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Gene: ENSG00000071051 |
Summary for NCK2 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000071051 | Gene symbol | NCK2 |
| Gene name | NCK adaptor protein 2 | |
| HGNC | 7665 | |
| Entrez ID | 8440 | |
| Gene type | protein_coding | |
| Synonyms | NCK2|NCKbeta | |
| UniProtAcc | O43639 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for NCK2 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| NCK2 | 3.20e+03 | 2.23e+00 | 3.74e-01 | 5.97e+00 | 2.31e-09 | 3.01e-08 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| NCK2 | 1.32e+03 | 1.06e+00 | 2.58e-01 | 4.11e+00 | 3.97e-05 | 1.40e-04 | LIHC |
Top |
Sex-biased somatic mutation for NCK2 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for NCK2 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LIHC | cg13427834 | chr2:105745760 | CGI:chr2:105744575-105745761 | UTR,promoter,exon,gene body | 1.18e-01 | 2.19e-01 | -5.70e+00 | 1.22e-08 | 2.03e-07 | -1.02e-01 |
| ACC | cg01577187 | chr2:105746375 | CGI:chr2:105744575-105745761 | promoter,gene body | 4.85e-01 | 6.04e-01 | -2.19e+00 | 2.86e-02 | 4.08e-02 | -1.19e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BLCA | cg01577187 | chr2:105746375 | CGI:chr2:105744575-105745761 | promoter,gene body | 1.76e-01 | 3.14e-01 | -2.99e+00 | 2.76e-03 | 5.07e-03 | -1.38e-01 |
| LIHC | cg20268893 | chr2:105746090 | CGI:chr2:105744575-105745761 | promoter,gene body | 2.17e-01 | 8.16e-02 | 5.23e+00 | 1.73e-07 | 8.33e-07 | 1.35e-01 |
| CHOL | cg01577187 | chr2:105746375 | CGI:chr2:105744575-105745761 | promoter,gene body | 1.02e-01 | 3.03e-01 | -3.46e+00 | 5.30e-04 | 8.63e-03 | -2.01e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUAD | cg01577187 | chr2:105746375 | CGI:chr2:105744575-105745761 | promoter,gene body | 1.93e-01 | 3.12e-01 | -3.36e+00 | 7.79e-04 | 2.71e-03 | -1.20e-01 |
| BLCA | cg14131038 | chr2:105744252 | CGI:chr2:105744575-105745761 | promoter | 2.46e-01 | 3.53e-01 | -2.44e+00 | 1.47e-02 | 2.22e-02 | -1.08e-01 |
| LIHC | cg14131038 | chr2:105744252 | CGI:chr2:105744575-105745761 | promoter | 3.38e-01 | 4.67e-01 | -3.49e+00 | 4.75e-04 | 1.27e-03 | -1.29e-01 |
| LIHC | cg01577187 | chr2:105746375 | CGI:chr2:105744575-105745761 | promoter,gene body | 2.91e-01 | 4.40e-01 | -3.36e+00 | 7.72e-04 | 1.85e-03 | -1.48e-01 |
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Exon skipping events with PSI in TCGA for NCK2 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for NCK2 |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
 |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| STAD | NCK2-005 | chr2_105892725_+ | 4.11e-01 | 2.79e-01 | 2.11e+00 | 3.50e-02 | 4.96e-02 | 1.31e-01 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for NCK2 |
| TFs related to NCK2. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| NCK2 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for NCK2 |
| RBPs related to ES in NCK2. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ACC | FXR2 | exon_skip_328405 | 8.01e+00 | 9.82e-01 | 7.57e+00 | 9.06e-03 | Male-biased |
| ACC | SAMD4A | exon_skip_328405 | 7.18e+00 | 9.86e-01 | 6.35e+00 | 8.90e-04 | Male-biased |
| UVM | FXR2 | exon_skip_328405 | 7.35e+00 | 3.53e-03 | 7.74e+00 | 9.87e-01 | Female-biased |
| UVM | FXR2 | exon_skip_328406 | 7.73e+00 | 9.81e-01 | 7.43e+00 | 9.08e-03 | Male-biased |
| UVM | SAMD4A | exon_skip_328405 | 6.08e+00 | 2.96e-04 | 6.71e+00 | 9.83e-01 | Female-biased |
| THYM | PPRC1 | exon_skip_328415 | 9.48e+00 | 9.86e-01 | 9.17e+00 | 1.14e-02 | Male-biased |
| LUAD | SAMD4A | exon_skip_328405 | 6.58e+00 | 9.82e-01 | 6.01e+00 | 8.87e-04 | Male-biased |
| KIRP | YB-1 | exon_skip_328402 | 9.45e+00 | 1.51e-02 | 9.75e+00 | 9.83e-01 | Female-biased |
| ESCA | YB-1 | exon_skip_328402 | 9.13e+00 | 1.15e-02 | 9.55e+00 | 9.86e-01 | Female-biased |
| READ | YB-1 | exon_skip_328402 | 9.23e+00 | 1.31e-02 | 9.54e+00 | 9.84e-01 | Female-biased |
| PCPG | SAMD4A | exon_skip_328405 | 6.25e+00 | 1.10e-03 | 6.77e+00 | 9.83e-01 | Female-biased |
| LGG | SAMD4A | exon_skip_328406 | 6.12e+00 | 2.16e-04 | 6.89e+00 | 9.85e-01 | Female-biased |
| PAAD | SAMD4A | exon_skip_328405 | 6.23e+00 | 2.12e-03 | 6.66e+00 | 9.81e-01 | Female-biased |
| SKCM | SAMD4A | exon_skip_328406 | 7.04e+00 | 9.81e-01 | 6.62e+00 | 5.13e-03 | Male-biased |
| SKCM | YB-1 | exon_skip_328402 | 9.57e+00 | 9.84e-01 | 9.24e+00 | 1.33e-02 | Male-biased |
| NCK2 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000071051 | AC007014.2,hsa-mir-429,NCK2 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000071051 | KCNQ1OT1,hsa-mir-429,NCK2 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000071051 | SNHG14,hsa-mir-429,NCK2 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000071051 | AC010168.2,hsa-mir-429,NCK2 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000071051 | AC245060.5,hsa-mir-429,NCK2 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000071051 | GARS1-DT,hsa-mir-429,NCK2 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000071051 | AC055822.1,hsa-mir-429,NCK2 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000071051 | AC011468.1,hsa-mir-429,NCK2 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000071051 | MCM3AP-AS1,hsa-mir-429,NCK2 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000071051 | Z95331.1,hsa-mir-429,NCK2 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000071051 | KCNQ1OT1,hsa-mir-496,NCK2 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000071051 | GARS1-DT,hsa-mir-496,NCK2 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000071051 | AP001062.1,hsa-mir-496,NCK2 | Female-specific ceRNA | TCGA-LIHC |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs34282570 | chr2:106213287:G:C | - | 0.304070102808074 | 3.36530526995943e-05 | GBM | Female-baised eQTL |
| rs79341573 | chr2:106223351:G:A | - | 0.304070102808074 | 3.36530526995943e-05 | GBM | Female-baised eQTL |
| rs185382450 | chr2:106258912:G:C | - | 0.304070102808074 | 3.36530526995943e-05 | GBM | Female-baised eQTL |
| rs112834930 | chr2:115425104:G:T | - | 0.284261067413732 | 0.000503318026456501 | GBM | Female-baised eQTL |
| rs75722481 | chr2:115432056:A:G | - | 0.284261067413732 | 0.000503318026456501 | GBM | Female-baised eQTL |
| rs116428381 | chr2:108716918:A:C | - | 0.188663820519763 | 0.0352499099269152 | GBM | Female-baised eQTL |
| rs139469649 | chr2:108726165:G:A | - | 0.188663820519763 | 0.0352499099269152 | GBM | Female-baised eQTL |
| rs140585189 | chr2:108726947:G:A | - | 0.188663820519763 | 0.0352499099269152 | GBM | Female-baised eQTL |
| rs7589975 | chr2:101093199:T:A | - | 0.142880096836353 | 0.0354973411376679 | GBM | Female-baised eQTL |
| rs62155199 | chr2:101093908:G:A | - | 0.142880096836353 | 0.0354973411376679 | GBM | Female-baised eQTL |
| rs6755081 | chr2:101094334:G:A | - | 0.142880096836353 | 0.0354973411376679 | GBM | Female-baised eQTL |
| rs1374320 | chr2:101096282:G:A | - | 0.142880096836353 | 0.0354973411376679 | GBM | Female-baised eQTL |
| rs1374321 | chr2:101096283:A:T | - | 0.142880096836353 | 0.0354973411376679 | GBM | Female-baised eQTL |
| rs7604548 | chr2:101096891:T:A | - | 0.142880096836353 | 0.0354973411376679 | GBM | Female-baised eQTL |
| rs11688666 | chr2:101098734:T:A | - | 0.142880096836353 | 0.0354973411376679 | GBM | Female-baised eQTL |
| rs115975243 | chr2:101099601:A:G | - | 0.142880096836353 | 0.0354973411376679 | GBM | Female-baised eQTL |
| rs142573476 | chr2:101099980:C:T | - | 0.142880096836353 | 0.0354973411376679 | GBM | Female-baised eQTL |
| rs34343486 | chr2:101101608:T:G | - | 0.142880096836353 | 0.0354973411376679 | GBM | Female-baised eQTL |
| rs35033622 | chr2:101101865:G:A | - | 0.142880096836353 | 0.0354973411376679 | GBM | Female-baised eQTL |
| rs75163266 | chr2:101102548:C:A | - | 0.142880096836353 | 0.0354973411376679 | GBM | Female-baised eQTL |
| rs11674692 | chr2:101104795:A:G | - | 0.142880096836353 | 0.0354973411376679 | GBM | Female-baised eQTL |
| rs3899062 | chr2:101105061:C:T | - | 0.142880096836353 | 0.0354973411376679 | GBM | Female-baised eQTL |
| rs4080660 | chr2:101109119:T:A | - | 0.142880096836353 | 0.0354973411376679 | GBM | Female-baised eQTL |
| rs62155205 | chr2:101110308:A:G | - | 0.142880096836353 | 0.0354973411376679 | GBM | Female-baised eQTL |
| rs7601088 | chr2:101111030:C:T | - | 0.142880096836353 | 0.0354973411376679 | GBM | Female-baised eQTL |
| rs7601203 | chr2:101111139:C:T | - | 0.142880096836353 | 0.0354973411376679 | GBM | Female-baised eQTL |
| rs141320079 | chr2:108732312:A:C | - | 0.188708413320713 | 0.035768292779624 | GBM | Female-baised eQTL |
| rs139730843 | chr2:108738317:C:T | - | 0.188708413320713 | 0.035768292779624 | GBM | Female-baised eQTL |
| rs116637277 | chr2:108738974:A:G | - | 0.188708413320713 | 0.035768292779624 | GBM | Female-baised eQTL |
| rs150844750 | chr2:108742827:T:C | - | 0.188708413320713 | 0.035768292779624 | GBM | Female-baised eQTL |
| rs147669619 | chr2:108743484:A:G | - | 0.188708413320713 | 0.035768292779624 | GBM | Female-baised eQTL |
| rs145128757 | chr2:108744305:G:A | - | 0.188708413320713 | 0.035768292779624 | GBM | Female-baised eQTL |
| rs143115410 | chr2:108760300:T:C | - | 0.188708413320713 | 0.035768292779624 | GBM | Female-baised eQTL |
| rs61748149 | chr2:108764982:A:G | - | 0.188708413320713 | 0.035768292779624 | GBM | Female-baised eQTL |
| rs148121874 | chr2:108768770:C:G | - | 0.188708413320713 | 0.035768292779624 | GBM | Female-baised eQTL |
| rs142488352 | chr2:108770706:G:T | - | 0.188708413320713 | 0.035768292779624 | GBM | Female-baised eQTL |
| rs17020526 | chr2:108777398:G:A | - | 0.188708413320713 | 0.035768292779624 | GBM | Female-baised eQTL |
| rs143535224 | chr2:108780594:A:G | - | 0.188708413320713 | 0.035768292779624 | GBM | Female-baised eQTL |
| rs35794776 | chr2:108791703:G:T | - | 0.188708413320713 | 0.035768292779624 | GBM | Female-baised eQTL |
| rs62155874 | chr2:105356637:A:G | - | 0.184996112909581 | 0.0389591237082909 | STAD | Female-baised eQTL |
| rs72832259 | chr2:105079307:A:G | - | 0.190629167477969 | 0.0120263583605242 | BLCA | Female-baised eQTL |
| rs68154520 | chr2:105080133:C:T | - | 0.190629167477969 | 0.0120263583605242 | BLCA | Female-baised eQTL |
| rs36060444 | chr2:105098685:G:T | - | 0.190629167477969 | 0.0120263583605242 | BLCA | Female-baised eQTL |
| rs11124016 | chr2:105017294:G:A | - | 0.18711124551074 | 0.0127001684960936 | BLCA | Female-baised eQTL |
| rs35672588 | chr2:105041763:C:A | - | 0.18711124551074 | 0.0127001684960936 | BLCA | Female-baised eQTL |
| rs112304389 | chr2:101600791:G:A | - | 0.0454793060062752 | 0.012436726323743 | LUAD | Female-baised eQTL |
| rs55888307 | chr2:101595855:C:T | - | 0.0446266017766837 | 0.0144429193497771 | LUAD | Female-baised eQTL |
| rs4851466 | chr2:101596987:G:A | - | 0.0381427478881705 | 0.0160240077024071 | LUAD | Female-baised eQTL |
| rs56335221 | chr2:101603244:C:T | - | 0.0370873083951056 | 0.0239834824280755 | LUAD | Female-baised eQTL |
| rs56374270 | chr2:101604473:C:G | - | 0.0370803114434033 | 0.0242397095388244 | LUAD | Female-baised eQTL |
| rs6543081 | chr2:101617269:C:T | - | 0.0414980891134082 | 0.0243510228865619 | LUAD | Female-baised eQTL |
| rs142165689 | chr2:101601117:G:A | - | 0.0404275461792186 | 0.0278455626062858 | LUAD | Female-baised eQTL |
| rs113801570 | chr2:101600351:C:T | - | 0.040214756970494 | 0.0280309267746841 | LUAD | Female-baised eQTL |
| rs111690880 | chr2:101600628:C:T | - | 0.040214756970494 | 0.0280309267746841 | LUAD | Female-baised eQTL |
| rs10171625 | chr2:101595764:A:G | - | 0.0401276224218109 | 0.030310931000673 | LUAD | Female-baised eQTL |
| rs56009034 | chr2:101603380:T:C | - | 0.0401908369703087 | 0.0304849575906853 | LUAD | Female-baised eQTL |
| rs112083224 | chr2:101612671:C:T | - | 0.0411170285232001 | 0.0336381593063783 | LUAD | Female-baised eQTL |
| rs17025851 | chr2:101615252:G:T | - | 0.0411170285232001 | 0.0336381593063783 | LUAD | Female-baised eQTL |
| rs13393896 | chr2:101617563:A:G | - | 0.0411170285232001 | 0.0336381593063783 | LUAD | Female-baised eQTL |
| rs13431759 | chr2:101617620:C:A | - | 0.0411170285232001 | 0.0336381593063783 | LUAD | Female-baised eQTL |
| rs7604367 | chr2:101587464:A:G | - | 0.0355790431292277 | 0.0350582005120877 | LUAD | Female-baised eQTL |
| rs28851613 | chr2:101585418:T:C | - | 0.0395064946784239 | 0.0360374378247687 | LUAD | Female-baised eQTL |
| rs10172037 | chr2:101596180:A:G | - | 0.0338748475295752 | 0.0373943342654197 | LUAD | Female-baised eQTL |
| rs7574626 | chr2:101588387:C:T | - | 0.0393128245130878 | 0.0380887936257817 | LUAD | Female-baised eQTL |
| rs11884391 | chr2:101598767:T:C | - | 0.0382012056580721 | 0.0385574614078189 | LUAD | Female-baised eQTL |
| rs13413645 | chr2:101609681:G:A | - | 0.0402552339589386 | 0.0403907356827547 | LUAD | Female-baised eQTL |
| rs56659134 | chr2:101610434:G:C | - | 0.0402552339589386 | 0.0403907356827547 | LUAD | Female-baised eQTL |
| rs75219107 | chr2:101591893:A:G | - | 0.0334465237151259 | 0.0412165425136932 | LUAD | Female-baised eQTL |
| rs76860867 | chr2:101571598:T:G | - | -0.100792994683679 | 0.0174171339760763 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs61661673 | chr2:96852905:C:T | - | 0.0842890535885296 | 0.0107069603045623 | LIHC | Male-baised eQTL |
| rs66716604 | chr2:108533414:T:C | - | 0.0777783209184864 | 0.0230131706211887 | LUAD | Male-baised eQTL |
| rs6709158 | chr2:113726208:T:A | - | -0.062078018019984 | 0.0162073221149465 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000071051 |
| CpG Site: cg25961567 | |
| Position to Gene: gene,enhancer | |
| Male Effect: - | |
| Female Effect: -0.411699542725327 | |
 | Gene ID: ENSG00000071051 |
| CpG Site: cg20703928 | |
| Position to Gene: gene,enhancer | |
| Male Effect: - | |
| Female Effect: -0.180056992729615 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg25961567 | chr2:105747146 | gene,enhancer | -0.411699542725327 | 2.97364560536622e-23 | -0.6067265301417553 | 1.249535429967278e-26 | LUAD |
| cg20703928 | chr2:105747772 | gene,enhancer | -0.180056992729615 | 4.30461690517769e-07 | -0.37455006552935005 | 1.1163794105875117e-09 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs1470590 | chr2:106806939:T:G | Distant downstream | -0.0330337232018715 | 0.00446153806855124 | LUAD | Female-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs7565766 | chr2:106798504:A:C | Distant downstream | -0.0320213153117938 | 0.004982724751905 | LUAD | Female-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs9308902 | chr2:106803953:T:C | Distant downstream | -0.0304980255479608 | 0.0089834728774561 | LUAD | Female-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs78744876 | chr2:105683192:T:G | Distant upstream | -0.0309275681875908 | 0.00706024263047711 | THCA | Female-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs6751770 | chr2:105657916:G:T | Distant upstream | -0.030463204574772 | 0.00836837770434608 | THCA | Female-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs12477407 | chr2:105661344:T:A | Distant upstream | -0.030463204574772 | 0.00836837770434608 | THCA | Female-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs12469790 | chr2:105673577:T:A | Distant upstream | -0.030463204574772 | 0.00836837770434608 | THCA | Female-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs77698625 | chr2:105677398:C:A | Distant upstream | -0.0304247602447432 | 0.00863910979988903 | THCA | Female-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs116723712 | chr2:105648695:G:A | Distant upstream | -0.0301915555669409 | 0.00951850207035405 | THCA | Female-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs12612312 | chr2:106098259:G:C | Distant downstream | -0.0238607026025963 | 0.0160290555522246 | THCA | Female-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs3820893 | chr2:106091521:T:C | Distant downstream | -0.0228425628591136 | 0.0194373194354504 | THCA | Female-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs12621836 | chr2:106089291:G:A | Distant downstream | -0.0226824534662983 | 0.0228145856239637 | THCA | Female-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs13001398 | chr2:106090184:A:G | Distant downstream | -0.0226824534662983 | 0.0228145856239637 | THCA | Female-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs2377451 | chr2:106092391:T:C | Distant downstream | 0.0221784052048927 | 0.0245049386078576 | THCA | Female-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs7599703 | chr2:106089473:G:C | Distant downstream | 0.0217795690840989 | 0.0327415589397456 | THCA | Female-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs13018816 | chr2:106124176:C:G | Distant downstream | -0.0290898135245288 | 0.0437617214095696 | THCA | Female-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs11681976 | chr2:106225135:C:A | Distant downstream | -0.0581384110167466 | 0.0196421849416539 | GBM | Female-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs3954088 | chr2:106243196:G:A | Distant downstream | -0.0577249082336783 | 0.0223191607530268 | GBM | Female-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs2556141 | chr2:106249031:G:A | Distant downstream | -0.0577249082336783 | 0.0223191607530268 | GBM | Female-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs2377534 | chr2:106250914:A:C | Distant downstream | -0.0577249082336783 | 0.0223191607530268 | GBM | Female-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs2377535 | chr2:106251083:C:T | Distant downstream | -0.0577249082336783 | 0.0223191607530268 | GBM | Female-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs74180267 | chr2:106252368:C:T | Distant downstream | -0.0577249082336783 | 0.0223191607530268 | GBM | Female-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs35626794 | chr2:106253352:C:T | Distant downstream | -0.0577249082336783 | 0.0223191607530268 | GBM | Female-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs62146781 | chr2:106253858:A:G | Distant downstream | -0.0577249082336783 | 0.0223191607530268 | GBM | Female-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs13036230 | chr2:106256532:C:T | Distant downstream | -0.0577249082336783 | 0.0223191607530268 | GBM | Female-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs12999705 | chr2:106221552:G:A | Distant downstream | -0.0568515074468001 | 0.0281160510390889 | GBM | Female-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs13011900 | chr2:106228603:G:C | Distant downstream | -0.0568515074468001 | 0.0281160510390889 | GBM | Female-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs7566680 | chr2:106235201:G:A | Distant downstream | -0.0568515074468001 | 0.0281160510390889 | GBM | Female-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs62146770 | chr2:106237821:C:T | Distant downstream | -0.0568515074468001 | 0.0281160510390889 | GBM | Female-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs4851945 | chr2:106223018:A:T | Distant downstream | 0.062246623956583 | 0.0435152728222037 | GBM | Female-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs4851946 | chr2:106223468:A:G | Distant downstream | 0.062246623956583 | 0.0435152728222037 | GBM | Female-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs13405550 | chr2:106227719:A:T | Distant downstream | 0.062246623956583 | 0.0435152728222037 | GBM | Female-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs62146769 | chr2:106231332:T:G | Distant downstream | 0.062246623956583 | 0.0435152728222037 | GBM | Female-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs4514893 | chr2:106236306:C:T | Distant downstream | 0.062246623956583 | 0.0435152728222037 | GBM | Female-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs7573839 | chr2:106236919:G:T | Distant downstream | 0.062246623956583 | 0.0435152728222037 | GBM | Female-baised sQTL |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs2125908 | chr2:106600280:A:G | Distant downstream | 0.0210932918307284 | 0.0366303039370784 | KIRC | Male-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs7591418 | chr2:106601495:G:A | Distant downstream | 0.0210932918307284 | 0.0366303039370784 | KIRC | Male-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs7568660 | chr2:106601744:C:T | Distant downstream | 0.0210932918307284 | 0.0366303039370784 | KIRC | Male-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs4572593 | chr2:106600480:G:A | Distant downstream | 0.021005468531238 | 0.0396746829326683 | KIRC | Male-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs7591991 | chr2:106596010:G:C | Distant downstream | 0.0207741132666512 | 0.0457428845173588 | KIRC | Male-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs7582751 | chr2:106596013:T:G | Distant downstream | 0.0207741132666512 | 0.0457428845173588 | KIRC | Male-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs10173040 | chr2:106589308:G:A | Distant downstream | 0.0209147717591783 | 0.0458942082771555 | KIRC | Male-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs1477514 | chr2:105913484:A:C | Distant downstream | -0.0295104320194613 | 0.0328960473872739 | THCA | Male-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs13405979 | chr2:106799279:G:C | Distant downstream | -0.0565721343420145 | 0.0164810177923692 | BLCA | Male-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs17681165 | chr2:106805080:A:T | Distant downstream | -0.0493934002412474 | 0.0498295069144452 | BLCA | Male-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs6543432 | chr2:106649644:C:T | Distant downstream | -0.0409605967741936 | 0.0250630295191375 | SARC | Male-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs7422311 | chr2:106675214:C:T | Distant downstream | -0.0409605967741936 | 0.0250630295191375 | SARC | Male-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs2169159 | chr2:106684689:G:T | Distant downstream | -0.0409605967741936 | 0.0250630295191375 | SARC | Male-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs1512095 | chr2:106699331:T:C | Distant downstream | -0.0409605967741936 | 0.0250630295191375 | SARC | Male-baised sQTL |
| exon_skip_328415 | chr2:105881327:105882049 | Frame-shift | rs1512094 | chr2:106705203:A:T | Distant downstream | -0.0408091333333333 | 0.0331635775523921 | SARC | Male-baised sQTL |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of NCK2 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000071051 | NCK2 | C0001925 | Albuminuria | 1 | CTD_human |
| ENSG00000071051 | NCK2 | C0027726 | Nephrotic Syndrome | 1 | CTD_human |
| ENSG00000071051 | NCK2 | C0033687 | Proteinuria | 1 | CTD_human |
