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Gene: ENSG00000038358 |
Summary for EDC4 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000038358 | Gene symbol | EDC4 |
| Gene name | enhancer of mRNA decapping 4 | |
| HGNC | 17157 | |
| Entrez ID | 23644 | |
| Gene type | protein_coding | |
| Synonyms | EDC4|RCD-8|Ge-1|HEDLS | |
| UniProtAcc | Q6P2E9 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for EDC4 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for EDC4 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for EDC4 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg06695812 | chr16:67871711 | CGI:chr16:67872906-67873408 | promoter | 8.21e-01 | 6.87e-01 | 1.26e+01 | 1.74e-36 | 6.60e-35 | 1.34e-01 |
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Exon skipping events with PSI in TCGA for EDC4 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for EDC4 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for EDC4 |
| TFs related to EDC4. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| EDC4 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for EDC4 |
| RBPs related to ES in EDC4. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ACC | ZNF638 | exon_skip_137869 | 1.44e+01 | 1.15e-03 | 1.51e+01 | 9.99e-01 | Female-biased |
| LIHC | ZNF638 | exon_skip_137869 | 1.51e+01 | 9.95e-01 | 1.46e+01 | 4.77e-03 | Male-biased |
| KIRP | ZNF638 | exon_skip_137869 | 1.46e+01 | 4.38e-04 | 1.53e+01 | 1.00e+00 | Female-biased |
| BRCA | SNRNP70 | exon_skip_137864 | 1.02e+01 | 9.86e-01 | 9.68e+00 | 1.26e-02 | Male-biased |
| THCA | SNRNP70 | exon_skip_137864 | 1.02e+01 | 9.87e-01 | 9.95e+00 | 1.19e-02 | Male-biased |
| PCPG | SNRNP70 | exon_skip_137864 | 1.03e+01 | 9.95e-01 | 9.84e+00 | 3.23e-03 | Male-biased |
| PCPG | ZNF638 | exon_skip_137869 | 1.51e+01 | 9.99e-01 | 1.45e+01 | 6.04e-04 | Male-biased |
| MESO | SNRNP70 | exon_skip_137864 | 1.03e+01 | 9.82e-01 | 9.98e+00 | 1.62e-02 | Male-biased |
| GBM | SNRNP70 | exon_skip_137864 | 1.03e+01 | 9.90e-01 | 9.95e+00 | 8.12e-03 | Male-biased |
| PAAD | FMR1 | exon_skip_137874 | 6.77e+00 | 9.83e-01 | 6.33e+00 | 1.86e-03 | Male-biased |
| PAAD | SNRNP70 | exon_skip_137864 | 1.02e+01 | 9.93e-01 | 9.90e+00 | 5.52e-03 | Male-biased |
| KIRC | SNRNP70 | exon_skip_137864 | 9.92e+00 | 1.42e-02 | 1.02e+01 | 9.84e-01 | Female-biased |
| KICH | SNRNP70 | exon_skip_137864 | 9.92e+00 | 1.18e-02 | 1.02e+01 | 9.87e-01 | Female-biased |
| SARC | ZNF638 | exon_skip_137869 | 1.45e+01 | 8.94e-04 | 1.52e+01 | 9.99e-01 | Female-biased |
| EDC4 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs68096928 | chr16:66960284:C:T | - | 0.162876209458385 | 0.00388999375634963 | BLCA | Female-baised eQTL |
| rs35319588 | chr16:62388428:G:A | - | 0.168801155703697 | 0.00648576309372141 | BLCA | Female-baised eQTL |
| rs34617529 | chr16:62389296:C:A | - | 0.168801155703697 | 0.00648576309372141 | BLCA | Female-baised eQTL |
| rs7202523 | chr16:66929505:T:C | - | 0.134950719497509 | 0.0428797684017008 | BLCA | Female-baised eQTL |
| rs7201673 | chr16:64381579:C:T | - | 0.113005006206229 | 0.0442640140770325 | BLCA | Female-baised eQTL |
| rs144730779 | chr16:70722983:G:A | - | 0.156654844282063 | 0.04652819967907 | BLCA | Female-baised eQTL |
| rs9928374 | chr16:67778027:G:A | - | -0.112007057043463 | 0.00303124752610355 | LUAD | Female-baised eQTL |
| rs8059990 | chr16:67820020:G:A | - | -0.11005722818677 | 0.00363740535080313 | LUAD | Female-baised eQTL |
| rs8052287 | chr16:67831170:G:A | - | -0.11005722818677 | 0.00363740535080313 | LUAD | Female-baised eQTL |
| rs5923 | chr16:67940050:G:A | - | -0.106475036654617 | 0.00565426182791395 | LUAD | Female-baised eQTL |
| rs1123072 | chr16:67864894:G:A | - | -0.100905342013587 | 0.0101281201810467 | LUAD | Female-baised eQTL |
| rs9935956 | chr16:63957970:A:G | - | 0.0557951307850458 | 0.0268934130768961 | LUAD | Female-baised eQTL |
| rs59376497 | chr16:67647267:C:T | - | -0.0906229871685484 | 0.0317116202927663 | LUAD | Female-baised eQTL |
| rs12924413 | chr16:72095846:T:C | - | -0.0503280768815438 | 0.0418201760990419 | LUAD | Female-baised eQTL |
| rs2072141 | chr16:72099312:G:A | - | -0.0503280768815438 | 0.0418201760990419 | LUAD | Female-baised eQTL |
| rs8043606 | chr16:72101420:T:C | - | -0.0503280768815438 | 0.0418201760990419 | LUAD | Female-baised eQTL |
| rs9941346 | chr16:72101808:C:G | - | -0.0503280768815438 | 0.0418201760990419 | LUAD | Female-baised eQTL |
| rs9932062 | chr16:72102156:T:C | - | -0.0503280768815438 | 0.0418201760990419 | LUAD | Female-baised eQTL |
| rs7194397 | chr16:72094400:C:T | - | -0.0502609748146674 | 0.0448637916789573 | LUAD | Female-baised eQTL |
| rs7499071 | chr16:65086964:C:A | - | -0.0834034232654488 | 0.0133299237274071 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs28628339 | chr16:68769941:A:G | - | -0.0610833525013313 | 0.041907578490535 | KIRC | Male-baised eQTL |
| rs12930572 | chr16:74782210:G:A | - | 0.0344256095301916 | 0.0272939479968485 | BLCA | Male-baised eQTL |
| rs8054422 | chr16:74795867:G:C | - | 0.0341992271570708 | 0.0276834956888275 | BLCA | Male-baised eQTL |
| rs35466549 | chr16:74794936:A:G | - | 0.0339510324517808 | 0.0303193097327584 | BLCA | Male-baised eQTL |
| rs76171566 | chr16:67146210:G:C | - | 0.0690859720929672 | 0.0424033449498607 | BLCA | Male-baised eQTL |
| rs433824 | chr16:77635175:C:G | - | 0.0783015742450305 | 0.0181482192106527 | COAD | Male-baised eQTL |
| rs56790580 | chr16:77634857:C:T | - | -0.0885812068761236 | 0.0194563614831092 | COAD | Male-baised eQTL |
| rs12598958 | chr16:64118024:C:T | - | -0.0687424832603489 | 0.0251745654310646 | COAD | Male-baised eQTL |
| rs1069572 | chr16:65840225:G:C | - | -0.0529850191492301 | 0.0254149298939817 | COAD | Male-baised eQTL |
| rs72792661 | chr16:64129313:A:T | - | -0.0673556015452442 | 0.0287494962725581 | COAD | Male-baised eQTL |
| rs7200699 | chr16:74172163:T:C | - | -0.049964203957581 | 0.036308081683212 | COAD | Male-baised eQTL |
| rs12923487 | chr16:74610214:G:T | - | -0.0602016515900209 | 0.0447312494400066 | COAD | Male-baised eQTL |
| rs12446691 | chr16:64151847:G:A | - | -0.0639006827238323 | 0.0484313635297594 | COAD | Male-baised eQTL |
| rs11866632 | chr16:73339733:T:G | - | 0.0494389491616616 | 0.0496320403796058 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of EDC4 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
