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Gene: ENSG00000007216 |
Summary for SLC13A2 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000007216 | Gene symbol | SLC13A2 |
| Gene name | solute carrier family 13 member 2 | |
| HGNC | 10917 | |
| Entrez ID | 9058 | |
| Gene type | protein_coding | |
| Synonyms | SLC13A2|NaDC-1 | |
| UniProtAcc | Q13183 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for SLC13A2 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| SLC13A2 | 3.35e+02 | -3.09e+00 | 7.14e-01 | -4.33e+00 | 1.48e-05 | 4.78e-04 | BRCA |
| SLC13A2 | 2.16e+02 | -1.05e+00 | 2.65e-01 | -3.94e+00 | 8.07e-05 | 9.36e-04 | LIHC |
| SLC13A2 | 1.69e+02 | 2.37e+00 | 6.15e-01 | 3.86e+00 | 1.12e-04 | 1.61e-02 | ESCA |
| SLC13A2 | 4.02e+02 | -3.97e+00 | 9.45e-01 | -4.20e+00 | 2.72e-05 | 8.93e-03 | CHOL |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| SLC13A2 | 1.32e+03 | -3.35e+00 | 6.50e-01 | -5.16e+00 | 2.53e-07 | 1.67e-06 | STAD |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| SLC13A2 | 2.93e+02 | 1.22e+00 | 5.09e-01 | 2.40e+00 | 1.62e-02 | 3.02e-02 | LIHC |
| SLC13A2 | 4.17e+02 | -1.81e+00 | 2.39e-01 | -7.57e+00 | 3.76e-14 | 9.90e-14 | BRCA |
Top |
Sex-biased somatic mutation for SLC13A2 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for SLC13A2 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg00085732 | chr17:28473802 | CGI:chr17:28405794-28406378 | promoter,gene body,CDS,UTR,exon | 6.12e-01 | 7.39e-01 | -3.59e+00 | 3.26e-04 | 1.28e-03 | -1.28e-01 |
| LIHC | cg11653858 | chr17:28472271 | CGI:chr17:28405794-28406378 | promoter | 5.99e-01 | 7.04e-01 | -5.11e+00 | 3.19e-07 | 1.40e-06 | -1.05e-01 |
| LIHC | cg00085732 | chr17:28473802 | CGI:chr17:28405794-28406378 | promoter,gene body,CDS,UTR,exon | 5.84e-01 | 7.16e-01 | -4.51e+00 | 6.35e-06 | 1.84e-05 | -1.32e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| COAD | cg00085732 | chr17:28473802 | CGI:chr17:28405794-28406378 | promoter,gene body,CDS,UTR,exon | 4.52e-01 | 3.27e-01 | 2.88e+00 | 3.99e-03 | 8.07e-03 | 1.25e-01 |
Top |
Exon skipping events with PSI in TCGA for SLC13A2 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for SLC13A2 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for SLC13A2 |
| TFs related to SLC13A2. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| SLC13A2 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for SLC13A2 |
| RBPs related to ES in SLC13A2. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| SLC13A2 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs7215650 | chr17:37813390:A:G | - | 0.225509126814661 | 0.00627920638015377 | KIRP | Female-baised eQTL |
| rs59415593 | chr17:19319911:T:G | - | 0.192795919901473 | 0.00838504557575205 | KIRP | Female-baised eQTL |
| rs4924986 | chr17:19339154:A:G | - | 0.192795919901473 | 0.00838504557575205 | KIRP | Female-baised eQTL |
| rs57433322 | chr17:19238269:C:G | - | 0.192590294113759 | 0.00901580316785715 | KIRP | Female-baised eQTL |
| rs16960499 | chr17:19299719:A:G | - | 0.192586922453556 | 0.00901938865316509 | KIRP | Female-baised eQTL |
| rs145863701 | chr17:30705804:T:C | - | 0.231268055490179 | 0.0100138182292534 | KIRP | Female-baised eQTL |
| rs115858898 | chr17:37690346:A:G | - | 0.231266683028973 | 0.031359912210051 | KIRP | Female-baised eQTL |
| rs2170849 | chr17:30700962:T:C | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs2129103 | chr17:30701263:A:G | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs28870673 | chr17:30701532:A:T | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs28622550 | chr17:30702260:G:A | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs138391160 | chr17:30703551:C:T | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs145534499 | chr17:30704325:G:A | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs116094236 | chr17:30704474:C:G | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs7221561 | chr17:30704640:C:T | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs7222061 | chr17:30704931:C:T | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs7207313 | chr17:30704948:T:G | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs73988149 | chr17:30705866:G:A | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs73988150 | chr17:30706325:A:G | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs9900572 | chr17:30707077:T:C | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs9900754 | chr17:30707129:T:A | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs7214159 | chr17:30708123:A:G | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs186310662 | chr17:30708776:G:C | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs114320910 | chr17:30709008:T:A | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs181437719 | chr17:30709036:T:G | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs186465651 | chr17:30709051:G:A | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs145512259 | chr17:30709922:C:T | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs28679270 | chr17:30710861:G:T | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs116082591 | chr17:30711188:C:G | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs6505201 | chr17:30713063:G:A | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs4055600 | chr17:30713813:A:G | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs73988151 | chr17:30714698:C:A | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs151199430 | chr17:30714995:G:A | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs7219234 | chr17:30715901:T:C | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs7213365 | chr17:30715965:G:T | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs7209007 | chr17:30716093:C:T | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs7208860 | chr17:30716746:G:A | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs7210962 | chr17:30716927:A:G | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs9909651 | chr17:30717055:T:C | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs73988155 | chr17:30717375:C:T | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs9903084 | chr17:30717822:G:A | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs9904748 | chr17:30717883:C:T | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs144072981 | chr17:30718710:A:G | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs141228105 | chr17:30718860:C:T | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs7211733 | chr17:30720267:C:A | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs73988156 | chr17:30720514:A:G | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs7223048 | chr17:30722021:A:G | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs7222231 | chr17:30722622:G:A | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs7223914 | chr17:30722902:C:T | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs147691960 | chr17:30723568:G:A | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs9912847 | chr17:30727027:A:G | - | 0.21823177306823 | 0.0371963144529119 | KIRP | Female-baised eQTL |
| rs2173166 | chr17:36826789:C:T | - | 0.162580706492266 | 0.0459119682084711 | KIRP | Female-baised eQTL |
| rs79259362 | chr17:19376976:A:G | - | 0.0934979091643043 | 0.0155781408384243 | STAD | Female-baised eQTL |
| rs75326834 | chr17:19377005:G:C | - | 0.0934175497767963 | 0.0160359987816544 | STAD | Female-baised eQTL |
| rs1054206 | chr17:19384106:G:C | - | 0.0820610994960561 | 0.0499543691339957 | STAD | Female-baised eQTL |
| rs6503542 | chr17:38356009:T:C | - | -0.0839515002553426 | 0.0075347467502249 | KIRC | Female-baised eQTL |
| rs1003837 | chr17:34126136:G:C | - | -0.0615164259490029 | 0.0114981849138109 | KIRC | Female-baised eQTL |
| rs17836708 | chr17:33180367:G:C | - | 0.0676978516204486 | 0.029941211016702 | KIRC | Female-baised eQTL |
| rs59687911 | chr17:34099630:A:G | - | -0.0569239827076566 | 0.0320519669382964 | KIRC | Female-baised eQTL |
| rs916901 | chr17:34110348:A:T | - | -0.0562506392845823 | 0.0397934298890457 | KIRC | Female-baised eQTL |
| rs9892028 | chr17:34108033:C:A | - | -0.0562446213507125 | 0.0402166605361967 | KIRC | Female-baised eQTL |
| rs2097763 | chr17:34076151:T:C | - | -0.0561537455130799 | 0.0416667652784614 | KIRC | Female-baised eQTL |
| rs9896741 | chr17:34090286:T:C | - | -0.0552561045874211 | 0.046038341819223 | KIRC | Female-baised eQTL |
| rs7212227 | chr17:34088866:T:C | - | -0.0552504054943348 | 0.0464873631063568 | KIRC | Female-baised eQTL |
| rs4795863 | chr17:34089236:A:G | - | -0.0552504054943348 | 0.0464873631063568 | KIRC | Female-baised eQTL |
| rs9897532 | chr17:34121249:C:A | - | -0.0551731672911295 | 0.0476924176700868 | KIRC | Female-baised eQTL |
| rs4078225 | chr17:38349401:G:C | - | 0.0980902199376985 | 0.00493080110507901 | COAD | Female-baised eQTL |
| rs28940 | chr17:33009620:G:A | - | 0.0806570969058766 | 0.0293050319799192 | COAD | Female-baised eQTL |
| rs7222814 | chr17:31897852:T:G | - | 0.104006433396129 | 0.0341310782662475 | COAD | Female-baised eQTL |
| rs16969810 | chr17:34425111:G:A | - | 0.11939329094069 | 0.049406826584961 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs8068619 | chr17:36955694:T:A | - | 0.208246400774275 | 0.017668945904319 | PAAD | Male-baised eQTL |
| rs1383542 | chr17:35212509:C:T | - | 0.115076935298524 | 0.0272477455616798 | PAAD | Male-baised eQTL |
| rs7217164 | chr17:35213640:C:T | - | 0.115076935298524 | 0.0272477455616798 | PAAD | Male-baised eQTL |
| rs17780520 | chr17:32611973:T:C | - | 0.0463998342062535 | 0.0243032431605987 | KIRC | Male-baised eQTL |
| rs35262048 | chr17:32612127:G:T | - | 0.0429529444882191 | 0.0433676246346848 | KIRC | Male-baised eQTL |
| rs205088 | chr17:19786246:C:T | - | -0.0926262405915147 | 3.96182368160553e-06 | LUAD | Male-baised eQTL |
| rs394008 | chr17:19879241:G:C | - | 0.0931340270935817 | 7.23674559454149e-05 | LUAD | Male-baised eQTL |
| rs4586510 | chr17:19880661:T:C | - | 0.0773280447756916 | 0.00102226662064323 | LUAD | Male-baised eQTL |
| rs205113 | chr17:19770567:A:C | - | -0.0551543929885901 | 0.00739127153759196 | LUAD | Male-baised eQTL |
| rs281346 | chr17:19848171:A:C | - | 0.0614872207804278 | 0.0112866720673883 | LUAD | Male-baised eQTL |
| rs1975974 | chr17:22180454:A:G | - | 0.0336163160203921 | 0.0351591523538545 | LUAD | Male-baised eQTL |
| rs17052337 | chr17:22184168:A:T | - | 0.0333802242520186 | 0.0371866256829854 | LUAD | Male-baised eQTL |
| rs111527438 | chr17:30925685:T:C | - | 0.0357998154329403 | 0.0276204463799211 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000007216 |
| CpG Site: cg00085732 | |
| Position to Gene: gene,CDS,UTR,promoter,exon | |
| Male Effect: - | |
| Female Effect: -0.345318631900237 | |
 | Gene ID: ENSG00000007216 |
| CpG Site: cg09740598 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.113331776600849 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg00085732 | chr17:28473802 | gene,CDS,UTR,promoter,exon | -0.345318631900237 | 1.31106618489501e-09 | -0.42725847687812785 | 9.73407163883522e-13 | LUAD |
| cg09740598 | chr17:28481407 | gene | -0.113331776600849 | 1.08649701123863e-05 | -0.3358770576354202 | 3.847397401874496e-08 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of SLC13A2 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
