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Gene: ENSG00000011451 |
Summary for WIZ |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000011451 | Gene symbol | WIZ |
| Gene name | WIZ zinc finger | |
| HGNC | 30917 | |
| Entrez ID | 58525 | |
| Gene type | protein_coding | |
| Synonyms | WIZ|ZNF803 | |
| UniProtAcc | O95785 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for WIZ |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| WIZ | 4.88e+03 | 1.03e+00 | 1.45e-01 | 7.09e+00 | 1.30e-12 | 1.18e-11 | KICH |
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Sex-biased somatic mutation for WIZ |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for WIZ |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg17296483 | chr19:15451433 | CGI:chr19:15453058-15453412 | promoter | 8.27e-01 | 7.10e-01 | 2.61e+00 | 9.19e-03 | 2.58e-02 | 1.17e-01 |
| DLBC | cg02849766 | chr19:15448308 | CGI:chr19:15453058-15453412 | promoter,exon,gene body | 5.95e-01 | 7.38e-01 | -2.52e+00 | 1.16e-02 | 2.51e-02 | -1.43e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg27278227 | chr19:15448016 | CGI:chr19:15453058-15453412 | promoter,gene body | 5.94e-01 | 7.90e-01 | -3.61e+00 | 3.09e-04 | 1.24e-03 | -1.96e-01 |
| LUSC | cg02849766 | chr19:15448308 | CGI:chr19:15453058-15453412 | promoter,exon,gene body | 6.55e-01 | 8.14e-01 | -3.74e+00 | 1.84e-04 | 9.29e-04 | -1.59e-01 |
| LIHC | cg27278227 | chr19:15448016 | CGI:chr19:15453058-15453412 | promoter,gene body | 6.53e-01 | 7.80e-01 | -3.40e+00 | 6.64e-04 | 1.10e-03 | -1.27e-01 |
| CHOL | cg23274381 | chr19:15451119 | CGI:chr19:15453058-15453412 | promoter | 5.20e-01 | 7.07e-01 | -3.10e+00 | 1.96e-03 | 1.07e-02 | -1.87e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg18763911 | chr19:15450226 | CGI:chr19:15453058-15453412 | promoter | 4.68e-01 | 2.12e-01 | 8.21e+00 | 2.24e-16 | 9.06e-16 | 2.56e-01 |
| LUAD | cg18763911 | chr19:15450226 | CGI:chr19:15453058-15453412 | promoter | 3.53e-01 | 2.37e-01 | 2.49e+00 | 1.28e-02 | 1.88e-02 | 1.16e-01 |
| LUAD | cg17296483 | chr19:15451433 | CGI:chr19:15453058-15453412 | promoter | 7.46e-01 | 6.11e-01 | 3.31e+00 | 9.18e-04 | 3.02e-03 | 1.35e-01 |
| HNSC | cg18763911 | chr19:15450226 | CGI:chr19:15453058-15453412 | promoter | 3.72e-01 | 1.99e-01 | 2.71e+00 | 6.64e-03 | 1.52e-02 | 1.74e-01 |
| BLCA | cg27278227 | chr19:15448016 | CGI:chr19:15453058-15453412 | promoter,gene body | 6.11e-01 | 7.31e-01 | -2.39e+00 | 1.70e-02 | 2.44e-02 | -1.20e-01 |
| LIHC | cg18763911 | chr19:15450226 | CGI:chr19:15453058-15453412 | promoter | 4.36e-01 | 3.25e-01 | 2.50e+00 | 1.23e-02 | 1.64e-02 | 1.11e-01 |
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Exon skipping events with PSI in TCGA for WIZ |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| CHOL | exon_skip_316087 | 6.43e-01 | 5.00e-01 | -2.49e+00 | 1.27e-02 | 2.56e-02 | 1.43e-01 |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| STAD | exon_skip_316087 | 7.09e-01 | 8.24e-01 | -2.33e+00 | 1.96e-02 | 3.34e-02 | -1.14e-01 |
| READ | exon_skip_316087 | 5.91e-01 | 7.44e-01 | -2.85e+00 | 4.32e-03 | 1.43e-02 | -1.52e-01 |
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RNA A-to-I editing events in TCGA for WIZ |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for WIZ |
| TFs related to WIZ. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BRCA | PLAGL2 | WIZ | 3.57e+00 | 8.98e-03 | 4.82e+00 | 9.85e-01 | Female-biased |
| WIZ related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for WIZ |
| RBPs related to ES in WIZ. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BRCA | RBM4 | exon_skip_316087 | 8.14e+00 | 6.77e-03 | 8.88e+00 | 9.88e-01 | Female-biased |
| BRCA | SAMD4A | exon_skip_316087 | 5.09e+00 | 1.88e-04 | 7.26e+00 | 9.88e-01 | Female-biased |
| WIZ related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs12459446 | chr19:15105533:T:A | - | 0.206365247374442 | 0.00813493750495111 | BLCA | Female-baised eQTL |
| rs12977092 | chr19:15106666:G:A | - | 0.206365247374442 | 0.00813493750495111 | BLCA | Female-baised eQTL |
| rs10423237 | chr19:18338959:C:T | - | -0.0696464456930568 | 0.0178361744105962 | LUAD | Female-baised eQTL |
| rs56104914 | chr19:18337591:G:A | - | -0.0694164234888064 | 0.0234091640486619 | LUAD | Female-baised eQTL |
| rs79058301 | chr19:18340520:C:T | - | -0.0684666855481747 | 0.0237737730181213 | LUAD | Female-baised eQTL |
| rs7255983 | chr19:18341949:C:T | - | -0.0676091967368089 | 0.0274443677336023 | LUAD | Female-baised eQTL |
| rs10424419 | chr19:18342661:G:C | - | -0.0673520176517781 | 0.0289806229024285 | LUAD | Female-baised eQTL |
| rs66732430 | chr19:18342819:G:A | - | -0.0673520176517781 | 0.0289806229024285 | LUAD | Female-baised eQTL |
| rs10403547 | chr19:18346216:T:C | - | -0.0673977408021661 | 0.0291704534947094 | LUAD | Female-baised eQTL |
| rs10421763 | chr19:18346235:G:A | - | -0.0673977408021661 | 0.0291704534947094 | LUAD | Female-baised eQTL |
| rs112475085 | chr19:18346690:T:G | - | -0.0673977408021661 | 0.0291704534947094 | LUAD | Female-baised eQTL |
| rs113641826 | chr19:18346798:G:T | - | -0.0673977408021661 | 0.0291704534947094 | LUAD | Female-baised eQTL |
| rs67348050 | chr19:18347193:C:T | - | -0.0673977408021661 | 0.0291704534947094 | LUAD | Female-baised eQTL |
| rs11882198 | chr19:18344671:C:T | - | -0.0674977597847458 | 0.0296224050761031 | LUAD | Female-baised eQTL |
| rs2106661 | chr19:14888861:C:T | - | -0.063957758738897 | 0.0310626118337195 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs2306965 | chr19:22608269:A:T | - | -0.0750023499070879 | 0.0477714439479047 | KIRC | Male-baised eQTL |
| rs11085149 | chr19:5859399:T:C | - | 0.0652492532815104 | 0.0223059244142058 | LUAD | Male-baised eQTL |
| rs7259226 | chr19:15154921:G:A | - | 0.074918133121865 | 0.027545837481364 | LUAD | Male-baised eQTL |
| rs4809026 | chr19:15159248:G:C | - | 0.074155190503258 | 0.033890703701231 | LUAD | Male-baised eQTL |
| rs768170 | chr19:15157708:A:G | - | 0.0739201201239319 | 0.0348652847886642 | LUAD | Male-baised eQTL |
| rs74428614 | chr19:10386684:G:A | - | 0.0802522339506168 | 0.0354638376585605 | LUAD | Male-baised eQTL |
| rs7259156 | chr19:10387790:G:A | - | 0.0802522339506168 | 0.0354638376585605 | LUAD | Male-baised eQTL |
| rs778988 | chr19:5858784:T:C | - | 0.0617463000065101 | 0.0494170164983059 | LUAD | Male-baised eQTL |
| rs112315719 | chr19:11398695:C:A | - | 0.0860606065136591 | 0.00905867016909367 | COAD | Male-baised eQTL |
| rs112073930 | chr19:11398822:G:C | - | 0.0860606065136591 | 0.00905867016909367 | COAD | Male-baised eQTL |
| rs111842975 | chr19:11398843:C:G | - | 0.0860606065136591 | 0.00905867016909367 | COAD | Male-baised eQTL |
| rs73510689 | chr19:11398877:G:A | - | 0.0860606065136591 | 0.00905867016909367 | COAD | Male-baised eQTL |
| rs317913 | chr19:11399638:A:G | - | 0.0786136025551381 | 0.0151548050246039 | COAD | Male-baised eQTL |
| rs10405248 | chr19:15190909:C:T | - | -0.059425855376582 | 0.0277603876591071 | COAD | Male-baised eQTL |
| rs12460706 | chr19:11035662:T:C | - | 0.0496051983840077 | 0.0304197080188708 | COAD | Male-baised eQTL |
| rs4808619 | chr19:14875839:T:A | - | 0.052817820167659 | 0.0347375795998784 | COAD | Male-baised eQTL |
| rs4804562 | chr19:11036939:G:A | - | 0.0485421781930005 | 0.0362125321945523 | COAD | Male-baised eQTL |
| rs34622780 | chr19:11037437:C:G | - | 0.048404004946224 | 0.0380444661933391 | COAD | Male-baised eQTL |
| rs10420397 | chr19:20331022:C:A | - | 0.070633320577949 | 0.0415117269521841 | COAD | Male-baised eQTL |
| rs11879528 | chr19:20333451:C:T | - | 0.070633320577949 | 0.0415117269521841 | COAD | Male-baised eQTL |
| rs16980016 | chr19:14874993:G:A | - | 0.0506273973903952 | 0.041684709696221 | COAD | Male-baised eQTL |
| rs55981116 | chr19:14875150:A:G | - | 0.0507462437544629 | 0.0418070802509995 | COAD | Male-baised eQTL |
| rs16980019 | chr19:14875159:G:A | - | 0.0507462437544629 | 0.0418070802509995 | COAD | Male-baised eQTL |
| rs10405163 | chr19:14876322:G:C | - | 0.0507462437544629 | 0.0418070802509995 | COAD | Male-baised eQTL |
| rs10415281 | chr19:9488358:T:C | - | 0.0421694586617498 | 0.0446814623183051 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000011451 |
| CpG Site: cg26003119 | |
| Position to Gene: gene | |
| Male Effect: -0.3635940428065 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg26003119 | chr19:15440798 | gene | -0.3635940428065 | 1.88813461872232e-10 | -0.4652329095242712 | 2.2370604461522678e-13 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of WIZ |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
