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Gene: ENSG00000068024 |
Summary for HDAC4 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000068024 | Gene symbol | HDAC4 |
| Gene name | histone deacetylase 4 | |
| HGNC | 14063 | |
| Entrez ID | 9759 | |
| Gene type | protein_coding | |
| Synonyms | HDAC4|KIAA0288|HDAC-A|HDACA|HD4|HA6116|HDAC-4 | |
| UniProtAcc | P56524 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| ENSG00000068024 | HDAC4 | DB01593 | Zinc | SmallMoleculeDrug |
| ENSG00000068024 | HDAC4 | DB06176 | Romidepsin | SmallMoleculeDrug |
| ENSG00000068024 | HDAC4 | DB07879 | N-hydroxy-5-[(3-phenyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)carbonyl]thiophene-2-carboxamide | SmallMoleculeDrug |
| ENSG00000068024 | HDAC4 | DB08613 | 2,2,2-TRIFLUORO-1-{5-[(3-PHENYL-5,6-DIHYDROIMIDAZO[1,2-A]PYRAZIN-7(8H)-YL)CARBONYL]THIOPHEN-2-YL}ETHANE-1,1-DIOL | SmallMoleculeDrug |
| ENSG00000068024 | HDAC4 | DB14487 | Zinc acetate | SmallMoleculeDrug |
| ENSG00000068024 | HDAC4 | DB14533 | Zinc chloride | SmallMoleculeDrug |
| ENSG00000068024 | HDAC4 | DB14548 | Zinc sulfate, unspecified form | SmallMoleculeDrug |
| ENSG00000068024 | HDAC4 | DB05015 | Belinostat | SmallMoleculeDrug |
| ENSG00000068024 | HDAC4 | DB06603 | Panobinostat | SmallMoleculeDrug |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
| ENSG00000068024 | HDAC4 | DB06176 | Romidepsin | SmallMoleculeDrug | Non-Hodgkin Lymphoma |
| ENSG00000068024 | HDAC4 | DB05015 | Belinostat | SmallMoleculeDrug | Non-Hodgkin Lymphoma |
Top |
Structure and expression level for HDAC4 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| HDAC4 | 4.52e+02 | 1.05e+00 | 2.16e-01 | 4.87e+00 | 1.14e-06 | 8.08e-06 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| HDAC4 | 2.21e+03 | -1.21e+00 | 2.87e-01 | -4.22e+00 | 2.47e-05 | 2.89e-04 | STAD |
| HDAC4 | 1.01e+03 | -1.14e+00 | 1.94e-01 | -5.86e+00 | 4.52e-09 | 7.88e-08 | READ |
Top |
Sex-biased somatic mutation for HDAC4 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for HDAC4 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Top |
Exon skipping events with PSI in TCGA for HDAC4 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for HDAC4 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for HDAC4 |
| TFs related to HDAC4. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| MESO | ARGFX | HDAC4 | 3.11e+00 | 1.06e-02 | 4.36e+00 | 9.80e-01 | Female-biased |
| MESO | FOXA1 | HDAC4 | 2.25e+00 | 2.31e-03 | 3.94e+00 | 9.82e-01 | Female-biased |
| MESO | NKX3-1 | HDAC4 | 2.77e+00 | 6.30e-03 | 4.18e+00 | 9.82e-01 | Female-biased |
| MESO | PHOX2B | HDAC4 | 2.72e+00 | 6.50e-03 | 4.11e+00 | 9.81e-01 | Female-biased |
| MESO | ZNF334 | HDAC4 | 1.98e+00 | 5.88e-04 | 4.03e+00 | 9.86e-01 | Female-biased |
| MESO | ZNF418 | HDAC4 | 1.48e+00 | 8.23e-05 | 3.99e+00 | 9.85e-01 | Female-biased |
| HDAC4 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for HDAC4 |
| RBPs related to ES in HDAC4. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| HDAC4 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000068024 | FAM66C,hsa-mir-223,HDAC4 | Female-specific ceRNA | TCGA-STAD |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs6747176 | chr2:233879896:T:A | - | 0.128262137161476 | 0.022870209672435 | HNSC | Female-baised eQTL |
| rs58334066 | chr2:233877940:T:C | - | 0.127657141746145 | 0.0246097303621585 | HNSC | Female-baised eQTL |
| rs11889966 | chr2:238024503:G:A | - | 0.189213483027709 | 0.0121773766635721 | SARC | Female-baised eQTL |
| rs11694673 | chr2:237971389:C:G | - | 0.2229121656135 | 0.0213515839399902 | SARC | Female-baised eQTL |
| rs72981226 | chr2:237978386:G:A | - | 0.175660810188159 | 0.0272501794757944 | SARC | Female-baised eQTL |
| rs6721313 | chr2:238010333:C:T | - | 0.175660810188159 | 0.0272501794757944 | SARC | Female-baised eQTL |
| rs113096700 | chr2:238034415:C:T | - | 0.175230881125743 | 0.0284024513667255 | SARC | Female-baised eQTL |
| rs10929263 | chr2:238031479:C:T | - | 0.193188054627675 | 0.0440763503266284 | SARC | Female-baised eQTL |
| rs2100335 | chr2:236669870:T:C | - | 0.0606530699047971 | 0.0158316257420934 | KIRC | Female-baised eQTL |
| rs2100334 | chr2:236669886:T:C | - | 0.0597806102399932 | 0.0173854867969579 | KIRC | Female-baised eQTL |
| rs2720111 | chr2:236670378:A:C | - | 0.0596257648657392 | 0.021192465039351 | KIRC | Female-baised eQTL |
| rs6707173 | chr2:240297366:A:G | - | -0.0842271605180331 | 0.0425421266785638 | KIRC | Female-baised eQTL |
| rs6414221 | chr2:240299205:A:G | - | -0.0842271605180331 | 0.0425421266785638 | KIRC | Female-baised eQTL |
| rs36030965 | chr2:241615411:C:A | - | 0.0619526756015594 | 0.00169216690858279 | LUAD | Female-baised eQTL |
| rs6704945 | chr2:241610891:G:A | - | 0.0615086944957565 | 0.00194203254238771 | LUAD | Female-baised eQTL |
| rs77289808 | chr2:241643616:A:G | - | 0.0624890196575565 | 0.00208362708726473 | LUAD | Female-baised eQTL |
| rs34692098 | chr2:241611120:T:G | - | 0.0612012063843764 | 0.00239241571321784 | LUAD | Female-baised eQTL |
| rs74270774 | chr2:241642393:T:A | - | 0.0616885464171274 | 0.00256670015959786 | LUAD | Female-baised eQTL |
| rs76623362 | chr2:241643576:A:G | - | 0.0616885464171274 | 0.00256670015959786 | LUAD | Female-baised eQTL |
| rs74270776 | chr2:241643879:G:A | - | 0.0616885464171274 | 0.00256670015959786 | LUAD | Female-baised eQTL |
| rs13419882 | chr2:241620877:T:C | - | 0.0604681220399632 | 0.00262498483464793 | LUAD | Female-baised eQTL |
| rs78065183 | chr2:241611955:T:C | - | 0.0605891924026847 | 0.00264485672728764 | LUAD | Female-baised eQTL |
| rs75334585 | chr2:241611959:G:A | - | 0.0605891924026847 | 0.00264485672728764 | LUAD | Female-baised eQTL |
| rs77031298 | chr2:241612964:T:C | - | 0.0605891924026847 | 0.00264485672728764 | LUAD | Female-baised eQTL |
| rs78208736 | chr2:241639860:G:T | - | 0.0612682703894578 | 0.00269266119912693 | LUAD | Female-baised eQTL |
| rs77584381 | chr2:241635088:C:T | - | 0.0609489810967872 | 0.00290463934557172 | LUAD | Female-baised eQTL |
| rs139536005 | chr2:241636401:G:A | - | 0.0609489810967872 | 0.00290463934557172 | LUAD | Female-baised eQTL |
| rs76235535 | chr2:241627178:T:C | - | 0.0608032313210814 | 0.00298983054247854 | LUAD | Female-baised eQTL |
| rs75369589 | chr2:241618139:C:T | - | 0.0594028016628861 | 0.00352208005070584 | LUAD | Female-baised eQTL |
| rs74270771 | chr2:241624150:A:G | - | 0.0599961123893753 | 0.00367787069117191 | LUAD | Female-baised eQTL |
| rs28881829 | chr2:241626224:T:C | - | 0.0599961123893753 | 0.00367787069117191 | LUAD | Female-baised eQTL |
| rs111750263 | chr2:241626762:C:G | - | 0.0599961123893753 | 0.00367787069117191 | LUAD | Female-baised eQTL |
| rs142425659 | chr2:241629347:T:C | - | 0.0599961123893753 | 0.00367787069117191 | LUAD | Female-baised eQTL |
| rs13419983 | chr2:241620926:T:C | - | 0.0593161214752816 | 0.00382510863036165 | LUAD | Female-baised eQTL |
| rs60760164 | chr2:231017241:A:G | - | 0.0809350953591558 | 0.00495043266766437 | LUAD | Female-baised eQTL |
| rs7557052 | chr2:241671087:G:T | - | -0.0413690915995065 | 0.00758261648412796 | LUAD | Female-baised eQTL |
| rs62190356 | chr2:241676459:T:C | - | -0.0418219750918591 | 0.00766152247041188 | LUAD | Female-baised eQTL |
| rs62190298 | chr2:241667432:T:C | - | -0.0410517178459769 | 0.00819105087514438 | LUAD | Female-baised eQTL |
| rs6757704 | chr2:241667096:T:C | - | -0.0408729136359219 | 0.00843078663350399 | LUAD | Female-baised eQTL |
| rs10204538 | chr2:232216873:T:C | - | 0.0748754609717961 | 0.00921275255129128 | LUAD | Female-baised eQTL |
| rs7559229 | chr2:241674345:T:C | - | -0.0406465604964101 | 0.00992807960185744 | LUAD | Female-baised eQTL |
| rs5860 | chr2:241676047:T:C | - | -0.0402172708620078 | 0.010593090058543 | LUAD | Female-baised eQTL |
| rs34127355 | chr2:241672927:G:T | - | -0.0389120535826146 | 0.0155245483680045 | LUAD | Female-baised eQTL |
| rs723044 | chr2:232014961:C:T | - | 0.0851706025166207 | 0.0160782107947735 | LUAD | Female-baised eQTL |
| rs3209928 | chr2:241673072:C:T | - | -0.0386310669342871 | 0.0165654053634384 | LUAD | Female-baised eQTL |
| rs4429463 | chr2:231018632:G:C | - | 0.0642441016523586 | 0.0339264487055509 | LUAD | Female-baised eQTL |
| rs1130905 | chr2:241673369:T:G | - | -0.0357180230914219 | 0.0348191545023504 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs371232045 | chr2:230844195:G:A | - | 0.0933613531863833 | 0.00429018339122562 | KIRC | Male-baised eQTL |
| rs79971534 | chr2:230856768:C:T | - | 0.0797112406770759 | 0.0126617244929495 | KIRC | Male-baised eQTL |
| rs1669071 | chr2:231328505:G:A | - | 0.0406114381034027 | 0.0204035494373027 | KIRC | Male-baised eQTL |
| rs1669072 | chr2:231328602:T:A | - | 0.0403881371857433 | 0.0209657667413672 | KIRC | Male-baised eQTL |
| rs1729079 | chr2:231328010:C:G | - | 0.0400505026775256 | 0.0225304008867526 | KIRC | Male-baised eQTL |
| rs1729080 | chr2:231328320:G:C | - | 0.0385597425487915 | 0.0328064667457817 | KIRC | Male-baised eQTL |
| rs13403951 | chr2:231328791:C:T | - | 0.0390226670401446 | 0.0370359604147318 | KIRC | Male-baised eQTL |
| rs11685399 | chr2:237734619:T:C | - | 0.0663511390790759 | 0.0380624404617657 | KIRC | Male-baised eQTL |
| rs4852079 | chr2:238977631:A:G | - | -0.0541973778159575 | 0.0158013117580289 | BLCA | Male-baised eQTL |
| rs72992617 | chr2:239298718:C:T | gene | 0.046767778176451 | 0.0103534051380494 | LUAD | Male-baised eQTL |
| rs76488131 | chr2:240292103:G:A | - | 0.0429944402674228 | 0.0192955210556452 | LUAD | Male-baised eQTL |
| rs6707173 | chr2:240297366:A:G | - | -0.0396158982902672 | 0.0277648770512887 | LUAD | Male-baised eQTL |
| rs13026302 | chr2:239700604:T:C | - | 0.0717710110947669 | 0.0176800838740162 | COAD | Male-baised eQTL |
| rs12694864 | chr2:230414506:C:T | - | 0.0986444136124171 | 0.0212701025027145 | COAD | Male-baised eQTL |
| rs12618815 | chr2:240132846:C:T | - | 0.0723211846678115 | 0.0294018963896989 | COAD | Male-baised eQTL |
| rs28513094 | chr2:240444661:C:G | - | -0.0620172097078841 | 0.0297623420852956 | COAD | Male-baised eQTL |
| rs10933603 | chr2:240444317:C:T | - | -0.0611939867613057 | 0.0316151669412518 | COAD | Male-baised eQTL |
| rs747740 | chr2:240133626:C:G | - | 0.0712144145151019 | 0.0316877082282511 | COAD | Male-baised eQTL |
| rs10933604 | chr2:240444550:G:A | - | -0.0607872761792676 | 0.0334930076531515 | COAD | Male-baised eQTL |
| rs10933602 | chr2:240444216:G:A | - | -0.0604997260720287 | 0.0360021784797516 | COAD | Male-baised eQTL |
| rs13427735 | chr2:242011715:A:G | - | 0.0615962460219948 | 0.0411901185423672 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000068024 |
| CpG Site: cg03743462 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.384924633951857 | |
 | Gene ID: ENSG00000068024 |
| CpG Site: cg21656251 | |
| Position to Gene: gene | |
| Male Effect: -0.489865920186861 | |
| Female Effect: - | |
 | Gene ID: ENSG00000068024 |
| CpG Site: cg06609498 | |
| Position to Gene: gene | |
| Male Effect: -0.489865920186861 | |
| Female Effect: - | |
 | Gene ID: ENSG00000068024 |
| CpG Site: cg10639368 | |
| Position to Gene: gene | |
| Male Effect: -0.489865920186861 | |
| Female Effect: - | |
 | Gene ID: ENSG00000068024 |
| CpG Site: cg10629128 | |
| Position to Gene: gene | |
| Male Effect: -0.489865920186861 | |
| Female Effect: - | |
 | Gene ID: ENSG00000068024 |
| CpG Site: cg15637254 | |
| Position to Gene: gene | |
| Male Effect: -0.489865920186861 | |
| Female Effect: - | |
 | Gene ID: ENSG00000068024 |
| CpG Site: cg18479711 | |
| Position to Gene: gene | |
| Male Effect: -0.247795192162107 | |
| Female Effect: - | |
 | Gene ID: ENSG00000068024 |
| CpG Site: cg07222900 | |
| Position to Gene: gene | |
| Male Effect: -0.128046274772122 | |
| Female Effect: - | |
 | Gene ID: ENSG00000068024 |
| CpG Site: cg07222900 | |
| Position to Gene: gene | |
| Male Effect: -0.413526364333295 | |
| Female Effect: - | |
 | Gene ID: ENSG00000068024 |
| CpG Site: cg05997414 | |
| Position to Gene: gene | |
| Male Effect: -0.433184371473996 | |
| Female Effect: - | |
 | Gene ID: ENSG00000068024 |
| CpG Site: cg14273620 | |
| Position to Gene: gene | |
| Male Effect: -0.433184371473996 | |
| Female Effect: - | |
 | Gene ID: ENSG00000068024 |
| CpG Site: cg07134930 | |
| Position to Gene: gene | |
| Male Effect: -0.433184371473996 | |
| Female Effect: - | |
 | Gene ID: ENSG00000068024 |
| CpG Site: cg09322899 | |
| Position to Gene: gene | |
| Male Effect: -0.433184371473996 | |
| Female Effect: - | |
 | Gene ID: ENSG00000068024 |
| CpG Site: cg15637254 | |
| Position to Gene: gene | |
| Male Effect: -0.432952154860738 | |
| Female Effect: - | |
 | Gene ID: ENSG00000068024 |
| CpG Site: cg06257052 | |
| Position to Gene: gene | |
| Male Effect: -0.195335721974621 | |
| Female Effect: - | |
 | Gene ID: ENSG00000068024 |
| CpG Site: cg03475776 | |
| Position to Gene: gene | |
| Male Effect: -0.396204805718364 | |
| Female Effect: - | |
 | Gene ID: ENSG00000068024 |
| CpG Site: cg25521439 | |
| Position to Gene: gene | |
| Male Effect: -0.396204805718364 | |
| Female Effect: - | |
 | Gene ID: ENSG00000068024 |
| CpG Site: cg27074582 | |
| Position to Gene: gene | |
| Male Effect: -0.396204805718364 | |
| Female Effect: - | |
 | Gene ID: ENSG00000068024 |
| CpG Site: cg06142743 | |
| Position to Gene: gene | |
| Male Effect: -0.396204805718364 | |
| Female Effect: - | |
 | Gene ID: ENSG00000068024 |
| CpG Site: cg03169059 | |
| Position to Gene: gene | |
| Male Effect: -0.396204805718364 | |
| Female Effect: - | |
 | Gene ID: ENSG00000068024 |
| CpG Site: cg17356036 | |
| Position to Gene: gene | |
| Male Effect: -0.396204805718364 | |
| Female Effect: - | |
 | Gene ID: ENSG00000068024 |
| CpG Site: cg10629128 | |
| Position to Gene: gene | |
| Male Effect: -0.396204805718364 | |
| Female Effect: - | |
 | Gene ID: ENSG00000068024 |
| CpG Site: cg27587095 | |
| Position to Gene: gene | |
| Male Effect: -0.402333931652788 | |
| Female Effect: - | |
 | Gene ID: ENSG00000068024 |
| CpG Site: cg10515232 | |
| Position to Gene: gene | |
| Male Effect: -0.402333931652788 | |
| Female Effect: - | |
 | Gene ID: ENSG00000068024 |
| CpG Site: cg20149840 | |
| Position to Gene: gene | |
| Male Effect: -0.402333931652788 | |
| Female Effect: - | |
 | Gene ID: ENSG00000068024 |
| CpG Site: cg16887422 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.396016822116834 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg21656251 | chr2:239110004 | gene | -0.489865920186861 | 3.32512998530014e-145 | -0.977358338691305 | 4.7196310122131344e-151 | LUAD |
| cg06609498 | chr2:239311545 | gene | -0.489865920186861 | 3.32512998530014e-145 | -0.977358338691305 | 4.7196310122131344e-151 | LUAD |
| cg10639368 | chr2:239319523 | gene | -0.489865920186861 | 3.32512998530014e-145 | -0.977358338691305 | 4.7196310122131344e-151 | LUAD |
| cg10629128 | chr2:239358343 | gene | -0.489865920186861 | 3.32512998530014e-145 | -0.977358338691305 | 4.7196310122131344e-151 | LUAD |
| cg15637254 | chr2:239358562 | gene | -0.489865920186861 | 3.32512998530014e-145 | -0.977358338691305 | 4.7196310122131344e-151 | LUAD |
| cg18479711 | chr2:239109758 | gene | -0.247795192162107 | 3.48650851627454e-28 | -0.6878665799105502 | 1.3647958647944613e-32 | LUAD |
| cg07222900 | chr2:239358281 | gene | -0.128046274772122 | 1.08803956925273e-12 | -0.5103708581153336 | 3.4282417331891834e-16 | LUAD |
| cg07222900 | chr2:239358281 | gene | -0.413526364333295 | 2.61277111465728e-15 | -0.5475221135319537 | 1.3177914754072583e-18 | STAD |
| cg05997414 | chr2:239230780 | gene | -0.433184371473996 | 1.50055850907307e-07 | -0.4008429794285136 | 6.727520537553894e-10 | STAD |
| cg14273620 | chr2:239249161 | gene | -0.433184371473996 | 1.50055850907307e-07 | -0.4008429794285136 | 6.727520537553894e-10 | STAD |
| cg07134930 | chr2:239254354 | gene | -0.433184371473996 | 1.50055850907307e-07 | -0.4008429794285136 | 6.727520537553894e-10 | STAD |
| cg09322899 | chr2:239358522 | gene | -0.433184371473996 | 1.50055850907307e-07 | -0.4008429794285136 | 6.727520537553894e-10 | STAD |
| cg15637254 | chr2:239358562 | gene | -0.432952154860738 | 1.53327006609414e-07 | -0.401752346193378 | 8.003595503942504e-10 | STAD |
| cg06257052 | chr2:239195526 | gene | -0.195335721974621 | 1.71928725812766e-07 | -0.4062819608755288 | 1.646798904042055e-09 | STAD |
| cg03475776 | chr2:239192602 | gene | -0.396204805718364 | 4.20286955904655e-06 | -0.37170035817346836 | 1.29393230281201e-08 | STAD |
| cg25521439 | chr2:239192652 | gene | -0.396204805718364 | 4.20286955904655e-06 | -0.37170035817346836 | 1.29393230281201e-08 | STAD |
| cg27074582 | chr2:239192710 | gene | -0.396204805718364 | 4.20286955904655e-06 | -0.37170035817346836 | 1.29393230281201e-08 | STAD |
| cg06142743 | chr2:239195209 | gene | -0.396204805718364 | 4.20286955904655e-06 | -0.37170035817346836 | 1.29393230281201e-08 | STAD |
| cg03169059 | chr2:239223326 | gene | -0.396204805718364 | 4.20286955904655e-06 | -0.37170035817346836 | 1.29393230281201e-08 | STAD |
| cg17356036 | chr2:239291362 | gene | -0.396204805718364 | 4.20286955904655e-06 | -0.37170035817346836 | 1.29393230281201e-08 | STAD |
| cg10629128 | chr2:239358343 | gene | -0.396204805718364 | 4.20286955904655e-06 | -0.37170035817346836 | 1.29393230281201e-08 | STAD |
| cg27587095 | chr2:239140490 | gene | -0.402333931652788 | 1.06951464910171e-08 | -0.37917986505672474 | 2.0330350966959374e-11 | SKCM |
| cg10515232 | chr2:239140657 | gene | -0.402333931652788 | 1.06951464910171e-08 | -0.37917986505672474 | 2.0330350966959374e-11 | SKCM |
| cg20149840 | chr2:239213381 | gene | -0.402333931652788 | 1.06951464910171e-08 | -0.37917986505672474 | 2.0330350966959374e-11 | SKCM |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg03743462 | chr2:239197262 | gene | -0.384924633951857 | 3.02593512731974e-06 | -0.6114750848258851 | 9.114863287879626e-09 | KIRP |
| cg16887422 | chr2:239113411 | gene | -0.396016822116834 | 1.0217338033135e-06 | -0.4336972314209872 | 1.3229207759944916e-09 | SKCM |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of HDAC4 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000068024 | HDAC4 | C0005684 | Malignant neoplasm of urinary bladder | 1 | CTD_human |
| ENSG00000068024 | HDAC4 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
| ENSG00000068024 | HDAC4 | C0009171 | Cocaine Abuse | 1 | CTD_human |
| ENSG00000068024 | HDAC4 | C0011570 | Mental Depression | 1 | PSYGENET |
| ENSG00000068024 | HDAC4 | C0011616 | Contact Dermatitis | 1 | CTD_human |
| ENSG00000068024 | HDAC4 | C0020796 | Profound Mental Retardation | 1 | CTD_human |
| ENSG00000068024 | HDAC4 | C0025363 | Mental Retardation, Psychosocial | 1 | CTD_human |
| ENSG00000068024 | HDAC4 | C0036341 | Schizophrenia | 2 | PSYGENET |
| ENSG00000068024 | HDAC4 | C0162351 | Contact hypersensitivity | 1 | CTD_human |
| ENSG00000068024 | HDAC4 | C0221357 | Brachydactyly | 1 | CTD_human |
| ENSG00000068024 | HDAC4 | C0236736 | Cocaine-Related Disorders | 1 | CTD_human |
| ENSG00000068024 | HDAC4 | C0340543 | Familial primary pulmonary hypertension | 1 | CTD_human |
| ENSG00000068024 | HDAC4 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
| ENSG00000068024 | HDAC4 | C0525045 | Mood Disorders | 1 | PSYGENET |
| ENSG00000068024 | HDAC4 | C0600427 | Cocaine Dependence | 1 | CTD_human |
| ENSG00000068024 | HDAC4 | C0917816 | Mental deficiency | 1 | CTD_human |
| ENSG00000068024 | HDAC4 | C1862102 | BRACHYDACTYLY, TYPE E1 | 1 | CTD_human |
| ENSG00000068024 | HDAC4 | C1969342 | PULMONARY HYPERTENSION, PRIMARY, DEXFENFLURAMINE-ASSOCIATED | 1 | CTD_human |
| ENSG00000068024 | HDAC4 | C1969343 | Pulmonary Hypertension, Primary, Fenfluramine-Associated | 1 | CTD_human |
| ENSG00000068024 | HDAC4 | C2931817 | Chromosome 2q37 deletion syndrome | 1 | CTD_human |
| ENSG00000068024 | HDAC4 | C3203102 | Idiopathic pulmonary arterial hypertension | 1 | CTD_human |
| ENSG00000068024 | HDAC4 | C3714756 | Intellectual Disability | 1 | CTD_human |
| ENSG00000068024 | HDAC4 | C3714844 | Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia | 1 | CTD_human |
| ENSG00000068024 | HDAC4 | C4552070 | Pulmonary Hypertension, Primary, 1 | 1 | CTD_human |
