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Gene: ENSG00000036672 |
Summary for USP2 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000036672 | Gene symbol | USP2 |
| Gene name | ubiquitin specific peptidase 2 | |
| HGNC | 12618 | |
| Entrez ID | 9099 | |
| Gene type | protein_coding | |
| Synonyms | USP2|UBP41 | |
| UniProtAcc | O75604 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for USP2 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| USP2 | 2.89e+03 | -1.67e+00 | 2.89e-01 | -5.79e+00 | 7.14e-09 | 3.57e-08 | KIRP |
| USP2 | 3.45e+03 | -1.06e+00 | 3.95e-01 | -2.68e+00 | 7.47e-03 | 1.55e-02 | KICH |
| USP2 | 3.91e+02 | -1.43e+00 | 4.87e-01 | -2.93e+00 | 3.35e-03 | 1.61e-02 | ESCA |
| USP2 | 4.86e+02 | -1.74e+00 | 6.71e-01 | -2.59e+00 | 9.73e-03 | 2.43e-02 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| USP2 | 2.27e+02 | -4.32e+00 | 2.97e-01 | -1.45e+01 | 6.56e-48 | 1.54e-45 | COAD |
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Sex-biased somatic mutation for USP2 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for USP2 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| DLBC | cg27234090 | chr11:119381144 | CGI:chr11:119381420-119381854 | promoter,gene body | 2.57e-01 | 3.61e-01 | -2.05e+00 | 4.05e-02 | 4.68e-02 | -1.04e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| HNSC | cg27234090 | chr11:119381144 | CGI:chr11:119381420-119381854 | promoter,gene body | 3.62e-01 | 2.31e-01 | 2.06e+00 | 3.95e-02 | 4.24e-02 | 1.31e-01 |
| HNSC | cg04451652 | chr11:119382270 | CGI:chr11:119381420-119381854 | promoter | 1.80e-01 | 7.67e-02 | 2.44e+00 | 1.46e-02 | 2.29e-02 | 1.04e-01 |
Top |
Exon skipping events with PSI in TCGA for USP2 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for USP2 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for USP2 |
| TFs related to USP2. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| USP2 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for USP2 |
| RBPs related to ES in USP2. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| KICH | BRUNOL6 | exon_skip_78118 | 8.83e+00 | 9.84e-01 | 8.52e+00 | 1.09e-02 | Male-biased |
| USP2 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000036672 | AC016876.2,hsa-mir-493,USP2 | Male-specific ceRNA | TCGA-LUSC |
| ENSG00000036672 | AC010538.1,hsa-mir-506,USP2 | Male-specific ceRNA | TCGA-LUSC |
| ENSG00000036672 | AC067852.3,hsa-mir-506,USP2 | Male-specific ceRNA | TCGA-LUSC |
| ENSG00000036672 | SGMS1-AS1,hsa-mir-506,USP2 | Male-specific ceRNA | TCGA-LUSC |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs61897865 | chr11:126703639:A:G | - | 0.196788775857956 | 0.02204584210629 | PAAD | Female-baised eQTL |
| rs3862635 | chr11:126712683:T:C | - | 0.196071151455395 | 0.0235358702941718 | PAAD | Female-baised eQTL |
| rs61897862 | chr11:126689316:A:G | - | 0.195687084904228 | 0.0238661544510396 | PAAD | Female-baised eQTL |
| rs117578420 | chr11:126694145:T:C | - | 0.195687084904228 | 0.0238661544510396 | PAAD | Female-baised eQTL |
| rs113656979 | chr11:126700640:T:C | - | 0.195687084904228 | 0.0238661544510396 | PAAD | Female-baised eQTL |
| rs3862636 | chr11:126712874:G:A | - | 0.195687084904228 | 0.0238661544510396 | PAAD | Female-baised eQTL |
| rs79958943 | chr11:111660031:G:A | - | 0.242119252304882 | 0.025476700903022 | PAAD | Female-baised eQTL |
| rs17474471 | chr11:111692694:T:A | - | 0.241675141278213 | 0.0259966721665873 | PAAD | Female-baised eQTL |
| rs45524342 | chr11:111710419:A:T | - | 0.241675141278213 | 0.0259966721665873 | PAAD | Female-baised eQTL |
| rs76313656 | chr11:126681680:C:T | - | 0.195170902115312 | 0.0260249010059222 | PAAD | Female-baised eQTL |
| rs12418859 | chr11:126713484:A:C | - | 0.184445741272906 | 0.0396124708506752 | PAAD | Female-baised eQTL |
| rs12362614 | chr11:115566516:C:T | - | 0.119680100814147 | 0.0452638517673756 | PAAD | Female-baised eQTL |
| rs7126475 | chr11:115586575:C:G | - | 0.11373230718886 | 0.0471832917587124 | PAAD | Female-baised eQTL |
| rs71491831 | chr11:124735887:G:A | - | 0.548544746404716 | 4.53147629720031e-07 | KIRP | Female-baised eQTL |
| rs34716506 | chr11:124736716:G:T | - | 0.548544746404716 | 4.53147629720031e-07 | KIRP | Female-baised eQTL |
| rs35306015 | chr11:124740877:A:G | - | 0.548544746404716 | 4.53147629720031e-07 | KIRP | Female-baised eQTL |
| rs12792040 | chr11:124754254:G:A | - | 0.450984880701582 | 9.18228534987891e-05 | KIRP | Female-baised eQTL |
| rs671176 | chr11:125929672:C:T | - | 0.286540464676875 | 0.0109632152180957 | KIRP | Female-baised eQTL |
| rs507800 | chr11:125936206:C:G | - | 0.286540464676875 | 0.0109632152180957 | KIRP | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs78461758 | chr11:109503991:A:T | - | 0.234779169500811 | 0.00955662666741506 | SARC | Male-baised eQTL |
| rs7940282 | chr11:115988695:T:C | - | 0.183910659157765 | 0.0487656679160089 | SARC | Male-baised eQTL |
| rs7925314 | chr11:115988752:A:C | - | 0.183910659157765 | 0.0487656679160089 | SARC | Male-baised eQTL |
| rs74793835 | chr11:115989380:G:C | - | 0.183910659157765 | 0.0487656679160089 | SARC | Male-baised eQTL |
| rs12285018 | chr11:115993547:C:G | - | 0.183910659157765 | 0.0487656679160089 | SARC | Male-baised eQTL |
| rs78301887 | chr11:115994694:C:T | - | 0.183910659157765 | 0.0487656679160089 | SARC | Male-baised eQTL |
| rs59393119 | chr11:115994879:A:G | - | 0.183910659157765 | 0.0487656679160089 | SARC | Male-baised eQTL |
| rs6589524 | chr11:115995837:T:C | - | 0.183910659157765 | 0.0487656679160089 | SARC | Male-baised eQTL |
| rs6589525 | chr11:115995907:C:T | - | 0.183910659157765 | 0.0487656679160089 | SARC | Male-baised eQTL |
| rs7951102 | chr11:115996605:T:C | - | 0.183910659157765 | 0.0487656679160089 | SARC | Male-baised eQTL |
| rs11215750 | chr11:115996954:G:T | - | 0.183910659157765 | 0.0487656679160089 | SARC | Male-baised eQTL |
| rs11215751 | chr11:115997264:A:C | - | 0.183910659157765 | 0.0487656679160089 | SARC | Male-baised eQTL |
| rs7119214 | chr11:115998315:C:G | - | 0.183910659157765 | 0.0487656679160089 | SARC | Male-baised eQTL |
| rs12284734 | chr11:115998888:G:A | - | 0.183910659157765 | 0.0487656679160089 | SARC | Male-baised eQTL |
| rs17119054 | chr11:116000121:G:A | - | 0.183910659157765 | 0.0487656679160089 | SARC | Male-baised eQTL |
| rs7127802 | chr11:116000455:A:G | - | 0.183910659157765 | 0.0487656679160089 | SARC | Male-baised eQTL |
| rs7928212 | chr11:116001998:C:T | - | 0.183910659157765 | 0.0487656679160089 | SARC | Male-baised eQTL |
| rs2157610 | chr11:116005051:A:G | - | 0.183910659157765 | 0.0487656679160089 | SARC | Male-baised eQTL |
| rs150656233 | chr11:116005749:C:T | - | 0.183910659157765 | 0.0487656679160089 | SARC | Male-baised eQTL |
| rs117047967 | chr11:116006027:C:A | - | 0.183910659157765 | 0.0487656679160089 | SARC | Male-baised eQTL |
| rs12420541 | chr11:126180146:G:A | - | 0.126945717151272 | 0.0156012508915207 | LIHC | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000036672 |
| CpG Site: cg12716639 | |
| Position to Gene: gene | |
| Male Effect: -0.424890286249446 | |
| Female Effect: - | |
 | Gene ID: ENSG00000036672 |
| CpG Site: cg24258886 | |
| Position to Gene: gene | |
| Male Effect: -0.290726940422262 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg12716639 | chr11:119363488 | gene | -0.424890286249446 | 3.06585407354657e-08 | -0.6178111331795842 | 1.2296711459525397e-11 | PAAD |
| cg24258886 | chr11:119368395 | gene | -0.290726940422262 | 2.22355890435314e-05 | -0.39675291997809603 | 9.483351072758855e-06 | SARC |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of USP2 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000036672 | USP2 | C2239176 | Liver carcinoma | 1 | CTD_human |
