.036694456887982	COAD	Male-baised sQTL
exon_skip_128127	chr15:63328097:63328130	In-frame	rs11853890	chr15:63537339:A:G	Distant upstream	-0.124588287286373	0.036694456887982	COAD	Male-baised sQTL
exon_skip_128127	chr15:63328097:63328130	In-frame	rs78328467	chr15:63542503:C:G	Distant upstream	-0.124588287286373	0.036694456887982	COAD	Male-baised sQTL
exon_skip_128127	chr15:63328097:63328130	In-frame	rs76540674	chr15:63542779:C:T	Distant upstream	-0.124588287286373	0.036694456887982	COAD	Male-baised sQTL
exon_skip_128127	chr15:63328097:63328130	In-frame	rs114975931	chr15:63548340:G:A	Distant upstream	-0.124588287286373	0.036694456887982	COAD	Male-baised sQTL
exon_skip_128127	chr15:63328097:63328130	In-frame	rs4775575	chr15:62972039:C:T	Distant downstream	0.0592424614082035	0.0460463804200478	COAD	Male-baised sQTL

Opposite sex-biased sQTL regulation.

ES ID

Skipped Exon

ORF Anno

SNP ID

SNP Info

SNP Position to ES

Male Effect

Male FDR

Female Effect

Female FDR

Cancer Type

Top

Sex-biased sQTM regulation of gene

Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).

sQTM

Description

Male-specific sQTM regulation.

EX ID

Skipped Exon

CPG Site

CPG Position

Position to EX Events

Effect Score

FDR

Cor.r

Cor.Pvalue

ORF_anno

Cancer Type

Female-specific sQTM regulation.

EX ID

Skipped Exon

CPG Site

CPG Position

Position to EX Events

Effect Score

FDR

Cor.r

Cor.Pvalue

ORF_anno

Cancer Type

Opposite sex-biased sQTM regulation.

EX ID

EX Info

Skipped Exon

CPG Site

CPG Position

CPG Island

Position to EX Events

Male Effect

Male FDR

Female Effect

Female FDR

Male Correlation

Male P-value

Female Correlation

Female P-value

ORF_anno

Cancer Type

Top

Related disease information of CA12

Diseases associated with this gene (DisGeNET).

Gene ID	Gene Symbol	Disease ID	Disease Name	Number of PMID	Source
ENSG00000074410	CA12	C0024121	Lung Neoplasms	1	CTD_human
ENSG00000074410	CA12	C0242379	Malignant neoplasm of lung	1	CTD_human
ENSG00000074410	CA12	C1840437	Isolated hyperchlorhidrosis	1	CTD_human

	Gene summary
	Gene structure and Gene expression level
	Sex-biased somatic mutation
	DNA methylation with beta values in gene
	Exon skipping events with PSI in TCGA
	RNA A-to-I editing events in TCGA
	Sex-biased TF-Gene network of gene
	Sex-biased RBP-ES network of gene
	Sex-biased CeRNA regulation of gene
	Sex-biased eQTL regulation of gene
	Sex-biased eQTM regulation of gene
	Sex-biased sQTL regulation of gene
	Sex-biased sQTM regulation of gene
	Related disease information of gene