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Gene: ENSG00000007062 |
Summary for PROM1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000007062 | Gene symbol | PROM1 |
| Gene name | prominin 1 | |
| HGNC | 9454 | |
| Entrez ID | 8842 | |
| Gene type | protein_coding | |
| Synonyms | PROM1|AC133|CD133|RP41|CORD12 | |
| UniProtAcc | O43490 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for PROM1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| PROM1 | 4.58e+03 | -3.52e+00 | 6.93e-01 | -5.08e+00 | 3.80e-07 | 2.91e-05 | BRCA |
| PROM1 | 4.35e+03 | 1.33e+00 | 2.15e-01 | 6.18e+00 | 6.33e-10 | 4.06e-08 | KIRC |
| PROM1 | 3.41e+02 | 1.37e+00 | 2.89e-01 | 4.74e+00 | 2.16e-06 | 2.19e-04 | BLCA |
| PROM1 | 2.12e+02 | -2.03e+00 | 3.39e-01 | -5.99e+00 | 2.08e-09 | 1.43e-07 | LIHC |
| PROM1 | 5.36e+02 | -1.66e+00 | 3.76e-01 | -4.40e+00 | 1.10e-05 | 3.44e-04 | SARC |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| PROM1 | 6.55e+03 | 1.32e+00 | 3.44e-01 | 3.85e+00 | 1.19e-04 | 4.25e-04 | STAD |
| PROM1 | 3.74e+03 | 3.67e+00 | 6.71e-01 | 5.46e+00 | 4.66e-08 | 4.57e-07 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| PROM1 | 3.01e+03 | -2.07e+00 | 6.17e-01 | -3.36e+00 | 7.94e-04 | 1.74e-03 | KIRC |
Top |
Sex-biased somatic mutation for PROM1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for PROM1 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg21647189 | chr4:16084191 | CGI:chr4:16082572-16084112 | UTR,promoter,exon,gene body | 3.96e-01 | 6.22e-01 | -3.31e+00 | 9.26e-04 | 9.01e-03 | -2.27e-01 |
| KIRP | cg21647189 | chr4:16084191 | CGI:chr4:16082572-16084112 | UTR,promoter,exon,gene body | 3.18e-01 | 1.60e-01 | 5.40e+00 | 6.53e-08 | 7.65e-07 | 1.58e-01 |
| KIRP | cg04203238 | chr4:16084079 | CGI:chr4:16082572-16084112 | UTR,promoter,exon,gene body | 2.45e-01 | 1.13e-01 | 4.98e+00 | 6.32e-07 | 6.94e-06 | 1.32e-01 |
| KIRP | cg26260038 | chr4:16084093 | CGI:chr4:16082572-16084112 | UTR,promoter,exon,gene body | 3.57e-01 | 1.89e-01 | 5.72e+00 | 1.06e-08 | 1.29e-07 | 1.68e-01 |
| SARC | cg14736058 | chr4:16083983 | CGI:chr4:16082572-16084112 | UTR,promoter,exon,gene body | 3.30e-01 | 2.25e-01 | 2.15e+00 | 3.13e-02 | 3.80e-02 | 1.05e-01 |
| READ | cg07656173 | chr4:16084400 | CGI:chr4:16082572-16084112 | promoter | 4.69e-01 | 5.71e-01 | -2.22e+00 | 2.63e-02 | 4.04e-02 | -1.02e-01 |
| CHOL | cg07656173 | chr4:16084400 | CGI:chr4:16082572-16084112 | promoter | 8.39e-01 | 6.46e-01 | 3.15e+00 | 1.62e-03 | 5.43e-03 | 1.93e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUAD | cg09024126 | chr4:16083980 | CGI:chr4:16082572-16084112 | UTR,promoter,exon,gene body | 3.23e-01 | 9.83e-02 | 3.53e+00 | 4.22e-04 | 9.40e-04 | 2.25e-01 |
| LUAD | cg14736058 | chr4:16083983 | CGI:chr4:16082572-16084112 | UTR,promoter,exon,gene body | 3.51e-01 | 1.49e-01 | 3.00e+00 | 2.69e-03 | 4.46e-03 | 2.02e-01 |
| LUSC | cg09532284 | chr4:16082624 | CGI:chr4:16082572-16084112 | promoter,gene body | 2.00e-01 | 1.61e-02 | 4.27e+00 | 1.98e-05 | 5.26e-04 | 1.84e-01 |
| LUSC | cg12839172 | chr4:16083454 | CGI:chr4:16082572-16084112 | UTR,promoter,exon,gene body | 3.98e-01 | 2.20e-02 | 4.25e+00 | 2.11e-05 | 5.26e-04 | 3.76e-01 |
| LUSC | cg09024126 | chr4:16083980 | CGI:chr4:16082572-16084112 | UTR,promoter,exon,gene body | 4.22e-01 | 1.33e-01 | 3.00e+00 | 2.74e-03 | 5.24e-03 | 2.89e-01 |
| LUSC | cg14736058 | chr4:16083983 | CGI:chr4:16082572-16084112 | UTR,promoter,exon,gene body | 4.50e-01 | 1.61e-01 | 2.85e+00 | 4.31e-03 | 7.31e-03 | 2.89e-01 |
| LUSC | cg19162333 | chr4:16083053 | CGI:chr4:16082572-16084112 | promoter,gene body | 3.03e-01 | 1.41e-01 | 2.45e+00 | 1.43e-02 | 1.83e-02 | 1.62e-01 |
| LUSC | cg03101849 | chr4:16083059 | CGI:chr4:16082572-16084112 | promoter,gene body | 2.90e-01 | 8.57e-02 | 2.95e+00 | 3.19e-03 | 5.86e-03 | 2.05e-01 |
| LUSC | cg13164157 | chr4:16083557 | CGI:chr4:16082572-16084112 | promoter,exon,gene body | 3.30e-01 | 4.06e-02 | 3.78e+00 | 1.58e-04 | 8.61e-04 | 2.90e-01 |
| LUSC | cg07817686 | chr4:16083778 | CGI:chr4:16082572-16084112 | promoter,gene body | 4.42e-01 | 1.34e-01 | 3.81e+00 | 1.39e-04 | 8.07e-04 | 3.08e-01 |
| BLCA | cg12839172 | chr4:16083454 | CGI:chr4:16082572-16084112 | UTR,promoter,exon,gene body | 3.34e-01 | 5.42e-02 | 3.68e+00 | 2.34e-04 | 7.45e-04 | 2.80e-01 |
| BLCA | cg14736058 | chr4:16083983 | CGI:chr4:16082572-16084112 | UTR,promoter,exon,gene body | 4.06e-01 | 1.55e-01 | 2.00e+00 | 4.56e-02 | 4.66e-02 | 2.51e-01 |
| BLCA | cg03101849 | chr4:16083059 | CGI:chr4:16082572-16084112 | promoter,gene body | 2.19e-01 | 9.46e-02 | 2.05e+00 | 4.07e-02 | 4.26e-02 | 1.24e-01 |
| BLCA | cg13164157 | chr4:16083557 | CGI:chr4:16082572-16084112 | promoter,exon,gene body | 2.34e-01 | 5.46e-02 | 3.38e+00 | 7.13e-04 | 1.75e-03 | 1.80e-01 |
| BLCA | cg07817686 | chr4:16083778 | CGI:chr4:16082572-16084112 | promoter,gene body | 3.68e-01 | 1.58e-01 | 2.91e+00 | 3.64e-03 | 6.32e-03 | 2.10e-01 |
| BLCA | cg08855742 | chr4:16084462 | CGI:chr4:16082572-16084112 | promoter | 3.93e-01 | 5.25e-01 | -2.95e+00 | 3.15e-03 | 5.63e-03 | -1.31e-01 |
| LIHC | cg26260038 | chr4:16084093 | CGI:chr4:16082572-16084112 | UTR,promoter,exon,gene body | 4.15e-01 | 2.66e-01 | 2.88e+00 | 3.98e-03 | 5.39e-03 | 1.50e-01 |
| KIRP | cg21647189 | chr4:16084191 | CGI:chr4:16082572-16084112 | UTR,promoter,exon,gene body | 1.60e-01 | 2.71e-01 | -3.75e+00 | 1.80e-04 | 4.26e-04 | -1.11e-01 |
| ESCA | cg12839172 | chr4:16083454 | CGI:chr4:16082572-16084112 | UTR,promoter,exon,gene body | 2.56e-01 | 7.27e-02 | 2.52e+00 | 1.17e-02 | 3.69e-02 | 1.83e-01 |
| ESCA | cg07817686 | chr4:16083778 | CGI:chr4:16082572-16084112 | promoter,gene body | 2.94e-01 | 1.43e-01 | 2.08e+00 | 3.71e-02 | 4.58e-02 | 1.51e-01 |
| ESCA | cg07656173 | chr4:16084400 | CGI:chr4:16082572-16084112 | promoter | 6.95e-01 | 4.89e-01 | 2.47e+00 | 1.34e-02 | 3.76e-02 | 2.05e-01 |
| ESCA | cg13117948 | chr4:16084428 | CGI:chr4:16082572-16084112 | promoter | 7.08e-01 | 5.68e-01 | 1.98e+00 | 4.82e-02 | 4.90e-02 | 1.39e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg21647189 | chr4:16084191 | CGI:chr4:16082572-16084112 | UTR,promoter,exon,gene body | 3.96e-01 | 2.84e-01 | 5.46e+00 | 4.86e-08 | 1.02e-07 | 1.12e-01 |
| BRCA | cg12839172 | chr4:16083454 | CGI:chr4:16082572-16084112 | UTR,promoter,exon,gene body | 2.67e-01 | 3.64e-02 | 9.62e+00 | 6.89e-22 | 4.39e-21 | 2.30e-01 |
| BRCA | cg09024126 | chr4:16083980 | CGI:chr4:16082572-16084112 | UTR,promoter,exon,gene body | 3.83e-01 | 9.68e-02 | 7.74e+00 | 9.62e-15 | 3.43e-14 | 2.86e-01 |
| BRCA | cg14736058 | chr4:16083983 | CGI:chr4:16082572-16084112 | UTR,promoter,exon,gene body | 4.10e-01 | 1.12e-01 | 7.53e+00 | 5.18e-14 | 1.75e-13 | 2.98e-01 |
| BRCA | cg04203238 | chr4:16084079 | CGI:chr4:16082572-16084112 | UTR,promoter,exon,gene body | 3.79e-01 | 1.17e-01 | 6.14e+00 | 8.46e-10 | 2.07e-09 | 2.62e-01 |
| BRCA | cg13164157 | chr4:16083557 | CGI:chr4:16082572-16084112 | promoter,exon,gene body | 2.33e-01 | 5.05e-02 | 8.23e+00 | 1.84e-16 | 7.51e-16 | 1.83e-01 |
| BRCA | cg07817686 | chr4:16083778 | CGI:chr4:16082572-16084112 | promoter,gene body | 3.31e-01 | 1.40e-01 | 7.57e+00 | 3.75e-14 | 1.28e-13 | 1.90e-01 |
| BRCA | cg10630155 | chr4:16084043 | CGI:chr4:16082572-16084112 | UTR,promoter,exon,gene body | 3.88e-01 | 2.46e-01 | 5.59e+00 | 2.24e-08 | 4.85e-08 | 1.42e-01 |
| BRCA | cg26260038 | chr4:16084093 | CGI:chr4:16082572-16084112 | UTR,promoter,exon,gene body | 4.68e-01 | 2.93e-01 | 5.41e+00 | 6.25e-08 | 1.30e-07 | 1.75e-01 |
| KIRC | cg09024126 | chr4:16083980 | CGI:chr4:16082572-16084112 | UTR,promoter,exon,gene body | 1.60e-01 | 2.69e-02 | 3.03e+00 | 2.48e-03 | 7.26e-03 | 1.33e-01 |
| KIRC | cg14736058 | chr4:16083983 | CGI:chr4:16082572-16084112 | UTR,promoter,exon,gene body | 1.72e-01 | 4.20e-02 | 2.44e+00 | 1.48e-02 | 2.21e-02 | 1.30e-01 |
| KIRC | cg04203238 | chr4:16084079 | CGI:chr4:16082572-16084112 | UTR,promoter,exon,gene body | 2.01e-01 | 7.15e-02 | 2.54e+00 | 1.12e-02 | 1.84e-02 | 1.29e-01 |
| KIRC | cg26260038 | chr4:16084093 | CGI:chr4:16082572-16084112 | UTR,promoter,exon,gene body | 3.70e-01 | 2.31e-01 | 2.32e+00 | 2.06e-02 | 2.75e-02 | 1.39e-01 |
| LUAD | cg08855742 | chr4:16084462 | CGI:chr4:16082572-16084112 | promoter | 4.37e-01 | 5.44e-01 | -2.52e+00 | 1.17e-02 | 1.77e-02 | -1.07e-01 |
| KIRP | cg12839172 | chr4:16083454 | CGI:chr4:16082572-16084112 | UTR,promoter,exon,gene body | 1.47e-01 | 1.88e-02 | 4.15e+00 | 3.36e-05 | 8.55e-04 | 1.28e-01 |
| KIRP | cg08855742 | chr4:16084462 | CGI:chr4:16082572-16084112 | promoter | 5.44e-01 | 4.37e-01 | 2.01e+00 | 4.44e-02 | 4.60e-02 | 1.08e-01 |
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Exon skipping events with PSI in TCGA for PROM1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for PROM1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
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| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| COAD | PROM1-203 | chr4_15973364_- | 2.37e-01 | 3.47e-01 | -2.19e+00 | 2.85e-02 | 3.85e-02 | -1.09e-01 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for PROM1 |
| TFs related to PROM1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| UVM | EN1 | PROM1 | 4.63e+00 | 9.83e-01 | 2.95e+00 | 4.55e-03 | Male-biased |
| UVM | GBX2 | PROM1 | 5.00e+00 | 9.83e-01 | 3.66e+00 | 9.63e-03 | Male-biased |
| UVM | IRF6 | PROM1 | 5.27e+00 | 9.81e-01 | 4.12e+00 | 1.42e-02 | Male-biased |
| UVM | MIXL1 | PROM1 | 5.03e+00 | 9.86e-01 | 3.48e+00 | 6.14e-03 | Male-biased |
| UVM | POU3F3 | PROM1 | 4.43e+00 | 9.82e-01 | 1.89e+00 | 5.49e-04 | Male-biased |
| UVM | POU4F1 | PROM1 | 4.53e+00 | 9.84e-01 | 2.36e+00 | 1.45e-03 | Male-biased |
| UVM | POU4F3 | PROM1 | 4.47e+00 | 9.81e-01 | 2.50e+00 | 2.34e-03 | Male-biased |
| UVM | POU6F2 | PROM1 | 4.72e+00 | 9.86e-01 | 2.82e+00 | 2.80e-03 | Male-biased |
| UVM | SOX14 | PROM1 | 4.56e+00 | 9.81e-01 | 2.86e+00 | 4.42e-03 | Male-biased |
| UVM | SOX18 | PROM1 | 4.60e+00 | 9.83e-01 | 2.78e+00 | 3.40e-03 | Male-biased |
| UVM | VENTX | PROM1 | 5.44e+00 | 9.85e-01 | 4.19e+00 | 1.18e-02 | Male-biased |
| UVM | ZNF334 | PROM1 | 4.33e+00 | 9.80e-01 | 1.11e+00 | 7.46e-05 | Male-biased |
| PROM1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for PROM1 |
| RBPs related to ES in PROM1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| KIRP | MBNL1 | exon_skip_428649 | 8.24e+00 | 6.86e-03 | 8.60e+00 | 9.87e-01 | Female-biased |
| PAAD | PABPC5 | exon_skip_428657 | 7.63e+00 | 9.87e-01 | 7.24e+00 | 3.32e-03 | Male-biased |
| PAAD | SNRNP70 | exon_skip_428649 | 8.44e+00 | 9.81e-01 | 8.16e+00 | 1.23e-02 | Male-biased |
| PROM1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs35618667 | chr4:23409713:T:C | - | 0.33001133714587 | 0.0464876346561634 | READ | Female-baised eQTL |
| rs35176124 | chr4:23410747:G:A | - | 0.33001133714587 | 0.0464876346561634 | READ | Female-baised eQTL |
| rs17710226 | chr4:6084448:A:T | - | 0.551336160892656 | 0.0192594963027921 | GBM | Female-baised eQTL |
| rs1494948 | chr4:14970937:C:T | - | -0.12407555698639 | 0.0497194488292101 | KIRP | Female-baised eQTL |
| rs6449051 | chr4:9843087:T:A | - | 0.117119298848546 | 0.00499888688870973 | LUSC | Female-baised eQTL |
| rs78549698 | chr4:24166478:G:T | - | 0.181096019731392 | 0.00593544834064997 | LUSC | Female-baised eQTL |
| rs12508318 | chr4:24167103:C:A | - | 0.129712239090108 | 0.0326087610280138 | LUSC | Female-baised eQTL |
| rs28407876 | chr4:9763541:G:A | - | 0.120718116385956 | 0.035882591426115 | LUSC | Female-baised eQTL |
| rs6812531 | chr4:9756029:G:T | - | 0.120439024069249 | 0.0371033732392673 | LUSC | Female-baised eQTL |
| rs10000818 | chr4:9756610:C:G | - | 0.11661470719705 | 0.0482173829415591 | LUSC | Female-baised eQTL |
| rs12643296 | chr4:9820128:G:A | - | 0.107519398031418 | 0.0494705754806548 | LUSC | Female-baised eQTL |
| rs9291412 | chr4:20725841:A:G | - | 0.144094229001951 | 0.0281122840191677 | STAD | Female-baised eQTL |
| rs17534953 | chr4:18969668:C:T | - | 0.161768842152182 | 0.000446659135427402 | LGG | Female-baised eQTL |
| rs10000605 | chr4:13874051:T:C | - | 0.0940562312859727 | 0.0145360621613348 | KIRC | Female-baised eQTL |
| rs1861135 | chr4:13859625:G:A | - | -0.0816435445066131 | 0.0287673171340152 | KIRC | Female-baised eQTL |
| rs10939518 | chr4:13858610:G:A | - | -0.0807166082584283 | 0.0317560647780219 | KIRC | Female-baised eQTL |
| rs4698568 | chr4:13857549:C:T | - | -0.0799392858344449 | 0.0342536294767535 | KIRC | Female-baised eQTL |
| rs12501032 | chr4:23949395:C:G | - | 0.112122085336511 | 0.0171042757710037 | BLCA | Female-baised eQTL |
| rs73089514 | chr4:8457328:G:A | - | 0.0904643203829493 | 0.00861919193812982 | LUAD | Female-baised eQTL |
| rs13141535 | chr4:8490046:G:A | - | 0.0791779097823531 | 0.0258460214361396 | LUAD | Female-baised eQTL |
| rs6814499 | chr4:14006540:C:A | - | 0.0583544529422049 | 0.0372111138911053 | LUAD | Female-baised eQTL |
| rs145740929 | chr4:14014814:T:G | - | 0.0583544529422049 | 0.0372111138911053 | LUAD | Female-baised eQTL |
| rs79150224 | chr4:11420383:T:C | - | 0.0857313413338212 | 0.0397657133200975 | LUAD | Female-baised eQTL |
| rs372860755 | chr4:14006162:G:T | - | 0.0656183412130185 | 0.0408390661499385 | LUAD | Female-baised eQTL |
| rs6839348 | chr4:14006598:A:G | - | 0.0656183412130185 | 0.0408390661499385 | LUAD | Female-baised eQTL |
| rs6839527 | chr4:14006675:A:G | - | 0.0656183412130185 | 0.0408390661499385 | LUAD | Female-baised eQTL |
| rs16889593 | chr4:14008102:A:T | - | 0.0656183412130185 | 0.0408390661499385 | LUAD | Female-baised eQTL |
| rs28654278 | chr4:14008197:C:T | - | 0.0656183412130185 | 0.0408390661499385 | LUAD | Female-baised eQTL |
| rs16889609 | chr4:14009097:G:A | - | 0.0656183412130185 | 0.0408390661499385 | LUAD | Female-baised eQTL |
| rs375040594 | chr4:14011919:C:G | - | 0.0656183412130185 | 0.0408390661499385 | LUAD | Female-baised eQTL |
| rs147963639 | chr4:14014931:C:G | - | 0.0656183412130185 | 0.0408390661499385 | LUAD | Female-baised eQTL |
| rs9760410 | chr4:14015134:C:T | - | 0.0656183412130185 | 0.0408390661499385 | LUAD | Female-baised eQTL |
| rs7666290 | chr4:14016591:A:G | - | 0.0656183412130185 | 0.0408390661499385 | LUAD | Female-baised eQTL |
| rs11933513 | chr4:14021123:G:T | - | 0.0656183412130185 | 0.0408390661499385 | LUAD | Female-baised eQTL |
| rs7665661 | chr4:13995665:G:T | - | 0.0574615710436675 | 0.0408827237649124 | LUAD | Female-baised eQTL |
| rs370914542 | chr4:14014745:G:T | - | 0.0575003003752685 | 0.041017398838195 | LUAD | Female-baised eQTL |
| rs9762135 | chr4:14015076:G:C | - | 0.0575003003752685 | 0.041017398838195 | LUAD | Female-baised eQTL |
| rs16889634 | chr4:14022012:G:A | - | 0.0575119461564577 | 0.0413304267612673 | LUAD | Female-baised eQTL |
| rs28674928 | chr4:14021827:C:A | - | 0.0654587843991865 | 0.041966742511095 | LUAD | Female-baised eQTL |
| rs114441333 | chr4:14017084:G:A | - | 0.0575577662009398 | 0.0425261672392728 | LUAD | Female-baised eQTL |
| rs16889627 | chr4:14018916:G:A | - | 0.0575577662009398 | 0.0425261672392728 | LUAD | Female-baised eQTL |
| rs10517019 | chr4:23595773:T:A | - | 0.0385317342999534 | 0.0469626701386747 | LUAD | Female-baised eQTL |
| rs61793418 | chr4:22507816:T:G | - | 0.0573670960632966 | 0.0479003751497718 | LUAD | Female-baised eQTL |
| rs115080606 | chr4:20641711:A:C | - | 0.129355986670885 | 0.0489951031377877 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs10024390 | chr4:12712345:G:C | - | -0.0784400961269186 | 0.0099707452568016 | KIRC | Male-baised eQTL |
| rs13131763 | chr4:23367016:C:T | - | 0.103459233040184 | 0.012307337989683 | KIRC | Male-baised eQTL |
| rs35630189 | chr4:23355792:A:T | - | 0.0955608970086411 | 0.0147504468619328 | KIRC | Male-baised eQTL |
| rs1979985 | chr4:23358834:G:A | - | 0.0955608970086411 | 0.0147504468619328 | KIRC | Male-baised eQTL |
| rs28676965 | chr4:10478135:G:A | - | 0.0564702134010415 | 0.0168015805313184 | KIRC | Male-baised eQTL |
| rs35257407 | chr4:10478197:A:G | - | 0.0564702134010415 | 0.0168015805313184 | KIRC | Male-baised eQTL |
| rs58421266 | chr4:10478518:G:T | - | 0.0537240383151375 | 0.0287806447368441 | KIRC | Male-baised eQTL |
| rs28556582 | chr4:23380233:G:A | - | 0.0942704761574032 | 0.0300420776499429 | KIRC | Male-baised eQTL |
| rs7665472 | chr4:11053268:A:G | - | 0.041020274066371 | 0.0307174574703976 | KIRC | Male-baised eQTL |
| rs16875527 | chr4:24300483:G:C | - | 0.0910526028988295 | 0.033342240225967 | KIRC | Male-baised eQTL |
| rs1879275 | chr4:12722366:A:T | - | -0.0738962903554523 | 0.0362371892633565 | KIRC | Male-baised eQTL |
| rs13148320 | chr4:23356760:C:T | - | 0.0778750420637257 | 0.0372970565639917 | KIRC | Male-baised eQTL |
| rs6831940 | chr4:12699911:G:A | - | -0.0728930687763426 | 0.038607227864773 | KIRC | Male-baised eQTL |
| rs2903351 | chr4:12705556:C:T | - | -0.0727158955260215 | 0.039772271324199 | KIRC | Male-baised eQTL |
| rs2866696 | chr4:12709472:T:C | - | -0.0727158955260215 | 0.039772271324199 | KIRC | Male-baised eQTL |
| rs12501880 | chr4:9716351:C:T | - | -0.037525205645074 | 0.0446701877467449 | KIRC | Male-baised eQTL |
| rs7693235 | chr4:12707562:C:G | - | -0.0714210963985666 | 0.0447163151324349 | KIRC | Male-baised eQTL |
| rs1520293 | chr4:12701770:A:G | - | -0.0716572784137895 | 0.0495561867437822 | KIRC | Male-baised eQTL |
| rs147331413 | chr4:16405134:C:G | - | -0.0509154296775808 | 0.00557631911452072 | BLCA | Male-baised eQTL |
| rs76123678 | chr4:11547803:A:C | - | 0.110239042782112 | 0.0300514507385039 | COAD | Male-baised eQTL |
| rs78151411 | chr4:11542039:G:T | - | 0.105396013697114 | 0.0444120841789846 | COAD | Male-baised eQTL |
| rs76031325 | chr4:11547417:G:A | - | 0.102041691604202 | 0.0499136742256678 | COAD | Male-baised eQTL |
| rs78756667 | chr4:11547570:T:C | - | 0.102041691604202 | 0.0499136742256678 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000007062 |
| CpG Site: cg17791799 | |
| Position to Gene: gene | |
| Male Effect: -0.424025803009202 | |
| Female Effect: - | |
 | Gene ID: ENSG00000007062 |
| CpG Site: cg07656173 | |
| Position to Gene: promoter | |
| Male Effect: -0.176564491223491 | |
| Female Effect: - | |
 | Gene ID: ENSG00000007062 |
| CpG Site: cg00708789 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.437131742886587 | |
 | Gene ID: ENSG00000007062 |
| CpG Site: cg13117948 | |
| Position to Gene: promoter | |
| Male Effect: - | |
| Female Effect: -0.436304302369386 | |
 | Gene ID: ENSG00000007062 |
| CpG Site: cg22867816 | |
| Position to Gene: gene | |
| Male Effect: -0.314703408037973 | |
| Female Effect: - | |
 | Gene ID: ENSG00000007062 |
| CpG Site: cg14527610 | |
| Position to Gene: gene | |
| Male Effect: -0.408865552739323 | |
| Female Effect: - | |
 | Gene ID: ENSG00000007062 |
| CpG Site: cg08855742 | |
| Position to Gene: promoter | |
| Male Effect: - | |
| Female Effect: -0.381329703033235 | |
 | Gene ID: ENSG00000007062 |
| CpG Site: cg19712821 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.26371772734001 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg17791799 | chr4:16034500 | gene | -0.424025803009202 | 9.92897778334443e-08 | -0.4897897584120155 | 9.937527679169994e-11 | COAD |
| cg07656173 | chr4:16084400 | promoter | -0.176564491223491 | 9.09972204426365e-05 | -0.33237472248858607 | 1.5211582256883328e-06 | KIRP |
| cg22867816 | chr4:16079582 | gene | -0.314703408037973 | 1.09597748851712e-06 | -0.41098499903071256 | 4.786839850932665e-10 | STAD |
| cg14527610 | chr4:16076230 | gene | -0.408865552739323 | 9.9385935792457e-06 | -0.37540164621457567 | 9.030796667977792e-09 | STAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg00708789 | chr4:16081817 | gene | -0.437131742886587 | 2.35648750157919e-11 | -0.4679773081664632 | 5.207142233664753e-15 | LUAD |
| cg13117948 | chr4:16084428 | promoter | -0.436304302369386 | 2.63489749834619e-11 | -0.45085779900359463 | 3.5904242051148407e-14 | LUAD |
| cg08855742 | chr4:16084462 | promoter | -0.381329703033235 | 5.14193993527565e-13 | -0.7191007862035794 | 1.5643725957717574e-16 | LUSC |
| cg19712821 | chr4:15963393 | gene | -0.26371772734001 | 5.57737080655911e-09 | -0.41274199035405723 | 3.010688126516524e-11 | LGG |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_428630 | chr4:15979394:15979463 | In-frame | rs17487543 | chr4:16282303:A:G | Distant upstream | -0.0801754916657576 | 0.00705391693440501 | COAD | Female-baised sQTL |
| exon_skip_428630 | chr4:15979394:15979463 | In-frame | rs6846543 | chr4:16283732:A:G | Distant upstream | -0.0801754916657576 | 0.00705391693440501 | COAD | Female-baised sQTL |
| exon_skip_428630 | chr4:15979394:15979463 | In-frame | rs17487141 | chr4:16271324:G:A | Distant upstream | -0.0765676957518539 | 0.01341391097384 | COAD | Female-baised sQTL |
| exon_skip_428630 | chr4:15979394:15979463 | In-frame | rs16893439 | chr4:16388387:G:T | Distant upstream | -0.0698888223288227 | 0.0239676488851905 | COAD | Female-baised sQTL |
| exon_skip_428630 | chr4:15979394:15979463 | In-frame | rs28619251 | chr4:16170401:A:T | Distant upstream | -0.064036612260183 | 0.0382954086059997 | COAD | Female-baised sQTL |
| exon_skip_428630 | chr4:15979394:15979463 | In-frame | rs2907370 | chr4:15914449:A:G | Distant downstream | 0.0552611184705628 | 0.0408882299750204 | COAD | Female-baised sQTL |
| exon_skip_428630 | chr4:15979394:15979463 | In-frame | rs28395234 | chr4:16165478:G:A | Distant upstream | -0.0630028804628214 | 0.0458017593037169 | COAD | Female-baised sQTL |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_428630 | chr4:15979394:15979463 | In-frame | rs16892805 | chr4:16017882:C:G | Distant upstream | -0.102245141001859 | 0.00303911547347137 | COAD | Male-baised sQTL |
| exon_skip_428630 | chr4:15979394:15979463 | In-frame | rs2531156 | chr4:16015908:G:C | Distant upstream | -0.0913929167768723 | 0.0189975664102515 | COAD | Male-baised sQTL |
| exon_skip_428630 | chr4:15979394:15979463 | In-frame | rs1134634 | chr4:15601446:G:C | Distant downstream | 0.0558393435838411 | 0.0367486511851909 | PAAD | Male-baised sQTL |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of PROM1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000007062 | PROM1 | C0007102 | Malignant tumor of colon | 1 | CTD_human |
| ENSG00000007062 | PROM1 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
| ENSG00000007062 | PROM1 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
| ENSG00000007062 | PROM1 | C0009402 | Colorectal Carcinoma | 1 | CTD_human |
| ENSG00000007062 | PROM1 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| ENSG00000007062 | PROM1 | C0017636 | Glioblastoma | 3 | CTD_human |
| ENSG00000007062 | PROM1 | C0041696 | Unipolar Depression | 1 | PSYGENET |
| ENSG00000007062 | PROM1 | C0042138 | Uterine Neoplasms | 1 | CTD_human |
| ENSG00000007062 | PROM1 | C0153567 | Uterine Cancer | 1 | CTD_human |
| ENSG00000007062 | PROM1 | C0206627 | Mixed Tumor, Mullerian | 1 | CTD_human |
| ENSG00000007062 | PROM1 | C0334588 | Giant Cell Glioblastoma | 3 | CTD_human |
| ENSG00000007062 | PROM1 | C0339512 | Bull's eye macular dystrophy | 1 | CTD_human |
| ENSG00000007062 | PROM1 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
| ENSG00000007062 | PROM1 | C1621958 | Glioblastoma Multiforme | 3 | CTD_human |
| ENSG00000007062 | PROM1 | C1863534 | Stargardt disease 4 | 1 | CTD_human |
| ENSG00000007062 | PROM1 | C2675210 | CONE-ROD DYSTROPHY 12 (disorder) | 1 | CTD_human |
| ENSG00000007062 | PROM1 | C2677516 | RETINITIS PIGMENTOSA 41 (disorder) | 1 | CTD_human |
