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Gene: ENSG00000003509 |
Summary for NDUFAF7 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000003509 | Gene symbol | NDUFAF7 |
| Gene name | NADH:ubiquinone oxidoreductase complex assembly factor 7 | |
| HGNC | 28816 | |
| Entrez ID | 55471 | |
| Gene type | protein_coding | |
| Synonyms | NDUFAF7|PRO1853|MidA | |
| UniProtAcc | Q7L592 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for NDUFAF7 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for NDUFAF7 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for NDUFAF7 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for NDUFAF7 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for NDUFAF7 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for NDUFAF7 |
| TFs related to NDUFAF7. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ESCA | ZNF235 | NDUFAF7 | 3.84e+00 | 9.81e-01 | 2.89e+00 | 2.55e-03 | Male-biased |
| NDUFAF7 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for NDUFAF7 |
| RBPs related to ES in NDUFAF7. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| STAD | ZCRB1 | exon_skip_324959 | 1.24e+01 | 1.35e-02 | 1.27e+01 | 9.86e-01 | Female-biased |
| THYM | ZCRB1 | exon_skip_324959 | 1.25e+01 | 7.06e-04 | 1.31e+01 | 9.99e-01 | Female-biased |
| LUAD | ZCRB1 | exon_skip_324959 | 1.25e+01 | 3.70e-03 | 1.29e+01 | 9.96e-01 | Female-biased |
| KIRP | ZCRB1 | exon_skip_324959 | 1.26e+01 | 1.00e-03 | 1.32e+01 | 9.99e-01 | Female-biased |
| ESCA | ZCRB1 | exon_skip_324959 | 1.20e+01 | 8.83e-03 | 1.24e+01 | 9.91e-01 | Female-biased |
| PCPG | ZCRB1 | exon_skip_324959 | 1.27e+01 | 1.54e-03 | 1.32e+01 | 9.98e-01 | Female-biased |
| LGG | ZCRB1 | exon_skip_324959 | 1.28e+01 | 9.97e-01 | 1.24e+01 | 2.93e-03 | Male-biased |
| SKCM | ZCRB1 | exon_skip_324959 | 1.29e+01 | 9.99e-01 | 1.24e+01 | 1.17e-03 | Male-biased |
| NDUFAF7 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs75424859 | chr2:43136854:T:G | - | 0.159627088245284 | 0.0331098941592538 | PCPG | Female-baised eQTL |
| rs79529395 | chr2:43137647:A:G | - | 0.159627088245284 | 0.0331098941592538 | PCPG | Female-baised eQTL |
| rs61559333 | chr2:43138186:G:A | - | 0.159627088245284 | 0.0331098941592538 | PCPG | Female-baised eQTL |
| rs72870265 | chr2:43138938:A:T | - | 0.159627088245284 | 0.0331098941592538 | PCPG | Female-baised eQTL |
| rs113714293 | chr2:43139280:C:T | - | 0.159627088245284 | 0.0331098941592538 | PCPG | Female-baised eQTL |
| rs17030418 | chr2:43140311:G:A | - | 0.159231668940274 | 0.0337443865805338 | PCPG | Female-baised eQTL |
| rs11896914 | chr2:37677509:C:T | - | 0.161027922752804 | 0.0273265938129351 | LUSC | Female-baised eQTL |
| rs111673372 | chr2:37691305:G:A | - | 0.151272726914662 | 0.0345574507400274 | LUSC | Female-baised eQTL |
| rs10179712 | chr2:31301398:A:G | - | 0.146818223018838 | 0.0148071060409544 | STAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs13002345 | chr2:37514434:G:T | - | -0.0596524411368224 | 0.0393563779294166 | LGG | Male-baised eQTL |
| rs13002004 | chr2:37514435:C:T | - | -0.0596524411368224 | 0.0393563779294166 | LGG | Male-baised eQTL |
| rs72859373 | chr2:31216988:C:A | - | 0.0882845019190608 | 0.0260934032131833 | KIRC | Male-baised eQTL |
| rs11675973 | chr2:36215925:G:A | - | -0.0499092407115528 | 0.0432953280894494 | KIRC | Male-baised eQTL |
| rs13405170 | chr2:36189649:A:G | - | 0.0614693436977171 | 0.0452150365754733 | KIRC | Male-baised eQTL |
| rs13430794 | chr2:36189530:G:T | - | 0.061345537135925 | 0.0458769064454947 | KIRC | Male-baised eQTL |
| rs4553801 | chr2:36218911:A:G | - | -0.0537037633794395 | 0.0478158020140542 | KIRC | Male-baised eQTL |
| rs4580429 | chr2:46664315:C:G | - | 0.0505779647774008 | 0.0490964327387737 | KIRC | Male-baised eQTL |
| rs13430287 | chr2:36189080:G:C | - | 0.0606648138021072 | 0.0498782510589157 | KIRC | Male-baised eQTL |
| rs10514787 | chr2:43703570:A:G | - | -0.0583934181434446 | 0.0336782036562301 | LUAD | Male-baised eQTL |
| rs10200337 | chr2:28038807:C:T | - | 0.0775244555815444 | 0.000170254831758155 | COAD | Male-baised eQTL |
| rs62133669 | chr2:34111544:C:T | - | 0.0968763978781061 | 0.000418523877479749 | COAD | Male-baised eQTL |
| rs59073173 | chr2:43138192:T:G | - | 0.0994067593964283 | 0.00309940467576542 | COAD | Male-baised eQTL |
| rs17510483 | chr2:37717282:C:T | - | 0.114913879129686 | 0.00605219014551798 | COAD | Male-baised eQTL |
| rs12104627 | chr2:35285913:A:T | - | 0.0646360537545021 | 0.00803056861623596 | COAD | Male-baised eQTL |
| rs6726118 | chr2:41607201:G:C | - | 0.127184242850388 | 0.0119612263205998 | COAD | Male-baised eQTL |
| rs79529395 | chr2:43137647:A:G | - | 0.103976848100743 | 0.0130940396742668 | COAD | Male-baised eQTL |
| rs11127241 | chr2:29857762:T:C | - | -0.0629036248755597 | 0.0150863694890381 | COAD | Male-baised eQTL |
| rs10200581 | chr2:33636226:C:A | - | 0.136825802886221 | 0.01538272459939 | COAD | Male-baised eQTL |
| rs7567732 | chr2:29548644:A:G | - | -0.116843482589571 | 0.0162119297626973 | COAD | Male-baised eQTL |
| rs72870265 | chr2:43138938:A:T | - | 0.102654403604004 | 0.0167427483349537 | COAD | Male-baised eQTL |
| rs113714293 | chr2:43139280:C:T | - | 0.102654403604004 | 0.0167427483349537 | COAD | Male-baised eQTL |
| rs114140811 | chr2:43966762:A:T | - | 0.0766326658233392 | 0.0167962261527761 | COAD | Male-baised eQTL |
| rs17031783 | chr2:43967740:C:T | - | 0.0766326658233392 | 0.0167962261527761 | COAD | Male-baised eQTL |
| rs12475386 | chr2:39866941:C:T | - | -0.0657752447123974 | 0.017077718973508 | COAD | Male-baised eQTL |
| rs62135103 | chr2:43958660:G:A | - | 0.0748029970486954 | 0.0176467100646966 | COAD | Male-baised eQTL |
| rs72880631 | chr2:45429214:G:A | - | 0.0843827298010719 | 0.0195752827795805 | COAD | Male-baised eQTL |
| rs146661665 | chr2:45430060:C:T | - | 0.0843827298010719 | 0.0195752827795805 | COAD | Male-baised eQTL |
| rs72880622 | chr2:45420959:C:T | - | 0.0843755696738656 | 0.0197345822752239 | COAD | Male-baised eQTL |
| rs6708163 | chr2:43138100:C:T | - | 0.103473637788607 | 0.0208004089264235 | COAD | Male-baised eQTL |
| rs144680070 | chr2:45431359:T:G | - | 0.0865657730171192 | 0.0214730048700244 | COAD | Male-baised eQTL |
| rs6734661 | chr2:45774286:G:A | - | 0.105826133543639 | 0.0228881218762174 | COAD | Male-baised eQTL |
| rs3915409 | chr2:45348878:G:A | - | 0.0764220294778229 | 0.0233633528461851 | COAD | Male-baised eQTL |
| rs72869110 | chr2:33639592:A:T | - | 0.128381618646514 | 0.0257784808405526 | COAD | Male-baised eQTL |
| rs71422154 | chr2:45350216:G:C | - | 0.0760119348105089 | 0.0261154390277314 | COAD | Male-baised eQTL |
| rs61559333 | chr2:43138186:G:A | - | 0.102547140157571 | 0.0271786076043942 | COAD | Male-baised eQTL |
| rs3770271 | chr2:45478521:G:T | - | 0.0744221232278962 | 0.0280922124185177 | COAD | Male-baised eQTL |
| rs10199608 | chr2:33641029:G:C | - | 0.126996342928015 | 0.0286755814758182 | COAD | Male-baised eQTL |
| rs77602453 | chr2:43140389:G:A | - | 0.0983193993446893 | 0.0290301270795386 | COAD | Male-baised eQTL |
| rs6754449 | chr2:45531231:A:C | - | 0.0549692343021061 | 0.0304340682773922 | COAD | Male-baised eQTL |
| rs11692413 | chr2:39863058:C:T | - | -0.0611604646239659 | 0.0305495158374135 | COAD | Male-baised eQTL |
| rs147248043 | chr2:45426303:C:T | - | 0.0798772056362804 | 0.0327114586024496 | COAD | Male-baised eQTL |
| rs4953237 | chr2:45531809:G:C | - | 0.0578509361645642 | 0.0327866350096557 | COAD | Male-baised eQTL |
| rs7594257 | chr2:38507293:G:A | - | 0.093809190802937 | 0.0353159898180369 | COAD | Male-baised eQTL |
| rs2278777 | chr2:46144515:T:G | - | 0.128470977889674 | 0.0356512765535723 | COAD | Male-baised eQTL |
| rs4952765 | chr2:45531929:G:T | - | 0.0573006340022612 | 0.0386748456491658 | COAD | Male-baised eQTL |
| rs2033649 | chr2:45533440:A:G | - | 0.0523573028566706 | 0.0388540432239927 | COAD | Male-baised eQTL |
| rs75424859 | chr2:43136854:T:G | - | 0.0968741929236833 | 0.0391877946068373 | COAD | Male-baised eQTL |
| rs13015575 | chr2:45479922:G:C | - | 0.0712715805351377 | 0.0392605165719553 | COAD | Male-baised eQTL |
| rs13023856 | chr2:45371578:T:C | - | 0.0766919419411254 | 0.0400241323525062 | COAD | Male-baised eQTL |
| rs77082450 | chr2:45378192:C:G | - | 0.0758848236647171 | 0.0401803379883186 | COAD | Male-baised eQTL |
| rs35552039 | chr2:45409234:T:C | - | 0.0757793694439224 | 0.0408077337059322 | COAD | Male-baised eQTL |
| rs1971866 | chr2:30039676:C:G | - | 0.0528281198295542 | 0.0416613185157316 | COAD | Male-baised eQTL |
| rs34872821 | chr2:46362072:C:T | - | 0.0752698796544067 | 0.0424510601788586 | COAD | Male-baised eQTL |
| rs6544826 | chr2:45539819:G:A | - | 0.0565784319111935 | 0.0440053645948981 | COAD | Male-baised eQTL |
| rs79668138 | chr2:45481372:G:A | - | 0.0703892514895397 | 0.0450227366307752 | COAD | Male-baised eQTL |
| rs2609914 | chr2:30739131:C:A | - | 0.0477456968244648 | 0.0463345893861188 | COAD | Male-baised eQTL |
| rs3821060 | chr2:45528634:T:A | - | 0.0553097523596374 | 0.0465971754030798 | COAD | Male-baised eQTL |
| rs3821061 | chr2:45528730:G:A | - | 0.0553097523596374 | 0.0465971754030798 | COAD | Male-baised eQTL |
| rs6718425 | chr2:45529499:G:A | - | 0.0553097523596374 | 0.0465971754030798 | COAD | Male-baised eQTL |
| rs7591686 | chr2:45528529:A:G | - | 0.055306500028992 | 0.0471103168629044 | COAD | Male-baised eQTL |
| rs7591687 | chr2:45528530:A:G | - | 0.055306500028992 | 0.0471103168629044 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_324931 | chr2:37236095:37236176 | In-frame | rs2373331 | chr2:38027115:T:C | Distant downstream | -0.0317809120700469 | 0.0109527145238919 | THCA | Female-baised sQTL |
| exon_skip_324956 | chr2:37242634:37242693 | Frame-shift | rs232564 | chr2:38168376:C:T | Distant downstream | -0.0304827690594126 | 0.0479447857289229 | STAD | Female-baised sQTL |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_324931 | chr2:37236095:37236176 | In-frame | rs10495875 | chr2:37827954:G:A | Distant downstream | -0.0456580206161745 | 0.00236365502243123 | STAD | Male-baised sQTL |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of NDUFAF7 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
