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Gene: ENSG00000049323 |
Summary for LTBP1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000049323 | Gene symbol | LTBP1 |
| Gene name | latent transforming growth factor beta binding protein 1 | |
| HGNC | 6714 | |
| Entrez ID | 4052 | |
| Gene type | protein_coding | |
| Synonyms | LTBP1| | |
| UniProtAcc | Q14766 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for LTBP1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| LTBP1 | 4.75e+03 | -1.54e+00 | 3.51e-01 | -4.38e+00 | 1.20e-05 | 6.95e-05 | BLCA |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| LTBP1 | 5.11e+03 | -1.41e+00 | 3.08e-01 | -4.58e+00 | 4.76e-06 | 1.55e-05 | KIRC |
Top |
Sex-biased somatic mutation for LTBP1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for LTBP1 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| ACC | cg26822501 | chr2:32946267 | CGI:chr2:32946381-32948097 | promoter | 3.35e-01 | 4.58e-01 | -2.31e+00 | 2.09e-02 | 3.62e-02 | -1.22e-01 |
| KICH | cg26822501 | chr2:32946267 | CGI:chr2:32946381-32948097 | promoter | 4.58e-01 | 3.34e-01 | 2.24e+00 | 2.53e-02 | 4.05e-02 | 1.24e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg26822501 | chr2:32946267 | CGI:chr2:32946381-32948097 | promoter | 2.72e-01 | 4.69e-01 | -4.39e+00 | 1.16e-05 | 5.26e-04 | -1.97e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg26822501 | chr2:32946267 | CGI:chr2:32946381-32948097 | promoter | 2.85e-01 | 4.41e-01 | -1.32e+01 | 1.07e-39 | 7.77e-38 | -1.57e-01 |
| HNSC | cg21139003 | chr2:32948234 | CGI:chr2:32946381-32948097 | promoter,gene body | 5.57e-01 | 4.20e-01 | 2.17e+00 | 2.99e-02 | 3.54e-02 | 1.37e-01 |
| COAD | cg21139003 | chr2:32948234 | CGI:chr2:32946381-32948097 | promoter,gene body | 4.92e-01 | 3.54e-01 | 3.00e+00 | 2.70e-03 | 6.06e-03 | 1.38e-01 |
| BLCA | cg27569706 | chr2:32948096 | CGI:chr2:32946381-32948097 | promoter,gene body | 1.54e-01 | 2.57e-01 | -3.28e+00 | 1.03e-03 | 4.88e-03 | -1.03e-01 |
| KIRP | cg27569706 | chr2:32948096 | CGI:chr2:32946381-32948097 | promoter,gene body | 3.55e-01 | 1.92e-01 | 2.71e+00 | 6.79e-03 | 1.30e-02 | 1.63e-01 |
Top |
Exon skipping events with PSI in TCGA for LTBP1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| BRCA | exon_skip_324787 | 9.01e-01 | 7.18e-01 | 1.36e+01 | 3.63e-42 | 7.10e-40 | 1.83e-01 |
| LUSC | exon_skip_324787 | 8.86e-01 | 7.82e-01 | 4.44e+00 | 8.83e-06 | 6.78e-05 | 1.03e-01 |
Top |
RNA A-to-I editing events in TCGA for LTBP1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for LTBP1 |
| TFs related to LTBP1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| MESO | ZNF418 | LTBP1 | 2.90e+00 | 8.22e-03 | 4.23e+00 | 9.81e-01 | Female-biased |
| READ | EMX2 | LTBP1 | 3.59e+00 | 7.88e-03 | 4.48e+00 | 9.84e-01 | Female-biased |
| READ | EN1 | LTBP1 | 4.03e+00 | 1.39e-02 | 4.78e+00 | 9.81e-01 | Female-biased |
| READ | FOXF1 | LTBP1 | 2.95e+00 | 3.34e-03 | 4.06e+00 | 9.81e-01 | Female-biased |
| READ | HIC1 | LTBP1 | 4.20e+00 | 9.84e-01 | 3.08e+00 | 2.96e-03 | Male-biased |
| READ | HOXA9 | LTBP1 | 3.40e+00 | 5.32e-03 | 4.39e+00 | 9.86e-01 | Female-biased |
| READ | MSX1 | LTBP1 | 3.08e+00 | 3.35e-03 | 4.19e+00 | 9.84e-01 | Female-biased |
| READ | MSX2 | LTBP1 | 3.04e+00 | 3.43e-03 | 4.14e+00 | 9.83e-01 | Female-biased |
| READ | NKX3-1 | LTBP1 | 2.96e+00 | 2.80e-03 | 4.11e+00 | 9.83e-01 | Female-biased |
| READ | NKX6-3 | LTBP1 | 3.78e+00 | 8.12e-03 | 4.67e+00 | 9.86e-01 | Female-biased |
| READ | PDX1 | LTBP1 | 3.66e+00 | 1.09e-02 | 4.46e+00 | 9.81e-01 | Female-biased |
| READ | POU4F1 | LTBP1 | 3.13e+00 | 3.36e-03 | 4.24e+00 | 9.85e-01 | Female-biased |
| READ | POU4F2 | LTBP1 | 2.92e+00 | 2.83e-03 | 4.07e+00 | 9.82e-01 | Female-biased |
| READ | POU4F3 | LTBP1 | 3.33e+00 | 5.54e-03 | 4.31e+00 | 9.84e-01 | Female-biased |
| READ | POU6F2 | LTBP1 | 3.62e+00 | 5.19e-03 | 4.62e+00 | 9.89e-01 | Female-biased |
| READ | ZNF580 | LTBP1 | 3.01e+00 | 3.87e-03 | 4.07e+00 | 9.81e-01 | Female-biased |
| LTBP1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for LTBP1 |
| RBPs related to ES in LTBP1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| LUSC | FMR1 | exon_skip_324778 | 6.27e+00 | 4.38e-04 | 6.99e+00 | 9.86e-01 | Female-biased |
| DLBC | FXR2 | exon_skip_324795 | 8.01e+00 | 9.86e-01 | 7.62e+00 | 5.49e-03 | Male-biased |
| DLBC | HNRNPA2B1 | exon_skip_324795 | 1.07e+01 | 9.98e-01 | 1.01e+01 | 1.01e-03 | Male-biased |
| LUAD | BRUNOL4 | exon_skip_324781 | 7.87e+00 | 1.03e-02 | 8.20e+00 | 9.82e-01 | Female-biased |
| LUAD | BRUNOL5 | exon_skip_324781 | 7.89e+00 | 1.03e-02 | 8.22e+00 | 9.82e-01 | Female-biased |
| LUAD | hnRNPLL | exon_skip_324781 | 7.78e+00 | 1.04e-02 | 8.11e+00 | 9.81e-01 | Female-biased |
| ESCA | FMR1 | exon_skip_324782 | 8.30e+00 | 9.34e-03 | 8.75e+00 | 9.86e-01 | Female-biased |
| ESCA | SFPQ | exon_skip_324764 | 9.99e+00 | 9.50e-03 | 1.04e+01 | 9.89e-01 | Female-biased |
| READ | SFPQ | exon_skip_324765 | 1.03e+01 | 4.59e-03 | 1.07e+01 | 9.94e-01 | Female-biased |
| MESO | HNRNPA2B1 | exon_skip_324795 | 1.02e+01 | 6.77e-03 | 1.05e+01 | 9.92e-01 | Female-biased |
| PAAD | BRUNOL4 | exon_skip_324781 | 8.21e+00 | 9.85e-01 | 7.89e+00 | 7.56e-03 | Male-biased |
| PAAD | BRUNOL5 | exon_skip_324781 | 8.22e+00 | 9.85e-01 | 7.90e+00 | 7.57e-03 | Male-biased |
| PAAD | hnRNPLL | exon_skip_324781 | 8.12e+00 | 9.84e-01 | 7.79e+00 | 7.52e-03 | Male-biased |
| LTBP1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000049323 | AC105942.1,hsa-mir-152,LTBP1 | Male-specific ceRNA | TCGA-BLCA |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs77601363 | chr2:38252080:T:C | - | 0.269434887908548 | 0.0329459189852598 | GBM | Female-baised eQTL |
| rs7565694 | chr2:38255369:A:G | - | 0.269434887908548 | 0.0329459189852598 | GBM | Female-baised eQTL |
| rs4670838 | chr2:38255782:T:G | - | 0.269434887908548 | 0.0329459189852598 | GBM | Female-baised eQTL |
| rs11127185 | chr2:28638201:G:A | - | 0.260208452146969 | 0.0037009224601935 | KIRP | Female-baised eQTL |
| rs72931145 | chr2:39433833:A:T | - | 0.289218888727179 | 0.0164708406839013 | KIRP | Female-baised eQTL |
| rs78462223 | chr2:39435402:T:C | - | 0.289218888727179 | 0.0164708406839013 | KIRP | Female-baised eQTL |
| rs7609233 | chr2:39437684:C:T | - | 0.289218888727179 | 0.0164708406839013 | KIRP | Female-baised eQTL |
| rs113074371 | chr2:39439134:G:T | - | 0.289218888727179 | 0.0164708406839013 | KIRP | Female-baised eQTL |
| rs17023994 | chr2:39587839:A:G | - | 0.210295981225067 | 0.0376135686290716 | KIRP | Female-baised eQTL |
| rs7581123 | chr2:39410187:T:C | - | 0.255683021188467 | 0.0487069372504891 | KIRP | Female-baised eQTL |
| rs79304293 | chr2:39419932:A:T | - | 0.255683021188467 | 0.0487069372504891 | KIRP | Female-baised eQTL |
| rs72931129 | chr2:39420529:G:A | - | 0.255683021188467 | 0.0487069372504891 | KIRP | Female-baised eQTL |
| rs72931131 | chr2:39421556:T:A | - | 0.255683021188467 | 0.0487069372504891 | KIRP | Female-baised eQTL |
| rs72931135 | chr2:39422528:C:T | - | 0.255683021188467 | 0.0487069372504891 | KIRP | Female-baised eQTL |
| rs7592925 | chr2:39422712:G:A | - | 0.255683021188467 | 0.0487069372504891 | KIRP | Female-baised eQTL |
| rs7566368 | chr2:39422924:A:T | - | 0.255683021188467 | 0.0487069372504891 | KIRP | Female-baised eQTL |
| rs137955203 | chr2:39424191:G:T | - | 0.255683021188467 | 0.0487069372504891 | KIRP | Female-baised eQTL |
| rs6759388 | chr2:39426184:C:A | - | 0.255683021188467 | 0.0487069372504891 | KIRP | Female-baised eQTL |
| rs72931150 | chr2:39438591:G:A | - | 0.255683021188467 | 0.0487069372504891 | KIRP | Female-baised eQTL |
| rs72931159 | chr2:39443879:C:A | - | 0.255683021188467 | 0.0487069372504891 | KIRP | Female-baised eQTL |
| rs72931161 | chr2:39443934:C:G | - | 0.255683021188467 | 0.0487069372504891 | KIRP | Female-baised eQTL |
| rs72925299 | chr2:39345291:A:G | - | 0.255117736496545 | 0.049398832029124 | KIRP | Female-baised eQTL |
| rs773810 | chr2:33870586:C:G | - | -0.143197902219791 | 0.0495547501176293 | LGG | Female-baised eQTL |
| rs13397483 | chr2:35907847:G:C | - | 0.0929617203667651 | 0.0129216354844731 | KIRC | Female-baised eQTL |
| rs4233711 | chr2:26163215:C:T | - | 0.075257600669338 | 0.0142607094960294 | KIRC | Female-baised eQTL |
| rs17025380 | chr2:40169477:G:A | - | 0.069059565876465 | 0.0423934161683389 | KIRC | Female-baised eQTL |
| rs111738935 | chr2:36693481:G:T | - | 0.138132343462932 | 0.0202412871655991 | BLCA | Female-baised eQTL |
| rs78948154 | chr2:36699853:C:A | - | 0.136989928678487 | 0.0225560516084916 | BLCA | Female-baised eQTL |
| rs114289367 | chr2:41169953:C:T | - | 0.136574227899211 | 0.0240518026471088 | BLCA | Female-baised eQTL |
| rs144736008 | chr2:41178615:T:C | - | 0.12760910553272 | 0.0454735132636655 | BLCA | Female-baised eQTL |
| rs7578659 | chr2:32778995:C:A | - | 0.0468060945052365 | 0.0321559624508523 | LUAD | Female-baised eQTL |
| rs71449518 | chr2:34411342:G:T | - | 0.107225299336177 | 0.00383391655634109 | COAD | Female-baised eQTL |
| rs34337993 | chr2:34408858:T:C | - | 0.106569904502473 | 0.00402551845766659 | COAD | Female-baised eQTL |
| rs35555071 | chr2:34411316:T:G | - | 0.106569904502473 | 0.00402551845766659 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs10197663 | chr2:29317968:G:A | - | 0.386423880378436 | 0.00295636918422371 | PCPG | Male-baised eQTL |
| rs10189673 | chr2:29318126:T:C | - | 0.386423880378436 | 0.00295636918422371 | PCPG | Male-baised eQTL |
| rs10195355 | chr2:29319257:T:C | - | 0.386423880378436 | 0.00295636918422371 | PCPG | Male-baised eQTL |
| rs75757684 | chr2:29321723:C:T | - | 0.386423880378436 | 0.00295636918422371 | PCPG | Male-baised eQTL |
| rs6718971 | chr2:29324091:A:G | - | 0.386423880378436 | 0.00295636918422371 | PCPG | Male-baised eQTL |
| rs79877195 | chr2:29324145:G:A | - | 0.386423880378436 | 0.00295636918422371 | PCPG | Male-baised eQTL |
| rs10168147 | chr2:29316095:C:T | - | 0.385831136997395 | 0.00317453219767943 | PCPG | Male-baised eQTL |
| rs13413749 | chr2:29316451:G:A | - | 0.385831136997395 | 0.00317453219767943 | PCPG | Male-baised eQTL |
| rs17783218 | chr2:29262056:C:A | - | 0.384554479807657 | 0.0293531638287076 | PCPG | Male-baised eQTL |
| rs74617983 | chr2:29265553:C:G | - | 0.384554479807657 | 0.0293531638287076 | PCPG | Male-baised eQTL |
| rs79419943 | chr2:29266776:T:C | - | 0.384554479807657 | 0.0293531638287076 | PCPG | Male-baised eQTL |
| rs78616665 | chr2:29267998:T:C | - | 0.384554479807657 | 0.0293531638287076 | PCPG | Male-baised eQTL |
| rs80293761 | chr2:29269288:G:T | - | 0.384554479807657 | 0.0293531638287076 | PCPG | Male-baised eQTL |
| rs76897964 | chr2:29270677:A:G | - | 0.384554479807657 | 0.0293531638287076 | PCPG | Male-baised eQTL |
| rs74419707 | chr2:29270800:A:G | - | 0.382527831397016 | 0.0317704381557056 | PCPG | Male-baised eQTL |
| rs78261232 | chr2:29270932:A:G | - | 0.382527831397016 | 0.0317704381557056 | PCPG | Male-baised eQTL |
| rs112085062 | chr2:29271191:T:C | - | 0.382527831397016 | 0.0317704381557056 | PCPG | Male-baised eQTL |
| rs56789266 | chr2:29271689:C:T | - | 0.382527831397016 | 0.0317704381557056 | PCPG | Male-baised eQTL |
| rs61238373 | chr2:29271753:A:G | - | 0.382527831397016 | 0.0317704381557056 | PCPG | Male-baised eQTL |
| rs56840835 | chr2:29271802:T:C | - | 0.382527831397016 | 0.0317704381557056 | PCPG | Male-baised eQTL |
| rs58058781 | chr2:29271820:T:C | - | 0.382527831397016 | 0.0317704381557056 | PCPG | Male-baised eQTL |
| rs76533309 | chr2:29272950:T:C | - | 0.382527831397016 | 0.0317704381557056 | PCPG | Male-baised eQTL |
| rs75376200 | chr2:29273112:T:G | - | 0.382527831397016 | 0.0317704381557056 | PCPG | Male-baised eQTL |
| rs112698361 | chr2:29273961:T:C | - | 0.382527831397016 | 0.0317704381557056 | PCPG | Male-baised eQTL |
| rs78046790 | chr2:29274391:A:G | - | 0.382527831397016 | 0.0317704381557056 | PCPG | Male-baised eQTL |
| rs77734716 | chr2:29282425:A:T | - | 0.380884361136346 | 0.034586492528461 | PCPG | Male-baised eQTL |
| rs112104474 | chr2:29283962:T:G | - | 0.380884361136346 | 0.034586492528461 | PCPG | Male-baised eQTL |
| rs17783146 | chr2:29260031:A:T | - | 0.358831679648609 | 0.0390793389781982 | PCPG | Male-baised eQTL |
| rs1406240 | chr2:29258967:A:G | - | 0.357589025245121 | 0.0405020619228523 | PCPG | Male-baised eQTL |
| rs1406239 | chr2:29259381:G:A | - | 0.357589025245121 | 0.0405020619228523 | PCPG | Male-baised eQTL |
| rs13031842 | chr2:26488268:C:T | - | 0.06398207127785 | 0.0412643602371814 | KIRP | Male-baised eQTL |
| rs7584368 | chr2:30554968:A:G | - | 0.0699715374302255 | 0.00238592683353107 | LIHC | Male-baised eQTL |
| rs6729941 | chr2:26410076:G:A | - | 0.0713907073709033 | 0.0255264044352165 | LIHC | Male-baised eQTL |
| rs17026655 | chr2:40789009:G:A | - | 0.0740864212111386 | 0.0247464340300876 | LGG | Male-baised eQTL |
| rs6545951 | chr2:25120256:C:T | - | 0.100549144646215 | 0.021709321578482 | KIRC | Male-baised eQTL |
| rs140953695 | chr2:28871166:C:A | - | 0.0935285759878265 | 0.0424941497042199 | LUAD | Male-baised eQTL |
| rs848534 | chr2:36463099:C:T | - | 0.0657872836911276 | 0.0126697010156386 | COAD | Male-baised eQTL |
| rs940294 | chr2:36459083:T:C | - | 0.0746777378756566 | 0.0141129785558585 | COAD | Male-baised eQTL |
| rs756203 | chr2:36459530:A:G | - | 0.0700444534177568 | 0.0243628814724873 | COAD | Male-baised eQTL |
| rs150632833 | chr2:36601664:T:C | - | 0.0605926912410037 | 0.0249032015245104 | COAD | Male-baised eQTL |
| rs848538 | chr2:36490981:G:C | - | 0.0564027541211423 | 0.0254221656916806 | COAD | Male-baised eQTL |
| rs74261721 | chr2:42819171:A:G | - | 0.135916612913492 | 0.0255132792983201 | COAD | Male-baised eQTL |
| rs59966191 | chr2:37435955:C:G | - | 0.103972045334795 | 0.0289923801619096 | COAD | Male-baised eQTL |
| rs11126857 | chr2:27074889:G:A | - | -0.0593302434347706 | 0.034876674996237 | COAD | Male-baised eQTL |
| rs848555 | chr2:36471108:G:T | - | 0.0593105818469497 | 0.035076603922942 | COAD | Male-baised eQTL |
| rs2304682 | chr2:27084901:G:C | - | 0.0596023632877203 | 0.0357284328096212 | COAD | Male-baised eQTL |
| rs940295 | chr2:36459280:C:A | - | 0.0673053057261625 | 0.0360880115688164 | COAD | Male-baised eQTL |
| rs848558 | chr2:36467416:C:T | - | 0.0591687698458946 | 0.0367703932328366 | COAD | Male-baised eQTL |
| rs11676071 | chr2:28968009:G:C | - | 0.0831100370061306 | 0.0384936055366435 | COAD | Male-baised eQTL |
| rs1043427 | chr2:26395521:C:T | - | 0.126963564133607 | 0.0387361954864477 | COAD | Male-baised eQTL |
| rs12997235 | chr2:27006211:A:C | - | -0.0568422407541607 | 0.0429687623978949 | COAD | Male-baised eQTL |
| rs7602823 | chr2:27086538:G:A | - | -0.0571250583691795 | 0.0462010624812235 | COAD | Male-baised eQTL |
| rs7567935 | chr2:28991427:T:C | - | -0.0801064680528983 | 0.046560502477729 | COAD | Male-baised eQTL |
| rs4665943 | chr2:27073017:C:T | - | -0.0585058311219315 | 0.0489976145131263 | COAD | Male-baised eQTL |
| rs4665440 | chr2:28985247:A:G | - | 0.0790118729538287 | 0.0494865000788285 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000049323 |
| CpG Site: cg21139003 | |
| Position to Gene: gene,promoter | |
| Male Effect: - | |
| Female Effect: -0.433574339371879 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg21139003 | chr2:32948234 | gene,promoter | -0.433574339371879 | 6.2279656652556e-08 | -0.3733531662057306 | 7.425498687592901e-10 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs10432654 | chr2:32684857:G:A | Distant upstream | 0.0241716030271902 | 0.0435895514693142 | LUAD | Female-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs2887089 | chr2:33629533:C:G | Distant downstream | -0.048053907780672 | 0.00197725863824436 | COAD | Female-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs12712342 | chr2:33607432:G:A | Distant downstream | -0.0705146451990101 | 0.00230690831160607 | COAD | Female-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs35630933 | chr2:33615450:C:G | Distant downstream | -0.0653702247279615 | 0.00419610414821422 | COAD | Female-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs12990303 | chr2:33615793:A:T | Distant downstream | -0.0653702247279615 | 0.00419610414821422 | COAD | Female-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs34321218 | chr2:33621944:G:A | Distant downstream | -0.0653702247279615 | 0.00419610414821422 | COAD | Female-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs34482270 | chr2:33623483:C:T | Distant downstream | -0.0653702247279615 | 0.00419610414821422 | COAD | Female-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs6724572 | chr2:33668030:G:A | Distant downstream | -0.0663506854882287 | 0.00556028552738269 | COAD | Female-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs17014880 | chr2:34212182:G:C | Distant downstream | -0.0589927677288833 | 0.00560203337875421 | COAD | Female-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs6543734 | chr2:33671460:G:A | Distant downstream | -0.0483283140251075 | 0.00782532495844661 | COAD | Female-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs6740009 | chr2:33633545:T:G | Distant downstream | -0.0598142435880859 | 0.0288871388666798 | COAD | Female-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs17011943 | chr2:32396075:T:C | Distant upstream | -0.0496908785874372 | 0.0302786252570684 | COAD | Female-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs57813560 | chr2:32396838:C:T | Distant upstream | -0.0496908785874372 | 0.0302786252570684 | COAD | Female-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs218184 | chr2:33091518:T:C | Distant upstream | 0.0308207671684764 | 0.0387747622929451 | COAD | Female-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs10209396 | chr2:34304177:G:C | Distant downstream | -0.037617725909072 | 0.0403523785790524 | COAD | Female-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs7584441 | chr2:32845627:C:T | Distant upstream | -0.050387344634749 | 0.0439642712523532 | COAD | Female-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs7584869 | chr2:32845835:G:A | Distant upstream | -0.050387344634749 | 0.0439642712523532 | COAD | Female-baised sQTL |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs7607820 | chr2:33015537:G:T | Distant upstream | 0.0970272913025353 | 0.00816060554588095 | LGG | Male-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs7607622 | chr2:33015552:C:G | Distant upstream | 0.0970272913025353 | 0.00816060554588095 | LGG | Male-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs59045998 | chr2:33021874:G:T | Distant upstream | 0.0967378030466265 | 0.00857262508863175 | LGG | Male-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs60485084 | chr2:32993662:G:A | Distant upstream | 0.0976489838836391 | 0.0152247652368655 | LGG | Male-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs13429370 | chr2:32994220:A:G | Distant upstream | 0.0907359907148022 | 0.0248670574959803 | LGG | Male-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs6722859 | chr2:33043460:A:G | Distant upstream | 0.0991459179491583 | 0.0335693887802635 | LGG | Male-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs57178729 | chr2:32990106:A:C | Distant upstream | 0.0876246929657043 | 0.0342259479012229 | LGG | Male-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs77825163 | chr2:33087209:G:A | Distant upstream | 0.0832716860120076 | 0.0433577756984397 | LGG | Male-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs7583652 | chr2:33079004:G:T | Distant upstream | 0.0828362731990984 | 0.0451906520578684 | LGG | Male-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs59437355 | chr2:33082120:C:T | Distant upstream | 0.0827637760569739 | 0.0458960076426329 | LGG | Male-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs9678178 | chr2:33082306:A:C | Distant upstream | 0.0827637760569739 | 0.0458960076426329 | LGG | Male-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs11124364 | chr2:34201924:G:A | Distant downstream | -0.0310463093734406 | 0.00686691265092752 | HNSC | Male-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs7608289 | chr2:34207127:C:T | Distant downstream | -0.0283557828931553 | 0.0164903044055465 | HNSC | Male-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs6732689 | chr2:34207709:A:C | Distant downstream | -0.028337775353732 | 0.0165637955310833 | HNSC | Male-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs61238644 | chr2:34208235:G:A | Distant downstream | -0.028337775353732 | 0.0165637955310833 | HNSC | Male-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs58729154 | chr2:34208286:A:G | Distant downstream | -0.028337775353732 | 0.0165637955310833 | HNSC | Male-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs11895051 | chr2:34208906:T:C | Distant downstream | -0.028337775353732 | 0.0165637955310833 | HNSC | Male-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs57232469 | chr2:34209133:C:T | Distant downstream | -0.028337775353732 | 0.0165637955310833 | HNSC | Male-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs6751419 | chr2:34210157:G:A | Distant downstream | -0.028337775353732 | 0.0165637955310833 | HNSC | Male-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs7604330 | chr2:34206064:C:A | Distant downstream | -0.0281920689470014 | 0.0186227419794214 | HNSC | Male-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs10490442 | chr2:34205258:A:G | Distant downstream | -0.0274113061030184 | 0.0193186594314418 | HNSC | Male-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs7608357 | chr2:34207038:G:C | Distant downstream | -0.0274113061030184 | 0.0193186594314418 | HNSC | Male-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs7581576 | chr2:34207075:A:G | Distant downstream | -0.0274113061030184 | 0.0193186594314418 | HNSC | Male-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs11680287 | chr2:32930838:T:C | Distant upstream | 0.0239939727597919 | 0.0140831037085204 | BLCA | Male-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs6543688 | chr2:32929059:A:G | Distant upstream | 0.0242562344357214 | 0.0147876106789948 | BLCA | Male-baised sQTL |
| exon_skip_324787 | chr2:33342837:33342963 | In-frame | rs1998258 | chr2:32930115:T:C | Distant upstream | 0.0234953301680686 | 0.0243813999332215 | BLCA | Male-baised sQTL |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of LTBP1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000049323 | LTBP1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| ENSG00000049323 | LTBP1 | C0409959 | Osteoarthritis, Knee | 1 | CTD_human |
