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Gene: ENSG00000008083 |
Summary for JARID2 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000008083 | Gene symbol | JARID2 |
| Gene name | jumonji and AT-rich interaction domain containing 2 | |
| HGNC | 6196 | |
| Entrez ID | 3720 | |
| Gene type | protein_coding | |
| Synonyms | JARID2| | |
| UniProtAcc | Q92833 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for JARID2 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for JARID2 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for JARID2 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for JARID2 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for JARID2 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for JARID2 |
| TFs related to JARID2. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| JARID2 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for JARID2 |
| RBPs related to ES in JARID2. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| COAD | ZC3H10 | exon_skip_448036 | 6.06e+00 | 2.15e-03 | 6.54e+00 | 9.80e-01 | Female-biased |
| SKCM | FMR1 | exon_skip_448039 | 6.44e+00 | 4.07e-03 | 6.89e+00 | 9.81e-01 | Female-biased |
| JARID2 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs3819399 | chr6:15403386:G:A | gene | 0.153966356923027 | 0.0283593505065709 | HNSC | Female-baised eQTL |
| rs6927319 | chr6:15403387:G:T | gene | 0.153966356923027 | 0.0283593505065709 | HNSC | Female-baised eQTL |
| rs2235493 | chr6:6693087:G:A | - | 0.18421979703857 | 0.0268810743584747 | BLCA | Female-baised eQTL |
| rs6918634 | chr6:6956733:C:T | - | 0.221734507507993 | 0.0418587601919349 | BLCA | Female-baised eQTL |
| rs74430362 | chr6:6954804:C:T | - | 0.220800185269881 | 0.0442677576615152 | BLCA | Female-baised eQTL |
| rs112046217 | chr6:6954872:C:T | - | 0.220800185269881 | 0.0442677576615152 | BLCA | Female-baised eQTL |
| rs9350131 | chr6:19388330:C:T | - | 0.0863030303990649 | 0.0412765339829833 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs7769758 | chr6:12950053:G:C | - | 0.123503456836055 | 0.0389800090532836 | LIHC | Male-baised eQTL |
| rs11243176 | chr6:7434053:G:T | - | -0.0584770340861687 | 0.0458242252006619 | LIHC | Male-baised eQTL |
| rs13209010 | chr6:7443223:G:C | - | -0.0600846809664842 | 0.0461018224981578 | LIHC | Male-baised eQTL |
| rs13213137 | chr6:7434369:T:C | - | -0.0583965350034236 | 0.0461855606611379 | LIHC | Male-baised eQTL |
| rs13209889 | chr6:7443239:C:G | - | -0.0600393916567442 | 0.0465268230101407 | LIHC | Male-baised eQTL |
| rs13209019 | chr6:7443250:G:A | - | -0.0600393916567442 | 0.0465268230101407 | LIHC | Male-baised eQTL |
| rs13209893 | chr6:7443257:C:A | - | -0.0600393916567442 | 0.0465268230101407 | LIHC | Male-baised eQTL |
| rs11753111 | chr6:7445764:A:G | - | -0.0586758248068302 | 0.0491037312288506 | LIHC | Male-baised eQTL |
| rs66497533 | chr6:7442799:C:T | - | -0.0581193384960033 | 0.0492640547778245 | LIHC | Male-baised eQTL |
| rs62404171 | chr6:22231262:G:A | - | 0.0766017286495441 | 0.0238269965850286 | STAD | Male-baised eQTL |
| rs6937402 | chr6:22224149:T:G | - | 0.0739057528009623 | 0.0307973381564196 | STAD | Male-baised eQTL |
| rs860305 | chr6:22333860:T:C | - | -0.0495534507914009 | 3.22222964002369e-05 | KIRC | Male-baised eQTL |
| rs864275 | chr6:22333432:T:A | - | -0.0497111063556065 | 3.24463705700462e-05 | KIRC | Male-baised eQTL |
| rs849880 | chr6:22330232:G:A | - | -0.0494526162546692 | 3.71327420389015e-05 | KIRC | Male-baised eQTL |
| rs62405537 | chr6:10311489:C:G | - | 0.0449417331187239 | 0.00583564937817787 | KIRC | Male-baised eQTL |
| rs12191256 | chr6:10310400:G:A | - | 0.0430981451512706 | 0.00798763772256377 | KIRC | Male-baised eQTL |
| rs9466716 | chr6:10553632:G:A | - | 0.0415001125394215 | 0.00936815651071156 | KIRC | Male-baised eQTL |
| rs77571968 | chr6:10545049:A:G | - | 0.0515621231117219 | 0.0103394975882589 | KIRC | Male-baised eQTL |
| rs67807149 | chr6:10546247:C:T | - | 0.0515621231117219 | 0.0103394975882589 | KIRC | Male-baised eQTL |
| rs67153505 | chr6:10543930:A:G | - | 0.0498398010527459 | 0.0149802843111074 | KIRC | Male-baised eQTL |
| rs9466128 | chr6:21606448:G:T | - | -0.0258816546519066 | 0.020191767427564 | KIRC | Male-baised eQTL |
| rs9460849 | chr6:10550398:A:G | - | 0.0430494788289639 | 0.033677904154134 | KIRC | Male-baised eQTL |
| rs604314 | chr6:10551734:C:T | - | 0.0373644604751927 | 0.0483925238047746 | KIRC | Male-baised eQTL |
| rs62395713 | chr6:18050397:G:T | - | 0.052597927263655 | 0.000468195021973994 | BLCA | Male-baised eQTL |
| rs116035527 | chr6:18049428:T:A | - | 0.0524740105436709 | 0.000470502657112285 | BLCA | Male-baised eQTL |
| rs6912447 | chr6:18054937:G:A | - | 0.0519838317703061 | 0.000493344421967737 | BLCA | Male-baised eQTL |
| rs4716213 | chr6:18052218:T:C | - | 0.0523735923716512 | 0.000497932183348708 | BLCA | Male-baised eQTL |
| rs4712323 | chr6:18035413:A:G | - | 0.0510604219150673 | 0.000711248302429101 | BLCA | Male-baised eQTL |
| rs62395674 | chr6:18034749:A:G | - | 0.0511427077721462 | 0.000718910631197395 | BLCA | Male-baised eQTL |
| rs4716212 | chr6:18035610:C:T | - | 0.0506333776935236 | 0.000849678389202188 | BLCA | Male-baised eQTL |
| rs20510 | chr6:18044541:G:A | - | 0.0504360700282524 | 0.000866173079035303 | BLCA | Male-baised eQTL |
| rs73367528 | chr6:12306535:C:T | - | 0.0567412121016841 | 0.00086817697885167 | BLCA | Male-baised eQTL |
| rs9477586 | chr6:18036065:G:A | - | 0.0503135131788308 | 0.000924447396558133 | BLCA | Male-baised eQTL |
| rs9477590 | chr6:18038912:A:G | - | 0.0503135131788308 | 0.000924447396558133 | BLCA | Male-baised eQTL |
| rs9477592 | chr6:18039935:C:T | - | 0.0503135131788308 | 0.000924447396558133 | BLCA | Male-baised eQTL |
| rs9465092 | chr6:18041425:G:A | - | 0.0503135131788308 | 0.000924447396558133 | BLCA | Male-baised eQTL |
| rs4072775 | chr6:18080020:T:C | - | 0.0332152983557486 | 0.0385405502649708 | BLCA | Male-baised eQTL |
| rs73367535 | chr6:12310719:C:T | - | 0.0673733569162847 | 0.0472952004123676 | BLCA | Male-baised eQTL |
| rs17641827 | chr6:16156888:C:G | - | 0.13928856156627 | 0.000405050436721255 | COAD | Male-baised eQTL |
| rs77227911 | chr6:19384540:A:G | - | 0.178954473015404 | 0.00381222428035979 | COAD | Male-baised eQTL |
| rs9466128 | chr6:21606448:G:T | - | -0.0658115959145607 | 0.00947691557628596 | COAD | Male-baised eQTL |
| rs6923088 | chr6:22933050:A:T | - | 0.0763034120692661 | 0.00966407998672679 | COAD | Male-baised eQTL |
| rs12214586 | chr6:9328286:T:C | - | 0.0664641688721208 | 0.011119083429637 | COAD | Male-baised eQTL |
| rs9467448 | chr6:25244876:G:T | - | 0.137019502193885 | 0.0113269982710395 | COAD | Male-baised eQTL |
| rs6923261 | chr6:22933133:A:G | - | 0.0750831163546976 | 0.0123070459026708 | COAD | Male-baised eQTL |
| rs555430 | chr6:16755538:A:G | - | 0.070645687072569 | 0.0136939876226668 | COAD | Male-baised eQTL |
| rs111582969 | chr6:16211008:A:G | - | 0.123314697942307 | 0.0143358596370132 | COAD | Male-baised eQTL |
| rs78406021 | chr6:16212143:G:A | - | 0.123314697942307 | 0.0143358596370132 | COAD | Male-baised eQTL |
| rs80324576 | chr6:16212176:C:T | - | 0.123314697942307 | 0.0143358596370132 | COAD | Male-baised eQTL |
| rs113088754 | chr6:16212691:A:C | - | 0.123314697942307 | 0.0143358596370132 | COAD | Male-baised eQTL |
| rs147845031 | chr6:16214996:A:C | - | 0.123314697942307 | 0.0143358596370132 | COAD | Male-baised eQTL |
| rs150341740 | chr6:16215101:C:T | - | 0.122912433540546 | 0.0150128282945452 | COAD | Male-baised eQTL |
| rs7773456 | chr6:19823007:T:G | - | 0.0651666743952962 | 0.0191475917489064 | COAD | Male-baised eQTL |
| rs961130 | chr6:19805310:A:G | - | 0.0918448954070916 | 0.0228418416673366 | COAD | Male-baised eQTL |
| rs236937 | chr6:16522863:G:T | - | 0.0972031554800861 | 0.0250661152233578 | COAD | Male-baised eQTL |
| rs183162113 | chr6:16445929:G:A | - | 0.124411413776605 | 0.0274937544487979 | COAD | Male-baised eQTL |
| rs6928905 | chr6:10503525:A:G | - | 0.0957499128057431 | 0.0327476717918993 | COAD | Male-baised eQTL |
| rs6928914 | chr6:10503533:A:G | - | 0.0957499128057431 | 0.0327476717918993 | COAD | Male-baised eQTL |
| rs146579968 | chr6:16218060:G:A | - | 0.11644782472822 | 0.0353079894457056 | COAD | Male-baised eQTL |
| rs114243415 | chr6:16218174:C:T | - | 0.11644782472822 | 0.0353079894457056 | COAD | Male-baised eQTL |
| rs79191285 | chr6:16226207:G:A | - | 0.11644782472822 | 0.0353079894457056 | COAD | Male-baised eQTL |
| rs2984100 | chr6:8592266:G:C | - | 0.0639130516807631 | 0.0412665299705378 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000008083 |
| CpG Site: cg14662750 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.40414821036558 | |
 | Gene ID: ENSG00000008083 |
| CpG Site: cg24408769 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.381347595856478 | |
 | Gene ID: ENSG00000008083 |
| CpG Site: cg12582616 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.392664919155997 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg14662750 | chr6:15279793 | gene | -0.40414821036558 | 1.75347565280835e-12 | -0.39561889688057733 | 3.0810912877959237e-15 | THCA |
| cg24408769 | chr6:15505854 | gene | -0.381347595856478 | 2.51631710587268e-07 | -0.5811850616957316 | 1.8361539135173537e-11 | KIRC |
| cg12582616 | chr6:15427258 | gene | -0.392664919155997 | 8.90810255865559e-09 | -0.4165291382596512 | 4.017813711684793e-12 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_448030 | chr6:15410223:15410365 | Frame-shift | rs9296929 | chr6:14397094:A:C | Distant upstream | -0.0286062589478208 | 0.00608773628970725 | HNSC | Male-baised sQTL |
| exon_skip_448030 | chr6:15410223:15410365 | Frame-shift | rs7739382 | chr6:14402460:C:T | Distant upstream | -0.0280307730033283 | 0.00805857504108375 | HNSC | Male-baised sQTL |
| exon_skip_448030 | chr6:15410223:15410365 | Frame-shift | rs7763009 | chr6:14402393:T:C | Distant upstream | -0.0280172942599898 | 0.00819743292880326 | HNSC | Male-baised sQTL |
| exon_skip_448030 | chr6:15410223:15410365 | Frame-shift | rs9370768 | chr6:14597701:G:C | Distant upstream | -0.0306041731591743 | 0.0345582013187671 | HNSC | Male-baised sQTL |
| exon_skip_448030 | chr6:15410223:15410365 | Frame-shift | rs6459353 | chr6:14428266:T:C | Distant upstream | -0.0238521393604726 | 0.0439018401337045 | HNSC | Male-baised sQTL |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of JARID2 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000008083 | JARID2 | C0036341 | Schizophrenia | 2 | PSYGENET |
| ENSG00000008083 | JARID2 | C1510586 | Autism Spectrum Disorders | 1 | CTD_human |
