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Gene: ENSG00000057294 |
Summary for PKP2 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000057294 | Gene symbol | PKP2 |
| Gene name | plakophilin 2 | |
| HGNC | 9024 | |
| Entrez ID | 5318 | |
| Gene type | protein_coding | |
| Synonyms | PKP2| | |
| UniProtAcc | Q99959 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for PKP2 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| PKP2 | 1.29e+03 | -1.44e+00 | 4.38e-01 | -3.29e+00 | 9.93e-04 | 3.37e-03 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for PKP2 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for PKP2 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| THCA | cg19677302 | chr12:32895325 | CGI:chr12:32896367-32897109 | promoter,gene body | 9.11e-01 | 8.00e-01 | 5.13e+00 | 2.87e-07 | 1.38e-05 | 1.12e-01 |
| COAD | cg19677302 | chr12:32895325 | CGI:chr12:32896367-32897109 | promoter,gene body | 3.58e-01 | 5.02e-01 | -3.31e+00 | 9.41e-04 | 2.14e-03 | -1.44e-01 |
| LIHC | cg19677302 | chr12:32895325 | CGI:chr12:32896367-32897109 | promoter,gene body | 7.69e-01 | 9.00e-01 | -3.36e+00 | 7.71e-04 | 1.26e-03 | -1.31e-01 |
| ESCA | cg19677302 | chr12:32895325 | CGI:chr12:32896367-32897109 | promoter,gene body | 6.87e-01 | 5.24e-01 | 1.99e+00 | 4.71e-02 | 4.87e-02 | 1.63e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Top |
Exon skipping events with PSI in TCGA for PKP2 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for PKP2 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for PKP2 |
| TFs related to PKP2. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| MESO | FOXL1 | PKP2 | 2.48e+00 | 3.04e-03 | 4.09e+00 | 9.84e-01 | Female-biased |
| MESO | FOXR2 | PKP2 | 2.47e+00 | 1.54e-03 | 4.27e+00 | 9.89e-01 | Female-biased |
| MESO | LMX1B | PKP2 | 2.92e+00 | 7.18e-03 | 4.29e+00 | 9.83e-01 | Female-biased |
| MESO | MEF2A | PKP2 | 2.64e+00 | 5.52e-03 | 4.08e+00 | 9.81e-01 | Female-biased |
| MESO | MSX1 | PKP2 | 3.20e+00 | 7.36e-03 | 4.57e+00 | 9.86e-01 | Female-biased |
| MESO | MSX2 | PKP2 | 3.16e+00 | 6.76e-03 | 4.55e+00 | 9.87e-01 | Female-biased |
| MESO | NKX2-2 | PKP2 | 3.48e+00 | 1.07e-02 | 4.73e+00 | 9.84e-01 | Female-biased |
| MESO | NKX3-1 | PKP2 | 3.43e+00 | 7.60e-03 | 4.79e+00 | 9.88e-01 | Female-biased |
| MESO | POU4F1 | PKP2 | 3.11e+00 | 7.24e-03 | 4.48e+00 | 9.85e-01 | Female-biased |
| MESO | POU4F3 | PKP2 | 3.14e+00 | 8.75e-03 | 4.45e+00 | 9.83e-01 | Female-biased |
| MESO | SRY | PKP2 | 3.46e+00 | 1.17e-02 | 4.68e+00 | 9.83e-01 | Female-biased |
| MESO | ZNF33B | PKP2 | 2.89e+00 | 4.26e-03 | 4.41e+00 | 9.88e-01 | Female-biased |
| MESO | ZNF35 | PKP2 | 2.83e+00 | 4.27e-03 | 4.35e+00 | 9.87e-01 | Female-biased |
| MESO | ZNF418 | PKP2 | 2.43e+00 | 2.14e-04 | 4.73e+00 | 9.95e-01 | Female-biased |
| MESO | ZNF79 | PKP2 | 2.59e+00 | 1.24e-03 | 4.45e+00 | 9.91e-01 | Female-biased |
| MESO | ZNF879 | PKP2 | 2.63e+00 | 3.12e-03 | 4.24e+00 | 9.86e-01 | Female-biased |
| PAAD | ZNF418 | PKP2 | 3.99e+00 | 9.84e-01 | 2.80e+00 | 1.53e-03 | Male-biased |
| SKCM | ATOH7 | PKP2 | 4.53e+00 | 9.23e-03 | 5.54e+00 | 9.88e-01 | Female-biased |
| SKCM | BHLHE22 | PKP2 | 4.18e+00 | 4.66e-03 | 5.42e+00 | 9.92e-01 | Female-biased |
| SKCM | HMX1 | PKP2 | 2.99e+00 | 1.40e-03 | 4.58e+00 | 9.87e-01 | Female-biased |
| SKCM | LMX1B | PKP2 | 2.28e+00 | 3.36e-04 | 4.26e+00 | 9.81e-01 | Female-biased |
| SKCM | MEF2B | PKP2 | 3.39e+00 | 4.53e-03 | 4.62e+00 | 9.84e-01 | Female-biased |
| SKCM | MSX1 | PKP2 | 2.74e+00 | 5.13e-04 | 4.61e+00 | 9.88e-01 | Female-biased |
| SKCM | MSX2 | PKP2 | 2.67e+00 | 4.31e-04 | 4.58e+00 | 9.88e-01 | Female-biased |
| SKCM | NEUROG1 | PKP2 | 4.62e+00 | 8.07e-03 | 5.68e+00 | 9.90e-01 | Female-biased |
| SKCM | NKX2-2 | PKP2 | 3.04e+00 | 1.38e-03 | 4.62e+00 | 9.87e-01 | Female-biased |
| SKCM | NKX3-1 | PKP2 | 2.71e+00 | 4.78e-04 | 4.60e+00 | 9.88e-01 | Female-biased |
| SKCM | OLIG1 | PKP2 | 4.33e+00 | 6.85e-03 | 5.44e+00 | 9.90e-01 | Female-biased |
| SKCM | OLIG2 | PKP2 | 5.08e+00 | 1.05e-02 | 6.05e+00 | 9.88e-01 | Female-biased |
| SKCM | POU4F1 | PKP2 | 2.70e+00 | 6.85e-04 | 4.49e+00 | 9.86e-01 | Female-biased |
| SKCM | POU4F3 | PKP2 | 2.82e+00 | 9.38e-04 | 4.51e+00 | 9.86e-01 | Female-biased |
| SKCM | SOX2 | PKP2 | 2.76e+00 | 9.98e-04 | 4.43e+00 | 9.84e-01 | Female-biased |
| SKCM | SRY | PKP2 | 2.91e+00 | 9.83e-04 | 4.59e+00 | 9.87e-01 | Female-biased |
| SKCM | ZNF33B | PKP2 | 2.37e+00 | 4.70e-04 | 4.26e+00 | 9.81e-01 | Female-biased |
| UVM | BHLHE22 | PKP2 | 5.23e+00 | 9.80e-01 | 4.11e+00 | 1.46e-02 | Male-biased |
| UVM | NKX3-1 | PKP2 | 4.77e+00 | 9.86e-01 | 2.96e+00 | 3.48e-03 | Male-biased |
| UVM | SRY | PKP2 | 4.70e+00 | 9.82e-01 | 3.14e+00 | 5.96e-03 | Male-biased |
| UVM | ZNF418 | PKP2 | 4.61e+00 | 9.87e-01 | 1.42e+00 | 8.63e-05 | Male-biased |
| PKP2 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for PKP2 |
| RBPs related to ES in PKP2. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| READ | PABPC5 | exon_skip_91101 | 8.95e+00 | 5.69e-03 | 9.33e+00 | 9.91e-01 | Female-biased |
| HNSC | PABPC5 | exon_skip_91101 | 9.33e+00 | 9.80e-01 | 9.03e+00 | 1.66e-02 | Male-biased |
| PKP2 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs9804875 | chr12:26084630:T:C | - | 0.133020534904825 | 0.0261397044351277 | LIHC | Female-baised eQTL |
| rs9804760 | chr12:26084837:C:T | - | 0.133020534904825 | 0.0261397044351277 | LIHC | Female-baised eQTL |
| rs11049923 | chr12:28933216:T:G | - | 0.19470463432885 | 1.11095827995683e-05 | BLCA | Female-baised eQTL |
| rs78184918 | chr12:28918380:G:A | - | 0.194591484941296 | 1.18107900090077e-05 | BLCA | Female-baised eQTL |
| rs149213142 | chr12:28923202:C:T | - | 0.194591484941296 | 1.18107900090077e-05 | BLCA | Female-baised eQTL |
| rs16933618 | chr12:28928890:T:A | - | 0.158915097231697 | 0.000310700170915186 | BLCA | Female-baised eQTL |
| rs7979310 | chr12:26968366:G:A | - | -0.136561107939711 | 0.00522830222293759 | BLCA | Female-baised eQTL |
| rs7314184 | chr12:26971943:T:G | - | -0.136561107939711 | 0.00522830222293759 | BLCA | Female-baised eQTL |
| rs7309280 | chr12:26977702:T:C | - | -0.136561107939711 | 0.00522830222293759 | BLCA | Female-baised eQTL |
| rs2087736 | chr12:26977946:G:A | - | -0.136561107939711 | 0.00522830222293759 | BLCA | Female-baised eQTL |
| rs12810799 | chr12:33592046:A:G | - | 0.137217489350697 | 0.00544010882347806 | BLCA | Female-baised eQTL |
| rs1844258 | chr12:28934512:T:A | - | 0.102838422724198 | 0.00816264934442134 | BLCA | Female-baised eQTL |
| rs708162 | chr12:26943574:C:A | - | 0.128766682256653 | 0.0102776065533225 | BLCA | Female-baised eQTL |
| rs864552 | chr12:26947559:T:A | - | 0.128766682256653 | 0.0102776065533225 | BLCA | Female-baised eQTL |
| rs2129092 | chr12:26954335:G:A | - | 0.128766682256653 | 0.0102776065533225 | BLCA | Female-baised eQTL |
| rs2046937 | chr12:26956722:A:G | - | 0.128766682256653 | 0.0102776065533225 | BLCA | Female-baised eQTL |
| rs10219552 | chr12:31774481:C:T | - | 0.145372551281194 | 0.0113770560532349 | BLCA | Female-baised eQTL |
| rs2113884 | chr12:27838184:A:C | - | -0.127966156220102 | 0.0180059230072999 | BLCA | Female-baised eQTL |
| rs7311408 | chr12:31784059:A:G | - | 0.137061363487502 | 0.0180733423766708 | BLCA | Female-baised eQTL |
| rs16918939 | chr12:31785680:C:T | - | 0.137061363487502 | 0.0180733423766708 | BLCA | Female-baised eQTL |
| rs11837449 | chr12:31787949:G:A | - | 0.137061363487502 | 0.0180733423766708 | BLCA | Female-baised eQTL |
| rs10506081 | chr12:31781964:T:C | - | 0.140504507460144 | 0.0192314985137695 | BLCA | Female-baised eQTL |
| rs78103963 | chr12:31788303:C:T | - | 0.140504507460144 | 0.0192314985137695 | BLCA | Female-baised eQTL |
| rs7136351 | chr12:31774039:C:T | - | 0.135362010161842 | 0.0215375378560697 | BLCA | Female-baised eQTL |
| rs983194 | chr12:41392834:G:T | - | 0.115575047609866 | 0.0224019583041674 | BLCA | Female-baised eQTL |
| rs60757758 | chr12:31775090:A:G | - | 0.137910305591568 | 0.0254532338949001 | BLCA | Female-baised eQTL |
| rs11831242 | chr12:31788375:G:A | - | 0.130249732278923 | 0.0256163100522739 | BLCA | Female-baised eQTL |
| rs11049953 | chr12:28958547:T:C | - | 0.0930392282095654 | 0.0259871065039106 | BLCA | Female-baised eQTL |
| rs11831167 | chr12:31788130:C:T | - | 0.129436470528285 | 0.0277812264879422 | BLCA | Female-baised eQTL |
| rs4931541 | chr12:27833927:C:T | - | -0.120423405689943 | 0.0302742919075777 | BLCA | Female-baised eQTL |
| rs12302464 | chr12:31788669:C:T | - | 0.131869037447602 | 0.0313889200387626 | BLCA | Female-baised eQTL |
| rs16918942 | chr12:31789046:T:C | - | 0.131869037447602 | 0.0313889200387626 | BLCA | Female-baised eQTL |
| rs10506079 | chr12:31789172:T:C | - | 0.131869037447602 | 0.0313889200387626 | BLCA | Female-baised eQTL |
| rs7296023 | chr12:31783139:T:C | - | 0.128083763575843 | 0.0321218456523697 | BLCA | Female-baised eQTL |
| rs12311217 | chr12:31777779:G:A | - | 0.131051163644461 | 0.0337457246417345 | BLCA | Female-baised eQTL |
| rs56802011 | chr12:31787271:T:C | - | 0.131051163644461 | 0.0337457246417345 | BLCA | Female-baised eQTL |
| rs7297347 | chr12:31787326:C:T | - | 0.131051163644461 | 0.0337457246417345 | BLCA | Female-baised eQTL |
| rs16925670 | chr12:23048765:C:T | - | 0.116155900217573 | 0.0399753785591101 | BLCA | Female-baised eQTL |
| rs16925675 | chr12:23050691:G:C | - | 0.116155900217573 | 0.0399753785591101 | BLCA | Female-baised eQTL |
| rs7136047 | chr12:31773882:A:G | - | 0.124980668532754 | 0.043233681226338 | BLCA | Female-baised eQTL |
| rs59280421 | chr12:31781093:G:A | - | 0.121434320177383 | 0.0450940977474688 | BLCA | Female-baised eQTL |
| rs71453797 | chr12:31018911:G:A | - | -0.101619324311639 | 0.0474405767162162 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs7310986 | chr12:26613787:G:A | - | 0.182450231438855 | 0.0213213385742115 | PCPG | Male-baised eQTL |
| rs61912237 | chr12:25018976:C:T | - | 0.168885904178916 | 0.00765020020568957 | PAAD | Male-baised eQTL |
| rs11047486 | chr12:24518727:A:T | - | 0.133695354472431 | 0.00926580576018304 | PAAD | Male-baised eQTL |
| rs11049885 | chr12:28867529:A:G | - | 0.120079293491143 | 0.0110495605744504 | PAAD | Male-baised eQTL |
| rs11609975 | chr12:32909884:G:A | - | 0.109899330987278 | 0.0167876507636761 | STAD | Male-baised eQTL |
| rs17531637 | chr12:28738441:A:G | - | 0.0699219557590317 | 0.00890317022995167 | BLCA | Male-baised eQTL |
| rs1480632 | chr12:28753687:A:G | - | 0.0667688512698948 | 0.0134495633324265 | BLCA | Male-baised eQTL |
| rs2617212 | chr12:28706914:A:C | - | 0.0577115814582843 | 0.0392750629417395 | BLCA | Male-baised eQTL |
| rs10771294 | chr12:26699211:A:C | - | 0.0443793599680495 | 0.046723695960765 | BLCA | Male-baised eQTL |
| rs7969065 | chr12:24402688:T:G | - | 0.0679494202159829 | 0.00633039954200852 | LUAD | Male-baised eQTL |
| rs10842337 | chr12:24401284:A:G | - | 0.0613015199420725 | 0.0174685421881239 | LUAD | Male-baised eQTL |
| rs11048910 | chr12:27193399:A:G | - | 0.0676714406348087 | 0.017802894754834 | LUAD | Male-baised eQTL |
| rs7303010 | chr12:41803879:C:T | - | -0.0736343011943015 | 0.0182684494373341 | LUAD | Male-baised eQTL |
| rs11610557 | chr12:42639202:T:A | - | 0.0631203273136632 | 0.0240022159696641 | LUAD | Male-baised eQTL |
| rs113219691 | chr12:40423116:G:A | - | 0.079221280594593 | 0.0339012760653142 | LUAD | Male-baised eQTL |
| rs17467192 | chr12:40423917:T:A | - | 0.079221280594593 | 0.0339012760653142 | LUAD | Male-baised eQTL |
| rs56024606 | chr12:41794401:G:A | - | 0.0857900258737985 | 0.0345912642310727 | LUAD | Male-baised eQTL |
| rs56129561 | chr12:41804924:C:T | - | 0.0836455260473793 | 0.0347137216986719 | LUAD | Male-baised eQTL |
| rs55935119 | chr12:41805206:G:A | - | 0.0836455260473793 | 0.0347137216986719 | LUAD | Male-baised eQTL |
| rs73126176 | chr12:41799578:G:T | - | 0.0833860099847447 | 0.0361252153539421 | LUAD | Male-baised eQTL |
| rs73126181 | chr12:41799767:A:G | - | 0.0833860099847447 | 0.0361252153539421 | LUAD | Male-baised eQTL |
| rs12830849 | chr12:42639148:C:G | - | 0.058908018985177 | 0.0404528493213971 | LUAD | Male-baised eQTL |
| rs11834039 | chr12:42640567:G:T | - | 0.058908018985177 | 0.0404528493213971 | LUAD | Male-baised eQTL |
| rs7963646 | chr12:40428930:C:T | - | 0.0753717264320906 | 0.0410945989273691 | LUAD | Male-baised eQTL |
| rs11564245 | chr12:40429552:G:C | - | 0.0753717264320906 | 0.0410945989273691 | LUAD | Male-baised eQTL |
| rs11181609 | chr12:42645695:T:C | - | 0.0581106396141286 | 0.0457176113980883 | LUAD | Male-baised eQTL |
| rs17444709 | chr12:40412028:T:C | - | 0.075575418265676 | 0.0463901119305524 | LUAD | Male-baised eQTL |
| rs10506162 | chr12:40432712:T:C | - | 0.0736866580035459 | 0.0498024445477316 | LUAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000057294 |
| CpG Site: cg19677302 | |
| Position to Gene: gene,promoter | |
| Male Effect: -0.45702803564478 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg19677302 | chr12:32895325 | gene,promoter | -0.45702803564478 | 7.5004276301826e-10 | -0.45766828426703 | 8.673396036776261e-13 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of PKP2 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000057294 | PKP2 | C0004238 | Atrial Fibrillation | 2 | CTD_human |
| ENSG00000057294 | PKP2 | C0235480 | Paroxysmal atrial fibrillation | 2 | CTD_human |
| ENSG00000057294 | PKP2 | C1836906 | Arrhythmogenic Right Ventricular Dysplasia, Familial, 9 | 1 | CTD_human |
| ENSG00000057294 | PKP2 | C2585653 | Persistent atrial fibrillation | 2 | CTD_human |
| ENSG00000057294 | PKP2 | C3468561 | familial atrial fibrillation | 2 | CTD_human |
