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Gene: ENSG00000067606 |
Summary for PRKCZ |
Gene summary |
| Gene information | Ensembl ID | ENSG00000067606 | Gene symbol | PRKCZ |
| Gene name | protein kinase C zeta | |
| HGNC | 9412 | |
| Entrez ID | 5590 | |
| Gene type | protein_coding | |
| Synonyms | PRKCZ|PKC2 | |
| UniProtAcc | Q05513 |
Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| ENSG00000067606 | PRKCZ | DB00675 | Tamoxifen | SmallMoleculeDrug |
| ENSG00000067606 | PRKCZ | DB09096 | Benzoyl peroxide | SmallMoleculeDrug |
Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
| ENSG00000067606 | PRKCZ | DB00675 | Tamoxifen | SmallMoleculeDrug | Prevent Breast Cancer,Treat Breast Cancer |
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Structure and expression level for PRKCZ |
AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
Landscape of gene expressions across multiple cancer types. |
Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| PRKCZ | 1.27e+03 | 1.44e+00 | 2.48e-01 | 5.81e+00 | 6.31e-09 | 8.50e-08 | BLCA |
Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for PRKCZ |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for PRKCZ |
Landscape of DNA methylation across multiple cancer types. |
Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| GBM | cg02347356 | chr1:2051564 | CGI:chr1:2049812-2051773 | promoter,gene body | 4.64e-01 | 5.70e-01 | -2.89e+00 | 3.87e-03 | 1.26e-02 | -1.06e-01 |
Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg02347356 | chr1:2051564 | CGI:chr1:2049812-2051773 | promoter,gene body | 5.43e-01 | 4.25e-01 | 5.68e+00 | 1.36e-08 | 9.36e-08 | 1.18e-01 |
| THCA | cg20285026 | chr1:2052335 | CGI:chr1:2049812-2051773 | promoter,gene body | 4.95e-01 | 3.35e-01 | 3.83e+00 | 1.29e-04 | 7.15e-04 | 1.60e-01 |
| LUSC | cg20285026 | chr1:2052335 | CGI:chr1:2049812-2051773 | promoter,gene body | 6.29e-01 | 4.35e-01 | 3.75e+00 | 1.74e-04 | 9.04e-04 | 1.94e-01 |
| LIHC | cg05929117 | chr1:2051594 | CGI:chr1:2049812-2051773 | promoter,gene body | 5.35e-01 | 4.20e-01 | 3.68e+00 | 2.36e-04 | 4.42e-04 | 1.15e-01 |
Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg20285026 | chr1:2052335 | CGI:chr1:2049812-2051773 | promoter,gene body | 7.27e-01 | 5.89e-01 | 9.13e+00 | 7.06e-20 | 3.78e-19 | 1.37e-01 |
| COAD | cg02347356 | chr1:2051564 | CGI:chr1:2049812-2051773 | promoter,gene body | 5.28e-01 | 4.28e-01 | 2.47e+00 | 1.33e-02 | 1.94e-02 | 1.00e-01 |
| BLCA | cg05929117 | chr1:2051594 | CGI:chr1:2049812-2051773 | promoter,gene body | 3.15e-01 | 4.17e-01 | -2.57e+00 | 1.02e-02 | 1.76e-02 | -1.02e-01 |
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Exon skipping events with PSI in TCGA for PRKCZ |
| ∗Please access ExonSkipDB for exon skipping annotation. |
Landscape of exon skipping events across multiple cancer types. |
Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for PRKCZ |
| ∗Please access CAeditome for RNA editing annotation. |
Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for PRKCZ |
TFs related to PRKCZ.∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
PRKCZ related gene.∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for PRKCZ |
RBPs related to ES in PRKCZ.∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| STAD | ZC3H10 | exon_skip_343 | 7.69e+00 | 9.86e-01 | 7.24e+00 | 4.20e-03 | Male-biased |
| UVM | SRSF7 | exon_skip_350 | 8.30e+00 | 6.29e-03 | 8.64e+00 | 9.88e-01 | Female-biased |
| THYM | PABPN1 | exon_skip_337 | 7.18e+00 | 9.33e-03 | 7.51e+00 | 9.80e-01 | Female-biased |
| LIHC | FMR1 | exon_skip_345 | 6.90e+00 | 9.80e-01 | 6.41e+00 | 4.65e-03 | Male-biased |
| LIHC | RBM4 | exon_skip_348 | 1.11e+01 | 7.56e-03 | 1.15e+01 | 9.92e-01 | Female-biased |
| LUSC | ZC3H10 | exon_skip_343 | 7.42e+00 | 9.24e-03 | 7.79e+00 | 9.82e-01 | Female-biased |
| KIRP | RBM4 | exon_skip_348 | 1.09e+01 | 9.75e-03 | 1.12e+01 | 9.89e-01 | Female-biased |
| PCPG | RBM4 | exon_skip_348 | 1.12e+01 | 9.96e-01 | 1.08e+01 | 2.65e-03 | Male-biased |
| MESO | FMR1 | exon_skip_344 | 6.59e+00 | 2.58e-03 | 7.07e+00 | 9.84e-01 | Female-biased |
| MESO | RBM4 | exon_skip_348 | 1.09e+01 | 4.05e-03 | 1.14e+01 | 9.95e-01 | Female-biased |
| MESO | SRSF7 | exon_skip_350 | 8.64e+00 | 1.19e-02 | 8.97e+00 | 9.83e-01 | Female-biased |
| GBM | BRUNOL6 | exon_skip_363 | 6.73e+00 | 9.84e-01 | 5.98e+00 | 1.82e-04 | Male-biased |
| KIRC | RBM4 | exon_skip_348 | 1.12e+01 | 5.31e-03 | 1.16e+01 | 9.94e-01 | Female-biased |
| KICH | CNOT4 | exon_skip_346 | 6.89e+00 | 9.81e-01 | 6.51e+00 | 4.81e-03 | Male-biased |
| KICH | ZC3H10 | exon_skip_343 | 7.63e+00 | 9.83e-01 | 7.28e+00 | 7.47e-03 | Male-biased |
| SKCM | ZC3H10 | exon_skip_343 | 7.92e+00 | 9.89e-01 | 7.40e+00 | 2.24e-03 | Male-biased |
| HNSC | RBM4 | exon_skip_348 | 1.11e+01 | 1.11e-02 | 1.14e+01 | 9.88e-01 | Female-biased |
PRKCZ related ES.∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000067606 | LINC00663,hsa-mir-152,PRKCZ | Male-specific ceRNA | TCGA-BLCA |
| ENSG00000067606 | AC232271.1,hsa-mir-582,PRKCZ | Male-specific ceRNA | TCGA-BLCA |
| ENSG00000067606 | PAXIP1-AS2,hsa-mir-582,PRKCZ | Male-specific ceRNA | TCGA-BLCA |
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Sex-biased eQTL regulation of gene |
Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs11121559 | chr1:10395091:G:A | - | 0.18534369879222 | 0.00174119414095908 | PAAD | Female-baised eQTL |
| rs11121542 | chr1:10333862:G:A | - | 0.146830177124294 | 0.0214559099960319 | PAAD | Female-baised eQTL |
| rs12125492 | chr1:10361820:A:G | - | 0.146356490126946 | 0.0223801865091324 | PAAD | Female-baised eQTL |
| rs12135774 | chr1:10326448:T:C | - | 0.135877219036287 | 0.0434686845238998 | PAAD | Female-baised eQTL |
| rs4846204 | chr1:10248900:C:T | - | 0.135726356415808 | 0.0441405463846695 | PAAD | Female-baised eQTL |
| rs17400878 | chr1:10256671:A:G | - | 0.135726356415808 | 0.0441405463846695 | PAAD | Female-baised eQTL |
| rs997482 | chr1:10213121:C:T | - | 0.135498016860425 | 0.0457464290944505 | PAAD | Female-baised eQTL |
| rs6702280 | chr1:10220716:G:A | - | 0.135498016860425 | 0.0457464290944505 | PAAD | Female-baised eQTL |
| rs2817591 | chr1:11523169:G:T | - | 0.0909031684519572 | 0.0464993364543222 | COAD | Female-baised eQTL |
| rs2072996 | chr1:11518916:T:C | - | 0.0906360625778856 | 0.048678830813149 | COAD | Female-baised eQTL |
Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs4654510 | chr1:4203003:G:T | - | 0.0515455879200232 | 0.0494934218610437 | BLCA | Male-baised eQTL |
Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg20285026 | chr1:2052335 | gene,promoter | -0.213816086133009 | 5.16411105147997e-08 | -0.4160451292004399 | 9.55403387221515e-11 | LUAD |
| cg08109625 | chr1:2105204 | gene | -0.296491258235601 | 1.16751669466466e-14 | -0.4653255545930203 | 8.563727290782469e-18 | BLCA |
| cg16599817 | chr1:2104844 | gene,exon,UTR | -0.396670129475714 | 6.46044941711444e-13 | -0.44072350522793907 | 6.329460339724482e-16 | BLCA |
| cg06315149 | chr1:2104959 | gene | -0.396670129475714 | 6.46044941711444e-13 | -0.44072350522793907 | 6.329460339724482e-16 | BLCA |
Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg17426766 | chr1:2115425 | gene | -0.481215002452817 | 3.83019696058089e-46 | -0.9728889072140912 | 2.3327481062962574e-51 | PAAD |
| cg22366001 | chr1:2134567 | gene | -0.481215002452817 | 3.83019696058089e-46 | -0.9728889072140912 | 2.3327481062962574e-51 | PAAD |
| cg24776480 | chr1:2135007 | gene,exon,UTR | -0.481215002452817 | 3.83019696058089e-46 | -0.9728889072140912 | 2.3327481062962574e-51 | PAAD |
| cg24577455 | chr1:2137573 | gene | -0.481215002452817 | 3.83019696058089e-46 | -0.9728889072140912 | 2.3327481062962574e-51 | PAAD |
| cg02481000 | chr1:2150910 | gene,exon,CDS,UTR | -0.481215002452817 | 3.83019696058089e-46 | -0.9728889072140912 | 2.3327481062962574e-51 | PAAD |
| cg17435831 | chr1:2151083 | gene | -0.481215002452817 | 3.83019696058089e-46 | -0.9728889072140912 | 2.3327481062962574e-51 | PAAD |
| cg04347414 | chr1:2153080 | gene | -0.481215002452817 | 3.83019696058089e-46 | -0.9728889072140912 | 2.3327481062962574e-51 | PAAD |
| cg24578937 | chr1:2159375 | gene | -0.481215002452817 | 3.83019696058089e-46 | -0.9728889072140912 | 2.3327481062962574e-51 | PAAD |
| cg07222721 | chr1:2168306 | gene | -0.481215002452817 | 3.83019696058089e-46 | -0.9728889072140912 | 2.3327481062962574e-51 | PAAD |
| cg16644344 | chr1:2168730 | gene | -0.481215002452817 | 3.83019696058089e-46 | -0.9728889072140912 | 2.3327481062962574e-51 | PAAD |
| cg17156349 | chr1:2168793 | gene | -0.481215002452817 | 3.83019696058089e-46 | -0.9728889072140912 | 2.3327481062962574e-51 | PAAD |
| cg17025688 | chr1:2175971 | gene | -0.481215002452817 | 3.83019696058089e-46 | -0.9728889072140912 | 2.3327481062962574e-51 | PAAD |
| cg05929117 | chr1:2051594 | gene,promoter | -0.246740560830156 | 3.84062733226711e-09 | -0.6722350955202472 | 8.632835969966565e-12 | PAAD |
| cg23648809 | chr1:2174961 | gene | -0.246740560830156 | 3.84062733226711e-09 | -0.6722350955202472 | 8.632835969966565e-12 | PAAD |
| cg02347356 | chr1:2051564 | gene,promoter | -0.414242204280078 | 6.0483936508578e-08 | -0.5504712078445723 | 6.113363974659033e-11 | LIHC |
| cg08109625 | chr1:2105204 | gene | -0.414242204280078 | 6.0483936508578e-08 | -0.5504712078445723 | 6.113363974659033e-11 | LIHC |
Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of PRKCZ |
Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000067606 | PRKCZ | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| ENSG00000067606 | PRKCZ | C0018800 | Cardiomegaly | 1 | CTD_human |
| ENSG00000067606 | PRKCZ | C0020429 | Hyperalgesia | 1 | CTD_human |
| ENSG00000067606 | PRKCZ | C0023418 | leukemia | 1 | CTD_human |
| ENSG00000067606 | PRKCZ | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| ENSG00000067606 | PRKCZ | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
| ENSG00000067606 | PRKCZ | C0458247 | Allodynia | 1 | CTD_human |
| ENSG00000067606 | PRKCZ | C0751211 | Hyperalgesia, Primary | 1 | CTD_human |
| ENSG00000067606 | PRKCZ | C0751212 | Hyperalgesia, Secondary | 1 | CTD_human |
| ENSG00000067606 | PRKCZ | C0751213 | Tactile Allodynia | 1 | CTD_human |
| ENSG00000067606 | PRKCZ | C0751214 | Hyperalgesia, Thermal | 1 | CTD_human |
| ENSG00000067606 | PRKCZ | C1383860 | Cardiac Hypertrophy | 1 | CTD_human |
| ENSG00000067606 | PRKCZ | C1839839 | MAJOR AFFECTIVE DISORDER 2 | 1 | PSYGENET |
| ENSG00000067606 | PRKCZ | C2936719 | Mechanical Allodynia | 1 | CTD_human |