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Gene: ENSG00000012171 |
Summary for SEMA3B |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000012171 | Gene symbol | SEMA3B |
| Gene name | semaphorin 3B | |
| HGNC | 10724 | |
| Entrez ID | 7869 | |
| Gene type | protein_coding | |
| Synonyms | SEMA3B|SemA|semaV|LUCA-1|sema5 | |
| UniProtAcc | Q13214 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for SEMA3B |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| SEMA3B | 2.43e+03 | -1.44e+00 | 5.26e-01 | -2.73e+00 | 6.25e-03 | 2.63e-02 | ESCA |
| SEMA3B | 1.08e+03 | 1.70e+00 | 5.95e-01 | 2.86e+00 | 4.25e-03 | 1.19e-02 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for SEMA3B |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for SEMA3B |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg13209298 | chr3:50266375 | CGI:chr3:50260008-50260665 | promoter | 5.84e-01 | 4.12e-01 | 3.07e+00 | 2.15e-03 | 1.41e-02 | 1.72e-01 |
| BRCA | cg22927302 | chr3:50267031 | CGI:chr3:50273014-50273966 | promoter | 5.10e-01 | 3.99e-01 | 2.43e+00 | 1.51e-02 | 3.14e-02 | 1.10e-01 |
| BRCA | cg15145767 | chr3:50268996 | CGI:chr3:50273014-50273966 | promoter,exon,gene body | 3.43e-01 | 2.04e-01 | 3.22e+00 | 1.30e-03 | 1.10e-02 | 1.39e-01 |
| BRCA | cg24784036 | chr3:50269447 | CGI:chr3:50273014-50273966 | promoter,gene body | 3.79e-01 | 2.37e-01 | 3.27e+00 | 1.07e-03 | 9.81e-03 | 1.42e-01 |
| GBM | cg25597623 | chr3:50269024 | CGI:chr3:50273014-50273966 | UTR,promoter,exon,gene body | 4.65e-01 | 5.81e-01 | -2.28e+00 | 2.27e-02 | 3.75e-02 | -1.17e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| THCA | cg02490920 | chr3:50266974 | CGI:chr3:50273014-50273966 | promoter | 5.31e-01 | 6.32e-01 | -3.18e+00 | 1.49e-03 | 4.18e-03 | -1.01e-01 |
| LIHC | cg12577320 | chr3:50266747 | CGI:chr3:50260008-50260665 | promoter | 6.20e-01 | 7.23e-01 | -2.84e+00 | 4.56e-03 | 6.08e-03 | -1.03e-01 |
| LIHC | cg24784036 | chr3:50269447 | CGI:chr3:50273014-50273966 | promoter,gene body | 4.81e-01 | 6.02e-01 | -4.80e+00 | 1.60e-06 | 5.57e-06 | -1.21e-01 |
| ESCA | cg22229016 | chr3:50266847 | CGI:chr3:50273014-50273966 | promoter | 8.53e-01 | 6.91e-01 | 2.66e+00 | 7.80e-03 | 3.55e-02 | 1.62e-01 |
| ESCA | cg20116935 | chr3:50266325 | CGI:chr3:50260008-50260665 | promoter | 4.40e-01 | 3.20e-01 | 2.45e+00 | 1.42e-02 | 3.78e-02 | 1.20e-01 |
| ESCA | cg13209298 | chr3:50266375 | CGI:chr3:50260008-50260665 | promoter | 7.28e-01 | 5.26e-01 | 2.60e+00 | 9.30e-03 | 3.58e-02 | 2.02e-01 |
| ESCA | cg12577320 | chr3:50266747 | CGI:chr3:50260008-50260665 | promoter | 6.38e-01 | 5.15e-01 | 2.62e+00 | 8.77e-03 | 3.58e-02 | 1.24e-01 |
| ESCA | cg02490920 | chr3:50266974 | CGI:chr3:50273014-50273966 | promoter | 5.55e-01 | 3.94e-01 | 2.85e+00 | 4.38e-03 | 3.41e-02 | 1.61e-01 |
| ESCA | cg22927302 | chr3:50267031 | CGI:chr3:50273014-50273966 | promoter | 5.17e-01 | 3.50e-01 | 2.73e+00 | 6.33e-03 | 3.50e-02 | 1.67e-01 |
| ESCA | cg25597623 | chr3:50269024 | CGI:chr3:50273014-50273966 | UTR,promoter,exon,gene body | 4.43e-01 | 3.42e-01 | 2.14e+00 | 3.20e-02 | 4.44e-02 | 1.01e-01 |
| CHOL | cg15145767 | chr3:50268996 | CGI:chr3:50273014-50273966 | promoter,exon,gene body | 4.33e-01 | 6.82e-01 | -3.10e+00 | 1.96e-03 | 1.07e-02 | -2.48e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg25597623 | chr3:50269024 | CGI:chr3:50273014-50273966 | UTR,promoter,exon,gene body | 4.39e-01 | 5.49e-01 | -5.74e+00 | 9.73e-09 | 2.18e-08 | -1.10e-01 |
| THCA | cg01988285 | chr3:50268675 | CGI:chr3:50273014-50273966 | promoter,gene body | 4.20e-01 | 5.20e-01 | -4.54e+00 | 5.64e-06 | 2.71e-05 | -1.00e-01 |
| HNSC | cg12999941 | chr3:50267498 | CGI:chr3:50273014-50273966 | promoter | 1.99e-01 | 4.32e-02 | 2.65e+00 | 8.13e-03 | 1.67e-02 | 1.56e-01 |
| HNSC | cg11039694 | chr3:50267509 | CGI:chr3:50273014-50273966 | promoter | 1.57e-01 | 4.06e-02 | 2.07e+00 | 3.85e-02 | 4.17e-02 | 1.17e-01 |
| HNSC | cg13209298 | chr3:50266375 | CGI:chr3:50260008-50260665 | promoter | 7.84e-01 | 6.75e-01 | 2.78e+00 | 5.40e-03 | 1.38e-02 | 1.09e-01 |
| HNSC | cg02490920 | chr3:50266974 | CGI:chr3:50273014-50273966 | promoter | 6.06e-01 | 4.69e-01 | 2.65e+00 | 8.13e-03 | 1.67e-02 | 1.37e-01 |
| HNSC | cg22927302 | chr3:50267031 | CGI:chr3:50273014-50273966 | promoter | 5.84e-01 | 4.74e-01 | 2.19e+00 | 2.82e-02 | 3.41e-02 | 1.10e-01 |
| HNSC | cg01988285 | chr3:50268675 | CGI:chr3:50273014-50273966 | promoter,gene body | 5.12e-01 | 3.19e-01 | 2.92e+00 | 3.52e-03 | 1.16e-02 | 1.93e-01 |
| HNSC | cg15145767 | chr3:50268996 | CGI:chr3:50273014-50273966 | promoter,exon,gene body | 4.04e-01 | 2.41e-01 | 3.04e+00 | 2.35e-03 | 1.02e-02 | 1.62e-01 |
| HNSC | cg25597623 | chr3:50269024 | CGI:chr3:50273014-50273966 | UTR,promoter,exon,gene body | 5.22e-01 | 3.62e-01 | 2.38e+00 | 1.75e-02 | 2.55e-02 | 1.59e-01 |
| HNSC | cg24784036 | chr3:50269447 | CGI:chr3:50273014-50273966 | promoter,gene body | 4.53e-01 | 2.93e-01 | 2.87e+00 | 4.07e-03 | 1.23e-02 | 1.60e-01 |
| BLCA | cg25597623 | chr3:50269024 | CGI:chr3:50273014-50273966 | UTR,promoter,exon,gene body | 4.12e-01 | 5.73e-01 | -2.17e+00 | 3.00e-02 | 3.54e-02 | -1.61e-01 |
| LIHC | cg20116935 | chr3:50266325 | CGI:chr3:50260008-50260665 | promoter | 5.56e-01 | 6.66e-01 | -3.55e+00 | 3.84e-04 | 1.08e-03 | -1.10e-01 |
| LIHC | cg22927302 | chr3:50267031 | CGI:chr3:50273014-50273966 | promoter | 6.19e-01 | 7.40e-01 | -4.40e+00 | 1.09e-05 | 7.33e-05 | -1.21e-01 |
| KIRP | cg02490920 | chr3:50266974 | CGI:chr3:50273014-50273966 | promoter | 5.85e-01 | 4.66e-01 | 2.11e+00 | 3.53e-02 | 3.93e-02 | 1.19e-01 |
Top |
Exon skipping events with PSI in TCGA for SEMA3B |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for SEMA3B |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for SEMA3B |
| TFs related to SEMA3B. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| GBM | SNAI1 | SEMA3B | 4.28e+00 | 9.81e-01 | 3.15e+00 | 8.65e-03 | Male-biased |
| GBM | TCF3 | SEMA3B | 4.36e+00 | 9.83e-01 | 3.23e+00 | 8.71e-03 | Male-biased |
| SEMA3B related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for SEMA3B |
| RBPs related to ES in SEMA3B. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| SEMA3B related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs73072330 | chr3:48123599:G:A | - | 0.166220842964727 | 0.0111074892755298 | HNSC | Female-baised eQTL |
| rs56298666 | chr3:47625728:A:G | - | 0.145922264413347 | 0.0398886714213208 | HNSC | Female-baised eQTL |
| rs13076033 | chr3:52864411:T:C | - | 0.190355801045953 | 0.00448542313109488 | LIHC | Female-baised eQTL |
| rs33999310 | chr3:52849316:G:A | - | 0.170295571902451 | 0.00777205406311638 | LIHC | Female-baised eQTL |
| rs11626 | chr3:52839968:C:T | - | 0.153204697134853 | 0.0154010364542472 | LIHC | Female-baised eQTL |
| rs77572134 | chr3:52861918:T:C | - | 0.158003427824825 | 0.0183433599880076 | LIHC | Female-baised eQTL |
| rs11708390 | chr3:52862393:C:A | - | 0.158003427824825 | 0.0183433599880076 | LIHC | Female-baised eQTL |
| rs11718060 | chr3:52841530:G:A | - | 0.146668520665353 | 0.0204493896378703 | LIHC | Female-baised eQTL |
| rs2001732 | chr3:52846724:C:T | - | 0.146668520665353 | 0.0204493896378703 | LIHC | Female-baised eQTL |
| rs13080929 | chr3:52851096:A:C | - | 0.145976157542661 | 0.0226243324968192 | LIHC | Female-baised eQTL |
| rs4687556 | chr3:52856459:T:C | - | -0.133924163655266 | 0.0476180652834532 | LIHC | Female-baised eQTL |
| rs4687676 | chr3:52856402:C:T | - | -0.135146487286248 | 0.0478431848029744 | LIHC | Female-baised eQTL |
| rs9637477 | chr3:52857410:G:C | - | -0.133923301708055 | 0.0486089363671692 | LIHC | Female-baised eQTL |
| rs141256528 | chr3:55864212:C:T | - | 0.137869508417147 | 0.0397433774386747 | LUSC | Female-baised eQTL |
| rs6445953 | chr3:58178174:A:C | - | -0.0738614264065476 | 0.0415995596273076 | LGG | Female-baised eQTL |
| rs7616808 | chr3:44113413:A:G | - | 0.0861197462318002 | 0.000245140568805299 | LUAD | Female-baised eQTL |
| rs72869240 | chr3:44113985:G:A | - | 0.0861197462318002 | 0.000245140568805299 | LUAD | Female-baised eQTL |
| rs7611175 | chr3:44105985:A:G | - | 0.0855252816622635 | 0.000283640148863798 | LUAD | Female-baised eQTL |
| rs72869231 | chr3:44110079:C:T | - | 0.0855252816622635 | 0.000283640148863798 | LUAD | Female-baised eQTL |
| rs57281609 | chr3:44110682:T:C | - | 0.0855252816622635 | 0.000283640148863798 | LUAD | Female-baised eQTL |
| rs6441821 | chr3:44111329:A:G | - | 0.0855252816622635 | 0.000283640148863798 | LUAD | Female-baised eQTL |
| rs59068097 | chr3:44112029:C:A | - | 0.0855252816622635 | 0.000283640148863798 | LUAD | Female-baised eQTL |
| rs72869235 | chr3:44112390:C:T | - | 0.0855252816622635 | 0.000283640148863798 | LUAD | Female-baised eQTL |
| rs72869236 | chr3:44112811:C:G | - | 0.0855252816622635 | 0.000283640148863798 | LUAD | Female-baised eQTL |
| rs15965 | chr3:44121992:G:A | - | 0.0856650025313441 | 0.000284926073741724 | LUAD | Female-baised eQTL |
| rs7618961 | chr3:44158266:C:T | - | 0.0867823329588265 | 0.000287861559959159 | LUAD | Female-baised eQTL |
| rs34329021 | chr3:44109539:T:C | - | 0.0824536479554835 | 0.000381406667926534 | LUAD | Female-baised eQTL |
| rs6809200 | chr3:44105472:A:G | - | 0.0849976234525505 | 0.000382826870152088 | LUAD | Female-baised eQTL |
| rs6796191 | chr3:44125897:A:G | - | 0.0848744489660075 | 0.000383214071726522 | LUAD | Female-baised eQTL |
| rs75200914 | chr3:44156363:T:A | - | 0.0851891252073921 | 0.000515273356667955 | LUAD | Female-baised eQTL |
| rs57734587 | chr3:44156839:G:A | - | 0.0851891252073921 | 0.000515273356667955 | LUAD | Female-baised eQTL |
| rs7643865 | chr3:44157357:A:G | - | 0.0851891252073921 | 0.000515273356667955 | LUAD | Female-baised eQTL |
| rs11709146 | chr3:44108966:C:T | - | 0.0804725333676346 | 0.000781525679462332 | LUAD | Female-baised eQTL |
| rs72869230 | chr3:44109614:T:C | - | 0.0804725333676346 | 0.000781525679462332 | LUAD | Female-baised eQTL |
| rs73832241 | chr3:44160946:G:A | - | 0.0733444125869695 | 0.00297126656372814 | LUAD | Female-baised eQTL |
| rs17077678 | chr3:45331655:A:G | - | 0.0716986892731669 | 0.00366065713891522 | LUAD | Female-baised eQTL |
| rs7644142 | chr3:45320955:C:T | - | 0.0732251996000853 | 0.00441586041807178 | LUAD | Female-baised eQTL |
| rs7624100 | chr3:45295104:A:G | - | 0.0653255757209447 | 0.00557124719561861 | LUAD | Female-baised eQTL |
| rs7630233 | chr3:45299287:G:A | - | 0.0653255757209447 | 0.00557124719561861 | LUAD | Female-baised eQTL |
| rs7620365 | chr3:45299506:A:C | - | 0.0653255757209447 | 0.00557124719561861 | LUAD | Female-baised eQTL |
| rs9821911 | chr3:45300171:C:T | - | 0.0654555544223897 | 0.00575511868067778 | LUAD | Female-baised eQTL |
| rs1873049 | chr3:44173288:G:A | - | 0.070960411548912 | 0.00575931698381114 | LUAD | Female-baised eQTL |
| rs6805666 | chr3:45318999:A:C | - | 0.0672744403288743 | 0.00698539505716011 | LUAD | Female-baised eQTL |
| rs1515358 | chr3:45311639:G:T | - | 0.0662619702547482 | 0.00726322144952459 | LUAD | Female-baised eQTL |
| rs59183345 | chr3:45314917:G:A | - | 0.0662619702547482 | 0.00726322144952459 | LUAD | Female-baised eQTL |
| rs17077625 | chr3:45298970:T:C | - | 0.0656483220839796 | 0.00772351827186508 | LUAD | Female-baised eQTL |
| rs72876765 | chr3:45315029:G:A | - | 0.0674034020950034 | 0.00828158240713832 | LUAD | Female-baised eQTL |
| rs55697014 | chr3:45293368:G:C | - | 0.0652778931328764 | 0.00831741130303616 | LUAD | Female-baised eQTL |
| rs7651014 | chr3:45293436:C:T | - | 0.0652778931328764 | 0.00831741130303616 | LUAD | Female-baised eQTL |
| rs74955730 | chr3:44141069:G:T | - | 0.0937807687328238 | 0.00849506445450961 | LUAD | Female-baised eQTL |
| rs7626631 | chr3:44155766:C:T | - | 0.0679641905821696 | 0.00850828138990689 | LUAD | Female-baised eQTL |
| rs6786985 | chr3:45302590:T:A | - | 0.0636331949554844 | 0.00859661052511673 | LUAD | Female-baised eQTL |
| rs59580360 | chr3:45304845:A:G | - | 0.0661809180529374 | 0.00867993888958478 | LUAD | Female-baised eQTL |
| rs139157764 | chr3:44148979:G:C | - | 0.0922300735137698 | 0.00892565447429364 | LUAD | Female-baised eQTL |
| rs6763193 | chr3:45320007:T:G | - | 0.0677435723736328 | 0.00904778900917728 | LUAD | Female-baised eQTL |
| rs12633555 | chr3:45300027:T:A | - | 0.0650396112749766 | 0.00917526757536159 | LUAD | Female-baised eQTL |
| rs56275768 | chr3:45300476:G:T | - | 0.0650396112749766 | 0.00917526757536159 | LUAD | Female-baised eQTL |
| rs6771038 | chr3:45301918:C:G | - | 0.0647773181261097 | 0.00978796882341861 | LUAD | Female-baised eQTL |
| rs73832220 | chr3:44111092:C:T | - | 0.0852964492558667 | 0.010223707650518 | LUAD | Female-baised eQTL |
| rs6801752 | chr3:45316562:C:T | - | 0.064782725146603 | 0.0105433673455956 | LUAD | Female-baised eQTL |
| rs7617429 | chr3:45292493:T:C | - | 0.0635249632752836 | 0.0108006588321452 | LUAD | Female-baised eQTL |
| rs72871735 | chr3:45279961:G:C | - | 0.0673229827618105 | 0.0125424134690057 | LUAD | Female-baised eQTL |
| rs77582632 | chr3:44151822:C:T | - | 0.089711465786491 | 0.0140865715280936 | LUAD | Female-baised eQTL |
| rs11718031 | chr3:44150850:A:G | - | 0.0893740634479881 | 0.0148434322293707 | LUAD | Female-baised eQTL |
| rs56067512 | chr3:44137774:T:G | - | 0.0828640010518072 | 0.0166515070257141 | LUAD | Female-baised eQTL |
| rs73832234 | chr3:44136759:C:T | - | 0.0805175907194082 | 0.0180203961487134 | LUAD | Female-baised eQTL |
| rs17077580 | chr3:45271646:T:G | - | 0.0636901105931579 | 0.0183145992220165 | LUAD | Female-baised eQTL |
| rs73832233 | chr3:44136603:A:G | - | 0.0801867249108963 | 0.018851266904514 | LUAD | Female-baised eQTL |
| rs61587915 | chr3:45266679:C:T | - | 0.0667391819486124 | 0.0189516814654502 | LUAD | Female-baised eQTL |
| rs2372876 | chr3:45288285:G:A | - | 0.061781788859295 | 0.0190317172459034 | LUAD | Female-baised eQTL |
| rs6441909 | chr3:45289525:C:A | - | 0.061781788859295 | 0.0190317172459034 | LUAD | Female-baised eQTL |
| rs6441910 | chr3:45289539:G:A | - | 0.061781788859295 | 0.0190317172459034 | LUAD | Female-baised eQTL |
| rs17077598 | chr3:45290357:C:T | - | 0.061781788859295 | 0.0190317172459034 | LUAD | Female-baised eQTL |
| rs113244626 | chr3:45264875:C:G | - | 0.0620585499159779 | 0.0230843025785471 | LUAD | Female-baised eQTL |
| rs17077548 | chr3:45268008:C:T | - | 0.0636997185743409 | 0.0243466053127002 | LUAD | Female-baised eQTL |
| rs192581595 | chr3:44141954:G:C | - | 0.0819116742648242 | 0.0254003641585193 | LUAD | Female-baised eQTL |
| rs11705779 | chr3:44146630:C:G | - | 0.0808006276152531 | 0.0259377434227418 | LUAD | Female-baised eQTL |
| rs145933088 | chr3:44148366:T:C | - | 0.0808006276152531 | 0.0259377434227418 | LUAD | Female-baised eQTL |
| rs73832237 | chr3:44137699:T:C | - | 0.0813443243127202 | 0.026183236774189 | LUAD | Female-baised eQTL |
| rs114566374 | chr3:44152098:C:T | - | 0.0784124087612657 | 0.0376371035529721 | LUAD | Female-baised eQTL |
| rs77024452 | chr3:44152292:A:G | - | 0.0784124087612657 | 0.0376371035529721 | LUAD | Female-baised eQTL |
| rs10510766 | chr3:53777314:G:A | - | -0.0538218697175257 | 0.0444362841990369 | LUAD | Female-baised eQTL |
| rs79215573 | chr3:44138042:C:T | - | 0.076536881157611 | 0.048009402018119 | LUAD | Female-baised eQTL |
| rs76885598 | chr3:44153011:T:G | - | 0.0758878960219015 | 0.0487339393126196 | LUAD | Female-baised eQTL |
| rs80006272 | chr3:44153014:C:A | - | 0.0758878960219015 | 0.0487339393126196 | LUAD | Female-baised eQTL |
| rs79876572 | chr3:44153222:T:C | - | 0.0758878960219015 | 0.0487339393126196 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs780712 | chr3:59883281:G:A | - | -0.0350740004824952 | 0.0287104833360738 | KIRC | Male-baised eQTL |
| rs687069 | chr3:59885287:A:G | - | -0.0324143250842604 | 0.0326608523654547 | KIRC | Male-baised eQTL |
| rs13093282 | chr3:46523851:C:T | - | 0.12399853651692 | 0.0039218113650655 | COAD | Male-baised eQTL |
| rs35056755 | chr3:46524752:T:C | - | 0.12399853651692 | 0.0039218113650655 | COAD | Male-baised eQTL |
| rs73067779 | chr3:46484897:C:T | - | 0.123853169713135 | 0.00399480592953296 | COAD | Male-baised eQTL |
| rs13083022 | chr3:46535426:T:C | - | 0.123304127710198 | 0.00430119504431321 | COAD | Male-baised eQTL |
| rs73069952 | chr3:46540877:G:C | - | 0.123304127710198 | 0.00430119504431321 | COAD | Male-baised eQTL |
| rs13069424 | chr3:46484018:C:G | - | 0.121923467517314 | 0.00445586915451782 | COAD | Male-baised eQTL |
| rs67647205 | chr3:46490722:A:T | - | 0.118630046298286 | 0.00530573226940623 | COAD | Male-baised eQTL |
| rs35760835 | chr3:46491251:G:A | - | 0.118630046298286 | 0.00530573226940623 | COAD | Male-baised eQTL |
| rs67222447 | chr3:46491957:G:C | - | 0.118630046298286 | 0.00530573226940623 | COAD | Male-baised eQTL |
| rs369307109 | chr3:46494228:C:A | - | 0.118630046298286 | 0.00530573226940623 | COAD | Male-baised eQTL |
| rs3934895 | chr3:46485651:C:T | - | 0.11808100189608 | 0.00570339774813753 | COAD | Male-baised eQTL |
| rs67091203 | chr3:46486624:C:T | - | 0.11808100189608 | 0.00570339774813753 | COAD | Male-baised eQTL |
| rs67962987 | chr3:46486850:C:T | - | 0.11808100189608 | 0.00570339774813753 | COAD | Male-baised eQTL |
| rs34668230 | chr3:46488968:A:G | - | 0.11808100189608 | 0.00570339774813753 | COAD | Male-baised eQTL |
| rs35740565 | chr3:46489028:C:G | - | 0.11808100189608 | 0.00570339774813753 | COAD | Male-baised eQTL |
| rs66826527 | chr3:46476526:T:A | - | 0.11299923164229 | 0.00571036383912475 | COAD | Male-baised eQTL |
| rs7625793 | chr3:46544442:G:C | - | 0.119611111198792 | 0.00602617878208614 | COAD | Male-baised eQTL |
| rs68095529 | chr3:46473428:A:T | - | 0.117789851922992 | 0.00650071014839046 | COAD | Male-baised eQTL |
| rs67228693 | chr3:46475503:G:C | - | 0.117789851922992 | 0.00650071014839046 | COAD | Male-baised eQTL |
| rs67305272 | chr3:46516322:A:G | - | 0.11880009453204 | 0.0065482001281636 | COAD | Male-baised eQTL |
| rs13099992 | chr3:46519254:C:G | - | 0.11880009453204 | 0.0065482001281636 | COAD | Male-baised eQTL |
| rs66627456 | chr3:46522332:G:T | - | 0.11880009453204 | 0.0065482001281636 | COAD | Male-baised eQTL |
| rs66702674 | chr3:46510554:C:G | - | 0.118665225098261 | 0.00668436457344595 | COAD | Male-baised eQTL |
| rs17078930 | chr3:46510923:T:C | - | 0.118665225098261 | 0.00668436457344595 | COAD | Male-baised eQTL |
| rs6770016 | chr3:46511844:G:A | - | 0.118665225098261 | 0.00668436457344595 | COAD | Male-baised eQTL |
| rs35124447 | chr3:46497079:G:A | - | 0.113988995370484 | 0.0083694797348277 | COAD | Male-baised eQTL |
| rs6801427 | chr3:46504437:A:G | - | 0.11409861843566 | 0.00841350036277016 | COAD | Male-baised eQTL |
| rs7624932 | chr3:46501782:C:G | - | 0.114718568561314 | 0.00859551542856735 | COAD | Male-baised eQTL |
| rs13061783 | chr3:46502358:G:A | - | 0.114718568561314 | 0.00859551542856735 | COAD | Male-baised eQTL |
| rs13062049 | chr3:46502641:C:A | - | 0.114718568561314 | 0.00859551542856735 | COAD | Male-baised eQTL |
| rs6792420 | chr3:46505450:C:T | - | 0.114852920067695 | 0.00940836770993519 | COAD | Male-baised eQTL |
| rs6442001 | chr3:46505992:T:C | - | 0.114852920067695 | 0.00940836770993519 | COAD | Male-baised eQTL |
| rs7648827 | chr3:46544689:C:T | - | 0.11485438116937 | 0.0105131492308603 | COAD | Male-baised eQTL |
| rs7626061 | chr3:46544753:G:A | - | 0.11485438116937 | 0.0105131492308603 | COAD | Male-baised eQTL |
| rs7628435 | chr3:46544888:G:C | - | 0.11485438116937 | 0.0105131492308603 | COAD | Male-baised eQTL |
| rs55689943 | chr3:46506815:A:G | - | 0.113649223991744 | 0.0108902039906616 | COAD | Male-baised eQTL |
| rs56288081 | chr3:46507212:G:C | - | 0.113649223991744 | 0.0108902039906616 | COAD | Male-baised eQTL |
| rs190682753 | chr3:46508428:C:A | - | 0.113649223991744 | 0.0108902039906616 | COAD | Male-baised eQTL |
| rs73069915 | chr3:46508972:T:C | - | 0.113649223991744 | 0.0108902039906616 | COAD | Male-baised eQTL |
| rs56106816 | chr3:46509353:C:T | - | 0.113649223991744 | 0.0108902039906616 | COAD | Male-baised eQTL |
| rs35082490 | chr3:46539340:A:T | - | 0.112729761284203 | 0.0119624930748792 | COAD | Male-baised eQTL |
| rs377050860 | chr3:46508478:A:G | - | 0.110469916347045 | 0.0141088120593989 | COAD | Male-baised eQTL |
| rs17051505 | chr3:40852907:T:C | - | 0.120938047050572 | 0.0188209297445507 | COAD | Male-baised eQTL |
| rs17286758 | chr3:46545132:T:C | - | 0.102615594349444 | 0.028687123150171 | COAD | Male-baised eQTL |
| rs74388308 | chr3:45346335:T:C | - | 0.133138166256197 | 0.0317474518379042 | COAD | Male-baised eQTL |
| rs28617572 | chr3:46551405:G:A | - | 0.0995775947741507 | 0.0437453551959731 | COAD | Male-baised eQTL |
| rs62242415 | chr3:45321800:G:T | - | 0.0718483678013038 | 0.0466659848274896 | COAD | Male-baised eQTL |
| rs4974166 | chr3:56088106:T:C | - | -0.0861701059413301 | 0.0472568435766457 | COAD | Male-baised eQTL |
| rs28687398 | chr3:46551497:A:G | - | 0.0986031407610699 | 0.0477968573672487 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000012171 |
| CpG Site: cg25635916 | |
| Position to Gene: gene,enhancer | |
| Male Effect: - | |
| Female Effect: -0.301237754631844 | |
 | Gene ID: ENSG00000012171 |
| CpG Site: cg22093095 | |
| Position to Gene: gene,exon,UTR | |
| Male Effect: - | |
| Female Effect: 0.205655115653786 | |
 | Gene ID: ENSG00000012171 |
| CpG Site: cg25597623 | |
| Position to Gene: gene,exon,promoter,UTR | |
| Male Effect: -0.147302146833928 | |
| Female Effect: - | |
 | Gene ID: ENSG00000012171 |
| CpG Site: cg01988285 | |
| Position to Gene: gene,promoter | |
| Male Effect: -0.213959951834592 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg25597623 | chr3:50269024 | gene,exon,promoter,UTR | -0.147302146833928 | 9.17411241322418e-09 | -0.4355655773538905 | 7.469625216593385e-11 | KIRC |
| cg01988285 | chr3:50268675 | gene,promoter | -0.213959951834592 | 1.16517481271372e-06 | -0.38574719081539977 | 2.517006166787165e-09 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg25635916 | chr3:50269606 | gene,enhancer | -0.301237754631844 | 1.15013830832063e-34 | -0.6067005323045086 | 2.2666978078671796e-38 | THCA |
| cg22093095 | chr3:50273141 | gene,exon,UTR | 0.205655115653786 | 7.86822862451444e-06 | 0.7115923659065918 | 1.7095399263747943e-12 | KIRP |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of SEMA3B |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000012171 | SEMA3B | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
| ENSG00000012171 | SEMA3B | C0027819 | Neuroblastoma | 1 | CTD_human |
| ENSG00000012171 | SEMA3B | C0476089 | Endometrial Carcinoma | 1 | CTD_human |
