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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000073060

Summary for SCARB1

check button Gene summary

Gene informationEnsembl ID

ENSG00000073060

Gene symbol

SCARB1

Gene namescavenger receptor class B member 1
HGNC

1664

Entrez ID

949

Gene typeprotein_coding
SynonymsSCARB1|SRB1|CLA-1|CLA1|SR-BI
UniProtAcc

Q8WTV0


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type
ENSG00000073060SCARB1DB00144Phosphatidyl serineSmallMoleculeDrug

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

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Structure and expression level for SCARB1

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
SCARB12.88e+031.11e+003.29e-013.37e+007.64e-042.63e-03BLCA
SCARB14.61e+031.31e+003.44e-013.79e+001.49e-041.36e-03ESCA
SCARB18.41e+03-2.35e+005.18e-01-4.54e+005.76e-063.44e-05CHOL

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
SCARB14.46e+031.05e+003.14e-013.35e+007.99e-044.66e-03STAD
SCARB15.13e+031.76e+003.16e-015.56e+002.75e-083.80e-07READ

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Sex-biased somatic mutation for SCARB1

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for SCARB1

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta

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Exon skipping events with PSI in TCGA for SCARB1

∗Please access ExonSkipDB for exon skipping annotation.
check buttonLandscape of exon skipping events across multiple cancer types.
AS event heatmap

check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI
BLCAexon_skip_985378.89e-017.18e-012.98e+002.88e-031.03e-021.71e-01

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

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RNA A-to-I editing events in TCGA for SCARB1

∗Please access CAeditome for RNA editing annotation.
check buttonLandscape of RNA editing events across multiple cancer types.
ED heatmap

check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre
KIRCSCARB1-007chr12_124783279_-3.05e-012.71e-012.20e+002.79e-024.61e-023.40e-02
KIRCSCARB1-007chr12_124783357_-6.22e-015.79e-012.60e+009.29e-034.20e-024.22e-02
KIRCSCARB1-007chr12_124783723_-3.25e-011.93e-013.16e+001.59e-033.61e-021.32e-01
KIRCSCARB1-007chr12_124783736_-3.72e-012.45e-012.18e+002.90e-024.62e-021.26e-01
SKCMSCARB1-007chr12_124783279_-3.00e-012.13e-012.75e+005.92e-034.90e-028.73e-02
STADSCARB1-007chr12_124783356_-2.43e-014.35e-01-2.69e+007.05e-034.96e-02-1.92e-01

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre
BRCASCARB1-007chr12_124783254_-2.56e-011.56e-012.76e+005.76e-038.80e-031.01e-01
BRCASCARB1-007chr12_124783311_-4.32e-013.33e-012.47e+001.35e-021.79e-029.91e-02
BRCASCARB1-007chr12_124783316_-4.46e-013.34e-012.59e+009.53e-031.34e-021.12e-01
BRCASCARB1-007chr12_124783356_-3.42e-012.88e-012.08e+003.77e-024.02e-025.33e-02

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for SCARB1

check buttonTFs related to SCARB1.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType

check buttonSCARB1 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for SCARB1

check buttonRBPs related to ES in SCARB1.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
RBP ES
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
ACCZC3H10exon_skip_985979.46e+009.81e-019.09e+001.61e-02Male-biased
UVMELAVL2exon_skip_985399.43e+001.32e-029.71e+009.84e-01Female-biased
UVMRBM4exon_skip_986368.22e+009.90e-017.79e+002.01e-03Male-biased
LIHCZC3H10exon_skip_985579.58e+006.63e-031.00e+019.91e-01Female-biased
LUSCELAVL2exon_skip_985379.42e+009.85e-019.07e+001.26e-02Male-biased
LUSCSAMD4Aexon_skip_986386.01e+007.56e-046.66e+009.83e-01Female-biased
LUSCZC3H10exon_skip_985979.43e+009.86e-019.07e+001.16e-02Male-biased
COADELAVL2exon_skip_985379.50e+009.80e-019.21e+001.68e-02Male-biased
LUADRBM4exon_skip_986368.50e+007.92e-038.85e+009.87e-01Female-biased
BRCASAMD4Aexon_skip_986386.42e+009.81e-014.90e+002.77e-04Male-biased
ESCAYBX2exon_skip_986331.10e+011.47e-021.14e+019.85e-01Female-biased
ESCAZC3H10exon_skip_985979.53e+009.93e-018.98e+004.95e-03Male-biased
READYB-1exon_skip_986336.59e+003.64e-037.01e+009.83e-01Female-biased
READYBX2exon_skip_986331.12e+014.68e-031.16e+019.95e-01Female-biased
PCPGZC3H10exon_skip_985979.11e+009.48e-039.43e+009.88e-01Female-biased
MESORBM4exon_skip_986368.29e+009.12e-038.65e+009.85e-01Female-biased
LGGFMR1exon_skip_986306.63e+005.83e-037.01e+009.81e-01Female-biased
GBMRBM4exon_skip_986368.23e+003.61e-038.67e+009.91e-01Female-biased
PAADSAMD4Aexon_skip_986386.02e+001.22e-036.50e+009.81e-01Female-biased
PAADYB-1exon_skip_986307.58e+004.96e-037.94e+009.86e-01Female-biased
KICHFusip1exon_skip_986118.94e+009.93e-018.49e+002.85e-03Male-biased
BLCARBM4exon_skip_986368.21e+001.31e-028.54e+009.80e-01Female-biased
SKCMZC3H10exon_skip_985579.72e+009.92e-019.30e+005.26e-03Male-biased

check buttonSCARB1 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs60294875chr12:127362208:A:G-0.2681347991539139.82070321928237e-06KIRPFemale-baised eQTL
rs77642724chr12:127365577:G:A-0.2681347991539139.82070321928237e-06KIRPFemale-baised eQTL
rs6489122chr12:126696962:C:T--0.2106516239602270.0022271605894519KIRPFemale-baised eQTL
rs2137202chr12:126697571:A:G--0.2106516239602270.0022271605894519KIRPFemale-baised eQTL
rs7315198chr12:126697261:G:A--0.2424119061974390.00493654611183799KIRPFemale-baised eQTL
rs77791445chr12:132819654:G:A-0.1847424541499460.00594612092817088KIRPFemale-baised eQTL
rs957801chr12:132827096:T:G-0.1740364118282370.0112405867357419KIRPFemale-baised eQTL
rs73415457chr12:124827849:C:Tgene0.2156104400588870.0171512684327657KIRPFemale-baised eQTL
rs57166543chr12:132818712:A:G-0.1675790826680160.0213875682886876KIRPFemale-baised eQTL
rs11068661chr12:117733008:G:A-0.1644213612821540.0293179806459616KIRPFemale-baised eQTL
rs1554780chr12:131591537:A:C-0.1773064842152880.0313123000740784KIRPFemale-baised eQTL
rs10850433chr12:115057424:C:G-0.1099193118184540.0218283742014594KIRCFemale-baised eQTL
rs10850434chr12:115057474:G:A-0.1077895728623390.0306461922947KIRCFemale-baised eQTL
rs74560309chr12:123891178:A:G-0.1619419453841170.028136765912656BLCAFemale-baised eQTL
rs11831541chr12:123891886:T:C-0.1619419453841170.028136765912656BLCAFemale-baised eQTL
rs7967147chr12:123892974:C:T-0.1619419453841170.028136765912656BLCAFemale-baised eQTL
rs111598290chr12:123894403:T:C-0.1619419453841170.028136765912656BLCAFemale-baised eQTL
rs73424821chr12:123895645:G:T-0.1619419453841170.028136765912656BLCAFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs61942194chr12:125930451:A:G-0.1294431770809560.0321470464712358PAADMale-baised eQTL
rs61928444chr12:115823660:G:T-0.2262734234779870.0158932429832419SARCMale-baised eQTL
rs4766819chr12:116977169:C:T-0.08022202038643110.0270116547856798KIRPMale-baised eQTL
rs11058913chr12:127014615:T:A-0.1090146336890870.0414607815515683LGGMale-baised eQTL
rs11058915chr12:127016307:C:T-0.1110403189908120.0422054941912227LGGMale-baised eQTL
rs11058921chr12:127018139:G:A-0.1096789265506330.0443046625716224LGGMale-baised eQTL
rs6486613chr12:130909133:T:A--0.04566056771116270.0278839115317691LUADMale-baised eQTL
rs9738957chr12:130904256:T:C--0.04403078699473780.0368459023066069LUADMale-baised eQTL
rs7299940chr12:130906209:C:G--0.04312479879637410.0446012145012239LUADMale-baised eQTL
rs2895125chr12:129196400:G:T--0.05099658638200020.0220165921960839COADMale-baised eQTL
rs11611911chr12:115729719:C:T-0.0580113875699950.0311302095044302COADMale-baised eQTL
rs2650175chr12:118229615:A:T-0.05727168007988880.0354989462673083COADMale-baised eQTL
rs424034chr12:118234629:A:G-0.05357724770192480.0392608220206496COADMale-baised eQTL
rs12424955chr12:115643421:G:A--0.1039179813858720.0392905181249375COADMale-baised eQTL
rs12304274chr12:115279141:G:A-0.05200616521260690.0399845590163763COADMale-baised eQTL
rs7294415chr12:129427488:T:A--0.04947915439223990.0440992016483074COADMale-baised eQTL
rs464781chr12:118252011:T:C-0.05235597347253850.0475490186592001COADMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000073060
CpG Site: cg09789874
Position to Gene: gene,exon,UTR
Male Effect: -
Female Effect: -0.162673479420171
eQTM boxplot analysisGene ID: ENSG00000073060
CpG Site: cg01663970
Position to Gene: gene
Male Effect: -
Female Effect: -0.200530953198217

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg09789874chr12:124777499gene,exon,UTR-0.1626734794201712.24350478364335e-07-0.37440564039942276.596331473868871e-10LUAD
cg01663970chr12:124815140gene-0.2005309531982171.92470353386299e-05-0.318394553498516642.0449556016559272e-07LUAD

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of SCARB1

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource
ENSG00000073060SCARB1C0006868Cannabis Abuse1CTD_human
ENSG00000073060SCARB1C0006870Cannabis Dependence1CTD_human
ENSG00000073060SCARB1C0007097Carcinoma1CTD_human
ENSG00000073060SCARB1C0007134Renal Cell Carcinoma1CTD_human
ENSG00000073060SCARB1C0009171Cocaine Abuse1CTD_human
ENSG00000073060SCARB1C0016427Follicular cyst1CTD_human
ENSG00000073060SCARB1C0018614Hashish Abuse1CTD_human
ENSG00000073060SCARB1C0019196Hepatitis C1CTD_human
ENSG00000073060SCARB1C0022661Kidney Failure, Chronic1CTD_human
ENSG00000073060SCARB1C0024667Animal Mammary Neoplasms1CTD_human
ENSG00000073060SCARB1C0024668Mammary Neoplasms, Experimental1CTD_human
ENSG00000073060SCARB1C0024809Marijuana Abuse1CTD_human
ENSG00000073060SCARB1C0031391Phencyclidine Abuse1CTD_human
ENSG00000073060SCARB1C0205696Anaplastic carcinoma1CTD_human
ENSG00000073060SCARB1C0205697Carcinoma, Spindle-Cell1CTD_human
ENSG00000073060SCARB1C0205698Undifferentiated carcinoma1CTD_human
ENSG00000073060SCARB1C0205699Carcinomatosis1CTD_human
ENSG00000073060SCARB1C0236735Cannabis-Related Disorder1CTD_human
ENSG00000073060SCARB1C0236736Cocaine-Related Disorders1CTD_human
ENSG00000073060SCARB1C0236742Phencyclidine-Related Disorders1CTD_human
ENSG00000073060SCARB1C0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
ENSG00000073060SCARB1C0400966Non-alcoholic Fatty Liver Disease1CTD_human
ENSG00000073060SCARB1C0600427Cocaine Dependence1CTD_human
ENSG00000073060SCARB1C1257925Mammary Carcinoma, Animal1CTD_human
ENSG00000073060SCARB1C1266042Chromophobe Renal Cell Carcinoma1CTD_human
ENSG00000073060SCARB1C1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
ENSG00000073060SCARB1C1266044Collecting Duct Carcinoma of the Kidney1CTD_human
ENSG00000073060SCARB1C1306837Papillary Renal Cell Carcinoma1CTD_human
ENSG00000073060SCARB1C1853096HIGH DENSITY LIPOPROTEIN CHOLESTEROL LEVEL QUANTITATIVE TRAIT LOCUS 61CTD_human
ENSG00000073060SCARB1C3241937Nonalcoholic Steatohepatitis1CTD_human