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Gene: ENSG00000068985 |
Summary for PAGE1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000068985 | Gene symbol | PAGE1 |
| Gene name | PAGE family member 1 | |
| HGNC | 4107 | |
| Entrez ID | 8712 | |
| Gene type | protein_coding | |
| Synonyms | PAGE1|PAGE-1|GAGE-9|CT16.3 | |
| UniProtAcc | O75459 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for PAGE1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| PAGE1 | 1.96e+01 | -1.70e+00 | 3.41e-01 | -4.98e+00 | 6.27e-07 | 1.06e-04 | STAD |
| PAGE1 | 4.57e+01 | 1.38e+00 | 5.28e-01 | 2.62e+00 | 8.83e-03 | 3.62e-02 | LIHC |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| PAGE1 | 4.94e+00 | 3.43e+00 | 8.51e-01 | 4.03e+00 | 5.48e-05 | 9.49e-05 | LUSC |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| PAGE1 | 3.17e+01 | 4.75e+00 | 1.20e+00 | 3.94e+00 | 8.03e-05 | 7.55e-04 | STAD |
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Sex-biased somatic mutation for PAGE1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for PAGE1 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LGG | cg03369828 | chrX:49695805 | CGI:chrX:49598934-49599547 | promoter,gene body | 7.34e-01 | 9.19e-01 | -1.52e+01 | 5.28e-52 | 5.85e-51 | -1.86e-01 |
| THCA | cg03369828 | chrX:49695805 | CGI:chrX:49598934-49599547 | promoter,gene body | 7.90e-01 | 9.06e-01 | -1.28e+01 | 1.78e-37 | 1.43e-36 | -1.16e-01 |
| LIHC | cg10796634 | chrX:49696002 | CGI:chrX:49598934-49599547 | promoter | 3.83e-01 | 2.81e-01 | -3.85e+00 | 1.20e-04 | 8.09e-04 | 1.02e-01 |
| GBM | cg03369828 | chrX:49695805 | CGI:chrX:49598934-49599547 | promoter,gene body | 6.60e-01 | 8.13e-01 | -2.69e+00 | 7.05e-03 | 1.96e-02 | -1.52e-01 |
| CHOL | cg10796634 | chrX:49696002 | CGI:chrX:49598934-49599547 | promoter | 7.43e-01 | 8.61e-01 | -2.90e+00 | 3.77e-03 | 1.04e-02 | -1.18e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUAD | cg07882687 | chrX:49696005 | CGI:chrX:49598934-49599547 | promoter | 8.32e-01 | 9.51e-01 | -4.09e+00 | 4.27e-05 | 1.38e-04 | -1.19e-01 |
| LUSC | cg03369828 | chrX:49695805 | CGI:chrX:49598934-49599547 | promoter,gene body | 6.62e-01 | 9.51e-01 | -4.14e+00 | 3.54e-05 | 5.30e-04 | -2.89e-01 |
| LUSC | cg07882687 | chrX:49696005 | CGI:chrX:49598934-49599547 | promoter | 7.58e-01 | 9.49e-01 | -3.80e+00 | 1.44e-04 | 8.22e-04 | -1.91e-01 |
| ESCA | cg07882687 | chrX:49696005 | CGI:chrX:49598934-49599547 | promoter | 7.75e-01 | 9.35e-01 | -2.46e+00 | 1.38e-02 | 3.76e-02 | -1.60e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg10796634 | chrX:49696002 | CGI:chrX:49598934-49599547 | promoter | 6.63e-01 | 9.39e-01 | -1.08e+01 | 2.66e-27 | 2.84e-26 | -2.76e-01 |
| BRCA | cg03369828 | chrX:49695805 | CGI:chrX:49598934-49599547 | promoter,gene body | 5.73e-01 | 8.65e-01 | -1.24e+01 | 2.45e-35 | 7.63e-34 | -2.92e-01 |
| BRCA | cg07882687 | chrX:49696005 | CGI:chrX:49598934-49599547 | promoter | 7.31e-01 | 9.20e-01 | -1.08e+01 | 5.08e-27 | 5.27e-26 | -1.89e-01 |
| KIRC | cg03369828 | chrX:49695805 | CGI:chrX:49598934-49599547 | promoter,gene body | 7.92e-01 | 9.40e-01 | -3.25e+00 | 1.17e-03 | 4.87e-03 | -1.47e-01 |
| LUAD | cg10796634 | chrX:49696002 | CGI:chrX:49598934-49599547 | promoter | 8.26e-01 | 9.53e-01 | -2.68e+00 | 7.42e-03 | 1.27e-02 | -1.26e-01 |
| THCA | cg03369828 | chrX:49695805 | CGI:chrX:49598934-49599547 | promoter,gene body | 7.90e-01 | 9.20e-01 | -7.40e+00 | 1.35e-13 | 8.74e-12 | -1.30e-01 |
| HNSC | cg10796634 | chrX:49696002 | CGI:chrX:49598934-49599547 | promoter | 7.62e-01 | 9.52e-01 | -2.94e+00 | 3.27e-03 | 1.13e-02 | -1.90e-01 |
| COAD | cg10796634 | chrX:49696002 | CGI:chrX:49598934-49599547 | promoter | 8.04e-01 | 9.52e-01 | -2.27e+00 | 2.30e-02 | 2.88e-02 | -1.48e-01 |
| BLCA | cg10796634 | chrX:49696002 | CGI:chrX:49598934-49599547 | promoter | 5.12e-01 | 9.39e-01 | -3.44e+00 | 5.71e-04 | 3.81e-03 | -4.26e-01 |
| LIHC | cg10796634 | chrX:49696002 | CGI:chrX:49598934-49599547 | promoter | 3.83e-01 | 8.68e-01 | -3.07e+00 | 2.11e-03 | 4.06e-03 | -4.84e-01 |
| KIRP | cg10796634 | chrX:49696002 | CGI:chrX:49598934-49599547 | promoter | 8.63e-01 | 9.64e-01 | -3.37e+00 | 7.47e-04 | 3.27e-03 | -1.01e-01 |
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Exon skipping events with PSI in TCGA for PAGE1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for PAGE1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for PAGE1 |
| TFs related to PAGE1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BRCA | POU3F3 | PAGE1 | 3.28e+00 | 4.89e-03 | 4.72e+00 | 9.88e-01 | Female-biased |
| BRCA | ZNF423 | PAGE1 | 4.57e+00 | 9.85e-01 | 3.26e+00 | 7.81e-03 | Male-biased |
| BRCA | ZNF879 | PAGE1 | 2.61e+00 | 6.58e-04 | 4.68e+00 | 9.92e-01 | Female-biased |
| SARC | PATZ1 | PAGE1 | 4.12e+00 | 9.83e-01 | 3.37e+00 | 3.27e-03 | Male-biased |
| PAGE1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for PAGE1 |
| RBPs related to ES in PAGE1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| PAGE1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000068985 |
| CpG Site: cg03369828 | |
| Position to Gene: gene,promoter | |
| Male Effect: -0.124860667193947 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg03369828 | chrX:49695805 | gene,promoter | -0.124860667193947 | 1.26777461166986e-06 | -0.3879062789234077 | 2.0152233119889075e-09 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of PAGE1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
