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Gene: ENSG00000011132 |
Summary for APBA3 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000011132 | Gene symbol | APBA3 |
| Gene name | amyloid beta precursor protein binding family A member 3 | |
| HGNC | 580 | |
| Entrez ID | 9546 | |
| Gene type | protein_coding | |
| Synonyms | APBA3|X11L2|mint3 | |
| UniProtAcc | O96018 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for APBA3 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| APBA3 | 7.45e+02 | 1.04e+00 | 3.18e-01 | 3.26e+00 | 1.10e-03 | 3.78e-03 | READ |
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Sex-biased somatic mutation for APBA3 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for APBA3 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| CHOL | cg20366831 | chr19:3760957 | CGI:chr19:3761495-3761828 | promoter,gene body | 7.79e-01 | 6.58e-01 | 2.07e+00 | 3.85e-02 | 4.47e-02 | 1.20e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg20366831 | chr19:3760957 | CGI:chr19:3761495-3761828 | promoter,gene body | 5.13e-01 | 6.86e-01 | -3.84e+00 | 1.21e-04 | 7.60e-04 | -1.73e-01 |
| BLCA | cg20366831 | chr19:3760957 | CGI:chr19:3761495-3761828 | promoter,gene body | 5.39e-01 | 7.41e-01 | -4.08e+00 | 4.55e-05 | 2.33e-04 | -2.02e-01 |
| LIHC | cg20366831 | chr19:3760957 | CGI:chr19:3761495-3761828 | promoter,gene body | 5.25e-01 | 6.62e-01 | -4.65e+00 | 3.26e-06 | 1.03e-05 | -1.37e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for APBA3 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for APBA3 |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
 |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| KIRC | APBA3-005 | chr19_3758383_- | 2.68e-01 | 2.36e-01 | 2.28e+00 | 2.28e-02 | 4.56e-02 | 3.19e-02 |
| KIRC | APBA3-005 | chr19_3758965_- | 2.56e-01 | 2.15e-01 | 1.98e+00 | 4.78e-02 | 4.96e-02 | 4.08e-02 |
| LUAD | APBA3-005 | chr19_3758456_- | 2.46e-01 | 2.01e-01 | 2.56e+00 | 1.06e-02 | 2.93e-02 | 4.54e-02 |
| LUAD | APBA3-005 | chr19_3758505_- | 2.88e-01 | 2.48e-01 | 2.17e+00 | 3.03e-02 | 4.31e-02 | 4.05e-02 |
| LUAD | APBA3-005 | chr19_3759112_- | 2.42e-01 | 1.67e-01 | 2.19e+00 | 2.83e-02 | 4.18e-02 | 7.53e-02 |
| HNSC | APBA3-005 | chr19_3758296_- | 3.24e-01 | 3.72e-01 | -2.25e+00 | 2.46e-02 | 4.34e-02 | -4.81e-02 |
| LUSC | APBA3-005 | chr19_3758356_- | 1.80e-01 | 1.45e-01 | 2.12e+00 | 3.39e-02 | 4.91e-02 | 3.42e-02 |
| LUSC | APBA3-005 | chr19_3758440_- | 1.96e-01 | 1.45e-01 | 2.00e+00 | 4.53e-02 | 4.91e-02 | 5.15e-02 |
| LUSC | APBA3-005 | chr19_3758531_- | 2.44e-01 | 1.71e-01 | 2.31e+00 | 2.07e-02 | 4.91e-02 | 7.35e-02 |
| SKCM | APBA3-005 | chr19_3758296_- | 3.83e-01 | 3.09e-01 | 3.17e+00 | 1.53e-03 | 4.90e-02 | 7.44e-02 |
| COAD | APBA3-005 | chr19_3758531_- | 2.28e-01 | 3.26e-01 | -2.40e+00 | 1.64e-02 | 2.97e-02 | -9.80e-02 |
| STAD | APBA3-005 | chr19_3759153_- | 3.29e-01 | 3.96e-01 | -2.39e+00 | 1.69e-02 | 4.96e-02 | -6.69e-02 |
| KIRP | APBA3-005 | chr19_3759153_- | 2.91e-01 | 2.29e-01 | 2.09e+00 | 3.64e-02 | 4.80e-02 | 6.21e-02 |
| SARC | APBA3-005 | chr19_3758970_- | 2.75e-01 | 1.77e-01 | 1.98e+00 | 4.81e-02 | 4.97e-02 | 9.75e-02 |
| PCPG | APBA3-005 | chr19_3759509_- | 2.31e-01 | 1.54e-01 | 2.40e+00 | 1.63e-02 | 4.98e-02 | 7.68e-02 |
| READ | APBA3-005 | chr19_3758397_- | 5.32e-01 | 4.54e-01 | 2.42e+00 | 1.54e-02 | 4.85e-02 | 7.84e-02 |
| GBM | APBA3-005 | chr19_3758623_- | 2.12e-01 | 3.92e-01 | -2.29e+00 | 2.23e-02 | 4.96e-02 | -1.79e-01 |
| GBM | APBA3-005 | chr19_3759121_- | 1.46e-01 | 2.22e-01 | -2.41e+00 | 1.59e-02 | 4.96e-02 | -7.68e-02 |
| ESCA | APBA3-005 | chr19_3758296_- | 4.68e-01 | 3.12e-01 | 2.05e+00 | 4.07e-02 | 4.99e-02 | 1.57e-01 |
| ESCA | APBA3-005 | chr19_3758383_- | 2.62e-01 | 3.38e-01 | -2.06e+00 | 3.96e-02 | 4.99e-02 | -7.53e-02 |
| ACC | APBA3-005 | chr19_3759153_- | 2.53e-01 | 1.78e-01 | 2.00e+00 | 4.55e-02 | 4.94e-02 | 7.53e-02 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| LUSC | APBA3-005 | chr19_3759153_- | 2.43e-01 | 3.16e-01 | -1.97e+00 | 4.90e-02 | 4.94e-02 | -7.24e-02 |
| COAD | APBA3-005 | chr19_3758397_- | 5.20e-01 | 3.70e-01 | 2.68e+00 | 7.32e-03 | 1.44e-02 | 1.50e-01 |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| THCA | APBA3-005 | chr19_3759153_- | 2.69e-01 | 2.15e-01 | 2.12e+00 | 3.43e-02 | 3.91e-02 | 5.37e-02 |
| LUSC | APBA3-005 | chr19_3758505_- | 2.02e-01 | 2.78e-01 | -2.31e+00 | 2.09e-02 | 3.28e-02 | -7.68e-02 |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for APBA3 |
| TFs related to APBA3. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BRCA | PLAGL2 | APBA3 | 3.21e+00 | 6.61e-03 | 4.55e+00 | 9.84e-01 | Female-biased |
| APBA3 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for APBA3 |
| RBPs related to ES in APBA3. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| STAD | HNRNPH2 | exon_skip_313083 | 8.59e+00 | 9.91e-01 | 8.12e+00 | 3.54e-03 | Male-biased |
| THYM | HNRNPH2 | exon_skip_313083 | 8.04e+00 | 6.95e-03 | 8.39e+00 | 9.86e-01 | Female-biased |
| LIHC | HNRNPH2 | exon_skip_313083 | 8.09e+00 | 1.66e-03 | 8.74e+00 | 9.93e-01 | Female-biased |
| LIHC | RBM4 | exon_skip_313089 | 1.14e+01 | 9.91e-01 | 1.10e+01 | 8.00e-03 | Male-biased |
| LUSC | HNRNPH2 | exon_skip_313083 | 8.19e+00 | 5.84e-03 | 8.60e+00 | 9.88e-01 | Female-biased |
| LUSC | RBM4 | exon_skip_313089 | 1.13e+01 | 9.89e-01 | 1.09e+01 | 9.99e-03 | Male-biased |
| LUAD | HNRNPH2 | exon_skip_313083 | 8.05e+00 | 4.88e-03 | 8.45e+00 | 9.88e-01 | Female-biased |
| CHOL | RBM4 | exon_skip_313089 | 1.15e+01 | 9.94e-01 | 1.10e+01 | 5.21e-03 | Male-biased |
| PCPG | HNRNPH2 | exon_skip_313083 | 8.33e+00 | 9.80e-01 | 8.03e+00 | 1.27e-02 | Male-biased |
| KIRC | HNRNPH2 | exon_skip_313083 | 8.10e+00 | 1.29e-02 | 8.40e+00 | 9.80e-01 | Female-biased |
| APBA3 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs668692 | chr19:5469821:A:G | - | -0.0461470427430417 | 0.0360244102882617 | BLCA | Male-baised eQTL |
| rs3745815 | chr19:2761605:C:T | - | 0.0355482480378577 | 0.0354005279713574 | COAD | Male-baised eQTL |
| rs3745814 | chr19:2761360:G:A | - | 0.0355482439797549 | 0.03567191735702 | COAD | Male-baised eQTL |
| rs1128925 | chr19:2767194:G:T | - | 0.0349516730395064 | 0.0402970256929251 | COAD | Male-baised eQTL |
| rs759066 | chr19:2775339:G:T | - | 0.0349516730395064 | 0.0402970256929251 | COAD | Male-baised eQTL |
| rs4807330 | chr19:2777664:G:A | - | 0.0349516730395064 | 0.0402970256929251 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
 | EX ID: exon_skip_313096 |
| CpG Site: cg25058957 | |
| Position to EX: Distant upstream | |
| Male Effect: - | |
| Female Effect: 0.1878116166031 |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| exon_skip_313096 | chr19:3759560:3759600 | cg25058957 | chr19:3771685 | Distant upstream | 0.1878116166031 | 7.56546041828139e-08 | 0.44507846265966106 | 1.5811434813828371e-07 | Frame-shift | SARC |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of APBA3 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
