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Gene: ENSG00000065717 |
Summary for TLE2 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000065717 | Gene symbol | TLE2 |
| Gene name | TLE family member 2, transcriptional corepressor | |
| HGNC | 11838 | |
| Entrez ID | 7089 | |
| Gene type | protein_coding | |
| Synonyms | TLE2|ESG2|GRG2|ESG|FLJ41188 | |
| UniProtAcc | Q04725 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for TLE2 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| TLE2 | 1.08e+03 | -1.23e+00 | 4.34e-01 | -2.84e+00 | 4.55e-03 | 2.05e-02 | ESCA |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| TLE2 | 1.51e+03 | -1.08e+00 | 3.34e-01 | -3.22e+00 | 1.27e-03 | 6.75e-03 | STAD |
| TLE2 | 4.11e+03 | 1.02e+00 | 2.44e-01 | 4.16e+00 | 3.20e-05 | 9.36e-05 | KICH |
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Sex-biased somatic mutation for TLE2 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for TLE2 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg03148858 | chr19:3047980 | CGI:chr19:3047180-3047446 | promoter | 2.71e-02 | 1.41e-01 | -5.25e+00 | 1.52e-07 | 7.13e-07 | -1.14e-01 |
| LUSC | cg17693604 | chr19:3046807 | CGI:chr19:3047180-3047446 | promoter,gene body | 6.68e-01 | 7.74e-01 | -2.86e+00 | 4.25e-03 | 7.22e-03 | -1.06e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for TLE2 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for TLE2 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for TLE2 |
| TFs related to TLE2. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BRCA | PLAGL2 | TLE2 | 3.41e+00 | 1.06e-02 | 4.61e+00 | 9.81e-01 | Female-biased |
| TLE2 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for TLE2 |
| RBPs related to ES in TLE2. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| STAD | BRUNOL6 | exon_skip_312912 | 7.17e+00 | 9.84e-01 | 6.72e+00 | 3.85e-03 | Male-biased |
| STAD | FMR1 | exon_skip_312912 | 6.99e+00 | 9.84e-01 | 6.44e+00 | 2.01e-03 | Male-biased |
| THYM | LIN28A | exon_skip_312899 | 9.23e+00 | 1.26e-02 | 9.53e+00 | 9.85e-01 | Female-biased |
| READ | LIN28A | exon_skip_312899 | 9.14e+00 | 1.58e-02 | 9.44e+00 | 9.81e-01 | Female-biased |
| PCPG | PABPC5 | exon_skip_312899 | 7.08e+00 | 8.05e-03 | 7.41e+00 | 9.81e-01 | Female-biased |
| PAAD | LIN28A | exon_skip_312899 | 9.45e+00 | 9.90e-01 | 9.12e+00 | 7.28e-03 | Male-biased |
| TLE2 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs10426826 | chr19:8996756:T:C | - | 0.0886093385573318 | 0.0171404299189028 | KIRC | Female-baised eQTL |
| rs10424893 | chr19:12075333:T:C | - | 0.0939530000230959 | 0.0233813157283529 | KIRC | Female-baised eQTL |
| rs10406268 | chr19:12061189:C:T | - | 0.0973466167457494 | 0.026545112823424 | KIRC | Female-baised eQTL |
| rs8105983 | chr19:12061707:C:G | - | 0.0973466167457494 | 0.026545112823424 | KIRC | Female-baised eQTL |
| rs7249543 | chr19:12064051:T:C | - | 0.0921465684695547 | 0.041119163653118 | KIRC | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs10426080 | chr19:12847036:A:G | - | 0.0692864417278668 | 0.0223031514657171 | KIRC | Male-baised eQTL |
| rs10424001 | chr19:12837648:A:G | - | 0.0691405397553047 | 0.0243273930863389 | KIRC | Male-baised eQTL |
| rs8111370 | chr19:12838050:G:T | - | 0.067749587577671 | 0.0246622815523104 | KIRC | Male-baised eQTL |
| rs4804737 | chr19:12837124:T:C | - | 0.065664308002515 | 0.0250252732428176 | KIRC | Male-baised eQTL |
| rs1985646 | chr19:12864182:T:C | - | 0.0690411569878375 | 0.0251575721590246 | KIRC | Male-baised eQTL |
| rs6511843 | chr19:12844730:A:C | - | 0.0672672656333388 | 0.0282798065498985 | KIRC | Male-baised eQTL |
| rs2085466 | chr19:12877614:T:C | - | 0.0683022093716016 | 0.0283565432018662 | KIRC | Male-baised eQTL |
| rs2290689 | chr19:12847546:T:C | - | 0.0679813305143111 | 0.0300306273619192 | KIRC | Male-baised eQTL |
| rs2290688 | chr19:12847883:T:C | - | 0.0679813305143111 | 0.0300306273619192 | KIRC | Male-baised eQTL |
| rs8099965 | chr19:12849889:T:C | - | 0.0679813305143111 | 0.0300306273619192 | KIRC | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000065717 |
| CpG Site: cg19400163 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.417799085724057 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg19400163 | chr19:3029787 | gene | -0.417799085724057 | 4.69194341304427e-11 | -0.7379219496659599 | 5.7814305359395724e-15 | PAAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
 | EX ID: exon_skip_312918 |
| CpG Site: cg13535593 | |
| Position to EX: Distant upstream | |
| Male Effect: -0.0340814852241705 | |
| Female Effect: - | |
 | EX ID: exon_skip_312918 |
| CpG Site: cg17097950 | |
| Position to EX: Distant upstream | |
| Male Effect: -0.0270775388133362 | |
| Female Effect: - |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| exon_skip_312918 | chr19:3017839:3017859 | cg13535593 | chr19:3786127 | Distant upstream | -0.0340814852241705 | 3.34799070649358e-08 | -0.408073757498721 | 1.2517838926049154e-09 | Frame-shift | LUAD |
| exon_skip_312918 | chr19:3017839:3017859 | cg17097950 | chr19:3881143 | Distant upstream | -0.0270775388133362 | 5.18811613684535e-05 | -0.3678449633831328 | 5.7637533450917814e-08 | Frame-shift | LUAD |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of TLE2 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
