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Gene: ENSG00000071082 |
Summary for RPL31 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000071082 | Gene symbol | RPL31 |
| Gene name | ribosomal protein L31 | |
| HGNC | 10334 | |
| Entrez ID | 6160 | |
| Gene type | protein_coding | |
| Synonyms | RPL31|L31 | |
| UniProtAcc | P62899 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for RPL31 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for RPL31 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for RPL31 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| CHOL | cg21475150 | chr2:101001786 | CGI:chr2:101001785-101002196 | UTR,promoter,exon,gene body | 5.97e-01 | 4.06e-01 | 2.10e+00 | 3.56e-02 | 4.34e-02 | 1.91e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| THCA | cg22809047 | chr2:101001799 | CGI:chr2:101001785-101002196 | UTR,promoter,exon,gene body | 6.33e-01 | 5.22e-01 | 3.47e+00 | 5.13e-04 | 1.93e-03 | 1.11e-01 |
| BLCA | cg21475150 | chr2:101001786 | CGI:chr2:101001785-101002196 | UTR,promoter,exon,gene body | 4.49e-01 | 5.78e-01 | -2.11e+00 | 3.45e-02 | 3.75e-02 | -1.30e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg21475150 | chr2:101001786 | CGI:chr2:101001785-101002196 | UTR,promoter,exon,gene body | 6.19e-01 | 4.72e-01 | 6.31e+00 | 2.81e-10 | 7.14e-10 | 1.47e-01 |
| BRCA | cg22809047 | chr2:101001799 | CGI:chr2:101001785-101002196 | UTR,promoter,exon,gene body | 6.14e-01 | 4.91e-01 | 7.24e+00 | 4.47e-13 | 1.41e-12 | 1.23e-01 |
| KIRC | cg21475150 | chr2:101001786 | CGI:chr2:101001785-101002196 | UTR,promoter,exon,gene body | 7.72e-01 | 6.50e-01 | 2.61e+00 | 9.07e-03 | 1.60e-02 | 1.22e-01 |
| KIRC | cg22809047 | chr2:101001799 | CGI:chr2:101001785-101002196 | UTR,promoter,exon,gene body | 7.13e-01 | 6.01e-01 | 2.77e+00 | 5.63e-03 | 1.18e-02 | 1.12e-01 |
| LUAD | cg10148764 | chr2:101001932 | CGI:chr2:101001785-101002196 | UTR,promoter,exon,gene body | 1.88e-01 | 6.76e-02 | 3.22e+00 | 1.29e-03 | 3.79e-03 | 1.21e-01 |
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Exon skipping events with PSI in TCGA for RPL31 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for RPL31 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for RPL31 |
| TFs related to RPL31. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| READ | GLIS1 | RPL31 | 4.13e+00 | 9.83e-01 | 2.88e+00 | 1.76e-03 | Male-biased |
| READ | PHF1 | RPL31 | 4.20e+00 | 9.84e-01 | 3.00e+00 | 2.26e-03 | Male-biased |
| READ | ZNF22 | RPL31 | 1.68e+00 | 6.41e-05 | 3.97e+00 | 9.82e-01 | Female-biased |
| READ | ZNF235 | RPL31 | 1.40e+00 | 7.67e-06 | 4.29e+00 | 9.90e-01 | Female-biased |
| READ | ZNF287 | RPL31 | 1.58e+00 | 2.66e-05 | 4.13e+00 | 9.86e-01 | Female-biased |
| READ | ZNF443 | RPL31 | 2.42e+00 | 7.16e-04 | 3.96e+00 | 9.81e-01 | Female-biased |
| RPL31 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for RPL31 |
| RBPs related to ES in RPL31. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| STAD | RBMS1 | exon_skip_328145 | 1.18e+01 | 5.69e-03 | 1.23e+01 | 9.94e-01 | Female-biased |
| LIHC | RBMS1 | exon_skip_328145 | 1.24e+01 | 3.49e-03 | 1.29e+01 | 9.96e-01 | Female-biased |
| COAD | RBMS1 | exon_skip_328145 | 1.25e+01 | 9.96e-01 | 1.21e+01 | 3.49e-03 | Male-biased |
| LUAD | RBMS1 | exon_skip_328145 | 1.25e+01 | 9.96e-01 | 1.21e+01 | 3.21e-03 | Male-biased |
| CHOL | RBMS1 | exon_skip_328145 | 1.23e+01 | 1.79e-03 | 1.30e+01 | 9.98e-01 | Female-biased |
| KIRP | ENOX1 | exon_skip_328132 | 9.36e+00 | 5.10e-03 | 9.75e+00 | 9.93e-01 | Female-biased |
| KIRP | RBMS1 | exon_skip_328145 | 1.26e+01 | 1.39e-03 | 1.31e+01 | 9.98e-01 | Female-biased |
| BRCA | RBMS1 | exon_skip_328145 | 1.23e+01 | 9.81e-01 | 1.18e+01 | 1.84e-02 | Male-biased |
| READ | G3BP2 | exon_skip_328145 | 6.96e+00 | 4.43e-03 | 7.36e+00 | 9.85e-01 | Female-biased |
| READ | RBMS1 | exon_skip_328145 | 1.20e+01 | 7.61e-03 | 1.24e+01 | 9.92e-01 | Female-biased |
| PCPG | RBMS1 | exon_skip_328145 | 1.29e+01 | 9.99e-01 | 1.24e+01 | 9.84e-04 | Male-biased |
| MESO | RBMS1 | exon_skip_328145 | 1.23e+01 | 1.69e-03 | 1.29e+01 | 9.98e-01 | Female-biased |
| MESO | SART3 | exon_skip_328117 | 8.71e+00 | 1.39e-02 | 9.03e+00 | 9.82e-01 | Female-biased |
| BLCA | RBMS1 | exon_skip_328145 | 1.27e+01 | 1.12e-02 | 1.30e+01 | 9.88e-01 | Female-biased |
| HNSC | RBMS1 | exon_skip_328145 | 1.20e+01 | 6.47e-03 | 1.24e+01 | 9.93e-01 | Female-biased |
| SARC | RBMS1 | exon_skip_328145 | 1.24e+01 | 5.03e-03 | 1.28e+01 | 9.95e-01 | Female-biased |
| RPL31 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs57038644 | chr2:109238024:G:A | - | 0.185825551474801 | 0.0118342818218108 | GBM | Female-baised eQTL |
| rs11904539 | chr2:104440999:T:A | - | 0.105371888422751 | 0.0399321524338336 | LUSC | Female-baised eQTL |
| rs57252716 | chr2:104448277:T:C | - | 0.104412283039416 | 0.0418659986588411 | LUSC | Female-baised eQTL |
| rs6708679 | chr2:104451677:C:T | - | 0.104412283039416 | 0.0418659986588411 | LUSC | Female-baised eQTL |
| rs6729889 | chr2:104444737:G:A | - | 0.103612363856722 | 0.0480822937204873 | LUSC | Female-baised eQTL |
| rs4012760 | chr2:106061381:T:C | - | 0.0531567946128873 | 0.0253234023027992 | COAD | Female-baised eQTL |
| rs7557576 | chr2:106061994:G:A | - | 0.0531280752536791 | 0.0254826631866182 | COAD | Female-baised eQTL |
| rs1077397 | chr2:106060723:G:A | - | 0.0517536026943321 | 0.0324064895457281 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs6734156 | chr2:105956328:C:T | - | 0.161182701963452 | 0.0204807364028365 | PAAD | Male-baised eQTL |
| rs17030912 | chr2:105443567:C:T | - | 0.316973522664519 | 0.0184592140439109 | GBM | Male-baised eQTL |
| rs112566500 | chr2:96358661:C:G | - | 0.0704979751197334 | 0.00246559329402776 | LUSC | Male-baised eQTL |
| rs3849368 | chr2:105954568:A:G | - | 0.0546716643180886 | 0.0173342822933202 | KIRC | Male-baised eQTL |
| rs2889607 | chr2:105951784:C:T | - | 0.0842048258440867 | 0.0390856520962573 | KIRC | Male-baised eQTL |
| rs7591921 | chr2:105968577:C:T | - | 0.0836979516326333 | 0.048106619447708 | KIRC | Male-baised eQTL |
| rs77747563 | chr2:105975037:C:T | - | 0.0809507185035964 | 0.0485816847202819 | KIRC | Male-baised eQTL |
| rs1451973 | chr2:103561122:G:T | - | 0.160282457992732 | 0.004728455071598 | LUAD | Male-baised eQTL |
| rs76625583 | chr2:103579841:T:C | - | 0.160282457992732 | 0.004728455071598 | LUAD | Male-baised eQTL |
| rs10174685 | chr2:103581177:G:A | - | 0.160282457992732 | 0.004728455071598 | LUAD | Male-baised eQTL |
| rs10194908 | chr2:103570620:A:C | - | 0.156555176675542 | 0.00543590211396469 | LUAD | Male-baised eQTL |
| rs13423794 | chr2:103570466:G:T | - | 0.148719867381996 | 0.00984018408343913 | LUAD | Male-baised eQTL |
| rs78157469 | chr2:103576744:C:G | - | 0.148719867381996 | 0.00984018408343913 | LUAD | Male-baised eQTL |
| rs6543219 | chr2:103573860:T:G | - | 0.14863998907522 | 0.00989023311397675 | LUAD | Male-baised eQTL |
| rs6543212 | chr2:103497586:C:T | - | 0.139537472226941 | 0.020241330702116 | LUAD | Male-baised eQTL |
| rs10209699 | chr2:103549537:T:C | - | 0.129876973969691 | 0.031347222094345 | LUAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000071082 |
| CpG Site: cg21475150 | |
| Position to Gene: gene,exon,promoter,UTR | |
| Male Effect: -0.409965924835403 | |
| Female Effect: - | |
 | Gene ID: ENSG00000071082 |
| CpG Site: cg22809047 | |
| Position to Gene: gene,exon,promoter,UTR | |
| Male Effect: -0.409965924835403 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg21475150 | chr2:101001786 | gene,exon,promoter,UTR | -0.409965924835403 | 5.98830078072822e-14 | -0.7045087118162748 | 5.758455248914804e-16 | PAAD |
| cg22809047 | chr2:101001799 | gene,exon,promoter,UTR | -0.409965924835403 | 5.98830078072822e-14 | -0.7045087118162748 | 5.758455248914804e-16 | PAAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of RPL31 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000071082 | RPL31 | C0006142 | Malignant neoplasm of breast | 1 | CTD_human |
| ENSG00000071082 | RPL31 | C0678222 | Breast Carcinoma | 1 | CTD_human |
| ENSG00000071082 | RPL31 | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human |
| ENSG00000071082 | RPL31 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| ENSG00000071082 | RPL31 | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |
