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Gene: ENSG00000070366 |
Summary for SMG6 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000070366 | Gene symbol | SMG6 |
| Gene name | SMG6 nonsense mediated mRNA decay factor | |
| HGNC | 17809 | |
| Entrez ID | 23293 | |
| Gene type | protein_coding | |
| Synonyms | SMG6|KIAA0732|SMG-6|EST1A | |
| UniProtAcc | Q86US8 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| ENSG00000070366 | SMG6 | DB05036 | Grn163l | SmallMoleculeDrug |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for SMG6 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| SMG6 | 8.96e+02 | -1.01e+00 | 2.32e-01 | -4.37e+00 | 1.24e-05 | 7.13e-05 | BLCA |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for SMG6 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for SMG6 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Top |
Exon skipping events with PSI in TCGA for SMG6 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for SMG6 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for SMG6 |
| TFs related to SMG6. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| DLBC | ZNF418 | SMG6 | 1.54e+00 | 4.58e-05 | 4.14e+00 | 9.88e-01 | Female-biased |
| DLBC | ZNF79 | SMG6 | 2.08e+00 | 4.75e-04 | 3.84e+00 | 9.81e-01 | Female-biased |
| LGG | ZNF418 | SMG6 | 4.30e+00 | 9.88e-01 | 3.47e+00 | 1.48e-03 | Male-biased |
| PAAD | FOXL1 | SMG6 | 3.92e+00 | 9.82e-01 | 2.76e+00 | 1.77e-03 | Male-biased |
| PAAD | NKX3-1 | SMG6 | 4.27e+00 | 9.82e-01 | 3.40e+00 | 7.82e-03 | Male-biased |
| PAAD | NKX6-1 | SMG6 | 3.91e+00 | 9.81e-01 | 2.77e+00 | 1.89e-03 | Male-biased |
| PAAD | POU6F2 | SMG6 | 4.44e+00 | 9.82e-01 | 3.62e+00 | 1.07e-02 | Male-biased |
| PAAD | ZNF25 | SMG6 | 3.93e+00 | 9.83e-01 | 2.72e+00 | 1.31e-03 | Male-biased |
| PAAD | ZNF334 | SMG6 | 4.19e+00 | 9.89e-01 | 2.74e+00 | 3.93e-04 | Male-biased |
| PAAD | ZNF418 | SMG6 | 4.06e+00 | 9.87e-01 | 2.34e+00 | 8.06e-05 | Male-biased |
| PAAD | ZNF79 | SMG6 | 4.14e+00 | 9.88e-01 | 2.77e+00 | 6.12e-04 | Male-biased |
| SMG6 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for SMG6 |
| RBPs related to ES in SMG6. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| STAD | SAMD4A | exon_skip_285374 | 9.24e+00 | 9.95e-01 | 8.66e+00 | 1.64e-03 | Male-biased |
| UVM | PABPC3 | exon_skip_285379 | 8.48e+00 | 9.86e-01 | 8.16e+00 | 7.70e-03 | Male-biased |
| COAD | SAMD4A | exon_skip_285374 | 8.02e+00 | 2.88e-04 | 8.76e+00 | 9.94e-01 | Female-biased |
| LUAD | SAMD4A | exon_skip_285374 | 8.69e+00 | 9.84e-01 | 8.36e+00 | 9.95e-03 | Male-biased |
| MESO | SAMD4A | exon_skip_285374 | 8.77e+00 | 9.89e-01 | 8.37e+00 | 6.00e-03 | Male-biased |
| LGG | G3BP2 | exon_skip_285382 | 8.90e+00 | 1.07e-02 | 9.22e+00 | 9.86e-01 | Female-biased |
| KIRC | SAMD4A | exon_skip_285374 | 8.20e+00 | 2.86e-04 | 8.89e+00 | 9.95e-01 | Female-biased |
| SMG6 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs7213226 | chr17:11739753:G:A | - | 0.263613481067184 | 0.0433495525781099 | GBM | Female-baised eQTL |
| rs610542 | chr17:803934:C:G | - | 0.113533837245981 | 0.00789593635629312 | SARC | Female-baised eQTL |
| rs769433 | chr17:3116496:A:G | - | 0.0619289474573226 | 0.0455962392326499 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs8075754 | chr17:4012984:C:T | - | 0.0631845970058281 | 0.0118383296389578 | KIRC | Male-baised eQTL |
| rs3809805 | chr17:3801189:G:A | - | 0.059339014344566 | 0.0119122897900986 | KIRC | Male-baised eQTL |
| rs8075562 | chr17:4013529:G:A | - | 0.0633825581005605 | 0.0134664084692522 | KIRC | Male-baised eQTL |
| rs7213058 | chr17:4018961:C:T | - | 0.0634685819096304 | 0.0139813039581696 | KIRC | Male-baised eQTL |
| rs34673556 | chr17:1419725:C:T | - | 0.0718877103358339 | 0.0170454736111938 | KIRC | Male-baised eQTL |
| rs8072805 | chr17:4028722:A:G | - | 0.0604373316099534 | 0.0172912448534679 | KIRC | Male-baised eQTL |
| rs8070640 | chr17:1428512:A:G | - | 0.0712450855238524 | 0.0177101987539431 | KIRC | Male-baised eQTL |
| rs6502684 | chr17:1429366:T:C | - | 0.0712450855238524 | 0.0177101987539431 | KIRC | Male-baised eQTL |
| rs8079713 | chr17:1418658:G:A | - | 0.0716423539612317 | 0.0209644877509923 | KIRC | Male-baised eQTL |
| rs7219694 | chr17:4030984:G:A | - | 0.0599180793138258 | 0.0229658889734517 | KIRC | Male-baised eQTL |
| rs7215140 | chr17:4021019:A:G | - | 0.0597836166796905 | 0.0239075833980741 | KIRC | Male-baised eQTL |
| rs2290440 | chr17:4032581:T:C | - | 0.0594563216372192 | 0.0251649124854164 | KIRC | Male-baised eQTL |
| rs28384085 | chr17:4032584:C:A | - | 0.0594563216372192 | 0.0251649124854164 | KIRC | Male-baised eQTL |
| rs17175962 | chr17:4032749:C:T | - | 0.0594563216372192 | 0.0251649124854164 | KIRC | Male-baised eQTL |
| rs968114 | chr17:4032076:G:C | - | 0.0592780223206924 | 0.0264356673097893 | KIRC | Male-baised eQTL |
| rs8077342 | chr17:4017138:G:A | - | 0.0591103317888399 | 0.0340205701785602 | KIRC | Male-baised eQTL |
| rs938624 | chr17:4011190:T:C | - | 0.0545462964408239 | 0.0372840698261909 | KIRC | Male-baised eQTL |
| rs7216360 | chr17:4016185:C:T | - | 0.0584411157518128 | 0.0376691200758342 | KIRC | Male-baised eQTL |
| rs142930007 | chr17:4015594:G:A | - | 0.0578173819856567 | 0.0421823127550911 | KIRC | Male-baised eQTL |
| rs7219971 | chr17:3934175:C:T | - | 0.0884618454088645 | 0.000762999714587297 | BLCA | Male-baised eQTL |
| rs2309409 | chr17:5816429:G:A | - | -0.0759681946279133 | 0.0200934187125377 | BLCA | Male-baised eQTL |
| rs2003219 | chr17:5818129:T:C | - | 0.0759329657129643 | 0.020284008268971 | BLCA | Male-baised eQTL |
| rs8070115 | chr17:5815679:A:G | - | -0.0743387211290523 | 0.0248764505101483 | BLCA | Male-baised eQTL |
| rs144081692 | chr17:10461718:A:G | - | 0.153781678815968 | 0.000277248946902732 | COAD | Male-baised eQTL |
| rs76739945 | chr17:1513661:C:T | - | 0.143299886904252 | 0.000784581254769353 | COAD | Male-baised eQTL |
| rs79951144 | chr17:1515271:G:A | - | 0.14313361463 | 0.000971937856216233 | COAD | Male-baised eQTL |
| rs330996 | chr17:711141:T:A | - | 0.0828686862315662 | 0.00119930502317642 | COAD | Male-baised eQTL |
| rs79149826 | chr17:1515689:C:T | - | 0.140146915985283 | 0.00120461120851019 | COAD | Male-baised eQTL |
| rs863331 | chr17:675441:C:T | - | 0.0861053731014871 | 0.00129093072835806 | COAD | Male-baised eQTL |
| rs2740366 | chr17:684861:G:A | - | 0.0861053731014871 | 0.00129093072835806 | COAD | Male-baised eQTL |
| rs2740365 | chr17:685091:T:C | - | 0.0861053731014871 | 0.00129093072835806 | COAD | Male-baised eQTL |
| rs112040320 | chr17:1503153:T:C | - | 0.132883166553678 | 0.0017086530890954 | COAD | Male-baised eQTL |
| rs8069517 | chr17:1504603:G:A | - | 0.132883166553678 | 0.0017086530890954 | COAD | Male-baised eQTL |
| rs79052505 | chr17:1506565:C:T | - | 0.132883166553678 | 0.0017086530890954 | COAD | Male-baised eQTL |
| rs78092914 | chr17:1507163:G:C | - | 0.132883166553678 | 0.0017086530890954 | COAD | Male-baised eQTL |
| rs79638085 | chr17:1507386:T:C | - | 0.132883166553678 | 0.0017086530890954 | COAD | Male-baised eQTL |
| rs111839189 | chr17:1507390:T:C | - | 0.132883166553678 | 0.0017086530890954 | COAD | Male-baised eQTL |
| rs76565961 | chr17:1507543:T:G | - | 0.132883166553678 | 0.0017086530890954 | COAD | Male-baised eQTL |
| rs112877133 | chr17:1507588:T:G | - | 0.132883166553678 | 0.0017086530890954 | COAD | Male-baised eQTL |
| rs80111666 | chr17:1503880:G:A | - | 0.132250328627187 | 0.00186356084757181 | COAD | Male-baised eQTL |
| rs4968101 | chr17:707786:C:A | - | -0.0770647701061505 | 0.00234664114399778 | COAD | Male-baised eQTL |
| rs430526 | chr17:651618:T:C | - | 0.0777441725228563 | 0.0042969786344135 | COAD | Male-baised eQTL |
| rs11870439 | chr17:930550:G:T | - | 0.0683574274167543 | 0.00499082674271844 | COAD | Male-baised eQTL |
| rs11870473 | chr17:930682:G:T | - | 0.0677963361994523 | 0.00601909858871836 | COAD | Male-baised eQTL |
| rs11867490 | chr17:930747:C:T | - | 0.0677963361994523 | 0.00601909858871836 | COAD | Male-baised eQTL |
| rs61635664 | chr17:930810:T:C | - | 0.0677963361994523 | 0.00601909858871836 | COAD | Male-baised eQTL |
| rs62067206 | chr17:930935:C:G | - | 0.0677963361994523 | 0.00601909858871836 | COAD | Male-baised eQTL |
| rs56272814 | chr17:931168:G:T | - | 0.0675946554095853 | 0.00904103722630544 | COAD | Male-baised eQTL |
| rs55990547 | chr17:931178:A:G | - | 0.0675946554095853 | 0.00904103722630544 | COAD | Male-baised eQTL |
| rs62067210 | chr17:931223:G:T | - | 0.0675946554095853 | 0.00904103722630544 | COAD | Male-baised eQTL |
| rs5019588 | chr17:8723539:T:G | - | -0.0761183168345513 | 0.0102265933030981 | COAD | Male-baised eQTL |
| rs78479027 | chr17:11693554:C:T | - | 0.0898439526202688 | 0.0131431297899163 | COAD | Male-baised eQTL |
| rs4791326 | chr17:8728470:G:A | - | -0.0733105173081461 | 0.0150297643530681 | COAD | Male-baised eQTL |
| rs399840 | chr17:694767:G:A | - | 0.0759606534237536 | 0.0171011880447472 | COAD | Male-baised eQTL |
| rs4791747 | chr17:8723377:A:G | - | -0.0714687388810756 | 0.0189039962470077 | COAD | Male-baised eQTL |
| rs7224930 | chr17:1526393:T:A | - | 0.112589988477043 | 0.0296117687077946 | COAD | Male-baised eQTL |
| rs11867444 | chr17:930497:C:T | - | 0.061803234881518 | 0.0302444961037176 | COAD | Male-baised eQTL |
| rs448465 | chr17:656648:A:T | - | 0.0585767192584404 | 0.0321891856848928 | COAD | Male-baised eQTL |
| rs736626 | chr17:11670266:A:G | - | 0.0794523586045952 | 0.0368541066742422 | COAD | Male-baised eQTL |
| rs483734 | chr17:10708112:G:A | - | 0.0551938168042244 | 0.0385995226832379 | COAD | Male-baised eQTL |
| rs6502938 | chr17:6242338:T:C | - | 0.0608414407394821 | 0.0399215078895575 | COAD | Male-baised eQTL |
| rs78211011 | chr17:11674584:A:G | - | 0.0767235643079127 | 0.0452723946993015 | COAD | Male-baised eQTL |
| rs7215874 | chr17:8725314:T:C | - | -0.0584000698058573 | 0.0472023222342064 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000070366 |
| CpG Site: cg26927232 | |
| Position to Gene: gene | |
| Male Effect: -0.246627369662041 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg26927232 | chr17:2232337 | gene | -0.246627369662041 | 1.70970855212228e-06 | -0.3853002499979309 | 2.6350299051346593e-09 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of SMG6 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
