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Gene: ENSG00000005073

Summary for HOXA11

Gene summary

Gene information	Ensembl ID	ENSG00000005073
	Gene symbol	HOXA11
	Gene name	homeobox A11
	HGNC	5101
	Entrez ID	3207
	Gene type	protein_coding
	Synonyms	HOXA11\|
	UniProtAcc	P31270

Drugs associated with this gene(DrugBank).

Gene ID

Gene Symbol

Drug ID

Drug Name

Drug Type

Cancer therapeutic drugs associated with this gene(NCI).

Gene ID

Gene Name

Drug ID

Drug Name

Drug Type

Cancer

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Structure and expression level for HOXA11

AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.

Landscape of gene expressions across multiple cancer types.

Differentially expressed gene analysis between tumor male and tumor female samples.

Coding Name	Base Mean	log2FoldChange	lfcSE	Stat	P value	P.adjust Value	Cancer Type
HOXA11	1.52e+02	-1.52e+00	2.46e-01	-6.18e+00	6.43e-10	3.78e-08	KIRP
HOXA11	7.88e+02	-1.54e+00	2.51e-01	-6.16e+00	7.15e-10	9.86e-08	SARC

Differentially expressed gene analysis between tumor male and normal male samples.

Coding Name	Base Mean	log2FoldChange	lfcSE	Stat	P value	P.adjust Value	Cancer Type
HOXA11	3.49e+02	-1.07e+00	4.32e-01	-2.48e+00	1.32e-02	3.03e-02	BLCA

Differentially expressed gene analysis between tumor female and normal female samples.

Coding Name

Base Mean

log2FoldChange

lfcSE

Stat

P value

P.adjust Value

Cancer Type

Top

Sex-biased somatic mutation for HOXA11

∗For more information on exon skipping events please check the ExonskipDB database.

Gene ID

Cancer Type

Hugo Symbol

Male

Female

pval

ci.up

ci.low

adjPval

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DNA methylation with beta values for HOXA11

Landscape of DNA methylation across multiple cancer types.

Differentially expressed CpG sites between male tumor and female tumor patients.

Cancer Type	CpG Site	Position	CpG Island	Position to Gene	ave1	ave2	wilcoxon.w	wilcoxon.p	padj	dBeta
BRCA	cg09219451	chr7:27184504	CGI:chr7:27184648-27184977	promoter,exon,CDS,gene body	1.23e-01	2.70e-01	-2.22e+00	2.62e-02	3.88e-02	-1.46e-01
BRCA	cg03785696	chr7:27184841	CGI:chr7:27184648-27184977	promoter,exon,CDS,gene body	9.52e-02	2.33e-01	-2.57e+00	1.03e-02	2.69e-02	-1.37e-01
BRCA	cg04619603	chr7:27184473	CGI:chr7:27184648-27184977	promoter,exon,CDS,gene body	1.44e-01	3.77e-01	-2.71e+00	6.78e-03	2.30e-02	-2.32e-01
BRCA	cg08863848	chr7:27184692	CGI:chr7:27184648-27184977	promoter,exon,CDS,gene body	6.64e-02	2.00e-01	-2.39e+00	1.69e-02	3.28e-02	-1.34e-01
BRCA	cg15623480	chr7:27184724	CGI:chr7:27184648-27184977	promoter,exon,CDS,gene body	8.88e-02	2.19e-01	-2.78e+00	5.40e-03	2.10e-02	-1.30e-01
BRCA	cg21447117	chr7:27185254	CGI:chr7:27185431-27186010	promoter	3.37e-01	6.34e-01	-3.16e+00	1.59e-03	1.21e-02	-2.97e-01
BRCA	cg26435572	chr7:27184063	CGI:chr7:27184648-27184977	promoter,gene body	3.18e-01	6.57e-01	-3.68e+00	2.31e-04	3.39e-03	-3.39e-01
BRCA	cg14785681	chr7:27184073	CGI:chr7:27184648-27184977	promoter,gene body	2.23e-01	4.54e-01	-3.03e+00	2.47e-03	1.51e-02	-2.31e-01
BRCA	cg24709033	chr7:27184949	CGI:chr7:27184648-27184977	promoter,exon,CDS,gene body	5.60e-01	7.72e-01	-3.00e+00	2.71e-03	1.57e-02	-2.13e-01
BRCA	cg17950095	chr7:27185081	CGI:chr7:27184648-27184977	promoter,exon,CDS,gene body	4.59e-01	5.99e-01	-2.18e+00	2.90e-02	4.04e-02	-1.40e-01
BRCA	cg08479590	chr7:27185176	CGI:chr7:27184648-27184977	promoter,gene body,CDS,UTR,exon	3.69e-01	5.34e-01	-2.43e+00	1.52e-02	3.15e-02	-1.65e-01
SARC	cg05311410	chr7:27185904	CGI:chr7:27185431-27186010	promoter	4.20e-01	5.38e-01	-2.50e+00	1.24e-02	2.12e-02	-1.18e-01
SARC	cg01729491	chr7:27186153	CGI:chr7:27185431-27186010	promoter	4.56e-01	5.67e-01	-2.92e+00	3.52e-03	8.93e-03	-1.11e-01
SARC	cg18978493	chr7:27186236	CGI:chr7:27185431-27186010	promoter	4.74e-01	5.91e-01	-2.95e+00	3.18e-03	8.32e-03	-1.17e-01
SARC	cg16038003	chr7:27186529	CGI:chr7:27185431-27186010	promoter	4.49e-01	5.71e-01	-3.22e+00	1.29e-03	4.25e-03	-1.23e-01
SARC	cg00705992	chr7:27186710	CGI:chr7:27185431-27186010	promoter	6.81e-01	7.99e-01	-2.73e+00	6.31e-03	1.35e-02	-1.18e-01
ACC	cg24709033	chr7:27184949	CGI:chr7:27184648-27184977	promoter,exon,CDS,gene body	1.58e-01	2.74e-01	-2.33e+00	1.98e-02	3.54e-02	-1.17e-01

Differentially expressed CpG sites between male tumor and male normal patients.

Cancer Type	CpG Site	Position	CpG Island	Position to Gene	ave1	ave2	wilcoxon.w	wilcoxon.p	padj	dBeta
KIRC	cg04709357	chr7:27183250	CGI:chr7:27184648-27184977	promoter,gene body	2.75e-01	1.66e-01	2.75e+00	5.98e-03	7.57e-03	1.09e-01
THCA	cg05977669	chr7:27185451	CGI:chr7:27185431-27186010	promoter	4.46e-01	2.86e-01	4.65e+00	3.30e-06	5.90e-05	1.60e-01
THCA	cg24446586	chr7:27185459	CGI:chr7:27185431-27186010	promoter	4.14e-01	2.79e-01	3.16e+00	1.59e-03	4.38e-03	1.34e-01
THCA	cg26435572	chr7:27184063	CGI:chr7:27184648-27184977	promoter,gene body	2.04e-01	9.08e-02	3.51e+00	4.55e-04	1.77e-03	1.14e-01
THCA	cg15916646	chr7:27185508	CGI:chr7:27185431-27186010	promoter	3.65e-01	2.64e-01	3.71e+00	2.09e-04	1.01e-03	1.01e-01
THCA	cg01729491	chr7:27186153	CGI:chr7:27185431-27186010	promoter	3.31e-01	2.22e-01	3.98e+00	6.88e-05	4.60e-04	1.10e-01
HNSC	cg08479590	chr7:27185176	CGI:chr7:27184648-27184977	promoter,gene body,CDS,UTR,exon	3.07e-01	1.73e-01	2.31e+00	2.09e-02	2.39e-02	1.34e-01
LUSC	cg27309564	chr7:27183478	CGI:chr7:27184648-27184977	promoter,gene body	4.20e-01	2.83e-01	2.56e+00	1.05e-02	1.44e-02	1.37e-01
LUSC	cg03767515	chr7:27183600	CGI:chr7:27184648-27184977	promoter,gene body	3.11e-01	6.76e-02	2.73e+00	6.39e-03	9.82e-03	2.44e-01
LUSC	cg13352750	chr7:27185504	CGI:chr7:27185431-27186010	promoter	4.59e-01	6.71e-02	4.11e+00	3.92e-05	5.33e-04	3.92e-01
LUSC	cg17466857	chr7:27185909	CGI:chr7:27185431-27186010	promoter	4.86e-01	3.17e-02	4.37e+00	1.26e-05	5.26e-04	4.54e-01
LUSC	cg12997720	chr7:27185439	CGI:chr7:27185431-27186010	promoter	4.90e-01	1.09e-01	3.64e+00	2.77e-04	1.16e-03	3.81e-01
LUSC	cg05977669	chr7:27185451	CGI:chr7:27185431-27186010	promoter	5.38e-01	3.42e-01	3.05e+00	2.31e-03	4.62e-03	1.96e-01
LUSC	cg24446586	chr7:27185459	CGI:chr7:27185431-27186010	promoter	5.30e-01	3.05e-01	3.22e+00	1.30e-03	3.09e-03	2.26e-01
LUSC	cg09661370	chr7:27185680	CGI:chr7:27185431-27186010	promoter	5.95e-01	2.80e-01	4.19e+00	2.76e-05	5.26e-04	3.16e-01
LUSC	cg26857670	chr7:27185829	CGI:chr7:27185431-27186010	promoter	4.71e-01	8.39e-02	4.20e+00	2.65e-05	5.26e-04	3.87e-01
LUSC	cg05311410	chr7:27185904	CGI:chr7:27185431-27186010	promoter	5.65e-01	2.47e-02	4.33e+00	1.47e-05	5.26e-04	5.40e-01
LUSC	cg04709357	chr7:27183250	CGI:chr7:27184648-27184977	promoter,gene body	4.07e-01	1.53e-01	3.36e+00	7.84e-04	2.21e-03	2.54e-01
LUSC	cg24932686	chr7:27185335	CGI:chr7:27185431-27186010	promoter	1.58e-01	5.58e-02	3.40e+00	6.84e-04	2.02e-03	1.02e-01
LUSC	cg15916646	chr7:27185508	CGI:chr7:27185431-27186010	promoter	5.55e-01	3.68e-01	3.67e+00	2.43e-04	1.08e-03	1.87e-01
LUSC	cg10767141	chr7:27185524	CGI:chr7:27185431-27186010	promoter	4.83e-01	1.28e-01	4.23e+00	2.29e-05	5.26e-04	3.55e-01
LUSC	cg15760840	chr7:27185603	CGI:chr7:27185431-27186010	promoter	4.20e-01	9.54e-02	4.04e+00	5.31e-05	5.65e-04	3.25e-01
LUSC	cg12810084	chr7:27185700	CGI:chr7:27185431-27186010	promoter	5.56e-01	2.50e-01	4.08e+00	4.52e-05	5.47e-04	3.06e-01
LUSC	cg09495769	chr7:27185723	CGI:chr7:27185431-27186010	promoter	4.58e-01	1.13e-01	4.16e+00	3.19e-05	5.26e-04	3.45e-01
LUSC	cg24988255	chr7:27185777	CGI:chr7:27185431-27186010	promoter	5.96e-01	2.16e-01	4.24e+00	2.20e-05	5.26e-04	3.80e-01
LUSC	cg15431544	chr7:27185857	CGI:chr7:27185431-27186010	promoter	4.98e-01	1.76e-01	4.17e+00	3.07e-05	5.26e-04	3.22e-01
LUSC	cg25901381	chr7:27185866	CGI:chr7:27185431-27186010	promoter	5.01e-01	1.31e-01	4.30e+00	1.70e-05	5.26e-04	3.70e-01
LUSC	cg10657141	chr7:27185924	CGI:chr7:27185431-27186010	promoter	5.08e-01	2.29e-01	4.20e+00	2.71e-05	5.26e-04	2.79e-01
LUSC	cg07116997	chr7:27186114	CGI:chr7:27185431-27186010	promoter	4.82e-01	1.83e-01	4.09e+00	4.34e-05	5.42e-04	3.00e-01
LUSC	cg01729491	chr7:27186153	CGI:chr7:27185431-27186010	promoter	5.96e-01	3.05e-01	4.13e+00	3.69e-05	5.31e-04	2.91e-01
LUSC	cg04340874	chr7:27186192	CGI:chr7:27185431-27186010	promoter	4.50e-01	2.36e-01	3.81e+00	1.39e-04	8.07e-04	2.14e-01
LUSC	cg18978493	chr7:27186236	CGI:chr7:27185431-27186010	promoter	5.32e-01	2.25e-01	4.05e+00	5.10e-05	5.60e-04	3.07e-01
LUSC	cg16608407	chr7:27186246	CGI:chr7:27185431-27186010	promoter	4.44e-01	2.31e-01	3.76e+00	1.71e-04	8.95e-04	2.13e-01
LUSC	cg04822748	chr7:27186278	CGI:chr7:27185431-27186010	promoter	4.22e-01	1.69e-01	3.98e+00	6.75e-05	6.04e-04	2.53e-01
LUSC	cg16038003	chr7:27186529	CGI:chr7:27185431-27186010	promoter	4.16e-01	2.19e-01	3.40e+00	6.72e-04	2.00e-03	1.97e-01
LUSC	cg00705992	chr7:27186710	CGI:chr7:27185431-27186010	promoter	7.57e-01	5.29e-01	4.11e+00	3.92e-05	5.33e-04	2.28e-01
BLCA	cg27309564	chr7:27183478	CGI:chr7:27184648-27184977	promoter,gene body	2.76e-01	1.72e-01	2.01e+00	4.48e-02	4.59e-02	1.04e-01
BLCA	cg13352750	chr7:27185504	CGI:chr7:27185431-27186010	promoter	3.73e-01	8.87e-02	3.54e+00	4.04e-04	1.13e-03	2.84e-01
BLCA	cg21447117	chr7:27185254	CGI:chr7:27185431-27186010	promoter	1.68e-01	2.74e-02	2.03e+00	4.21e-02	4.38e-02	1.40e-01
BLCA	cg12997720	chr7:27185439	CGI:chr7:27185431-27186010	promoter	3.66e-01	6.86e-02	2.66e+00	7.77e-03	1.16e-02	2.97e-01
BLCA	cg05977669	chr7:27185451	CGI:chr7:27185431-27186010	promoter	4.41e-01	2.08e-01	2.99e+00	2.83e-03	5.17e-03	2.34e-01
BLCA	cg24446586	chr7:27185459	CGI:chr7:27185431-27186010	promoter	4.15e-01	1.54e-01	2.78e+00	5.48e-03	8.76e-03	2.61e-01
BLCA	cg09661370	chr7:27185680	CGI:chr7:27185431-27186010	promoter	5.39e-01	2.99e-01	3.49e+00	4.79e-04	1.28e-03	2.40e-01
BLCA	cg04709357	chr7:27183250	CGI:chr7:27184648-27184977	promoter,gene body	3.32e-01	1.56e-01	2.82e+00	4.83e-03	7.92e-03	1.76e-01
BLCA	cg08479590	chr7:27185176	CGI:chr7:27184648-27184977	promoter,gene body,CDS,UTR,exon	2.42e-01	8.10e-02	2.21e+00	2.73e-02	3.12e-02	1.61e-01
BLCA	cg15916646	chr7:27185508	CGI:chr7:27185431-27186010	promoter	4.87e-01	2.47e-01	3.29e+00	9.97e-04	2.27e-03	2.40e-01
BLCA	cg15760840	chr7:27185603	CGI:chr7:27185431-27186010	promoter	3.58e-01	1.16e-01	3.16e+00	1.57e-03	3.24e-03	2.43e-01
BLCA	cg24988255	chr7:27185777	CGI:chr7:27185431-27186010	promoter	5.44e-01	2.23e-01	3.51e+00	4.46e-04	1.21e-03	3.21e-01
BLCA	cg10657141	chr7:27185924	CGI:chr7:27185431-27186010	promoter	4.72e-01	2.13e-01	3.48e+00	4.99e-04	1.32e-03	2.59e-01
BLCA	cg07116997	chr7:27186114	CGI:chr7:27185431-27186010	promoter	4.39e-01	2.09e-01	3.47e+00	5.20e-04	1.37e-03	2.30e-01
BLCA	cg01729491	chr7:27186153	CGI:chr7:27185431-27186010	promoter	5.41e-01	2.70e-01	3.55e+00	3.88e-04	1.09e-03	2.72e-01
BLCA	cg04340874	chr7:27186192	CGI:chr7:27185431-27186010	promoter	4.10e-01	2.45e-01	2.99e+00	2.76e-03	5.07e-03	1.65e-01
BLCA	cg16608407	chr7:27186246	CGI:chr7:27185431-27186010	promoter	4.21e-01	2.33e-01	3.30e+00	9.58e-04	2.20e-03	1.88e-01
BLCA	cg04822748	chr7:27186278	CGI:chr7:27185431-27186010	promoter	3.68e-01	2.07e-01	3.00e+00	2.69e-03	4.97e-03	1.62e-01
BLCA	cg16038003	chr7:27186529	CGI:chr7:27185431-27186010	promoter	4.02e-01	1.89e-01	3.38e+00	7.13e-04	1.75e-03	2.13e-01
LIHC	cg15623480	chr7:27184724	CGI:chr7:27184648-27184977	promoter,exon,CDS,gene body	1.99e-01	3.60e-02	3.30e+00	9.66e-04	1.54e-03	1.63e-01
LIHC	cg24709033	chr7:27184949	CGI:chr7:27184648-27184977	promoter,exon,CDS,gene body	5.95e-01	4.86e-01	3.38e+00	7.12e-04	1.17e-03	1.08e-01
KIRP	cg27309564	chr7:27183478	CGI:chr7:27184648-27184977	promoter,gene body	4.49e-01	3.42e-01	2.95e+00	3.15e-03	4.81e-03	1.07e-01
KIRP	cg05977669	chr7:27185451	CGI:chr7:27185431-27186010	promoter	4.97e-01	3.83e-01	2.63e+00	8.50e-03	1.12e-02	1.14e-01
KIRP	cg24446586	chr7:27185459	CGI:chr7:27185431-27186010	promoter	4.62e-01	3.57e-01	2.70e+00	6.84e-03	9.30e-03	1.06e-01
KIRP	cg24709033	chr7:27184949	CGI:chr7:27184648-27184977	promoter,exon,CDS,gene body	4.56e-01	3.31e-01	2.86e+00	4.25e-03	6.22e-03	1.25e-01
KIRP	cg10767141	chr7:27185524	CGI:chr7:27185431-27186010	promoter	3.61e-01	2.02e-01	2.84e+00	4.49e-03	6.51e-03	1.58e-01
KIRP	cg15760840	chr7:27185603	CGI:chr7:27185431-27186010	promoter	3.54e-01	2.06e-01	2.21e+00	2.73e-02	2.99e-02	1.47e-01
KIRP	cg25901381	chr7:27185866	CGI:chr7:27185431-27186010	promoter	4.12e-01	2.75e-01	2.67e+00	7.68e-03	1.03e-02	1.36e-01
KIRP	cg04340874	chr7:27186192	CGI:chr7:27185431-27186010	promoter	5.65e-01	4.30e-01	4.07e+00	4.60e-05	1.35e-04	1.35e-01
KIRP	cg16608407	chr7:27186246	CGI:chr7:27185431-27186010	promoter	5.42e-01	4.05e-01	4.16e+00	3.23e-05	1.00e-04	1.38e-01
KIRP	cg16038003	chr7:27186529	CGI:chr7:27185431-27186010	promoter	6.72e-01	4.74e-01	4.34e+00	1.39e-05	4.92e-05	1.99e-01
ESCA	cg17466857	chr7:27185909	CGI:chr7:27185431-27186010	promoter	4.54e-01	2.50e-01	1.99e+00	4.71e-02	4.87e-02	2.05e-01
ESCA	cg05311410	chr7:27185904	CGI:chr7:27185431-27186010	promoter	5.06e-01	2.67e-01	2.11e+00	3.45e-02	4.51e-02	2.39e-01
ESCA	cg12810084	chr7:27185700	CGI:chr7:27185431-27186010	promoter	5.29e-01	3.85e-01	1.99e+00	4.71e-02	4.87e-02	1.43e-01
ESCA	cg04340874	chr7:27186192	CGI:chr7:27185431-27186010	promoter	4.33e-01	2.92e-01	2.12e+00	3.36e-02	4.49e-02	1.41e-01
ESCA	cg18978493	chr7:27186236	CGI:chr7:27185431-27186010	promoter	5.12e-01	3.31e-01	2.09e+00	3.62e-02	4.56e-02	1.80e-01
ESCA	cg16608407	chr7:27186246	CGI:chr7:27185431-27186010	promoter	4.24e-01	2.79e-01	2.14e+00	3.20e-02	4.44e-02	1.45e-01
ESCA	cg00705992	chr7:27186710	CGI:chr7:27185431-27186010	promoter	6.96e-01	5.20e-01	2.45e+00	1.42e-02	3.78e-02	1.76e-01
CHOL	cg03785696	chr7:27184841	CGI:chr7:27184648-27184977	promoter,exon,CDS,gene body	2.14e-01	2.85e-02	2.65e+00	7.96e-03	1.92e-02	1.86e-01
CHOL	cg13352750	chr7:27185504	CGI:chr7:27185431-27186010	promoter	4.44e-01	5.02e-02	2.95e+00	3.19e-03	1.32e-02	3.94e-01
CHOL	cg17466857	chr7:27185909	CGI:chr7:27185431-27186010	promoter	4.86e-01	4.55e-02	3.10e+00	1.96e-03	1.07e-02	4.40e-01
CHOL	cg04619603	chr7:27184473	CGI:chr7:27184648-27184977	promoter,exon,CDS,gene body	3.30e-01	2.44e-02	2.06e+00	3.90e-02	4.26e-02	3.06e-01
CHOL	cg08863848	chr7:27184692	CGI:chr7:27184648-27184977	promoter,exon,CDS,gene body	1.45e-01	2.91e-02	2.14e+00	3.25e-02	3.87e-02	1.16e-01
CHOL	cg12997720	chr7:27185439	CGI:chr7:27185431-27186010	promoter	6.04e-01	1.31e-01	3.02e+00	2.51e-03	1.19e-02	4.73e-01
CHOL	cg05977669	chr7:27185451	CGI:chr7:27185431-27186010	promoter	5.83e-01	3.76e-01	2.43e+00	1.50e-02	2.65e-02	2.06e-01
CHOL	cg24446586	chr7:27185459	CGI:chr7:27185431-27186010	promoter	5.78e-01	2.98e-01	2.65e+00	7.96e-03	1.92e-02	2.80e-01
CHOL	cg09661370	chr7:27185680	CGI:chr7:27185431-27186010	promoter	4.71e-01	2.68e-01	2.06e+00	3.90e-02	4.26e-02	2.04e-01
CHOL	cg26857670	chr7:27185829	CGI:chr7:27185431-27186010	promoter	3.04e-01	7.14e-02	2.29e+00	2.23e-02	3.24e-02	2.32e-01
CHOL	cg05311410	chr7:27185904	CGI:chr7:27185431-27186010	promoter	5.33e-01	3.02e-02	3.10e+00	1.96e-03	1.07e-02	5.02e-01
CHOL	cg04709357	chr7:27183250	CGI:chr7:27184648-27184977	promoter,gene body	3.80e-01	1.29e-01	2.73e+00	6.38e-03	1.82e-02	2.52e-01
CHOL	cg08479590	chr7:27185176	CGI:chr7:27184648-27184977	promoter,gene body,CDS,UTR,exon	3.67e-01	1.76e-01	2.21e+00	2.70e-02	3.50e-02	1.92e-01
CHOL	cg15916646	chr7:27185508	CGI:chr7:27185431-27186010	promoter	5.91e-01	3.76e-01	2.73e+00	6.38e-03	1.82e-02	2.15e-01
CHOL	cg15760840	chr7:27185603	CGI:chr7:27185431-27186010	promoter	2.35e-01	8.16e-02	2.58e+00	9.87e-03	2.15e-02	1.53e-01
CHOL	cg12810084	chr7:27185700	CGI:chr7:27185431-27186010	promoter	4.71e-01	3.02e-01	2.06e+00	3.90e-02	4.26e-02	1.69e-01
CHOL	cg24988255	chr7:27185777	CGI:chr7:27185431-27186010	promoter	4.26e-01	2.06e-01	2.29e+00	2.23e-02	3.24e-02	2.20e-01
CHOL	cg15431544	chr7:27185857	CGI:chr7:27185431-27186010	promoter	4.33e-01	2.00e-01	2.58e+00	9.87e-03	2.15e-02	2.33e-01
CHOL	cg25901381	chr7:27185866	CGI:chr7:27185431-27186010	promoter	4.47e-01	1.51e-01	2.51e+00	1.22e-02	2.39e-02	2.96e-01
CHOL	cg10657141	chr7:27185924	CGI:chr7:27185431-27186010	promoter	5.24e-01	2.96e-01	2.80e+00	5.09e-03	1.63e-02	2.28e-01
CHOL	cg07116997	chr7:27186114	CGI:chr7:27185431-27186010	promoter	4.59e-01	1.41e-01	2.88e+00	4.04e-03	1.47e-02	3.18e-01
CHOL	cg01729491	chr7:27186153	CGI:chr7:27185431-27186010	promoter	5.74e-01	2.56e-01	2.80e+00	5.09e-03	1.63e-02	3.19e-01
CHOL	cg04340874	chr7:27186192	CGI:chr7:27185431-27186010	promoter	3.36e-01	1.64e-01	1.99e+00	4.65e-02	4.65e-02	1.72e-01
CHOL	cg18978493	chr7:27186236	CGI:chr7:27185431-27186010	promoter	5.49e-01	1.88e-01	3.54e+00	4.02e-04	8.32e-03	3.61e-01
CHOL	cg16608407	chr7:27186246	CGI:chr7:27185431-27186010	promoter	4.65e-01	1.70e-01	3.17e+00	1.52e-03	1.07e-02	2.95e-01
CHOL	cg04822748	chr7:27186278	CGI:chr7:27185431-27186010	promoter	4.08e-01	1.09e-01	3.39e+00	6.96e-04	9.20e-03	2.99e-01
CHOL	cg16038003	chr7:27186529	CGI:chr7:27185431-27186010	promoter	4.50e-01	1.13e-01	3.54e+00	4.02e-04	8.32e-03	3.38e-01
CHOL	cg00705992	chr7:27186710	CGI:chr7:27185431-27186010	promoter	7.64e-01	4.46e-01	3.54e+00	4.02e-04	8.32e-03	3.18e-01

Differentially expressed CpG sites between female tumor and female normal patients.

Cancer Type	CpG Site	Position	CpG Island	Position to Gene	ave1	ave2	wilcoxon.w	wilcoxon.p	padj	dBeta
BRCA	cg03767515	chr7:27183600	CGI:chr7:27184648-27184977	promoter,gene body	2.00e-01	8.28e-02	5.01e+00	5.57e-07	1.06e-06	1.18e-01
BRCA	cg09219451	chr7:27184504	CGI:chr7:27184648-27184977	promoter,exon,CDS,gene body	1.23e-01	2.26e-02	5.55e+00	2.84e-08	6.10e-08	1.00e-01
BRCA	cg13352750	chr7:27185504	CGI:chr7:27185431-27186010	promoter	4.45e-01	2.73e-01	8.72e+00	2.80e-18	1.32e-17	1.72e-01
BRCA	cg17466857	chr7:27185909	CGI:chr7:27185431-27186010	promoter	5.45e-01	3.44e-01	8.66e+00	4.91e-18	2.26e-17	2.01e-01
BRCA	cg04619603	chr7:27184473	CGI:chr7:27184648-27184977	promoter,exon,CDS,gene body	1.44e-01	1.79e-02	6.32e+00	2.64e-10	6.73e-10	1.27e-01
BRCA	cg21447117	chr7:27185254	CGI:chr7:27185431-27186010	promoter	3.37e-01	1.01e-01	6.50e+00	8.13e-11	2.15e-10	2.36e-01
BRCA	cg12997720	chr7:27185439	CGI:chr7:27185431-27186010	promoter	6.19e-01	4.04e-01	9.65e+00	4.78e-22	3.09e-21	2.15e-01
BRCA	cg05977669	chr7:27185451	CGI:chr7:27185431-27186010	promoter	6.34e-01	4.96e-01	9.66e+00	4.64e-22	3.00e-21	1.38e-01
BRCA	cg24446586	chr7:27185459	CGI:chr7:27185431-27186010	promoter	6.13e-01	4.73e-01	9.83e+00	8.67e-23	5.98e-22	1.40e-01
BRCA	cg09661370	chr7:27185680	CGI:chr7:27185431-27186010	promoter	5.99e-01	4.93e-01	8.98e+00	2.74e-19	1.40e-18	1.06e-01
BRCA	cg26857670	chr7:27185829	CGI:chr7:27185431-27186010	promoter	4.52e-01	3.31e-01	7.61e+00	2.76e-14	9.52e-14	1.21e-01
BRCA	cg05311410	chr7:27185904	CGI:chr7:27185431-27186010	promoter	6.33e-01	4.16e-01	9.19e+00	3.83e-20	2.10e-19	2.16e-01
BRCA	cg26435572	chr7:27184063	CGI:chr7:27184648-27184977	promoter,gene body	3.18e-01	1.21e-01	5.45e+00	5.13e-08	1.08e-07	1.97e-01
BRCA	cg14785681	chr7:27184073	CGI:chr7:27184648-27184977	promoter,gene body	2.23e-01	7.01e-02	5.83e+00	5.43e-09	1.24e-08	1.53e-01
BRCA	cg24709033	chr7:27184949	CGI:chr7:27184648-27184977	promoter,exon,CDS,gene body	5.60e-01	4.17e-01	6.71e+00	1.91e-11	5.32e-11	1.42e-01
BRCA	cg17950095	chr7:27185081	CGI:chr7:27184648-27184977	promoter,exon,CDS,gene body	4.59e-01	3.48e-01	6.74e+00	1.59e-11	4.46e-11	1.11e-01
BRCA	cg08479590	chr7:27185176	CGI:chr7:27184648-27184977	promoter,gene body,CDS,UTR,exon	3.69e-01	2.55e-01	4.94e+00	7.65e-07	1.44e-06	1.14e-01
BRCA	cg15916646	chr7:27185508	CGI:chr7:27185431-27186010	promoter	6.16e-01	4.29e-01	1.28e+01	1.22e-37	5.73e-36	1.87e-01
BRCA	cg10767141	chr7:27185524	CGI:chr7:27185431-27186010	promoter	4.69e-01	2.96e-01	9.47e+00	2.80e-21	1.69e-20	1.73e-01
BRCA	cg24988255	chr7:27185777	CGI:chr7:27185431-27186010	promoter	6.09e-01	4.90e-01	7.70e+00	1.38e-14	4.88e-14	1.19e-01
BRCA	cg15431544	chr7:27185857	CGI:chr7:27185431-27186010	promoter	5.14e-01	3.96e-01	8.59e+00	8.59e-18	3.88e-17	1.18e-01
BRCA	cg25901381	chr7:27185866	CGI:chr7:27185431-27186010	promoter	5.04e-01	3.60e-01	9.66e+00	4.33e-22	2.81e-21	1.45e-01
BRCA	cg10657141	chr7:27185924	CGI:chr7:27185431-27186010	promoter	5.50e-01	4.40e-01	9.04e+00	1.61e-19	8.37e-19	1.10e-01
BRCA	cg01729491	chr7:27186153	CGI:chr7:27185431-27186010	promoter	6.56e-01	5.35e-01	9.26e+00	2.06e-20	1.15e-19	1.20e-01
BRCA	cg16038003	chr7:27186529	CGI:chr7:27185431-27186010	promoter	5.12e-01	6.15e-01	-4.68e+00	2.92e-06	5.18e-06	-1.02e-01
LUAD	cg27309564	chr7:27183478	CGI:chr7:27184648-27184977	promoter,gene body	3.90e-01	2.58e-01	3.17e+00	1.54e-03	4.27e-03	1.32e-01
HNSC	cg21447117	chr7:27185254	CGI:chr7:27185431-27186010	promoter	2.04e-01	3.78e-02	1.98e+00	4.78e-02	4.82e-02	1.66e-01
HNSC	cg16038003	chr7:27186529	CGI:chr7:27185431-27186010	promoter	4.00e-01	2.84e-01	2.14e+00	3.25e-02	3.74e-02	1.16e-01
HNSC	cg00705992	chr7:27186710	CGI:chr7:27185431-27186010	promoter	7.58e-01	6.05e-01	3.28e+00	1.04e-03	9.05e-03	1.53e-01
LIHC	cg15760840	chr7:27185603	CGI:chr7:27185431-27186010	promoter	2.80e-01	9.82e-02	3.48e+00	4.98e-04	1.31e-03	1.82e-01
LIHC	cg09495769	chr7:27185723	CGI:chr7:27185431-27186010	promoter	2.81e-01	1.41e-01	1.97e+00	4.89e-02	4.90e-02	1.40e-01

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Exon skipping events with PSI in TCGA for HOXA11

∗Please access ExonSkipDB for exon skipping annotation.

Differentially expressed exon skipping events between male tumor and female tumor patients.

Cancer Type

Exon Skipping

ave.female_T

ave.female_N

wilcoxon.w

wilcoxon.p

padj

dPSI

Differentially expressed exon skipping events between male tumor and male normal patients.

Cancer Type

Exon Skipping

ave.female_T

ave.female_N

wilcoxon.w

wilcoxon.p

padj

dPSI

Differentially expressed exon skipping events between female tumor and female normal patients.

Cancer Type

Exon Skipping

ave.female_T

ave.female_N

wilcoxon.w

wilcoxon.p

padj

dPSI

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RNA A-to-I editing events in TCGA for HOXA11

∗Please access CAeditome for RNA editing annotation.

Differentially expressed RNA editing events between male tumor and female tumor patients.

Cancer Type

Transcript

Editing

ave.male_T

ave.female_T

wilcoxon.w

wilcoxon.p

p_adj

dFre

Differentially expressed RNA editing events between male tumor and male normal patients.

Cancer Type

Transcript

Editing

ave.male_T

ave.female_T

wilcoxon.w

wilcoxon.p

p_adj

dFre

Differentially expressed RNA editing events between female tumor and female normal patients.

Cancer Type

Transcript

Editing

ave.male_T

ave.female_T

wilcoxon.w

wilcoxon.p

p_adj

dFre

Protein coding RNA editing(s).

Editing Position

Variant Type

Gene Symbol

Transcript ID

NTchange

AAchange

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Sex-biased TF-Gene network for HOXA11

TFs related to HOXA11.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.

Cancer Type	TF	Target Gene	Male Edge Score	Male Edge Threshold	Female Edge Score	Female Edge Threshold	Type
BRCA	KLF3	HOXA11	2.08e+00	2.88e-04	4.37e+00	9.87e-01	Female-biased
BRCA	PATZ1	HOXA11	1.98e+00	2.49e-04	4.32e+00	9.86e-01	Female-biased
BRCA	PLAG1	HOXA11	2.13e+00	4.95e-04	4.28e+00	9.85e-01	Female-biased
BRCA	PRDM6	HOXA11	4.29e+00	9.90e-01	1.17e+00	2.45e-05	Male-biased
BRCA	ZIM2	HOXA11	2.44e+00	1.79e-03	4.19e+00	9.81e-01	Female-biased
BRCA	ZNF141	HOXA11	2.20e+00	2.08e-04	4.59e+00	9.92e-01	Female-biased
BRCA	ZNF182	HOXA11	4.23e+00	9.88e-01	1.44e+00	6.85e-05	Male-biased
BRCA	ZNF22	HOXA11	4.18e+00	9.88e-01	1.30e+00	5.11e-05	Male-biased
BRCA	ZNF225	HOXA11	4.24e+00	9.89e-01	1.43e+00	6.45e-05	Male-biased
BRCA	ZNF23	HOXA11	2.37e+00	1.14e-03	4.27e+00	9.84e-01	Female-biased
BRCA	ZNF235	HOXA11	4.74e+00	9.95e-01	1.00e+00	4.19e-06	Male-biased
BRCA	ZNF28	HOXA11	2.14e+00	2.10e-04	4.52e+00	9.91e-01	Female-biased
BRCA	ZNF287	HOXA11	4.60e+00	9.94e-01	1.24e+00	1.19e-05	Male-biased
BRCA	ZNF300	HOXA11	2.21e+00	7.00e-04	4.25e+00	9.84e-01	Female-biased
BRCA	ZNF320	HOXA11	2.57e+00	2.55e-03	4.20e+00	9.80e-01	Female-biased
BRCA	ZNF37A	HOXA11	2.45e+00	1.60e-03	4.24e+00	9.82e-01	Female-biased
BRCA	ZNF460	HOXA11	2.43e+00	9.18e-04	4.39e+00	9.87e-01	Female-biased
BRCA	ZNF487	HOXA11	4.49e+00	9.93e-01	1.29e+00	1.92e-05	Male-biased
BRCA	ZNF492	HOXA11	4.08e+00	9.85e-01	1.67e+00	2.58e-04	Male-biased
BRCA	ZNF530	HOXA11	2.43e+00	1.34e-03	4.28e+00	9.84e-01	Female-biased
BRCA	ZNF611	HOXA11	2.37e+00	1.43e-03	4.19e+00	9.81e-01	Female-biased
BRCA	ZNF613	HOXA11	3.93e+00	9.81e-01	1.63e+00	3.65e-04	Male-biased
BRCA	ZNF641	HOXA11	3.05e+00	3.60e-03	4.59e+00	9.88e-01	Female-biased
BRCA	ZNF662	HOXA11	2.35e+00	1.12e-03	4.25e+00	9.83e-01	Female-biased
BRCA	ZNF740	HOXA11	2.06e+00	2.48e-04	4.40e+00	9.88e-01	Female-biased
BRCA	ZNF816	HOXA11	2.31e+00	5.00e-04	4.45e+00	9.89e-01	Female-biased
BRCA	ZNF98	HOXA11	4.17e+00	9.87e-01	1.69e+00	1.96e-04	Male-biased
MESO	ZNF611	HOXA11	4.53e+00	9.81e-01	3.40e+00	1.27e-02	Male-biased
READ	INSM1	HOXA11	4.11e+00	9.82e-01	2.96e+00	2.56e-03	Male-biased
READ	KLF3	HOXA11	4.17e+00	9.81e-01	3.16e+00	4.57e-03	Male-biased
READ	PATZ1	HOXA11	4.18e+00	9.83e-01	3.09e+00	3.30e-03	Male-biased
READ	PLAG1	HOXA11	4.20e+00	9.83e-01	3.09e+00	3.15e-03	Male-biased
READ	ZNF141	HOXA11	4.30e+00	9.84e-01	3.32e+00	5.10e-03	Male-biased
READ	ZNF28	HOXA11	4.44e+00	9.87e-01	3.38e+00	3.76e-03	Male-biased
READ	ZNF300	HOXA11	4.20e+00	9.84e-01	3.09e+00	3.09e-03	Male-biased
READ	ZNF460	HOXA11	4.25e+00	9.82e-01	3.32e+00	6.20e-03	Male-biased
READ	ZNF662	HOXA11	4.25e+00	9.84e-01	3.19e+00	3.68e-03	Male-biased
READ	ZNF740	HOXA11	4.17e+00	9.82e-01	3.12e+00	3.84e-03	Male-biased
READ	ZNF816	HOXA11	4.36e+00	9.87e-01	3.22e+00	2.73e-03	Male-biased

HOXA11 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for HOXA11

RBPs related to ES in HOXA11.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.

Cancer Type

RBP

Target ES

Male Edge Score

Male Edge Threshold

Female Edge Score

Female Edge Threshold

Type

HOXA11 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

Sex-biased CeRNA regulation of gene.

Gene ID	ceRNA(lncRNA-miRNA-mRNA)	Group	Cancer Type
ENSG00000005073	LINC01649,hsa-mir-335,HOXA11	Tumor-specific sex-biased ceRNA	TCGA-KIRP
ENSG00000005073	AC007938.2,hsa-mir-335,HOXA11	Tumor-specific sex-biased ceRNA	TCGA-KIRP

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Sex-biased eQTL regulation of gene

Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).

eQTL

Description

Male-specific eQTL regulation.

SNP ID	SNP Info	Position to Gene	Effect Score	FDR	Cancer Type	Biased Type
rs2049725	chr7:18157924:G:C	-	0.203872055259214	0.00542462283875364	BLCA	Female-baised eQTL
rs17138717	chr7:18167403:T:C	-	0.186566932452409	0.0165543982981223	BLCA	Female-baised eQTL
rs73682657	chr7:21636776:G:A	-	0.156811194647696	0.0200986394240033	BLCA	Female-baised eQTL
rs73078403	chr7:20049583:T:A	-	0.204929938101445	0.0314978758542858	BLCA	Female-baised eQTL
rs73078405	chr7:20049584:C:A	-	0.204929938101445	0.0314978758542858	BLCA	Female-baised eQTL
rs60253697	chr7:21461000:G:C	-	0.209315001353959	0.0372517527491767	BLCA	Female-baised eQTL
rs1637634	chr7:18128111:C:T	-	0.120359639664907	0.0478819396914124	BLCA	Female-baised eQTL
rs1528678	chr7:18153258:A:T	-	0.151339421454018	0.0479868932912042	BLCA	Female-baised eQTL
rs1528677	chr7:18153318:A:C	-	0.151339421454018	0.0479868932912042	BLCA	Female-baised eQTL
rs6971014	chr7:18154096:T:C	-	0.151339421454018	0.0479868932912042	BLCA	Female-baised eQTL

Female-specific eQTL regulation.

SNP ID	SNP Info	Position to Gene	Effect Score	FDR	Cancer Type	Biased Type
rs74692172	chr7:20337338:A:G	-	0.0767340423326544	0.0294603606248299	BLCA	Male-baised eQTL
rs17142711	chr7:20337608:T:A	-	0.0767340423326544	0.0294603606248299	BLCA	Male-baised eQTL

Opposite sex-biased eQTL regulation.

SNP ID

SNP Info

Position to Gene

Male Effect

Male FDR

Female Effect

Female FDR

Sex-biased Gene in Cancer

Cancer Type

Top

Sex-biased eQTM regulation of gene

Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).

eQTM	Description
	Gene ID: ENSG00000005073
	CpG Site: cg12810084
	Position to Gene: promoter
	Male Effect: -
	Female Effect: -0.29066285968799
	Gene ID: ENSG00000005073
	CpG Site: cg25901381
	Position to Gene: promoter
	Male Effect: -
	Female Effect: -0.292194459891672
	Gene ID: ENSG00000005073
	CpG Site: cg05516617
	Position to Gene: gene,exon,UTR
	Male Effect: -0.462342349691844
	Female Effect: -

Male-specific eQTM regulation.

CpG Site	CpG Postion	Position to Gene	Effect Score	FDR	Cor.r	Cor.Pvalue	Cancer Type
cg05516617	chr7:27182070	gene,exon,UTR	-0.462342349691844	1.51938230527169e-10	-0.4624360229768305	4.682198774650817e-13	STAD

Female-specific eQTM regulation.

CpG Site	CpG Postion	Position to Gene	Effect Score	FDR	Cor.r	Cor.Pvalue	Cancer Type
cg12810084	chr7:27185700	promoter	-0.29066285968799	9.97658579690782e-08	-0.515119023826847	3.953218943682436e-11	SARC
cg25901381	chr7:27185866	promoter	-0.292194459891672	7.45389021664368e-07	-0.47513579808567363	1.773462462822915e-09	SARC

Opposite sex-biased eQTM regulation.

CpG Site

CpG Postion

CpG Island

Position to Gene

Male Effect

Male FDR

Female Effect

Female FDR

Male Cor

Male P-value

Female Cor

Female P-value

Sex-biased Coding Gene

Cancer Type

Top

Sex-biased sQTL regulation of gene

Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).

sQTL

Description

Male-specific sQTL regulation.

ES ID

Skipped Exon

ORF Anno

SNP ID

SNP Info

SNP Position to ES

Effect Score

FDR

Cancer Type

Biased Type

Female-specific sQTL regulation.

ES ID

Skipped Exon

ORF Anno

SNP ID

SNP Info

SNP Position to ES

Effect Score

FDR

Cancer Type

Biased Type

Opposite sex-biased sQTL regulation.

ES ID

Skipped Exon

ORF Anno

SNP ID

SNP Info

SNP Position to ES

Male Effect

Male FDR

Female Effect

Female FDR

Cancer Type

Top

Sex-biased sQTM regulation of gene

Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).

sQTM

Description

Male-specific sQTM regulation.

EX ID

Skipped Exon

CPG Site

CPG Position

Position to EX Events

Effect Score

FDR

Cor.r

Cor.Pvalue

ORF_anno

Cancer Type

Female-specific sQTM regulation.

EX ID

Skipped Exon

CPG Site

CPG Position

Position to EX Events

Effect Score

FDR

Cor.r

Cor.Pvalue

ORF_anno

Cancer Type

Opposite sex-biased sQTM regulation.

EX ID

EX Info

Skipped Exon

CPG Site

CPG Position

CPG Island

Position to EX Events

Male Effect

Male FDR

Female Effect

Female FDR

Male Correlation

Male P-value

Female Correlation

Female P-value

ORF_anno

Cancer Type

Top

Related disease information of HOXA11

Diseases associated with this gene (DisGeNET).

Gene ID	Gene Symbol	Disease ID	Disease Name	Number of PMID	Source
ENSG00000005073	HOXA11	C0014170	Endometrial Neoplasms	1	CTD_human
ENSG00000005073	HOXA11	C0022658	Kidney Diseases	1	CTD_human
ENSG00000005073	HOXA11	C0206762	Limb Deformities, Congenital	1	CTD_human
ENSG00000005073	HOXA11	C0476089	Endometrial Carcinoma	1	CTD_human
ENSG00000005073	HOXA11	C1720887	Female Urogenital Diseases	1	CTD_human
ENSG00000005073	HOXA11	C1854273	Radioulnar Synostosis with Amegakaryocytic Thrombocytopenia	1	CTD_human

	Gene summary
	Gene structure and Gene expression level
	Sex-biased somatic mutation
	DNA methylation with beta values in gene
	Exon skipping events with PSI in TCGA
	RNA A-to-I editing events in TCGA
	Sex-biased TF-Gene network of gene
	Sex-biased RBP-ES network of gene
	Sex-biased CeRNA regulation of gene
	Sex-biased eQTL regulation of gene
	Sex-biased eQTM regulation of gene
	Sex-biased sQTL regulation of gene
	Sex-biased sQTM regulation of gene
	Related disease information of gene