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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000067606

Summary for PRKCZ

check button Gene summary

Gene informationEnsembl ID

ENSG00000067606

Gene symbol

PRKCZ

Gene nameprotein kinase C zeta
HGNC

9412

Entrez ID

5590

Gene typeprotein_coding
SynonymsPRKCZ|PKC2
UniProtAcc

Q05513


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type
ENSG00000067606PRKCZDB00675TamoxifenSmallMoleculeDrug
ENSG00000067606PRKCZDB09096Benzoyl peroxideSmallMoleculeDrug

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer
ENSG00000067606PRKCZDB00675TamoxifenSmallMoleculeDrugPrevent Breast Cancer,Treat Breast Cancer

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Structure and expression level for PRKCZ

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
PRKCZ1.27e+031.44e+002.48e-015.81e+006.31e-098.50e-08BLCA

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

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Sex-biased somatic mutation for PRKCZ

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for PRKCZ

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
GBMcg02347356chr1:2051564CGI:chr1:2049812-2051773promoter,gene body4.64e-015.70e-01-2.89e+003.87e-031.26e-02-1.06e-01

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
KIRCcg02347356chr1:2051564CGI:chr1:2049812-2051773promoter,gene body5.43e-014.25e-015.68e+001.36e-089.36e-081.18e-01
THCAcg20285026chr1:2052335CGI:chr1:2049812-2051773promoter,gene body4.95e-013.35e-013.83e+001.29e-047.15e-041.60e-01
LUSCcg20285026chr1:2052335CGI:chr1:2049812-2051773promoter,gene body6.29e-014.35e-013.75e+001.74e-049.04e-041.94e-01
LIHCcg05929117chr1:2051594CGI:chr1:2049812-2051773promoter,gene body5.35e-014.20e-013.68e+002.36e-044.42e-041.15e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg20285026chr1:2052335CGI:chr1:2049812-2051773promoter,gene body7.27e-015.89e-019.13e+007.06e-203.78e-191.37e-01
COADcg02347356chr1:2051564CGI:chr1:2049812-2051773promoter,gene body5.28e-014.28e-012.47e+001.33e-021.94e-021.00e-01
BLCAcg05929117chr1:2051594CGI:chr1:2049812-2051773promoter,gene body3.15e-014.17e-01-2.57e+001.02e-021.76e-02-1.02e-01

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Exon skipping events with PSI in TCGA for PRKCZ

∗Please access ExonSkipDB for exon skipping annotation.
check buttonLandscape of exon skipping events across multiple cancer types.
AS event heatmap

check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

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RNA A-to-I editing events in TCGA for PRKCZ

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for PRKCZ

check buttonTFs related to PRKCZ.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType

check buttonPRKCZ related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for PRKCZ

check buttonRBPs related to ES in PRKCZ.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
RBP ES
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
STADZC3H10exon_skip_3437.69e+009.86e-017.24e+004.20e-03Male-biased
UVMSRSF7exon_skip_3508.30e+006.29e-038.64e+009.88e-01Female-biased
THYMPABPN1exon_skip_3377.18e+009.33e-037.51e+009.80e-01Female-biased
LIHCFMR1exon_skip_3456.90e+009.80e-016.41e+004.65e-03Male-biased
LIHCRBM4exon_skip_3481.11e+017.56e-031.15e+019.92e-01Female-biased
LUSCZC3H10exon_skip_3437.42e+009.24e-037.79e+009.82e-01Female-biased
KIRPRBM4exon_skip_3481.09e+019.75e-031.12e+019.89e-01Female-biased
PCPGRBM4exon_skip_3481.12e+019.96e-011.08e+012.65e-03Male-biased
MESOFMR1exon_skip_3446.59e+002.58e-037.07e+009.84e-01Female-biased
MESORBM4exon_skip_3481.09e+014.05e-031.14e+019.95e-01Female-biased
MESOSRSF7exon_skip_3508.64e+001.19e-028.97e+009.83e-01Female-biased
GBMBRUNOL6exon_skip_3636.73e+009.84e-015.98e+001.82e-04Male-biased
KIRCRBM4exon_skip_3481.12e+015.31e-031.16e+019.94e-01Female-biased
KICHCNOT4exon_skip_3466.89e+009.81e-016.51e+004.81e-03Male-biased
KICHZC3H10exon_skip_3437.63e+009.83e-017.28e+007.47e-03Male-biased
SKCMZC3H10exon_skip_3437.92e+009.89e-017.40e+002.24e-03Male-biased
HNSCRBM4exon_skip_3481.11e+011.11e-021.14e+019.88e-01Female-biased

check buttonPRKCZ related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type
ENSG00000067606LINC00663,hsa-mir-152,PRKCZMale-specific ceRNATCGA-BLCA
ENSG00000067606AC232271.1,hsa-mir-582,PRKCZMale-specific ceRNATCGA-BLCA
ENSG00000067606PAXIP1-AS2,hsa-mir-582,PRKCZMale-specific ceRNATCGA-BLCA

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs11121559chr1:10395091:G:A-0.185343698792220.00174119414095908PAADFemale-baised eQTL
rs11121542chr1:10333862:G:A-0.1468301771242940.0214559099960319PAADFemale-baised eQTL
rs12125492chr1:10361820:A:G-0.1463564901269460.0223801865091324PAADFemale-baised eQTL
rs12135774chr1:10326448:T:C-0.1358772190362870.0434686845238998PAADFemale-baised eQTL
rs4846204chr1:10248900:C:T-0.1357263564158080.0441405463846695PAADFemale-baised eQTL
rs17400878chr1:10256671:A:G-0.1357263564158080.0441405463846695PAADFemale-baised eQTL
rs997482chr1:10213121:C:T-0.1354980168604250.0457464290944505PAADFemale-baised eQTL
rs6702280chr1:10220716:G:A-0.1354980168604250.0457464290944505PAADFemale-baised eQTL
rs2817591chr1:11523169:G:T-0.09090316845195720.0464993364543222COADFemale-baised eQTL
rs2072996chr1:11518916:T:C-0.09063606257788560.048678830813149COADFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs4654510chr1:4203003:G:T-0.05154558792002320.0494934218610437BLCAMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000067606
CpG Site: cg17426766
Position to Gene: gene
Male Effect: -
Female Effect: -0.481215002452817
eQTM boxplot analysisGene ID: ENSG00000067606
CpG Site: cg22366001
Position to Gene: gene
Male Effect: -
Female Effect: -0.481215002452817
eQTM boxplot analysisGene ID: ENSG00000067606
CpG Site: cg24776480
Position to Gene: gene,exon,UTR
Male Effect: -
Female Effect: -0.481215002452817
eQTM boxplot analysisGene ID: ENSG00000067606
CpG Site: cg24577455
Position to Gene: gene
Male Effect: -
Female Effect: -0.481215002452817
eQTM boxplot analysisGene ID: ENSG00000067606
CpG Site: cg02481000
Position to Gene: gene,exon,CDS,UTR
Male Effect: -
Female Effect: -0.481215002452817
eQTM boxplot analysisGene ID: ENSG00000067606
CpG Site: cg17435831
Position to Gene: gene
Male Effect: -
Female Effect: -0.481215002452817
eQTM boxplot analysisGene ID: ENSG00000067606
CpG Site: cg04347414
Position to Gene: gene
Male Effect: -
Female Effect: -0.481215002452817
eQTM boxplot analysisGene ID: ENSG00000067606
CpG Site: cg24578937
Position to Gene: gene
Male Effect: -
Female Effect: -0.481215002452817
eQTM boxplot analysisGene ID: ENSG00000067606
CpG Site: cg07222721
Position to Gene: gene
Male Effect: -
Female Effect: -0.481215002452817
eQTM boxplot analysisGene ID: ENSG00000067606
CpG Site: cg16644344
Position to Gene: gene
Male Effect: -
Female Effect: -0.481215002452817
eQTM boxplot analysisGene ID: ENSG00000067606
CpG Site: cg17156349
Position to Gene: gene
Male Effect: -
Female Effect: -0.481215002452817
eQTM boxplot analysisGene ID: ENSG00000067606
CpG Site: cg17025688
Position to Gene: gene
Male Effect: -
Female Effect: -0.481215002452817
eQTM boxplot analysisGene ID: ENSG00000067606
CpG Site: cg05929117
Position to Gene: gene,promoter
Male Effect: -
Female Effect: -0.246740560830156
eQTM boxplot analysisGene ID: ENSG00000067606
CpG Site: cg23648809
Position to Gene: gene
Male Effect: -
Female Effect: -0.246740560830156
eQTM boxplot analysisGene ID: ENSG00000067606
CpG Site: cg20285026
Position to Gene: gene,promoter
Male Effect: -0.213816086133009
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000067606
CpG Site: cg02347356
Position to Gene: gene,promoter
Male Effect: -
Female Effect: -0.414242204280078
eQTM boxplot analysisGene ID: ENSG00000067606
CpG Site: cg08109625
Position to Gene: gene
Male Effect: -
Female Effect: -0.414242204280078
eQTM boxplot analysisGene ID: ENSG00000067606
CpG Site: cg08109625
Position to Gene: gene
Male Effect: -0.296491258235601
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000067606
CpG Site: cg16599817
Position to Gene: gene,exon,UTR
Male Effect: -0.396670129475714
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000067606
CpG Site: cg06315149
Position to Gene: gene
Male Effect: -0.396670129475714
Female Effect: -

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg20285026chr1:2052335gene,promoter-0.2138160861330095.16411105147997e-08-0.41604512920043999.55403387221515e-11LUAD
cg08109625chr1:2105204gene-0.2964912582356011.16751669466466e-14-0.46532555459302038.563727290782469e-18BLCA
cg16599817chr1:2104844gene,exon,UTR-0.3966701294757146.46044941711444e-13-0.440723505227939076.329460339724482e-16BLCA
cg06315149chr1:2104959gene-0.3966701294757146.46044941711444e-13-0.440723505227939076.329460339724482e-16BLCA

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg17426766chr1:2115425gene-0.4812150024528173.83019696058089e-46-0.97288890721409122.3327481062962574e-51PAAD
cg22366001chr1:2134567gene-0.4812150024528173.83019696058089e-46-0.97288890721409122.3327481062962574e-51PAAD
cg24776480chr1:2135007gene,exon,UTR-0.4812150024528173.83019696058089e-46-0.97288890721409122.3327481062962574e-51PAAD
cg24577455chr1:2137573gene-0.4812150024528173.83019696058089e-46-0.97288890721409122.3327481062962574e-51PAAD
cg02481000chr1:2150910gene,exon,CDS,UTR-0.4812150024528173.83019696058089e-46-0.97288890721409122.3327481062962574e-51PAAD
cg17435831chr1:2151083gene-0.4812150024528173.83019696058089e-46-0.97288890721409122.3327481062962574e-51PAAD
cg04347414chr1:2153080gene-0.4812150024528173.83019696058089e-46-0.97288890721409122.3327481062962574e-51PAAD
cg24578937chr1:2159375gene-0.4812150024528173.83019696058089e-46-0.97288890721409122.3327481062962574e-51PAAD
cg07222721chr1:2168306gene-0.4812150024528173.83019696058089e-46-0.97288890721409122.3327481062962574e-51PAAD
cg16644344chr1:2168730gene-0.4812150024528173.83019696058089e-46-0.97288890721409122.3327481062962574e-51PAAD
cg17156349chr1:2168793gene-0.4812150024528173.83019696058089e-46-0.97288890721409122.3327481062962574e-51PAAD
cg17025688chr1:2175971gene-0.4812150024528173.83019696058089e-46-0.97288890721409122.3327481062962574e-51PAAD
cg05929117chr1:2051594gene,promoter-0.2467405608301563.84062733226711e-09-0.67223509552024728.632835969966565e-12PAAD
cg23648809chr1:2174961gene-0.2467405608301563.84062733226711e-09-0.67223509552024728.632835969966565e-12PAAD
cg02347356chr1:2051564gene,promoter-0.4142422042800786.0483936508578e-08-0.55047120784457236.113363974659033e-11LIHC
cg08109625chr1:2105204gene-0.4142422042800786.0483936508578e-08-0.55047120784457236.113363974659033e-11LIHC

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of PRKCZ

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource
ENSG00000067606PRKCZC0005586Bipolar Disorder1PSYGENET
ENSG00000067606PRKCZC0018800Cardiomegaly1CTD_human
ENSG00000067606PRKCZC0020429Hyperalgesia1CTD_human
ENSG00000067606PRKCZC0023418leukemia1CTD_human
ENSG00000067606PRKCZC0033578Prostatic Neoplasms1CTD_human
ENSG00000067606PRKCZC0376358Malignant neoplasm of prostate1CTD_human
ENSG00000067606PRKCZC0458247Allodynia1CTD_human
ENSG00000067606PRKCZC0751211Hyperalgesia, Primary1CTD_human
ENSG00000067606PRKCZC0751212Hyperalgesia, Secondary1CTD_human
ENSG00000067606PRKCZC0751213Tactile Allodynia1CTD_human
ENSG00000067606PRKCZC0751214Hyperalgesia, Thermal1CTD_human
ENSG00000067606PRKCZC1383860Cardiac Hypertrophy1CTD_human
ENSG00000067606PRKCZC1839839MAJOR AFFECTIVE DISORDER 21PSYGENET
ENSG00000067606PRKCZC2936719Mechanical Allodynia1CTD_human