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Gene: ENSG00000044115 |
Summary for CTNNA1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000044115 | Gene symbol | CTNNA1 |
| Gene name | catenin alpha 1 | |
| HGNC | 2509 | |
| Entrez ID | 1495 | |
| Gene type | protein_coding | |
| Synonyms | CTNNA1|CAP102 | |
| UniProtAcc | P35221 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for CTNNA1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for CTNNA1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for CTNNA1 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg10920316 | chr5:138610910 | CGI:chr5:138575244-138575948 | promoter | 4.07e-01 | 2.85e-01 | 2.05e+00 | 4.05e-02 | 4.20e-02 | 1.22e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BLCA | cg10920316 | chr5:138610910 | CGI:chr5:138575244-138575948 | promoter | 4.10e-01 | 2.94e-01 | 1.99e+00 | 4.69e-02 | 4.77e-02 | 1.16e-01 |
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Exon skipping events with PSI in TCGA for CTNNA1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for CTNNA1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
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| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| COAD | CTNNA1-202 | chr5_138879491_+ | 2.62e-01 | 6.67e-01 | -3.37e+00 | 7.47e-04 | 1.45e-02 | -4.05e-01 |
| STAD | CTNNA1-202 | chr5_138879008_+ | 2.79e-01 | 4.07e-01 | -2.40e+00 | 1.66e-02 | 4.96e-02 | -1.28e-01 |
| STAD | CTNNA1-202 | chr5_138879107_+ | 2.31e-01 | 1.53e-01 | 2.72e+00 | 6.55e-03 | 4.96e-02 | 7.81e-02 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for CTNNA1 |
| TFs related to CTNNA1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BLCA | LHX6 | CTNNA1 | 3.85e+00 | 1.15e-02 | 4.67e+00 | 9.83e-01 | Female-biased |
| BLCA | NEUROG2 | CTNNA1 | 4.31e+00 | 1.43e-02 | 5.08e+00 | 9.83e-01 | Female-biased |
| BLCA | NFIL3 | CTNNA1 | 3.89e+00 | 1.28e-02 | 4.68e+00 | 9.82e-01 | Female-biased |
| DLBC | ZNF418 | CTNNA1 | 1.63e+00 | 6.58e-05 | 4.10e+00 | 9.87e-01 | Female-biased |
| CTNNA1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for CTNNA1 |
| RBPs related to ES in CTNNA1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| THYM | RBM6 | exon_skip_437823 | 7.50e+00 | 8.99e-03 | 7.83e+00 | 9.82e-01 | Female-biased |
| LIHC | KHDRBS2 | exon_skip_437817 | 1.04e+01 | 9.89e-01 | 1.00e+01 | 9.12e-03 | Male-biased |
| KIRP | KHDRBS2 | exon_skip_437817 | 1.03e+01 | 9.81e-01 | 1.00e+01 | 1.74e-02 | Male-biased |
| KIRP | SAMD4A | exon_skip_437853 | 8.34e+00 | 7.88e-03 | 8.69e+00 | 9.86e-01 | Female-biased |
| BRCA | SAMD4A | exon_skip_437853 | 8.66e+00 | 3.77e-03 | 9.58e+00 | 9.94e-01 | Female-biased |
| THCA | SAMD4A | exon_skip_437853 | 8.66e+00 | 9.93e-01 | 8.24e+00 | 1.77e-03 | Male-biased |
| PAAD | SAMD4A | exon_skip_437853 | 8.56e+00 | 9.90e-01 | 8.18e+00 | 3.48e-03 | Male-biased |
| KIRC | SAMD4A | exon_skip_437853 | 8.77e+00 | 9.95e-01 | 8.09e+00 | 1.60e-04 | Male-biased |
| SKCM | SAMD4A | exon_skip_437853 | 8.24e+00 | 1.51e-03 | 8.81e+00 | 9.93e-01 | Female-biased |
| HNSC | SAMD4A | exon_skip_437853 | 9.01e+00 | 9.95e-01 | 8.31e+00 | 4.63e-04 | Male-biased |
| SARC | SAMD4A | exon_skip_437853 | 8.95e+00 | 9.94e-01 | 8.32e+00 | 1.09e-03 | Male-biased |
| CTNNA1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs1566404 | chr5:136350696:C:A | - | -0.0959891668081334 | 0.0234205935944432 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs13166300 | chr5:146465351:T:C | - | 0.0602639467682861 | 0.0104739017669773 | LUAD | Male-baised eQTL |
| rs13189397 | chr5:133848392:G:C | - | 0.0732508960889016 | 0.0232913450892694 | LUAD | Male-baised eQTL |
| rs35445236 | chr5:133851067:A:G | - | 0.0708749578539349 | 0.0323656620651488 | LUAD | Male-baised eQTL |
| rs6868300 | chr5:146497409:C:T | - | 0.0550854715236915 | 0.0451866653182231 | LUAD | Male-baised eQTL |
| rs6889741 | chr5:146440849:C:T | - | 0.0547351654777634 | 0.0475711753567146 | LUAD | Male-baised eQTL |
| rs7702433 | chr5:146466332:G:A | - | 0.053576978494168 | 0.0492520326880765 | LUAD | Male-baised eQTL |
| rs6876812 | chr5:133120494:C:A | - | 0.0544217490474017 | 0.0333535915476618 | COAD | Male-baised eQTL |
| rs4358577 | chr5:133155299:C:T | - | 0.0675210660610456 | 0.0341111532311098 | COAD | Male-baised eQTL |
| rs10077159 | chr5:143442464:T:A | - | -0.0566441394125331 | 0.041121420955829 | COAD | Male-baised eQTL |
| rs11950238 | chr5:143448807:G:C | - | -0.0566441394125331 | 0.041121420955829 | COAD | Male-baised eQTL |
| rs10050413 | chr5:133121791:A:G | - | 0.0546657797460096 | 0.0438605985420592 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000044115 |
| CpG Site: cg02276665 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.117890219128955 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg02276665 | chr5:138752753 | gene | -0.117890219128955 | 5.03552134416466e-05 | -0.31870885656167464 | 1.9862799920272597e-07 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of CTNNA1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000044115 | CTNNA1 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
| ENSG00000044115 | CTNNA1 | C0026998 | Acute Myeloid Leukemia, M1 | 1 | CTD_human |
| ENSG00000044115 | CTNNA1 | C0238198 | Gastrointestinal Stromal Tumors | 1 | CTD_human |
| ENSG00000044115 | CTNNA1 | C1837029 | Macular Dystrophy, Butterfly-Shaped Pigmentary, 2 | 1 | CTD_human |
| ENSG00000044115 | CTNNA1 | C1868569 | Patterned dystrophy of retinal pigment epithelium | 1 | CTD_human |
| ENSG00000044115 | CTNNA1 | C1879321 | Acute Myeloid Leukemia (AML-M2) | 1 | CTD_human |
| ENSG00000044115 | CTNNA1 | C2713368 | Hematopoetic Myelodysplasia | 1 | CTD_human |
| ENSG00000044115 | CTNNA1 | C3179349 | Gastrointestinal Stromal Sarcoma | 1 | CTD_human |
| ENSG00000044115 | CTNNA1 | C3463824 | MYELODYSPLASTIC SYNDROME | 1 | CTD_human |
