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Gene: ENSG00000073060 |
Summary for SCARB1 |
Gene summary |
| Gene information | Ensembl ID | ENSG00000073060 | Gene symbol | SCARB1 |
| Gene name | scavenger receptor class B member 1 | |
| HGNC | 1664 | |
| Entrez ID | 949 | |
| Gene type | protein_coding | |
| Synonyms | SCARB1|SRB1|CLA-1|CLA1|SR-BI | |
| UniProtAcc | Q8WTV0 |
Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| ENSG00000073060 | SCARB1 | DB00144 | Phosphatidyl serine | SmallMoleculeDrug |
Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for SCARB1 |
AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
Landscape of gene expressions across multiple cancer types. |
Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| SCARB1 | 2.88e+03 | 1.11e+00 | 3.29e-01 | 3.37e+00 | 7.64e-04 | 2.63e-03 | BLCA |
| SCARB1 | 4.61e+03 | 1.31e+00 | 3.44e-01 | 3.79e+00 | 1.49e-04 | 1.36e-03 | ESCA |
| SCARB1 | 8.41e+03 | -2.35e+00 | 5.18e-01 | -4.54e+00 | 5.76e-06 | 3.44e-05 | CHOL |
Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| SCARB1 | 4.46e+03 | 1.05e+00 | 3.14e-01 | 3.35e+00 | 7.99e-04 | 4.66e-03 | STAD |
| SCARB1 | 5.13e+03 | 1.76e+00 | 3.16e-01 | 5.56e+00 | 2.75e-08 | 3.80e-07 | READ |
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Sex-biased somatic mutation for SCARB1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for SCARB1 |
Landscape of DNA methylation across multiple cancer types. |
Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for SCARB1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
Landscape of exon skipping events across multiple cancer types. |
Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| BLCA | exon_skip_98537 | 8.89e-01 | 7.18e-01 | 2.98e+00 | 2.88e-03 | 1.03e-02 | 1.71e-01 |
Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for SCARB1 |
| ∗Please access CAeditome for RNA editing annotation. |
Landscape of RNA editing events across multiple cancer types. |
Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| KIRC | SCARB1-007 | chr12_124783279_- | 3.05e-01 | 2.71e-01 | 2.20e+00 | 2.79e-02 | 4.61e-02 | 3.40e-02 |
| KIRC | SCARB1-007 | chr12_124783357_- | 6.22e-01 | 5.79e-01 | 2.60e+00 | 9.29e-03 | 4.20e-02 | 4.22e-02 |
| KIRC | SCARB1-007 | chr12_124783723_- | 3.25e-01 | 1.93e-01 | 3.16e+00 | 1.59e-03 | 3.61e-02 | 1.32e-01 |
| KIRC | SCARB1-007 | chr12_124783736_- | 3.72e-01 | 2.45e-01 | 2.18e+00 | 2.90e-02 | 4.62e-02 | 1.26e-01 |
| SKCM | SCARB1-007 | chr12_124783279_- | 3.00e-01 | 2.13e-01 | 2.75e+00 | 5.92e-03 | 4.90e-02 | 8.73e-02 |
| STAD | SCARB1-007 | chr12_124783356_- | 2.43e-01 | 4.35e-01 | -2.69e+00 | 7.05e-03 | 4.96e-02 | -1.92e-01 |
Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| BRCA | SCARB1-007 | chr12_124783254_- | 2.56e-01 | 1.56e-01 | 2.76e+00 | 5.76e-03 | 8.80e-03 | 1.01e-01 |
| BRCA | SCARB1-007 | chr12_124783311_- | 4.32e-01 | 3.33e-01 | 2.47e+00 | 1.35e-02 | 1.79e-02 | 9.91e-02 |
| BRCA | SCARB1-007 | chr12_124783316_- | 4.46e-01 | 3.34e-01 | 2.59e+00 | 9.53e-03 | 1.34e-02 | 1.12e-01 |
| BRCA | SCARB1-007 | chr12_124783356_- | 3.42e-01 | 2.88e-01 | 2.08e+00 | 3.77e-02 | 4.02e-02 | 5.33e-02 |
Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for SCARB1 |
TFs related to SCARB1.∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
SCARB1 related gene.∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for SCARB1 |
RBPs related to ES in SCARB1.∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ACC | ZC3H10 | exon_skip_98597 | 9.46e+00 | 9.81e-01 | 9.09e+00 | 1.61e-02 | Male-biased |
| UVM | ELAVL2 | exon_skip_98539 | 9.43e+00 | 1.32e-02 | 9.71e+00 | 9.84e-01 | Female-biased |
| UVM | RBM4 | exon_skip_98636 | 8.22e+00 | 9.90e-01 | 7.79e+00 | 2.01e-03 | Male-biased |
| LIHC | ZC3H10 | exon_skip_98557 | 9.58e+00 | 6.63e-03 | 1.00e+01 | 9.91e-01 | Female-biased |
| LUSC | ELAVL2 | exon_skip_98537 | 9.42e+00 | 9.85e-01 | 9.07e+00 | 1.26e-02 | Male-biased |
| LUSC | SAMD4A | exon_skip_98638 | 6.01e+00 | 7.56e-04 | 6.66e+00 | 9.83e-01 | Female-biased |
| LUSC | ZC3H10 | exon_skip_98597 | 9.43e+00 | 9.86e-01 | 9.07e+00 | 1.16e-02 | Male-biased |
| COAD | ELAVL2 | exon_skip_98537 | 9.50e+00 | 9.80e-01 | 9.21e+00 | 1.68e-02 | Male-biased |
| LUAD | RBM4 | exon_skip_98636 | 8.50e+00 | 7.92e-03 | 8.85e+00 | 9.87e-01 | Female-biased |
| BRCA | SAMD4A | exon_skip_98638 | 6.42e+00 | 9.81e-01 | 4.90e+00 | 2.77e-04 | Male-biased |
| ESCA | YBX2 | exon_skip_98633 | 1.10e+01 | 1.47e-02 | 1.14e+01 | 9.85e-01 | Female-biased |
| ESCA | ZC3H10 | exon_skip_98597 | 9.53e+00 | 9.93e-01 | 8.98e+00 | 4.95e-03 | Male-biased |
| READ | YB-1 | exon_skip_98633 | 6.59e+00 | 3.64e-03 | 7.01e+00 | 9.83e-01 | Female-biased |
| READ | YBX2 | exon_skip_98633 | 1.12e+01 | 4.68e-03 | 1.16e+01 | 9.95e-01 | Female-biased |
| PCPG | ZC3H10 | exon_skip_98597 | 9.11e+00 | 9.48e-03 | 9.43e+00 | 9.88e-01 | Female-biased |
| MESO | RBM4 | exon_skip_98636 | 8.29e+00 | 9.12e-03 | 8.65e+00 | 9.85e-01 | Female-biased |
| LGG | FMR1 | exon_skip_98630 | 6.63e+00 | 5.83e-03 | 7.01e+00 | 9.81e-01 | Female-biased |
| GBM | RBM4 | exon_skip_98636 | 8.23e+00 | 3.61e-03 | 8.67e+00 | 9.91e-01 | Female-biased |
| PAAD | SAMD4A | exon_skip_98638 | 6.02e+00 | 1.22e-03 | 6.50e+00 | 9.81e-01 | Female-biased |
| PAAD | YB-1 | exon_skip_98630 | 7.58e+00 | 4.96e-03 | 7.94e+00 | 9.86e-01 | Female-biased |
| KICH | Fusip1 | exon_skip_98611 | 8.94e+00 | 9.93e-01 | 8.49e+00 | 2.85e-03 | Male-biased |
| BLCA | RBM4 | exon_skip_98636 | 8.21e+00 | 1.31e-02 | 8.54e+00 | 9.80e-01 | Female-biased |
| SKCM | ZC3H10 | exon_skip_98557 | 9.72e+00 | 9.92e-01 | 9.30e+00 | 5.26e-03 | Male-biased |
SCARB1 related ES.∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs60294875 | chr12:127362208:A:G | - | 0.268134799153913 | 9.82070321928237e-06 | KIRP | Female-baised eQTL |
| rs77642724 | chr12:127365577:G:A | - | 0.268134799153913 | 9.82070321928237e-06 | KIRP | Female-baised eQTL |
| rs6489122 | chr12:126696962:C:T | - | -0.210651623960227 | 0.0022271605894519 | KIRP | Female-baised eQTL |
| rs2137202 | chr12:126697571:A:G | - | -0.210651623960227 | 0.0022271605894519 | KIRP | Female-baised eQTL |
| rs7315198 | chr12:126697261:G:A | - | -0.242411906197439 | 0.00493654611183799 | KIRP | Female-baised eQTL |
| rs77791445 | chr12:132819654:G:A | - | 0.184742454149946 | 0.00594612092817088 | KIRP | Female-baised eQTL |
| rs957801 | chr12:132827096:T:G | - | 0.174036411828237 | 0.0112405867357419 | KIRP | Female-baised eQTL |
| rs73415457 | chr12:124827849:C:T | gene | 0.215610440058887 | 0.0171512684327657 | KIRP | Female-baised eQTL |
| rs57166543 | chr12:132818712:A:G | - | 0.167579082668016 | 0.0213875682886876 | KIRP | Female-baised eQTL |
| rs11068661 | chr12:117733008:G:A | - | 0.164421361282154 | 0.0293179806459616 | KIRP | Female-baised eQTL |
| rs1554780 | chr12:131591537:A:C | - | 0.177306484215288 | 0.0313123000740784 | KIRP | Female-baised eQTL |
| rs10850433 | chr12:115057424:C:G | - | 0.109919311818454 | 0.0218283742014594 | KIRC | Female-baised eQTL |
| rs10850434 | chr12:115057474:G:A | - | 0.107789572862339 | 0.0306461922947 | KIRC | Female-baised eQTL |
| rs74560309 | chr12:123891178:A:G | - | 0.161941945384117 | 0.028136765912656 | BLCA | Female-baised eQTL |
| rs11831541 | chr12:123891886:T:C | - | 0.161941945384117 | 0.028136765912656 | BLCA | Female-baised eQTL |
| rs7967147 | chr12:123892974:C:T | - | 0.161941945384117 | 0.028136765912656 | BLCA | Female-baised eQTL |
| rs111598290 | chr12:123894403:T:C | - | 0.161941945384117 | 0.028136765912656 | BLCA | Female-baised eQTL |
| rs73424821 | chr12:123895645:G:T | - | 0.161941945384117 | 0.028136765912656 | BLCA | Female-baised eQTL |
Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs61942194 | chr12:125930451:A:G | - | 0.129443177080956 | 0.0321470464712358 | PAAD | Male-baised eQTL |
| rs61928444 | chr12:115823660:G:T | - | 0.226273423477987 | 0.0158932429832419 | SARC | Male-baised eQTL |
| rs4766819 | chr12:116977169:C:T | - | 0.0802220203864311 | 0.0270116547856798 | KIRP | Male-baised eQTL |
| rs11058913 | chr12:127014615:T:A | - | 0.109014633689087 | 0.0414607815515683 | LGG | Male-baised eQTL |
| rs11058915 | chr12:127016307:C:T | - | 0.111040318990812 | 0.0422054941912227 | LGG | Male-baised eQTL |
| rs11058921 | chr12:127018139:G:A | - | 0.109678926550633 | 0.0443046625716224 | LGG | Male-baised eQTL |
| rs6486613 | chr12:130909133:T:A | - | -0.0456605677111627 | 0.0278839115317691 | LUAD | Male-baised eQTL |
| rs9738957 | chr12:130904256:T:C | - | -0.0440307869947378 | 0.0368459023066069 | LUAD | Male-baised eQTL |
| rs7299940 | chr12:130906209:C:G | - | -0.0431247987963741 | 0.0446012145012239 | LUAD | Male-baised eQTL |
| rs2895125 | chr12:129196400:G:T | - | -0.0509965863820002 | 0.0220165921960839 | COAD | Male-baised eQTL |
| rs11611911 | chr12:115729719:C:T | - | 0.058011387569995 | 0.0311302095044302 | COAD | Male-baised eQTL |
| rs2650175 | chr12:118229615:A:T | - | 0.0572716800798888 | 0.0354989462673083 | COAD | Male-baised eQTL |
| rs424034 | chr12:118234629:A:G | - | 0.0535772477019248 | 0.0392608220206496 | COAD | Male-baised eQTL |
| rs12424955 | chr12:115643421:G:A | - | -0.103917981385872 | 0.0392905181249375 | COAD | Male-baised eQTL |
| rs12304274 | chr12:115279141:G:A | - | 0.0520061652126069 | 0.0399845590163763 | COAD | Male-baised eQTL |
| rs7294415 | chr12:129427488:T:A | - | -0.0494791543922399 | 0.0440992016483074 | COAD | Male-baised eQTL |
| rs464781 | chr12:118252011:T:C | - | 0.0523559734725385 | 0.0475490186592001 | COAD | Male-baised eQTL |
Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg09789874 | chr12:124777499 | gene,exon,UTR | -0.162673479420171 | 2.24350478364335e-07 | -0.3744056403994227 | 6.596331473868871e-10 | LUAD |
| cg01663970 | chr12:124815140 | gene | -0.200530953198217 | 1.92470353386299e-05 | -0.31839455349851664 | 2.0449556016559272e-07 | LUAD |
Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of SCARB1 |
Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000073060 | SCARB1 | C0006868 | Cannabis Abuse | 1 | CTD_human |
| ENSG00000073060 | SCARB1 | C0006870 | Cannabis Dependence | 1 | CTD_human |
| ENSG00000073060 | SCARB1 | C0007097 | Carcinoma | 1 | CTD_human |
| ENSG00000073060 | SCARB1 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
| ENSG00000073060 | SCARB1 | C0009171 | Cocaine Abuse | 1 | CTD_human |
| ENSG00000073060 | SCARB1 | C0016427 | Follicular cyst | 1 | CTD_human |
| ENSG00000073060 | SCARB1 | C0018614 | Hashish Abuse | 1 | CTD_human |
| ENSG00000073060 | SCARB1 | C0019196 | Hepatitis C | 1 | CTD_human |
| ENSG00000073060 | SCARB1 | C0022661 | Kidney Failure, Chronic | 1 | CTD_human |
| ENSG00000073060 | SCARB1 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| ENSG00000073060 | SCARB1 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| ENSG00000073060 | SCARB1 | C0024809 | Marijuana Abuse | 1 | CTD_human |
| ENSG00000073060 | SCARB1 | C0031391 | Phencyclidine Abuse | 1 | CTD_human |
| ENSG00000073060 | SCARB1 | C0205696 | Anaplastic carcinoma | 1 | CTD_human |
| ENSG00000073060 | SCARB1 | C0205697 | Carcinoma, Spindle-Cell | 1 | CTD_human |
| ENSG00000073060 | SCARB1 | C0205698 | Undifferentiated carcinoma | 1 | CTD_human |
| ENSG00000073060 | SCARB1 | C0205699 | Carcinomatosis | 1 | CTD_human |
| ENSG00000073060 | SCARB1 | C0236735 | Cannabis-Related Disorder | 1 | CTD_human |
| ENSG00000073060 | SCARB1 | C0236736 | Cocaine-Related Disorders | 1 | CTD_human |
| ENSG00000073060 | SCARB1 | C0236742 | Phencyclidine-Related Disorders | 1 | CTD_human |
| ENSG00000073060 | SCARB1 | C0279702 | Conventional (Clear Cell) Renal Cell Carcinoma | 1 | CTD_human |
| ENSG00000073060 | SCARB1 | C0400966 | Non-alcoholic Fatty Liver Disease | 1 | CTD_human |
| ENSG00000073060 | SCARB1 | C0600427 | Cocaine Dependence | 1 | CTD_human |
| ENSG00000073060 | SCARB1 | C1257925 | Mammary Carcinoma, Animal | 1 | CTD_human |
| ENSG00000073060 | SCARB1 | C1266042 | Chromophobe Renal Cell Carcinoma | 1 | CTD_human |
| ENSG00000073060 | SCARB1 | C1266043 | Sarcomatoid Renal Cell Carcinoma | 1 | CTD_human |
| ENSG00000073060 | SCARB1 | C1266044 | Collecting Duct Carcinoma of the Kidney | 1 | CTD_human |
| ENSG00000073060 | SCARB1 | C1306837 | Papillary Renal Cell Carcinoma | 1 | CTD_human |
| ENSG00000073060 | SCARB1 | C1853096 | HIGH DENSITY LIPOPROTEIN CHOLESTEROL LEVEL QUANTITATIVE TRAIT LOCUS 6 | 1 | CTD_human |
| ENSG00000073060 | SCARB1 | C3241937 | Nonalcoholic Steatohepatitis | 1 | CTD_human |