SexAnnoDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Gene summary

leaf

Gene structure and Gene expression level

leaf

Sex-biased somatic mutation

leaf

DNA methylation with beta values in gene

leaf

Exon skipping events with PSI in TCGA

leaf

RNA A-to-I editing events in TCGA

leaf

Sex-biased TF-Gene network of gene

leaf

Sex-biased RBP-ES network of gene

leaf

Sex-biased CeRNA regulation of gene

leaf

Sex-biased eQTL regulation of gene

leaf

Sex-biased eQTM regulation of gene

leaf

Sex-biased sQTL regulation of gene

leaf

Sex-biased sQTM regulation of gene

leaf

Related disease information of gene

Gene: ENSG00000003147

Summary for ICA1

check button Gene summary

Gene informationEnsembl ID

ENSG00000003147

Gene symbol

ICA1

Gene nameislet cell autoantigen 1
HGNC

5343

Entrez ID

3382

Gene typeprotein_coding
SynonymsICA1|ICAp69|ICA69
UniProtAcc

Q05084


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

Top

Structure and expression level for ICA1

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
ICA13.25e+02-1.60e+002.70e-01-5.92e+003.17e-091.73e-08HNSC
ICA12.42e+031.05e+001.37e-017.63e+002.29e-142.43e-13COAD

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
ICA12.39e+031.31e+002.40e-015.45e+005.03e-086.38e-07READ

Top

Sex-biased somatic mutation for ICA1

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

Top

DNA methylation with beta values for ICA1

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
SARCcg00507727chr7:8262561CGI:chr7:8261401-8262622UTR,promoter,exon,gene body2.26e-011.25e-012.15e+003.13e-023.80e-021.02e-01
SARCcg10798171chr7:8262671CGI:chr7:8261401-8262622UTR,promoter,exon,gene body3.50e-012.36e-013.79e+001.50e-047.28e-041.14e-01

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
HNSCcg11837701chr7:8263269CGI:chr7:8261401-8262622promoter6.86e-017.91e-01-2.08e+003.74e-023.91e-02-1.05e-01
COADcg16379704chr7:8262621CGI:chr7:8261401-8262622UTR,promoter,exon,gene body1.75e-013.05e-01-4.85e+001.25e-061.37e-05-1.29e-01
COADcg20641531chr7:8263101CGI:chr7:8261401-8262622promoter5.84e-017.16e-01-2.35e+001.86e-022.34e-02-1.31e-01
COADcg11837701chr7:8263269CGI:chr7:8261401-8262622promoter4.64e-015.78e-01-2.14e+003.27e-023.62e-02-1.14e-01
BLCAcg11837701chr7:8263269CGI:chr7:8261401-8262622promoter5.28e-017.03e-01-2.04e+004.10e-024.29e-02-1.74e-01
LIHCcg05434957chr7:8261805CGI:chr7:8261401-8262622promoter,gene body1.69e-016.25e-022.35e+001.90e-022.14e-021.07e-01
LIHCcg20371765chr7:8262641CGI:chr7:8261401-8262622UTR,promoter,exon,gene body4.03e-012.35e-012.46e+001.40e-021.64e-021.69e-01
LIHCcg11837701chr7:8263269CGI:chr7:8261401-8262622promoter7.63e-018.99e-01-2.63e+008.57e-031.06e-02-1.35e-01
KIRPcg16379704chr7:8262621CGI:chr7:8261401-8262622UTR,promoter,exon,gene body2.13e-013.16e-01-4.58e+004.74e-061.99e-05-1.03e-01
CHOLcg05822926chr7:8262605CGI:chr7:8261401-8262622UTR,promoter,exon,gene body1.40e-012.85e-01-3.02e+002.51e-031.19e-02-1.45e-01
CHOLcg16379704chr7:8262621CGI:chr7:8261401-8262622UTR,promoter,exon,gene body1.91e-013.75e-01-3.17e+001.52e-031.07e-02-1.84e-01
CHOLcg20371765chr7:8262641CGI:chr7:8261401-8262622UTR,promoter,exon,gene body1.17e-012.29e-01-2.14e+003.25e-023.87e-02-1.12e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg13394022chr7:8263201CGI:chr7:8261401-8262622promoter7.57e-018.99e-01-4.70e+002.59e-064.62e-06-1.42e-01
BRCAcg11837701chr7:8263269CGI:chr7:8261401-8262622promoter5.65e-018.16e-01-7.59e+003.16e-141.08e-13-2.51e-01
HNSCcg05822926chr7:8262605CGI:chr7:8261401-8262622UTR,promoter,exon,gene body3.34e-011.86e-012.35e+001.86e-022.64e-021.48e-01
HNSCcg10798171chr7:8262671CGI:chr7:8261401-8262622UTR,promoter,exon,gene body2.21e-019.60e-022.65e+008.13e-031.67e-021.25e-01
HNSCcg20641531chr7:8263101CGI:chr7:8261401-8262622promoter7.97e-019.24e-01-2.57e+001.02e-021.88e-02-1.27e-01

Top

Exon skipping events with PSI in TCGA for ICA1

∗Please access ExonSkipDB for exon skipping annotation.
check buttonLandscape of exon skipping events across multiple cancer types.
AS event heatmap

check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

Top

RNA A-to-I editing events in TCGA for ICA1

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

Top

Sex-biased TF-Gene network for ICA1

check buttonTFs related to ICA1.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
TF Gene
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
SKCMBARX2ICA13.58e+005.92e-034.73e+009.84e-01Female-biased
SKCMFOXA1ICA12.95e+002.66e-034.34e+009.81e-01Female-biased
SKCMFOXA2ICA13.17e+004.45e-034.40e+009.80e-01Female-biased
SKCMFOXB1ICA13.02e+002.96e-034.37e+009.81e-01Female-biased
SKCMSRYICA13.72e+007.33e-034.79e+009.84e-01Female-biased
SKCMZNF211ICA14.79e+001.42e-025.66e+009.83e-01Female-biased
SKCMZNF25ICA12.82e+001.89e-034.31e+009.81e-01Female-biased
SKCMZNF334ICA12.91e+009.82e-044.59e+009.87e-01Female-biased
SKCMZNF418ICA12.65e+003.50e-044.62e+009.88e-01Female-biased
SKCMZNF580ICA13.41e+004.30e-034.65e+009.85e-01Female-biased
SKCMZNF79ICA12.74e+001.18e-034.37e+009.83e-01Female-biased

check buttonICA1 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

Top

Sex-biased RBP-ES network for ICA1

check buttonRBPs related to ES in ICA1.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
RBP ES
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
STADSAMD4Aexon_skip_4737487.90e+001.54e-038.45e+009.92e-01Female-biased
UVMSAMD4Aexon_skip_4737488.22e+009.85e-017.90e+007.04e-03Male-biased
THYMSAMD4Aexon_skip_4737488.49e+009.91e-018.04e+002.48e-03Male-biased
LUSCSAMD4Aexon_skip_4737488.28e+007.71e-038.66e+009.87e-01Female-biased
CHOLPABPC3exon_skip_4737477.90e+005.41e-038.39e+009.87e-01Female-biased
CHOLSAMD4Aexon_skip_4737487.97e+004.96e-038.46e+009.88e-01Female-biased
CHOLZFP36exon_skip_4737706.14e+002.85e-036.72e+009.81e-01Female-biased
KIRPSAMD4Aexon_skip_4737487.82e+001.09e-028.14e+009.81e-01Female-biased
BRCASAMD4Aexon_skip_4737487.97e+009.82e-017.38e+008.94e-03Male-biased
THCARBM24exon_skip_4737511.06e+019.91e-011.03e+017.80e-03Male-biased
THCARBM24exon_skip_4737688.70e+009.91e-018.32e+003.18e-03Male-biased
THCASAMD4Aexon_skip_4737488.44e+009.89e-018.09e+004.25e-03Male-biased
PCPGRBM24exon_skip_4737511.03e+014.97e-031.06e+019.94e-01Female-biased
MESOKHDRBS2exon_skip_4737461.01e+011.32e-031.07e+019.97e-01Female-biased
MESORBM24exon_skip_4737511.02e+012.74e-031.06e+019.96e-01Female-biased
LGGSAMD4Aexon_skip_4737488.63e+009.93e-018.12e+001.66e-03Male-biased
GBMPABPC3exon_skip_4737478.00e+001.08e-028.33e+009.82e-01Female-biased
PAADZC3H10exon_skip_4737477.54e+009.89e-017.08e+001.30e-03Male-biased
KIRCPABPC3exon_skip_4737477.93e+009.91e-038.24e+009.83e-01Female-biased
KIRCRBM24exon_skip_4737511.01e+012.85e-031.05e+019.96e-01Female-biased
KIRCSAMD4Aexon_skip_4737488.15e+006.99e-038.49e+009.87e-01Female-biased
BLCASAMD4Aexon_skip_4737487.76e+009.45e-048.36e+009.92e-01Female-biased

check buttonICA1 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

Top

Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type

Top

Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs10268598chr7:8121897:C:Tgene0.07981146092046220.043004328050982LGGFemale-baised eQTL
rs17581161chr7:13614574:A:G--0.09308267635459590.0226530928478076COADFemale-baised eQTL
rs12533526chr7:13615108:A:C--0.09252465709053870.0239430697459771COADFemale-baised eQTL
rs73062546chr7:13616547:C:G--0.09158341260696610.0277137536896176COADFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs302135chr7:18255732:A:G--0.04575247423564620.037389825509491KIRCMale-baised eQTL
rs11773416chr7:4507238:C:T-0.03865593645260910.0392937042193867KIRCMale-baised eQTL
rs17138794chr7:18222650:A:T-0.04542868154947850.0403765213469895KIRCMale-baised eQTL
rs302142chr7:18242202:A:G--0.04500779827546470.0459135207106412KIRCMale-baised eQTL
rs17418362chr7:18229713:T:C-0.04502708734520890.0470385673769879KIRCMale-baised eQTL
rs2098214chr7:15070961:A:T-0.1006526783419130.00373603575228102BLCAMale-baised eQTL
rs28735425chr7:15070624:T:C-0.100559650659250.00389023496910769BLCAMale-baised eQTL
rs10479944chr7:15074211:T:A-0.08617038968565990.0214968041875458BLCAMale-baised eQTL
rs17168652chr7:15084985:A:G-0.09778726973691860.0268925993380599BLCAMale-baised eQTL
rs17168654chr7:15085122:G:A-0.09778726973691860.0268925993380599BLCAMale-baised eQTL
rs72583082chr7:15083700:A:G-0.09759861435756820.027237652636022BLCAMale-baised eQTL
rs72583073chr7:15076703:T:C-0.09739180235197660.0275295030344872BLCAMale-baised eQTL
rs11761802chr7:5789519:C:G--0.06269521582731350.028381759168566BLCAMale-baised eQTL
rs72583077chr7:15079714:A:T-0.09657293024587670.0303761598643526BLCAMale-baised eQTL
rs10277424chr7:14756156:C:A-0.08458994086028630.0379911952267958BLCAMale-baised eQTL
rs17168390chr7:14754467:T:A-0.08558107550313080.0382101751912624BLCAMale-baised eQTL
rs79396525chr7:14759371:C:T-0.08473120789885850.0420944305715303BLCAMale-baised eQTL
rs9886266chr7:14763365:T:G-0.08408114855403850.045556335499664BLCAMale-baised eQTL
rs10242452chr7:2094981:A:G-0.1186614190814910.00896493875460136COADMale-baised eQTL
rs10950449chr7:13295416:G:C-0.05885444127784470.0196134350498473COADMale-baised eQTL
rs4721164chr7:1892993:C:G-0.05721704755335160.030076169692002COADMale-baised eQTL
rs55944228chr7:3707602:G:A-0.1038411228420640.0322715669060506COADMale-baised eQTL
rs10250562chr7:3707203:T:C-0.1025140704776530.0329754270698282COADMale-baised eQTL
rs11762803chr7:1847169:A:G-0.06047427839887220.0347785005815631COADMale-baised eQTL
rs11764040chr7:1845194:G:C-0.06002207240759210.0376113190323145COADMale-baised eQTL
rs7789581chr7:3026991:G:C-0.06018313061625280.0384719099772411COADMale-baised eQTL
rs7803963chr7:3710107:T:C-0.09879613289548770.0416404601185697COADMale-baised eQTL
rs6943054chr7:3658723:T:G-0.06128438691149580.0422801895192048COADMale-baised eQTL
rs58673065chr7:1845964:A:G-0.05896512793399760.0444578465202706COADMale-baised eQTL
rs1009115chr7:8395352:C:T-0.06102988935778140.045179071224922COADMale-baised eQTL
rs2040768chr7:8522928:A:T-0.05337478489337490.0475366899566176COADMale-baised eQTL
rs12216659chr7:11971224:T:C-0.05205295154213260.0499660731141571COADMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

Top

Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000003147
CpG Site: cg13394022
Position to Gene: promoter
Male Effect: -0.398608261518707
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000003147
CpG Site: cg26826957
Position to Gene: gene
Male Effect: -0.18328951825488
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000003147
CpG Site: cg14430015
Position to Gene: gene
Male Effect: -
Female Effect: -0.105837904129126

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg13394022chr7:8263201promoter-0.3986082615187078.92087924270649e-06-0.57407990694734082.1061493459633413e-08PAAD
cg26826957chr7:8237182gene-0.183289518254888.82551258835501e-06-0.36181647443647273.076568109959024e-08LUAD

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg14430015chr7:8176266gene-0.1058379041291268.31453578532855e-05-0.35644391425966689.715910856255754e-07SKCM

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

Top

Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

Top

Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

Top

Related disease information of ICA1

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource