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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000043039

Summary for BARX2

check button Gene summary

Gene informationEnsembl ID

ENSG00000043039

Gene symbol

BARX2

Gene nameBARX homeobox 2
HGNC

956

Entrez ID

8538

Gene typeprotein_coding
SynonymsBARX2|
UniProtAcc

Q9UMQ3


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

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Structure and expression level for BARX2

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
BARX21.20e+03-2.10e+003.77e-01-5.57e+002.62e-082.15e-07STAD
BARX21.70e+032.03e+006.04e-013.36e+007.70e-045.12e-03ESCA
BARX24.04e+026.06e+001.05e+005.77e+007.71e-098.96e-08CHOL

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
BARX21.09e+031.26e+003.99e-013.16e+001.60e-033.38e-03KICH
BARX22.13e+02-1.71e+006.07e-01-2.82e+004.76e-031.32e-02READ

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Sex-biased somatic mutation for BARX2

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for BARX2

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
LIHCcg07355688chr11:129376823CGI:chr11:129372634-129376500promoter,gene body3.76e-012.44e-014.78e+001.72e-062.28e-051.32e-01
ESCAcg04299135chr11:129374546CGI:chr11:129372634-129376500promoter1.57e-015.02e-023.12e+001.80e-037.51e-031.06e-01
ESCAcg04094148chr11:129374628CGI:chr11:129372634-129376500promoter2.05e-017.08e-023.36e+007.75e-043.58e-031.34e-01
ESCAcg17692125chr11:129374610CGI:chr11:129372634-129376500promoter1.99e-015.48e-023.27e+001.07e-034.80e-031.45e-01
CHOLcg21697198chr11:129376499CGI:chr11:129372634-129376500promoter,gene body3.39e-012.03e-012.10e+003.56e-024.34e-021.36e-01

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
HNSCcg04094148chr11:129374628CGI:chr11:129372634-129376500promoter1.67e-014.29e-023.97e+007.23e-051.97e-041.24e-01
HNSCcg17692125chr11:129374610CGI:chr11:129372634-129376500promoter1.41e-013.15e-023.30e+009.75e-041.77e-031.09e-01
LUSCcg04299135chr11:129374546CGI:chr11:129372634-129376500promoter2.37e-014.14e-022.94e+003.29e-035.99e-031.96e-01
LUSCcg04094148chr11:129374628CGI:chr11:129372634-129376500promoter2.97e-018.23e-022.44e+001.49e-021.89e-022.15e-01
LUSCcg17692125chr11:129374610CGI:chr11:129372634-129376500promoter2.84e-015.37e-022.24e+002.53e-022.88e-022.31e-01
LUSCcg21697198chr11:129376499CGI:chr11:129372634-129376500promoter,gene body1.65e-015.85e-022.73e+006.39e-039.82e-031.07e-01
BLCAcg07355688chr11:129376823CGI:chr11:129372634-129376500promoter,gene body1.84e-013.29e-01-3.92e+008.96e-053.70e-04-1.45e-01
LIHCcg07355688chr11:129376823CGI:chr11:129372634-129376500promoter,gene body2.44e-013.48e-01-4.12e+003.77e-058.73e-05-1.04e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg04299135chr11:129374546CGI:chr11:129372634-129376500promoter1.84e-014.47e-026.76e+001.38e-113.89e-111.40e-01
BRCAcg04094148chr11:129374628CGI:chr11:129372634-129376500promoter2.33e-015.76e-027.10e+001.22e-123.73e-121.76e-01
BRCAcg17692125chr11:129374610CGI:chr11:129372634-129376500promoter2.16e-013.89e-026.22e+004.96e-101.24e-091.77e-01
BRCAcg07355688chr11:129376823CGI:chr11:129372634-129376500promoter,gene body2.19e-013.89e-01-1.28e+011.87e-378.45e-36-1.70e-01
LIHCcg04094148chr11:129374628CGI:chr11:129372634-129376500promoter2.08e-017.68e-022.07e+003.84e-024.05e-021.32e-01
LIHCcg17692125chr11:129374610CGI:chr11:129372634-129376500promoter2.09e-014.88e-023.13e+001.75e-033.50e-031.60e-01
LIHCcg21697198chr11:129376499CGI:chr11:129372634-129376500promoter,gene body2.86e-011.36e-012.77e+005.67e-038.86e-031.50e-01

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Exon skipping events with PSI in TCGA for BARX2

∗Please access ExonSkipDB for exon skipping annotation.
check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

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RNA A-to-I editing events in TCGA for BARX2

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for BARX2

check buttonTFs related to BARX2.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType

check buttonBARX2 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.
related_gene

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Sex-biased RBP-ES network for BARX2

check buttonRBPs related to ES in BARX2.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType

check buttonBARX2 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type
ENSG00000043039AC144831.1,hsa-mir-372,BARX2Tumor-specific sex-biased ceRNATCGA-LIHC
ENSG00000043039AC092756.1,hsa-mir-373,BARX2Male-specific ceRNATCGA-LIHC
ENSG00000043039AC087477.2,hsa-mir-373,BARX2Male-specific ceRNATCGA-LIHC
ENSG00000043039AC015712.2,hsa-mir-373,BARX2Male-specific ceRNATCGA-LIHC
ENSG00000043039AL136982.6,hsa-mir-373,BARX2Male-specific ceRNATCGA-STAD
ENSG00000043039LINC01395,hsa-mir-373,BARX2Male-specific ceRNATCGA-STAD

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs7125158chr11:120650596:A:C-0.2147712813851330.0171139770607079KIRPFemale-baised eQTL
rs329654chr11:133982713:C:T--0.1433051214922150.00494101430643953LUSCFemale-baised eQTL
rs329662chr11:133976009:T:A--0.1530531403364770.00512254894929006LUSCFemale-baised eQTL
rs329658chr11:133979386:T:C--0.1530531403364770.00512254894929006LUSCFemale-baised eQTL
rs329660chr11:133976604:A:G--0.1528200251499180.00521857092937153LUSCFemale-baised eQTL
rs329657chr11:133979508:G:A--0.1469231825548930.00772154997795892LUSCFemale-baised eQTL
rs329680chr11:133972585:T:C--0.1187473043645070.0354870109358729LUSCFemale-baised eQTL
rs3758770chr11:128802931:C:T-0.05076397013490210.000434374506994705LUADFemale-baised eQTL
rs2268611chr11:128798197:T:C-0.04941200525817680.000650570428800439LUADFemale-baised eQTL
rs59460980chr11:128799279:C:T-0.0493438026944870.000668458663360939LUADFemale-baised eQTL
rs2284788chr11:128800220:C:T-0.0493438026944870.000668458663360939LUADFemale-baised eQTL
rs2268608chr11:128797752:G:C-0.04050093092228470.00567290667414236LUADFemale-baised eQTL
rs2268598chr11:128794370:T:C-0.0393446128521860.00874329036146741LUADFemale-baised eQTL
rs34591296chr11:123679762:G:A-0.04153465446764870.00902039631294418LUADFemale-baised eQTL
rs2071617chr11:128806973:G:T-0.0377158769508330.010246052139595LUADFemale-baised eQTL
rs2071618chr11:128807018:A:G-0.0377158769508330.010246052139595LUADFemale-baised eQTL
rs2071619chr11:128807564:C:T-0.0377158769508330.010246052139595LUADFemale-baised eQTL
rs12421884chr11:128802289:G:A-0.03699703632985930.0132688296800904LUADFemale-baised eQTL
rs3758768chr11:128803284:A:C-0.03643341582558010.0138185594472319LUADFemale-baised eQTL
rs12417018chr11:128803340:G:A-0.03664087730715310.0138775309335432LUADFemale-baised eQTL
rs3781722chr11:128796701:G:A-0.03744762584545930.0143325899687683LUADFemale-baised eQTL
rs3824899chr11:128797133:G:A-0.03740161598447880.0146258798087329LUADFemale-baised eQTL
rs2268606chr11:128797501:A:C-0.03740161598447880.0146258798087329LUADFemale-baised eQTL
rs2268609chr11:128798053:G:C-0.03736246615517730.0148799468063065LUADFemale-baised eQTL
rs2268610chr11:128798105:A:G-0.03736246615517730.0148799468063065LUADFemale-baised eQTL
rs56075660chr11:128794112:A:G-0.03613967245699860.0164518455934233LUADFemale-baised eQTL
rs3781721chr11:128796852:A:G-0.03661199683920040.017679739748174LUADFemale-baised eQTL
rs2300594chr11:128793068:G:A-0.03590516691427570.017683462782613LUADFemale-baised eQTL
rs61909388chr11:128793356:G:A-0.03590516691427570.017683462782613LUADFemale-baised eQTL
rs61909389chr11:128793686:G:T-0.03590516691427570.017683462782613LUADFemale-baised eQTL
rs56259986chr11:128793930:G:T-0.03590516691427570.017683462782613LUADFemale-baised eQTL
rs56275929chr11:128794133:C:T-0.03590516691427570.017683462782613LUADFemale-baised eQTL
rs56275778chr11:128794200:A:G-0.03590516691427570.017683462782613LUADFemale-baised eQTL
rs2268597chr11:128794282:T:C-0.03590516691427570.017683462782613LUADFemale-baised eQTL
rs2268600chr11:128794695:C:T-0.03590516691427570.017683462782613LUADFemale-baised eQTL
rs2268601chr11:128794846:T:C-0.03590516691427570.017683462782613LUADFemale-baised eQTL
rs2268604chr11:128796210:C:A-0.03590516691427570.017683462782613LUADFemale-baised eQTL
rs2268605chr11:128796335:T:C-0.03590516691427570.017683462782613LUADFemale-baised eQTL
rs7111807chr11:128796379:G:A-0.03590516691427570.017683462782613LUADFemale-baised eQTL
rs56145199chr11:128793742:T:A-0.03586615392670080.0179815299635991LUADFemale-baised eQTL
rs35594775chr11:128505933:T:C-0.03576039421976080.0212470836980233LUADFemale-baised eQTL
rs2268612chr11:128801837:A:C-0.03434679510599610.0213159029635816LUADFemale-baised eQTL
rs3758767chr11:128804681:C:T-0.03368213966209380.0239194618475516LUADFemale-baised eQTL
rs7126946chr11:128804986:C:T-0.03368213966209380.0239194618475516LUADFemale-baised eQTL
rs7113191chr11:128805397:T:A-0.03368213966209380.0239194618475516LUADFemale-baised eQTL
rs7127621chr11:128805506:C:T-0.03368213966209380.0239194618475516LUADFemale-baised eQTL
rs7113735chr11:128805769:T:C-0.03368213966209380.0239194618475516LUADFemale-baised eQTL
rs41302399chr11:128806309:T:A-0.03368213966209380.0239194618475516LUADFemale-baised eQTL
rs7936133chr11:128802055:C:A-0.03221958436937320.0300152965398807LUADFemale-baised eQTL
rs2268599chr11:128794387:G:A-0.03297776263086350.0312195630159737LUADFemale-baised eQTL
rs17128425chr11:124112642:T:A-0.0342047485224380.0348548913151286LUADFemale-baised eQTL
rs61912960chr11:129265385:T:C-0.03574247494511770.0368885250385863LUADFemale-baised eQTL
rs3819826chr11:128780271:G:T-0.03131170143597560.0392347676830551LUADFemale-baised eQTL
rs17128423chr11:124112267:T:C-0.03174385488306280.0395201950835161LUADFemale-baised eQTL
rs3819825chr11:128780171:A:T-0.03126746269664470.0400899995443596LUADFemale-baised eQTL
rs4937409chr11:129286635:G:A-0.03474026735133510.0429607280932457LUADFemale-baised eQTL
rs2847376chr11:128781633:A:G-0.03088470321182850.0450826991979837LUADFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs2277271chr11:132529378:A:G--0.06705644087258620.0285780273079448KIRCMale-baised eQTL
rs7105281chr11:125312739:G:A-0.1290569385961250.0314237767907651KIRCMale-baised eQTL
rs7112944chr11:131597699:G:A-0.06093010103651790.0350722367152947KIRCMale-baised eQTL
rs4076811chr11:131614384:A:T-0.0580546533245680.0439459434331713KIRCMale-baised eQTL
rs11223641chr11:133950127:T:C-0.0572222228096350.0340583786578414BLCAMale-baised eQTL
rs182040912chr11:131873625:A:G-0.1760161960348540.0019164095612223COADMale-baised eQTL
rs1790174chr11:132072910:T:C-0.09788463062053140.0254617925610227COADMale-baised eQTL
rs1547897chr11:132076884:A:T-0.08856926770502210.0352752834641143COADMale-baised eQTL
rs114860627chr11:129497992:T:C--0.06780218611536090.0453405395118277COADMale-baised eQTL
rs3109663chr11:129496466:A:C--0.06739748711826770.048219979006612COADMale-baised eQTL
rs3018432chr11:132082305:A:T-0.09069952285041450.0486838821942858COADMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000043039
CpG Site: cg24095303
Position to Gene: gene,enhancer
Male Effect: -0.47651015035835
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000043039
CpG Site: cg24095303
Position to Gene: gene,enhancer
Male Effect: -
Female Effect: -0.493563402953508
eQTM boxplot analysisGene ID: ENSG00000043039
CpG Site: cg16283077
Position to Gene: gene,exon,CDS
Male Effect: -
Female Effect: -0.493563402953508
eQTM boxplot analysisGene ID: ENSG00000043039
CpG Site: cg05471602
Position to Gene: gene,exon,CDS
Male Effect: -
Female Effect: -0.243886303382881

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg24095303chr11:129379525gene,enhancer-0.476510150358355.36267013540706e-21-0.61857260929263351.3070493387750785e-22KIRP

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg24095303chr11:129379525gene,enhancer-0.4935634029535088.76091588907645e-114-0.93677773797654262.2580229917874803e-117LUAD
cg16283077chr11:129436835gene,exon,CDS-0.4935634029535088.76091588907645e-114-0.93677773797654262.2580229917874803e-117LUAD
cg05471602chr11:129436842gene,exon,CDS-0.2438863033828812.17441496247374e-28-0.65153441385108393.386456722780656e-32LUAD

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of BARX2

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource