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Gene: ENSG00000038382 |
Summary for TRIO |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000038382 | Gene symbol | TRIO |
| Gene name | trio Rho guanine nucleotide exchange factor | |
| HGNC | 12303 | |
| Entrez ID | 7204 | |
| Gene type | protein_coding | |
| Synonyms | TRIO|ARHGEF23 | |
| UniProtAcc | O75962 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for TRIO |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| TRIO | 2.68e+03 | 1.12e+00 | 2.08e-01 | 5.41e+00 | 6.33e-08 | 5.98e-07 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for TRIO |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| TCGA-STAD |
 |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
| ENSG00000038382 | STAD | TRIO | 5 | 8 | 3.67e-02 | 2.99e-01 | 1.06e+00 | 7.53e-02 | 6.97e-01 |
Top |
DNA methylation with beta values for TRIO |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg27465566 | chr5:14142465 | CGI:chr5:14142908-14145241 | promoter | 2.09e-01 | 8.37e-02 | 3.31e+00 | 9.29e-04 | 2.47e-03 | 1.25e-01 |
| CHOL | cg15637765 | chr5:14145572 | CGI:chr5:14142908-14145241 | promoter,gene body | 1.75e-01 | 2.88e-01 | -3.17e+00 | 1.52e-03 | 1.07e-02 | -1.14e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BLCA | cg15637765 | chr5:14145572 | CGI:chr5:14142908-14145241 | promoter,gene body | 1.62e-01 | 2.72e-01 | -3.25e+00 | 1.15e-03 | 5.14e-03 | -1.10e-01 |
Top |
Exon skipping events with PSI in TCGA for TRIO |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for TRIO |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
 |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| LUAD | TRIO-010 | chr5_14157840_+ | 1.65e-01 | 2.90e-01 | -2.32e+00 | 2.01e-02 | 3.80e-02 | -1.25e-01 |
| LUAD | TRIO-010 | chr5_14176717_+ | 2.08e-01 | 2.75e-01 | -2.39e+00 | 1.67e-02 | 3.53e-02 | -6.70e-02 |
| LUAD | TRIO-010 | chr5_14179828_+ | 2.98e-01 | 4.03e-01 | -2.11e+00 | 3.45e-02 | 4.44e-02 | -1.06e-01 |
| LUAD | TRIO-010 | chr5_14191414_+ | 2.67e-01 | 4.31e-01 | -2.83e+00 | 4.59e-03 | 2.29e-02 | -1.65e-01 |
| STAD | TRIO-010 | chr5_14180058_+ | 4.27e-01 | 2.70e-01 | 2.48e+00 | 1.33e-02 | 4.96e-02 | 1.57e-01 |
| STAD | TRIO-010 | chr5_14233243_+ | 2.51e-01 | 1.49e-01 | 2.62e+00 | 8.71e-03 | 4.96e-02 | 1.02e-01 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for TRIO |
| TFs related to TRIO. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| PAAD | FOXA3 | TRIO | 3.96e+00 | 9.81e-01 | 2.94e+00 | 3.58e-03 | Male-biased |
| PAAD | ZNF334 | TRIO | 3.92e+00 | 9.83e-01 | 2.51e+00 | 4.68e-04 | Male-biased |
| SKCM | BHLHE22 | TRIO | 4.68e+00 | 9.84e-01 | 3.50e+00 | 6.73e-03 | Male-biased |
| SKCM | CDC5L | TRIO | 4.44e+00 | 9.84e-01 | 3.01e+00 | 3.14e-03 | Male-biased |
| SKCM | OLIG1 | TRIO | 4.76e+00 | 9.81e-01 | 3.71e+00 | 9.94e-03 | Male-biased |
| SKCM | OLIG2 | TRIO | 5.36e+00 | 9.81e-01 | 4.46e+00 | 1.56e-02 | Male-biased |
| SKCM | POU3F4 | TRIO | 4.70e+00 | 9.81e-01 | 3.63e+00 | 9.32e-03 | Male-biased |
| SKCM | ZBTB32 | TRIO | 4.86e+00 | 9.81e-01 | 3.87e+00 | 1.18e-02 | Male-biased |
| SKCM | ZNF211 | TRIO | 4.84e+00 | 9.87e-01 | 3.60e+00 | 5.72e-03 | Male-biased |
| TRIO related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for TRIO |
| RBPs related to ES in TRIO. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| THYM | PCBP2 | exon_skip_434098 | 8.10e+00 | 8.04e-03 | 8.44e+00 | 9.85e-01 | Female-biased |
| LUSC | RBM4 | exon_skip_434040 | 7.79e+00 | 9.88e-01 | 7.28e+00 | 3.11e-03 | Male-biased |
| LUSC | RBM8A | exon_skip_434040 | 1.02e+01 | 9.83e-01 | 9.88e+00 | 1.52e-02 | Male-biased |
| COAD | RBM41 | exon_skip_434033 | 8.05e+00 | 9.80e-01 | 7.73e+00 | 1.14e-02 | Male-biased |
| BRCA | ESRP2 | exon_skip_434025 | 8.71e+00 | 9.81e-01 | 8.17e+00 | 1.28e-02 | Male-biased |
| BRCA | PCBP2 | exon_skip_434098 | 8.21e+00 | 3.83e-03 | 9.13e+00 | 9.92e-01 | Female-biased |
| READ | PPRC1 | exon_skip_434040 | 1.06e+01 | 9.97e-01 | 1.01e+01 | 1.77e-03 | Male-biased |
| READ | RBM8A | exon_skip_434040 | 1.04e+01 | 9.97e-01 | 9.92e+00 | 2.08e-03 | Male-biased |
| THCA | PPRC1 | exon_skip_434040 | 9.94e+00 | 9.86e-01 | 9.65e+00 | 1.18e-02 | Male-biased |
| THCA | RBM8A | exon_skip_434040 | 1.00e+01 | 9.87e-01 | 9.73e+00 | 1.06e-02 | Male-biased |
| PCPG | PPRC1 | exon_skip_434040 | 9.72e+00 | 9.88e-01 | 9.39e+00 | 9.33e-03 | Male-biased |
| PCPG | RBM8A | exon_skip_434040 | 9.85e+00 | 9.93e-01 | 9.47e+00 | 4.64e-03 | Male-biased |
| MESO | PPRC1 | exon_skip_434040 | 9.61e+00 | 7.17e-03 | 9.99e+00 | 9.91e-01 | Female-biased |
| MESO | RBM41 | exon_skip_434033 | 7.73e+00 | 7.46e-03 | 8.10e+00 | 9.84e-01 | Female-biased |
| MESO | RBM8A | exon_skip_434040 | 9.68e+00 | 6.50e-03 | 1.01e+01 | 9.92e-01 | Female-biased |
| LGG | ESRP2 | exon_skip_434025 | 8.25e+00 | 6.64e-03 | 8.62e+00 | 9.87e-01 | Female-biased |
| KIRC | PCBP2 | exon_skip_434098 | 8.42e+00 | 8.50e-03 | 8.75e+00 | 9.86e-01 | Female-biased |
| SKCM | RBM4 | exon_skip_434040 | 7.42e+00 | 9.61e-03 | 7.78e+00 | 9.81e-01 | Female-biased |
| SKCM | RBM41 | exon_skip_434033 | 7.51e+00 | 1.10e-02 | 7.86e+00 | 9.80e-01 | Female-biased |
| HNSC | PPRC1 | exon_skip_434040 | 9.92e+00 | 9.85e-01 | 9.60e+00 | 1.33e-02 | Male-biased |
| HNSC | ZC3H10 | exon_skip_434035 | 6.41e+00 | 1.65e-03 | 6.91e+00 | 9.84e-01 | Female-biased |
| TRIO related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs6897386 | chr5:6621335:C:T | - | 0.373911352011808 | 0.0252235570277464 | GBM | Female-baised eQTL |
| rs113247673 | chr5:6622676:C:T | - | 0.373911352011808 | 0.0252235570277464 | GBM | Female-baised eQTL |
| rs56735725 | chr5:6628085:T:C | - | 0.372436770259939 | 0.0263909974981661 | GBM | Female-baised eQTL |
| rs1022208 | chr5:19395102:T:C | - | 0.0642206492096815 | 0.0313303251785947 | THCA | Female-baised eQTL |
| rs34188153 | chr5:19387347:T:C | - | 0.0652380535152715 | 0.0442711575084798 | THCA | Female-baised eQTL |
| rs2921571 | chr5:5539781:T:C | - | -0.0603644323779298 | 0.0277549101098152 | LGG | Female-baised eQTL |
| rs10041091 | chr5:11709783:A:G | - | 0.151367998954571 | 0.0260577674998426 | BLCA | Female-baised eQTL |
| rs10035570 | chr5:11709682:G:A | - | 0.145354023074971 | 0.038540074427897 | BLCA | Female-baised eQTL |
| rs10035537 | chr5:11709686:C:A | - | 0.145354023074971 | 0.038540074427897 | BLCA | Female-baised eQTL |
| rs10041174 | chr5:11710081:A:G | - | 0.145354023074971 | 0.038540074427897 | BLCA | Female-baised eQTL |
| rs987730 | chr5:13079907:A:G | - | -0.0418246980970334 | 0.01480232490283 | LUAD | Female-baised eQTL |
| rs1174918 | chr5:5905997:G:A | - | 0.0434388200579868 | 0.0260594240735106 | LUAD | Female-baised eQTL |
| rs1175369 | chr5:5908557:T:G | - | 0.0434388200579868 | 0.0260594240735106 | LUAD | Female-baised eQTL |
| rs11952708 | chr5:15955046:C:A | - | 0.048327809352638 | 0.0264667614480173 | LUAD | Female-baised eQTL |
| rs6896565 | chr5:5903520:G:C | - | 0.0430071974755455 | 0.0277699461224102 | LUAD | Female-baised eQTL |
| rs67788322 | chr5:15944628:C:G | - | 0.0476803989615765 | 0.0305982815356714 | LUAD | Female-baised eQTL |
| rs17254676 | chr5:13087956:T:A | - | -0.0406944059809877 | 0.0337074625788783 | LUAD | Female-baised eQTL |
| rs35591137 | chr5:13092794:T:C | - | -0.0408490049076564 | 0.034861671237613 | LUAD | Female-baised eQTL |
| rs11134131 | chr5:5902613:C:T | - | 0.0420178802685383 | 0.0372694509294272 | LUAD | Female-baised eQTL |
| rs12651897 | chr5:23056248:A:G | - | 0.0570001500372466 | 0.0386292342793985 | LUAD | Female-baised eQTL |
| rs7708248 | chr5:5901965:A:C | - | 0.0418802108424289 | 0.0386322282877194 | LUAD | Female-baised eQTL |
| rs72750694 | chr5:23055073:C:G | - | 0.0562482091585183 | 0.0442034018518658 | LUAD | Female-baised eQTL |
| rs6899053 | chr5:23055766:A:C | - | 0.0562482091585183 | 0.0442034018518658 | LUAD | Female-baised eQTL |
| rs6555267 | chr5:4225119:A:G | - | 0.128219524326504 | 0.0137235741893735 | COAD | Female-baised eQTL |
| rs111866920 | chr5:22187265:T:A | - | 0.17273428262661 | 0.0437093256849135 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs7737956 | chr5:23686045:A:G | - | 0.132007741248518 | 0.0308347432716498 | GBM | Male-baised eQTL |
| rs6452131 | chr5:23686081:C:T | - | 0.132007741248518 | 0.0308347432716498 | GBM | Male-baised eQTL |
| rs6452132 | chr5:23686491:G:A | - | 0.132007741248518 | 0.0308347432716498 | GBM | Male-baised eQTL |
| rs6452133 | chr5:23686503:C:T | - | 0.132007741248518 | 0.0308347432716498 | GBM | Male-baised eQTL |
| rs6452134 | chr5:23686622:T:G | - | 0.132007741248518 | 0.0308347432716498 | GBM | Male-baised eQTL |
| rs6885030 | chr5:10905176:G:A | - | 0.120817947547463 | 0.0265366418629814 | LGG | Male-baised eQTL |
| rs6554614 | chr5:10905333:A:G | - | 0.111869585404048 | 0.0440957313494277 | LGG | Male-baised eQTL |
| rs17221318 | chr5:19742478:T:C | - | 0.0625680476984925 | 0.000434916924886665 | KIRC | Male-baised eQTL |
| rs17287316 | chr5:19745608:T:C | - | 0.0612367802282368 | 0.000665766852293366 | KIRC | Male-baised eQTL |
| rs62353612 | chr5:19757047:C:G | - | 0.057191260028081 | 0.00237260765359115 | KIRC | Male-baised eQTL |
| rs28648852 | chr5:19748950:T:C | - | 0.053655780692138 | 0.0025506371627988 | KIRC | Male-baised eQTL |
| rs6870271 | chr5:19745135:C:T | - | -0.0524025826802944 | 0.00265055347307779 | KIRC | Male-baised eQTL |
| rs62353614 | chr5:19760560:C:T | - | 0.0549250785701203 | 0.00294136472525735 | KIRC | Male-baised eQTL |
| rs28565564 | chr5:19748934:T:A | - | 0.0530690497809228 | 0.00333084239798481 | KIRC | Male-baised eQTL |
| rs17285038 | chr5:8584550:C:T | - | 0.055773354086045 | 0.00425408142693523 | KIRC | Male-baised eQTL |
| rs10941441 | chr5:19745346:A:C | - | -0.0434430891360091 | 0.0179226739758857 | KIRC | Male-baised eQTL |
| rs62355766 | chr5:19802852:A:T | - | 0.0561082581138945 | 0.0301042284342766 | KIRC | Male-baised eQTL |
| rs62342465 | chr5:7716895:A:G | - | 0.0472901841996815 | 0.0359603417807585 | KIRC | Male-baised eQTL |
| rs6451417 | chr5:19744380:G:C | - | -0.0406563105825373 | 0.036142647718778 | KIRC | Male-baised eQTL |
| rs6872084 | chr5:6328313:C:T | - | 0.0554117914742844 | 0.0363356776198478 | KIRC | Male-baised eQTL |
| rs62342466 | chr5:7720463:G:A | - | 0.0456969267819988 | 0.041225389945438 | KIRC | Male-baised eQTL |
| rs72717952 | chr5:6489639:T:C | - | 0.0683127374541655 | 0.0417329543408075 | KIRC | Male-baised eQTL |
| rs2387975 | chr5:19760285:C:G | - | -0.0377402262700808 | 0.0424872865261374 | KIRC | Male-baised eQTL |
| rs12522362 | chr5:4868620:C:T | - | 0.0652160836621151 | 0.0455416446439494 | KIRC | Male-baised eQTL |
| rs7733309 | chr5:4869298:C:T | - | 0.0652160836621151 | 0.0455416446439494 | KIRC | Male-baised eQTL |
| rs1553100 | chr5:19742862:C:T | - | -0.0395398141737661 | 0.0481608323213981 | KIRC | Male-baised eQTL |
| rs2964124 | chr5:8333600:C:T | - | -0.0691447244150482 | 0.000441406806241701 | BLCA | Male-baised eQTL |
| rs2940552 | chr5:8338029:G:A | - | -0.0641279883652933 | 0.00206070399069989 | BLCA | Male-baised eQTL |
| rs340679 | chr5:8384530:T:C | - | -0.0618534165602662 | 0.00219896535642623 | BLCA | Male-baised eQTL |
| rs439710 | chr5:8376742:C:G | - | -0.0614037399680431 | 0.00227166882811397 | BLCA | Male-baised eQTL |
| rs2388450 | chr5:8339861:T:C | - | -0.0639070999558577 | 0.00228460455493093 | BLCA | Male-baised eQTL |
| rs1588259 | chr5:8341388:T:G | - | -0.0635108244681943 | 0.00250850318657495 | BLCA | Male-baised eQTL |
| rs2964129 | chr5:8349118:C:T | - | -0.0636580085236314 | 0.00278455359560602 | BLCA | Male-baised eQTL |
| rs2457113 | chr5:8374797:A:G | - | -0.0653023447704799 | 0.00310836032078162 | BLCA | Male-baised eQTL |
| rs2962124 | chr5:8337415:A:C | - | -0.0624642453145131 | 0.00315500235525754 | BLCA | Male-baised eQTL |
| rs48400 | chr5:8385428:T:C | - | -0.0601864636196883 | 0.00350048410012314 | BLCA | Male-baised eQTL |
| rs340681 | chr5:8385182:T:C | - | -0.0600824650556032 | 0.00360307337668924 | BLCA | Male-baised eQTL |
| rs48399 | chr5:8385455:A:G | - | -0.0600824650556032 | 0.00360307337668924 | BLCA | Male-baised eQTL |
| rs10474832 | chr5:8378387:G:A | - | -0.0609054559141571 | 0.00397414625336479 | BLCA | Male-baised eQTL |
| rs2526124 | chr5:9351264:T:C | - | -0.0896792070458622 | 0.00407850429493356 | BLCA | Male-baised eQTL |
| rs199827615 | chr5:8377866:A:G | - | -0.061441037428803 | 0.00519423485116891 | BLCA | Male-baised eQTL |
| rs446249 | chr5:8376700:C:T | - | -0.0611679465866053 | 0.00606529399097039 | BLCA | Male-baised eQTL |
| rs2962120 | chr5:8376342:G:T | - | -0.0610112754997996 | 0.0064945744072564 | BLCA | Male-baised eQTL |
| rs2442092 | chr5:8380351:A:G | - | -0.0583312916287015 | 0.00749862833946118 | BLCA | Male-baised eQTL |
| rs6555602 | chr5:9332205:C:A | - | -0.112352196083082 | 0.00755619780617416 | BLCA | Male-baised eQTL |
| rs1601903 | chr5:8311533:G:T | - | -0.0668562751121262 | 0.0124489414624998 | BLCA | Male-baised eQTL |
| rs67300678 | chr5:8291386:G:T | - | -0.0662023277925248 | 0.0126222704513408 | BLCA | Male-baised eQTL |
| rs68066164 | chr5:8287632:C:T | - | -0.0669577050205005 | 0.0137426158364232 | BLCA | Male-baised eQTL |
| rs11750496 | chr5:8288771:A:T | - | -0.0650962295344518 | 0.0137778972063606 | BLCA | Male-baised eQTL |
| rs11743820 | chr5:8295602:A:G | - | -0.0655076942811213 | 0.0147368231953655 | BLCA | Male-baised eQTL |
| rs60852531 | chr5:8294610:A:G | - | -0.0674209734093931 | 0.0147754902929963 | BLCA | Male-baised eQTL |
| rs3822790 | chr5:9352102:T:G | - | -0.0859785576264509 | 0.0163967083747013 | BLCA | Male-baised eQTL |
| rs10475428 | chr5:8378625:C:T | - | -0.0555373835730286 | 0.0173273884565594 | BLCA | Male-baised eQTL |
| rs13361712 | chr5:8379412:G:T | - | -0.0553520729437035 | 0.0185185155549457 | BLCA | Male-baised eQTL |
| rs7710352 | chr5:17769351:C:T | - | 0.102957913052396 | 0.0189068106068019 | BLCA | Male-baised eQTL |
| rs11742474 | chr5:8285702:G:A | - | -0.0627397904060385 | 0.0218731598950438 | BLCA | Male-baised eQTL |
| rs148284497 | chr5:8285955:A:T | - | -0.0627397904060385 | 0.0218731598950438 | BLCA | Male-baised eQTL |
| rs2602521 | chr5:8132065:G:C | - | -0.0976989838814784 | 0.025143529200712 | BLCA | Male-baised eQTL |
| rs3777317 | chr5:9302623:T:A | - | -0.0668968626296921 | 0.0261275372507079 | BLCA | Male-baised eQTL |
| rs3777318 | chr5:9302625:T:A | - | -0.0668968626296921 | 0.0261275372507079 | BLCA | Male-baised eQTL |
| rs13163735 | chr5:9303600:C:T | - | -0.0668968626296921 | 0.0261275372507079 | BLCA | Male-baised eQTL |
| rs12658266 | chr5:9305613:C:T | - | -0.0668968626296921 | 0.0261275372507079 | BLCA | Male-baised eQTL |
| rs4122248 | chr5:17772553:G:A | - | 0.0957347592089388 | 0.0306033361398088 | BLCA | Male-baised eQTL |
| rs67402490 | chr5:8283239:C:T | - | -0.0624395067740663 | 0.0316691571594292 | BLCA | Male-baised eQTL |
| rs3777321 | chr5:9307591:G:A | - | -0.0654977857271733 | 0.0323185982706208 | BLCA | Male-baised eQTL |
| rs1015900 | chr5:9308331:G:T | - | -0.0654977857271733 | 0.0323185982706208 | BLCA | Male-baised eQTL |
| rs66970523 | chr5:8277835:T:C | - | -0.0616878620955461 | 0.0326385563018901 | BLCA | Male-baised eQTL |
| rs11746909 | chr5:8278730:T:A | - | -0.0616878620955461 | 0.0326385563018901 | BLCA | Male-baised eQTL |
| rs2388621 | chr5:8280516:A:G | - | -0.0616878620955461 | 0.0326385563018901 | BLCA | Male-baised eQTL |
| rs58737768 | chr5:8281369:A:T | - | -0.0616878620955461 | 0.0326385563018901 | BLCA | Male-baised eQTL |
| rs60319200 | chr5:8281762:T:C | - | -0.0616878620955461 | 0.0326385563018901 | BLCA | Male-baised eQTL |
| rs57936858 | chr5:8286416:G:A | - | -0.0598471606124289 | 0.0374503302412247 | BLCA | Male-baised eQTL |
| rs144307355 | chr5:8285571:G:C | - | -0.0597507278593044 | 0.0392777478631402 | BLCA | Male-baised eQTL |
| rs146543920 | chr5:8283891:G:A | - | -0.0594363749996918 | 0.0397016036242644 | BLCA | Male-baised eQTL |
| rs189429190 | chr5:8284298:G:A | - | -0.0594363749996918 | 0.0397016036242644 | BLCA | Male-baised eQTL |
| rs6863776 | chr5:8284917:A:G | - | -0.0594363749996918 | 0.0397016036242644 | BLCA | Male-baised eQTL |
| rs6868131 | chr5:8285023:T:C | - | -0.0594363749996918 | 0.0397016036242644 | BLCA | Male-baised eQTL |
| rs146279892 | chr5:8285427:C:T | - | -0.0594363749996918 | 0.0397016036242644 | BLCA | Male-baised eQTL |
| rs9686310 | chr5:8285924:A:G | - | -0.0594363749996918 | 0.0397016036242644 | BLCA | Male-baised eQTL |
| rs6555540 | chr5:8303322:C:T | - | -0.0583595659016504 | 0.0397410565673805 | BLCA | Male-baised eQTL |
| rs1989993 | chr5:9309573:T:A | - | -0.063847055613741 | 0.0397727208094642 | BLCA | Male-baised eQTL |
| rs1989992 | chr5:9309614:C:T | - | -0.063847055613741 | 0.0397727208094642 | BLCA | Male-baised eQTL |
| rs11742852 | chr5:8279133:C:A | - | -0.0609627181034984 | 0.0406390967975897 | BLCA | Male-baised eQTL |
| rs805145 | chr5:9315342:G:T | - | -0.0629675594902764 | 0.0416182594666257 | BLCA | Male-baised eQTL |
| rs10462855 | chr5:8240808:C:T | - | -0.0622525363388912 | 0.0427641292966165 | BLCA | Male-baised eQTL |
| rs2107480 | chr5:9311296:A:G | - | -0.0633735504301981 | 0.0431524953348017 | BLCA | Male-baised eQTL |
| rs1018956 | chr5:9310104:C:T | - | -0.0592158331453564 | 0.0447970873481927 | BLCA | Male-baised eQTL |
| rs6875199 | chr5:9317118:C:A | - | 0.0630391756320604 | 0.0454297711391927 | BLCA | Male-baised eQTL |
| rs10040952 | chr5:9317254:C:T | - | 0.0630391756320604 | 0.0454297711391927 | BLCA | Male-baised eQTL |
| rs6882802 | chr5:9317623:A:C | - | 0.0630391756320604 | 0.0454297711391927 | BLCA | Male-baised eQTL |
| rs7703278 | chr5:22215691:G:T | - | 0.086728520478476 | 0.0490445594662065 | BLCA | Male-baised eQTL |
| rs6869350 | chr5:13805660:G:T | - | 0.0883895061775966 | 0.00243359353936918 | LUAD | Male-baised eQTL |
| rs1505065 | chr5:9094634:C:T | - | 0.130966155524065 | 0.00883265033931555 | LUAD | Male-baised eQTL |
| rs59430708 | chr5:13802237:A:T | - | 0.0803923027148839 | 0.0100003993417644 | LUAD | Male-baised eQTL |
| rs62347165 | chr5:23865310:A:G | - | 0.0780372035693468 | 0.0120522858220146 | LUAD | Male-baised eQTL |
| rs6868758 | chr5:13805456:C:T | - | 0.0816641777869341 | 0.0152274888593959 | LUAD | Male-baised eQTL |
| rs16902778 | chr5:13819974:C:T | - | 0.0731067333750102 | 0.0244557780141396 | LUAD | Male-baised eQTL |
| rs73746923 | chr5:13822783:T:A | - | 0.0715497036085494 | 0.0263448333504271 | LUAD | Male-baised eQTL |
| rs76923326 | chr5:13802662:T:C | - | 0.0765892642709197 | 0.0286770407284778 | LUAD | Male-baised eQTL |
| rs16902820 | chr5:13834597:T:G | - | 0.0736334576615024 | 0.0301689005539715 | LUAD | Male-baised eQTL |
| rs57362365 | chr5:13833409:A:C | - | 0.0733198493365612 | 0.031205896020556 | LUAD | Male-baised eQTL |
| rs1589417 | chr5:23613451:T:A | - | -0.0971370379802858 | 0.0312639765030917 | LUAD | Male-baised eQTL |
| rs6896883 | chr5:13799822:T:G | - | 0.0730447934974673 | 0.0344150890471993 | LUAD | Male-baised eQTL |
| rs7715927 | chr5:23247681:A:G | - | 0.0860098477043626 | 0.00155413523001653 | COAD | Male-baised eQTL |
| rs250341 | chr5:16764225:C:T | - | -0.0752738995405166 | 0.00183811499524073 | COAD | Male-baised eQTL |
| rs2202445 | chr5:7328063:G:C | - | 0.0789855857168944 | 0.00484783010645627 | COAD | Male-baised eQTL |
| rs55990746 | chr5:7217829:C:G | - | 0.101520575821787 | 0.00888904914746646 | COAD | Male-baised eQTL |
| rs184504114 | chr5:7231025:G:A | - | 0.101520575821787 | 0.00888904914746646 | COAD | Male-baised eQTL |
| rs149920071 | chr5:7221834:T:G | - | 0.1017953005816 | 0.00916168214972239 | COAD | Male-baised eQTL |
| rs433758 | chr5:16586148:G:A | - | 0.138583255094395 | 0.0092405398153203 | COAD | Male-baised eQTL |
| rs9885544 | chr5:7316241:A:C | - | 0.0772251614497288 | 0.00942888241687534 | COAD | Male-baised eQTL |
| rs171610 | chr5:5015072:T:C | - | 0.111604345833149 | 0.0128414505574404 | COAD | Male-baised eQTL |
| rs249470 | chr5:5006335:G:C | - | 0.110968520885416 | 0.0128468053104625 | COAD | Male-baised eQTL |
| rs74970859 | chr5:5017587:A:G | - | 0.111452396913998 | 0.0129583172017134 | COAD | Male-baised eQTL |
| rs7731667 | chr5:5006689:C:G | - | 0.110452440557917 | 0.0137201898987665 | COAD | Male-baised eQTL |
| rs249466 | chr5:5008055:A:G | - | 0.110452440557917 | 0.0137201898987665 | COAD | Male-baised eQTL |
| rs30485 | chr5:5009344:A:G | - | 0.110452440557917 | 0.0137201898987665 | COAD | Male-baised eQTL |
| rs6555391 | chr5:6333300:A:G | - | 0.154166205549314 | 0.0157016838024081 | COAD | Male-baised eQTL |
| rs11750162 | chr5:7316843:A:G | - | 0.0739322431201597 | 0.0165764765446592 | COAD | Male-baised eQTL |
| rs2914758 | chr5:6256551:C:A | - | 0.0647562677310635 | 0.0167527051429174 | COAD | Male-baised eQTL |
| rs67061933 | chr5:7317848:A:G | - | 0.0739562267857878 | 0.016809969129677 | COAD | Male-baised eQTL |
| rs2964760 | chr5:6253726:A:G | - | 0.0652053861735114 | 0.0175763462688456 | COAD | Male-baised eQTL |
| rs2964758 | chr5:6256189:T:C | - | 0.0651974492245405 | 0.0175998577326535 | COAD | Male-baised eQTL |
| rs35869175 | chr5:20452796:T:C | - | -0.0876896173239437 | 0.0178340969089549 | COAD | Male-baised eQTL |
| rs30483 | chr5:5010019:G:T | - | 0.108444355995529 | 0.0181263674087859 | COAD | Male-baised eQTL |
| rs17810121 | chr5:7242021:A:G | - | 0.0910268602800338 | 0.0215690174696862 | COAD | Male-baised eQTL |
| rs2964759 | chr5:6253945:C:T | - | 0.0634469314192251 | 0.0227388447753713 | COAD | Male-baised eQTL |
| rs2925722 | chr5:6252275:A:G | - | 0.0631596398453175 | 0.0229380455856429 | COAD | Male-baised eQTL |
| rs1840842 | chr5:6252642:A:G | - | 0.0638364522883371 | 0.0231811346514568 | COAD | Male-baised eQTL |
| rs12659684 | chr5:20453386:A:G | - | -0.0853463330499702 | 0.0237163258694239 | COAD | Male-baised eQTL |
| rs2914742 | chr5:6252212:C:T | - | 0.0626614712974174 | 0.0239787181576069 | COAD | Male-baised eQTL |
| rs2914743 | chr5:6252230:A:G | - | 0.0626614712974174 | 0.0239787181576069 | COAD | Male-baised eQTL |
| rs16887159 | chr5:20452926:A:T | - | -0.0832071737423737 | 0.0248830953330722 | COAD | Male-baised eQTL |
| rs272192 | chr5:5050950:C:T | - | -0.0657666096480704 | 0.0257778993965932 | COAD | Male-baised eQTL |
| rs4401545 | chr5:7313924:C:T | - | 0.071173729033924 | 0.0265094213980442 | COAD | Male-baised eQTL |
| rs272191 | chr5:5050763:G:C | - | -0.0653314597479617 | 0.0271683101286314 | COAD | Male-baised eQTL |
| rs272188 | chr5:5050367:G:A | - | -0.0651442423176641 | 0.0280810208928071 | COAD | Male-baised eQTL |
| rs1396344 | chr5:20426475:C:G | - | 0.081215844557281 | 0.028920333043458 | COAD | Male-baised eQTL |
| rs1039779 | chr5:20416196:G:T | - | -0.0827273273550855 | 0.0293495829183499 | COAD | Male-baised eQTL |
| rs13166347 | chr5:24455453:T:A | - | -0.0662537013726623 | 0.0297400954041078 | COAD | Male-baised eQTL |
| rs272193 | chr5:5051052:C:T | - | -0.0647312445863699 | 0.0298710259847907 | COAD | Male-baised eQTL |
| rs9292940 | chr5:20447692:G:A | - | -0.0818162577799413 | 0.0301941313402482 | COAD | Male-baised eQTL |
| rs7721674 | chr5:20436865:C:T | - | -0.0818107637095501 | 0.0318415548103899 | COAD | Male-baised eQTL |
| rs17710382 | chr5:5154301:C:T | - | -0.0895717909032431 | 0.0330439931355627 | COAD | Male-baised eQTL |
| rs1472894 | chr5:20441839:C:A | - | 0.0813415847308456 | 0.0340916461919674 | COAD | Male-baised eQTL |
| rs1472893 | chr5:20442001:A:G | - | 0.0813415847308456 | 0.0340916461919674 | COAD | Male-baised eQTL |
| rs4866189 | chr5:20443405:A:T | - | 0.080405887823978 | 0.0358058797681519 | COAD | Male-baised eQTL |
| rs272196 | chr5:5053225:A:G | - | -0.0623204049034259 | 0.0388292104655317 | COAD | Male-baised eQTL |
| rs1353258 | chr5:14855550:G:T | - | 0.0606989401853291 | 0.041384094967122 | COAD | Male-baised eQTL |
| rs835153 | chr5:14877365:A:G | - | -0.0620398801217787 | 0.0430643577766309 | COAD | Male-baised eQTL |
| rs861147 | chr5:14836531:G:A | - | 0.0612608801071073 | 0.043181331508624 | COAD | Male-baised eQTL |
| rs10513194 | chr5:15002380:C:G | - | 0.0805436885787711 | 0.0464788391092133 | COAD | Male-baised eQTL |
| rs10053047 | chr5:7318478:C:T | - | 0.0673164330431005 | 0.0473570722282383 | COAD | Male-baised eQTL |
| rs504319 | chr5:21690715:T:C | - | 0.0663600215075011 | 0.0478865927184023 | COAD | Male-baised eQTL |
| rs1039781 | chr5:20416022:T:A | - | -0.0739110283415653 | 0.049485860355112 | COAD | Male-baised eQTL |
| rs6863165 | chr5:18229754:G:A | - | 0.112723613239418 | 0.0498455483944979 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000038382 |
| CpG Site: cg15143268 | |
| Position to Gene: gene | |
| Male Effect: -0.359251251834016 | |
| Female Effect: - | |
 | Gene ID: ENSG00000038382 |
| CpG Site: cg12294026 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.335398889094602 | |
 | Gene ID: ENSG00000038382 |
| CpG Site: cg02705758 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.382167212786725 | |
 | Gene ID: ENSG00000038382 |
| CpG Site: cg25585967 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.280283895030616 | |
 | Gene ID: ENSG00000038382 |
| CpG Site: cg05590156 | |
| Position to Gene: gene | |
| Male Effect: -0.381163892212505 | |
| Female Effect: - | |
 | Gene ID: ENSG00000038382 |
| CpG Site: cg26048333 | |
| Position to Gene: gene | |
| Male Effect: -0.381163892212505 | |
| Female Effect: - | |
 | Gene ID: ENSG00000038382 |
| CpG Site: cg14678088 | |
| Position to Gene: gene | |
| Male Effect: -0.227067182385459 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg15143268 | chr5:14405811 | gene | -0.359251251834016 | 7.6876840528888e-06 | -0.3229395567520965 | 0.0006148776527504816 | SARC |
| cg05590156 | chr5:14183759 | gene | -0.381163892212505 | 1.07119541949295e-07 | -0.3592375914761751 | 2.537259845060186e-10 | SKCM |
| cg26048333 | chr5:14217466 | gene | -0.381163892212505 | 1.07119541949295e-07 | -0.3592375914761751 | 2.537259845060186e-10 | SKCM |
| cg14678088 | chr5:14155599 | gene | -0.227067182385459 | 2.68122327770999e-05 | -0.3007671472232295 | 1.61207708246057e-07 | SKCM |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg12294026 | chr5:14452046 | gene | -0.335398889094602 | 2.25724881489074e-32 | -0.6991949897688037 | 2.129273641816155e-36 | LGG |
| cg02705758 | chr5:14449389 | gene | -0.382167212786725 | 2.05312440281488e-26 | -0.6496478355815244 | 4.826776478470788e-30 | LGG |
| cg25585967 | chr5:14451996 | gene | -0.280283895030616 | 3.06751047713418e-12 | -0.47792786793763964 | 4.828172966706156e-15 | LGG |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of TRIO |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000038382 | TRIO | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
| ENSG00000038382 | TRIO | C0023903 | Liver neoplasms | 1 | CTD_human |
| ENSG00000038382 | TRIO | C0026998 | Acute Myeloid Leukemia, M1 | 1 | CTD_human |
| ENSG00000038382 | TRIO | C0032927 | Precancerous Conditions | 1 | CTD_human |
| ENSG00000038382 | TRIO | C0282313 | Condition, Preneoplastic | 1 | CTD_human |
| ENSG00000038382 | TRIO | C0345904 | Malignant neoplasm of liver | 1 | CTD_human |
| ENSG00000038382 | TRIO | C1535926 | Neurodevelopmental Disorders | 1 | CTD_human |
| ENSG00000038382 | TRIO | C1879321 | Acute Myeloid Leukemia (AML-M2) | 1 | CTD_human |
| ENSG00000038382 | TRIO | C4310740 | MENTAL RETARDATION, AUTOSOMAL DOMINANT 44 | 1 | CTD_human |
