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Gene: ENSG00000033011 |
Summary for ALG1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000033011 | Gene symbol | ALG1 |
| Gene name | ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase | |
| HGNC | 18294 | |
| Entrez ID | 56052 | |
| Gene type | protein_coding | |
| Synonyms | ALG1|HMT-1|HMAT1|CDG1K|Mat-1 | |
| UniProtAcc | Q9BT22 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for ALG1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for ALG1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for ALG1 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg04899681 | chr16:5034544 | CGI:chr16:5033243-5034031 | promoter,gene body | 3.62e-01 | 5.26e-01 | -4.55e+00 | 5.48e-06 | 1.60e-05 | -1.64e-01 |
| LUAD | cg04899681 | chr16:5034544 | CGI:chr16:5033243-5034031 | promoter,gene body | 3.86e-01 | 5.12e-01 | -3.90e+00 | 9.59e-05 | 2.72e-04 | -1.26e-01 |
| LUSC | cg04899681 | chr16:5034544 | CGI:chr16:5033243-5034031 | promoter,gene body | 3.11e-01 | 5.37e-01 | -3.94e+00 | 8.07e-05 | 6.42e-04 | -2.26e-01 |
| LUSC | cg07202092 | chr16:5034831 | CGI:chr16:5033243-5034031 | promoter,gene body | 7.75e-01 | 9.64e-01 | -4.10e+00 | 4.09e-05 | 5.36e-04 | -1.90e-01 |
| CHOL | cg04899681 | chr16:5034544 | CGI:chr16:5033243-5034031 | promoter,gene body | 4.68e-01 | 6.58e-01 | -2.29e+00 | 2.23e-02 | 3.24e-02 | -1.90e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for ALG1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for ALG1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for ALG1 |
| TFs related to ALG1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ALG1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for ALG1 |
| RBPs related to ES in ALG1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| THYM | RBM5 | exon_skip_133187 | 9.00e+00 | 6.51e-03 | 9.36e+00 | 9.90e-01 | Female-biased |
| KIRP | PABPC5 | exon_skip_133195 | 9.41e+00 | 9.83e-01 | 9.11e+00 | 1.37e-02 | Male-biased |
| MESO | RBM5 | exon_skip_133187 | 8.99e+00 | 1.49e-02 | 9.31e+00 | 9.82e-01 | Female-biased |
| SARC | RBM5 | exon_skip_133187 | 8.99e+00 | 1.18e-02 | 9.33e+00 | 9.85e-01 | Female-biased |
| ALG1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs58892900 | chr16:8239259:G:A | - | 0.124328571509757 | 0.00320062654762383 | LUSC | Female-baised eQTL |
| rs55935331 | chr16:8236938:C:G | - | 0.115512767471561 | 0.00938655935355829 | LUSC | Female-baised eQTL |
| rs12597924 | chr16:8176773:G:T | - | 0.117677459062033 | 0.0166309847285973 | LUSC | Female-baised eQTL |
| rs59702456 | chr16:8245419:A:G | - | 0.106446760594756 | 0.0199805093756699 | LUSC | Female-baised eQTL |
| rs58335308 | chr16:8247336:G:A | - | 0.106446760594756 | 0.0199805093756699 | LUSC | Female-baised eQTL |
| rs17145520 | chr16:8247529:A:G | - | 0.106446760594756 | 0.0199805093756699 | LUSC | Female-baised eQTL |
| rs17145534 | chr16:8248524:G:T | - | 0.0994839435797207 | 0.0406018647277173 | LUSC | Female-baised eQTL |
| rs28734822 | chr16:5446433:C:T | - | 0.0865885311769122 | 0.0486977416533181 | LUSC | Female-baised eQTL |
| rs7194738 | chr16:5551074:A:G | - | -0.0488160376032271 | 0.0437457178179206 | LUAD | Female-baised eQTL |
| rs62018424 | chr16:5557274:T:C | - | -0.049618469047441 | 0.0487385420641629 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs2719636 | chr16:10744652:G:C | - | 0.0750655002618631 | 0.0445085528042033 | BLCA | Male-baised eQTL |
| rs2233531 | chr16:10744056:C:G | - | 0.0750794594901518 | 0.0445521293558403 | BLCA | Male-baised eQTL |
| rs4787065 | chr16:7720438:G:C | - | -0.119163541447534 | 0.00668000707221453 | COAD | Male-baised eQTL |
| rs29605 | chr16:8365919:C:T | - | -0.0804788780691847 | 0.00679793428591999 | COAD | Male-baised eQTL |
| rs2157024 | chr16:13489807:A:G | - | 0.0584044175270838 | 0.0169057978742662 | COAD | Male-baised eQTL |
| rs8049893 | chr16:6327254:G:A | - | -0.0844359648357138 | 0.0194761413248305 | COAD | Male-baised eQTL |
| rs56112642 | chr16:8397774:G:A | - | -0.0955190480790282 | 0.0227993979532962 | COAD | Male-baised eQTL |
| rs58614208 | chr16:8397775:C:T | - | -0.0955190480790282 | 0.0227993979532962 | COAD | Male-baised eQTL |
| rs6498142 | chr16:10987392:C:G | - | 0.0573586081343675 | 0.0236530346784537 | COAD | Male-baised eQTL |
| rs17145791 | chr16:8397265:C:G | - | -0.0915734953918045 | 0.028943082030571 | COAD | Male-baised eQTL |
| rs4781473 | chr16:13431784:G:A | - | -0.0531982056802915 | 0.0335434554164877 | COAD | Male-baised eQTL |
| rs145691831 | chr16:5869560:C:T | - | 0.106175701563316 | 0.0336700209028037 | COAD | Male-baised eQTL |
| rs78074816 | chr16:5870341:C:T | - | 0.106175701563316 | 0.0336700209028037 | COAD | Male-baised eQTL |
| rs2157023 | chr16:13489664:C:T | - | 0.0539798104326564 | 0.0363125221878919 | COAD | Male-baised eQTL |
| rs1041863 | chr16:13490377:T:C | - | 0.0539798104326564 | 0.0363125221878919 | COAD | Male-baised eQTL |
| rs7197293 | chr16:5865039:A:G | - | 0.091675383024945 | 0.0386563910733096 | COAD | Male-baised eQTL |
| rs11641984 | chr16:13493939:A:G | - | 0.0536697359084621 | 0.0388996830499649 | COAD | Male-baised eQTL |
| rs28510903 | chr16:5868408:G:C | - | 0.0901690364457705 | 0.0409543954397138 | COAD | Male-baised eQTL |
| rs28623442 | chr16:5868446:A:G | - | 0.0901690364457705 | 0.0409543954397138 | COAD | Male-baised eQTL |
| rs28607579 | chr16:5868472:G:A | - | 0.0901690364457705 | 0.0409543954397138 | COAD | Male-baised eQTL |
| rs28417475 | chr16:5868954:A:G | - | 0.0901690364457705 | 0.0409543954397138 | COAD | Male-baised eQTL |
| rs4781495 | chr16:13488449:G:C | - | 0.0537776622908505 | 0.0435972677680048 | COAD | Male-baised eQTL |
| rs9926433 | chr16:10986729:C:G | - | 0.0521593000295166 | 0.0441151055252248 | COAD | Male-baised eQTL |
| rs4267308 | chr16:5866157:T:C | - | 0.0890299808150642 | 0.045659407691683 | COAD | Male-baised eQTL |
| rs10521096 | chr16:13488020:C:T | - | 0.0536255888868176 | 0.0456948381652731 | COAD | Male-baised eQTL |
| rs12932807 | chr16:5888922:C:T | - | 0.0957685584971085 | 0.0460096386019887 | COAD | Male-baised eQTL |
| rs35899517 | chr16:13487980:A:G | - | 0.0531095631587111 | 0.0486947919941273 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000033011 |
| CpG Site: cg04899681 | |
| Position to Gene: gene,promoter | |
| Male Effect: - | |
| Female Effect: -0.0951820504333577 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg04899681 | chr16:5034544 | gene,promoter | -0.0951820504333577 | 1.48399833661178e-06 | -0.3594611824257515 | 4.216840749785513e-09 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_133184 | chr16:5079063:5079102 | In-frame | rs58623200 | chr16:5871821:G:A | Distant downstream | 0.0290420419192298 | 0.0365903495883884 | LGG | Female-baised sQTL |
| exon_skip_133184 | chr16:5079063:5079102 | In-frame | rs1898225 | chr16:5870510:G:T | Distant downstream | 0.033551966513227 | 0.049681995882579 | LGG | Female-baised sQTL |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_133184 | chr16:5079063:5079102 | In-frame | rs153042 | chr16:4169222:G:A | Distant upstream | 0.0248556319408037 | 0.0455703151128158 | LGG | Male-baised sQTL |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of ALG1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000033011 | ALG1 | C2931005 | Congenital disorder of glycosylation type 1K | 1 | CTD_human |
