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Gene: ENSG00000007080 |
Summary for CCDC124 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000007080 | Gene symbol | CCDC124 |
| Gene name | coiled-coil domain containing 124 | |
| HGNC | 25171 | |
| Entrez ID | 115098 | |
| Gene type | protein_coding | |
| Synonyms | CCDC124|Lso2|oxs1 | |
| UniProtAcc | Q96CT7 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for CCDC124 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for CCDC124 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for CCDC124 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LIHC | cg23095556 | chr19:17933902 | CGI:chr19:17932671-17933334 | promoter,gene body | 3.69e-01 | 4.89e-01 | -4.69e+00 | 2.71e-06 | 8.78e-06 | -1.20e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg23095556 | chr19:17933902 | CGI:chr19:17932671-17933334 | promoter,gene body | 3.86e-01 | 4.87e-01 | -2.63e+00 | 8.45e-03 | 1.53e-02 | -1.01e-01 |
| HNSC | cg23095556 | chr19:17933902 | CGI:chr19:17932671-17933334 | promoter,gene body | 3.84e-01 | 2.75e-01 | 2.47e+00 | 1.37e-02 | 2.21e-02 | 1.08e-01 |
| BLCA | cg07930940 | chr19:17933936 | CGI:chr19:17932671-17933334 | promoter,gene body | 4.34e-01 | 5.45e-01 | -2.54e+00 | 1.12e-02 | 1.86e-02 | -1.10e-01 |
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Exon skipping events with PSI in TCGA for CCDC124 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for CCDC124 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for CCDC124 |
| TFs related to CCDC124. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| CCDC124 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for CCDC124 |
| RBPs related to ES in CCDC124. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| CCDC124 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs7256630 | chr19:22606461:G:C | - | 0.0727053087289619 | 0.0136534088136856 | LUAD | Female-baised eQTL |
| rs2562408 | chr19:21527079:C:G | - | 0.0640964650057792 | 0.0326564602260257 | LUAD | Female-baised eQTL |
| rs2562466 | chr19:21531402:C:T | - | 0.0632106905470221 | 0.0333358728132044 | LUAD | Female-baised eQTL |
| rs2562468 | chr19:21532048:G:A | - | 0.0632106905470221 | 0.0333358728132044 | LUAD | Female-baised eQTL |
| rs2562471 | chr19:21533017:C:T | - | 0.0632106905470221 | 0.0333358728132044 | LUAD | Female-baised eQTL |
| rs2681377 | chr19:21533718:T:C | - | 0.0632106905470221 | 0.0333358728132044 | LUAD | Female-baised eQTL |
| rs4808267 | chr19:20747380:T:C | - | -0.0755800841106424 | 0.0352942921719775 | LUAD | Female-baised eQTL |
| rs112593326 | chr19:20765076:G:T | - | -0.0752437490230088 | 0.0385132609465713 | LUAD | Female-baised eQTL |
| rs8106399 | chr19:20746200:T:C | - | -0.0739487668616408 | 0.0395045183003796 | LUAD | Female-baised eQTL |
| rs12460029 | chr19:20746270:T:C | - | -0.0739487668616408 | 0.0395045183003796 | LUAD | Female-baised eQTL |
| rs2173727 | chr19:21491155:C:T | - | 0.0621059103902829 | 0.0396532791475166 | LUAD | Female-baised eQTL |
| rs2650792 | chr19:21491532:T:G | - | 0.0621059103902829 | 0.0396532791475166 | LUAD | Female-baised eQTL |
| rs10404496 | chr19:20745285:C:T | - | -0.0743250665121465 | 0.0397679578412454 | LUAD | Female-baised eQTL |
| rs8105400 | chr19:20746168:A:G | - | -0.0743250665121465 | 0.0397679578412454 | LUAD | Female-baised eQTL |
| rs2562417 | chr19:21528400:T:C | - | 0.0624243753341671 | 0.0426913622226743 | LUAD | Female-baised eQTL |
| rs2681376 | chr19:21532723:T:G | - | 0.0615718419455953 | 0.0434244429460193 | LUAD | Female-baised eQTL |
| rs1879234 | chr19:21521677:T:G | - | 0.0607140673901733 | 0.044856983493662 | LUAD | Female-baised eQTL |
| rs2562398 | chr19:21540147:A:G | - | 0.061316830687926 | 0.0451420069625467 | LUAD | Female-baised eQTL |
| rs62106004 | chr19:20745210:A:C | - | -0.0726635653181124 | 0.0469706589356811 | LUAD | Female-baised eQTL |
| rs10404924 | chr19:20745453:C:T | - | -0.0726635653181124 | 0.0469706589356811 | LUAD | Female-baised eQTL |
| rs8104970 | chr19:20745631:G:C | - | -0.0726635653181124 | 0.0469706589356811 | LUAD | Female-baised eQTL |
| rs8105859 | chr19:20745780:T:A | - | -0.0726635653181124 | 0.0469706589356811 | LUAD | Female-baised eQTL |
| rs8105877 | chr19:20745805:T:C | - | -0.0726635653181124 | 0.0469706589356811 | LUAD | Female-baised eQTL |
| rs8105489 | chr19:20746043:G:A | - | -0.0726635653181124 | 0.0469706589356811 | LUAD | Female-baised eQTL |
| rs8105584 | chr19:20746108:G:C | - | -0.0726635653181124 | 0.0469706589356811 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs17001086 | chr19:11006760:T:C | - | 0.0933373502896779 | 0.0318196006750936 | LIHC | Male-baised eQTL |
| rs4467196 | chr19:21767993:C:A | - | -0.0891789439527963 | 0.0274225118772496 | KIRC | Male-baised eQTL |
| rs4381720 | chr19:21733724:A:G | - | -0.087794713557639 | 0.0289321227996644 | KIRC | Male-baised eQTL |
| rs62110861 | chr19:21912962:C:T | - | 0.0525775218454914 | 0.00101393155047844 | COAD | Male-baised eQTL |
| rs62110863 | chr19:21917706:T:C | - | 0.0525775218454914 | 0.00101393155047844 | COAD | Male-baised eQTL |
| rs143883891 | chr19:21926955:G:C | - | 0.0525775218454914 | 0.00101393155047844 | COAD | Male-baised eQTL |
| rs1560717 | chr19:22109445:A:G | - | 0.0507880097910705 | 0.00168999364252431 | COAD | Male-baised eQTL |
| rs6511675 | chr19:23942485:G:A | - | -0.0655178269983523 | 0.00528626981591847 | COAD | Male-baised eQTL |
| rs62112373 | chr19:22137023:G:A | - | 0.0439315694761979 | 0.00735238128658809 | COAD | Male-baised eQTL |
| rs17701834 | chr19:21938656:T:G | - | 0.0449220936072752 | 0.0111340818554931 | COAD | Male-baised eQTL |
| rs8112975 | chr19:18230100:A:G | - | 0.0332893284648657 | 0.0126928775353764 | COAD | Male-baised eQTL |
| rs16980187 | chr19:15004945:C:T | - | 0.0351466211674041 | 0.0144087273177467 | COAD | Male-baised eQTL |
| rs73512449 | chr19:18012241:G:C | - | 0.0445735552506537 | 0.0165311481375433 | COAD | Male-baised eQTL |
| rs3816556 | chr19:10115006:G:C | - | 0.0386573146906705 | 0.0198912415880873 | COAD | Male-baised eQTL |
| rs3752196 | chr19:14880161:T:A | - | 0.0427016743918689 | 0.0240825248080082 | COAD | Male-baised eQTL |
| rs193933 | chr19:8266491:A:G | - | -0.0306601733654257 | 0.0247688333987464 | COAD | Male-baised eQTL |
| rs17620592 | chr19:27923726:C:G | - | -0.0365150164311755 | 0.0261139443947159 | COAD | Male-baised eQTL |
| rs10417567 | chr19:15197257:T:C | - | -0.0488347376134495 | 0.0263416772900385 | COAD | Male-baised eQTL |
| rs7249672 | chr19:22118721:C:T | - | -0.0292603155336388 | 0.0303066833522536 | COAD | Male-baised eQTL |
| rs7254235 | chr19:22029703:A:G | - | 0.031394999184253 | 0.0310636425328665 | COAD | Male-baised eQTL |
| rs4932955 | chr19:22090043:T:A | - | -0.0376914601471517 | 0.0319569979247934 | COAD | Male-baised eQTL |
| rs4932956 | chr19:22090995:T:G | - | -0.0376914601471517 | 0.0319569979247934 | COAD | Male-baised eQTL |
| rs4436884 | chr19:22102361:A:C | - | -0.0371784438052442 | 0.0359964143485171 | COAD | Male-baised eQTL |
| rs10419058 | chr19:22127170:A:C | - | -0.029010372725026 | 0.0370856017908116 | COAD | Male-baised eQTL |
| rs7255713 | chr19:27933961:C:G | - | -0.0349646416528186 | 0.0388340298013988 | COAD | Male-baised eQTL |
| rs12461719 | chr19:22110039:C:T | - | -0.0355675487639701 | 0.0401089692365838 | COAD | Male-baised eQTL |
| rs73021803 | chr19:22104096:A:T | - | -0.0379572748447404 | 0.0422788082514645 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000007080 |
| CpG Site: cg15231872 | |
| Position to Gene: gene,exon,UTR | |
| Male Effect: -0.314988822710759 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg15231872 | chr19:17943976 | gene,exon,UTR | -0.314988822710759 | 2.03052204404992e-06 | -0.37775134306597213 | 5.655048222183276e-09 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of CCDC124 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
