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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Aff4 (spascer ID:93736)

Gene summary for Aff4

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Aff4
	Gene ID	93736
	Gene name	AF4/FMR2 family, member 4
	Synonyms	AF5Q31\|Alf4\|Laf4l\|MCEF
	Cytomap	11\|11 B1.3
	Type of gene	protein-coding
	Description	AF4/FMR2 family member 4ALL1 fused gene from 5q31
	Modification date	20220424
	UniProtAcc	Q9ESC8

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Aff4	GO:0010468	regulation of gene expression	21873635	Process
Aff4	GO:0032783	super elongation complex	21873635	Component

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Spatial pattern events for Aff4

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Aff4	Mouse	Brain	S3	34413515	5.72e-15
Aff4	Mouse	Brain	S4	34413515	1.37e-15
Aff4	Mouse	Brain	S6	34413515	7.87e-14
Aff4	Mouse	Brain	S7	34413515	2.60e-11
Aff4	Mouse	Brain	38B	32637622	9.84e-07
Aff4	Mouse	Brain	rep_3	35141374	1.64e-15
Aff4	Mouse	Brain	rep_4	35141374	3.95e-06
Aff4	Mouse	Brain	rep_5	35141374	3.83e-08
Aff4	Mouse	Embryo	4E	34210887	1.99e-06
Aff4	Mouse	Embryo	rep_4	33188776	6.14e-11
Aff4	Mouse	Kidney	CLP	34003797	9.06e-14
Aff4	Mouse	Kidney	Sham	34003797	1.95e-10
Aff4	Mouse	Kidney	rep_1	34853151	1.87e-07
Aff4	Mouse	Kidney	rep_3	34853151	3.55e-14
Aff4	Mouse	Brain	rep_1	33469025	1.30e-15
Aff4	Mouse	Brain	rep_1	35027729	1.66e-15
Aff4	Mouse	Brain	rep_2	35027729	1.57e-15
Aff4	Mouse	Brain	rep_3	35027729	8.20e-14
Aff4	Mouse	Brain	rep_4	35027729	1.76e-15
Aff4	Mouse	Brain	rep_5	35027729	5.00e-15
Aff4	Mouse	Intestine	rep_1	35149721	2.37e-06
Aff4	Mouse	Intestine	rep_2	35149721	3.38e-06
Aff4	Mouse	Intestine	rep_3	35149721	2.93e-07
Aff4	Mouse	Brain	rep_1	35210624	1.74e-15
Aff4	Mouse	Brain	rep_2	35210624	1.74e-15
Aff4	Mouse	Brain	rep_3	35210624	7.16e-12
Aff4	Mouse	Brain	rep_4	35210624	1.37e-12
Aff4	Mouse	Brain	rep_5	35210624	2.07e-15
Aff4	Mouse	Brain	rep_6	35210624	6.92e-15
Aff4	Mouse	Brain	rep_7	35210624	1.87e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Kidney_CLP_H&E
Kidney_Sham_H&E
Kidney_rep_1_H&E
Kidney_rep_3_H&E
Brain_rep_1_H&E
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E

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Spatial pattern pathway has Aff4 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Aff4	GOBP_Developmental_Process_Involved_In_Reproduction	Mouse	Spinal cord	CN94_E1	3.2e-07
Aff4	GOBP_Gamete_Generation	Mouse	Spinal cord	CN94_E1	3.1e-07
Aff4	GOBP_Germ_Cell_Development	Mouse	Spinal cord	CN94_E1	6.4e-06
Aff4	GOBP_Male_Gamete_Generation	Mouse	Spinal cord	CN94_E1	4.7e-06
Aff4	GOBP_Reproduction	Mouse	Spinal cord	CN94_E1	7.8e-08
Aff4	GOBP_Spermatid_Differentiation	Mouse	Spinal cord	L7bCN02_E1	2.4e-06
Aff4	GOBP_Cellular_Process_Involved_In_Reproduction_In_Multicellular_Organism	Mouse	Spinal cord	L7CN45_C1	8.6e-09
Aff4	GOBP_Dna_Templated_Transcription_Elongation	Mouse	Spinal cord	L7CN45_C1	6.4e-06
Aff4	GOBP_Multicellular_Organism_Reproduction	Mouse	Spinal cord	L7CN45_C1	7.1e-07
Aff4	GOBP_Transcription_Elongation_From_Rna_Polymerase_Ii_Promoter	Mouse	Spinal cord	L7CN45_C1	9.0e-07
Aff4	GOBP_Gamete_Generation	Mouse	Brain	rep_27	5.2e-05
Aff4	GOBP_Germ_Cell_Development	Mouse	Brain	rep_27	9.0e-05
Aff4	GOBP_Transcription_Elongation_From_Rna_Polymerase_Ii_Promoter	Mouse	Brain	rep_27	4.7e-08
Aff4	GOBP_Cellular_Process_Involved_In_Reproduction_In_Multicellular_Organism	Mouse	Brain	rep_3	3.6e-171
Aff4	GOBP_Developmental_Process_Involved_In_Reproduction	Mouse	Brain	rep_3	2.9e-159
Aff4	GOBP_Dna_Templated_Transcription_Elongation	Mouse	Brain	rep_3	5.9e-172
Aff4	GOBP_Gamete_Generation	Mouse	Brain	rep_3	1.3e-194
Aff4	GOBP_Germ_Cell_Development	Mouse	Brain	rep_3	7.6e-194
Aff4	GOBP_Male_Gamete_Generation	Mouse	Brain	rep_3	1.6e-190
Aff4	GOBP_Multicellular_Organism_Reproduction	Mouse	Brain	rep_3	1.2e-58
Aff4	GOBP_Reproduction	Mouse	Brain	rep_3	3.4e-125
Aff4	GOBP_Spermatid_Differentiation	Mouse	Brain	rep_3	1.1e-186
Aff4	GOBP_Transcription_Elongation_From_Rna_Polymerase_Ii_Promoter	Mouse	Brain	rep_3	1.1e-174
Aff4	GOBP_Cellular_Process_Involved_In_Reproduction_In_Multicellular_Organism	Mouse	Embryo	rep_14	4.3e-09
Aff4	GOBP_Dna_Templated_Transcription_Elongation	Mouse	Embryo	rep_14	1.0e-14
Aff4	GOBP_Gamete_Generation	Mouse	Embryo	rep_14	6.5e-07
Aff4	GOBP_Germ_Cell_Development	Mouse	Embryo	rep_14	2.1e-19
Aff4	GOBP_Multicellular_Organism_Reproduction	Mouse	Embryo	rep_14	5.9e-07
Aff4	GOBP_Transcription_Elongation_From_Rna_Polymerase_Ii_Promoter	Mouse	Embryo	rep_14	2.0e-22
Aff4	GOBP_Dna_Templated_Transcription_Elongation	Mouse	Embryo	rep_1	0.0e+00
Aff4	GOBP_Male_Gamete_Generation	Mouse	Embryo	rep_1	0.0e+00
Aff4	GOBP_Transcription_Elongation_From_Rna_Polymerase_Ii_Promoter	Mouse	Embryo	rep_1	0.0e+00
Aff4	GOBP_Germ_Cell_Development	Mouse	Embryo	rep_2	2.4e-67
Aff4	GOBP_Cellular_Process_Involved_In_Reproduction_In_Multicellular_Organism	Mouse	Embryo	rep_3	6.9e-27
Aff4	GOBP_Gamete_Generation	Mouse	Embryo	rep_3	2.1e-220
Aff4	GOBP_Multicellular_Organism_Reproduction	Mouse	Embryo	rep_3	8.7e-222
Aff4	GOBP_Cellular_Process_Involved_In_Reproduction_In_Multicellular_Organism	Mouse	Kidney	rep_2	1.1e-18
Aff4	GOBP_Developmental_Process_Involved_In_Reproduction	Mouse	Kidney	rep_2	3.6e-46
Aff4	GOBP_Dna_Templated_Transcription_Elongation	Mouse	Kidney	rep_2	5.3e-82
Aff4	GOBP_Gamete_Generation	Mouse	Kidney	rep_2	5.0e-33
Aff4	GOBP_Germ_Cell_Development	Mouse	Kidney	rep_2	1.5e-12
Aff4	GOBP_Male_Gamete_Generation	Mouse	Kidney	rep_2	5.8e-51
Aff4	GOBP_Multicellular_Organism_Reproduction	Mouse	Kidney	rep_2	1.6e-53
Aff4	GOBP_Reproduction	Mouse	Kidney	rep_2	9.0e-46
Aff4	GOBP_Transcription_Elongation_From_Rna_Polymerase_Ii_Promoter	Mouse	Kidney	rep_2	3.3e-51
Aff4	GOBP_Dna_Templated_Transcription_Elongation	Mouse	Liver	CN16-D2	6.9e-09
Aff4	GOBP_Cellular_Process_Involved_In_Reproduction_In_Multicellular_Organism	Mouse	Lymph	MS-1	2.1e-08
Aff4	GOBP_Developmental_Process_Involved_In_Reproduction	Mouse	Lymph	MS-1	2.2e-10
Aff4	GOBP_Gamete_Generation	Mouse	Lymph	MS-1	7.7e-08
Aff4	GOBP_Germ_Cell_Development	Mouse	Lymph	MS-1	4.9e-12
Aff4	GOBP_Male_Gamete_Generation	Mouse	Lymph	MS-1	1.6e-08
Aff4	GOBP_Multicellular_Organism_Reproduction	Mouse	Lymph	MS-1	1.1e-09
Aff4	GOBP_Reproduction	Mouse	Lymph	MS-1	1.1e-09
Aff4	GOBP_Spermatid_Differentiation	Mouse	Lymph	MS-1	4.7e-08
Aff4	GOBP_Reproduction	Mouse	Lung	rep_1	9.6e-12
Aff4	GOBP_Cellular_Process_Involved_In_Reproduction_In_Multicellular_Organism	Mouse	Brain	HP_ad_rep7	6.0e-15
Aff4	GOBP_Developmental_Process_Involved_In_Reproduction	Mouse	Brain	HP_ad_rep7	2.5e-08
Aff4	GOBP_Dna_Templated_Transcription_Elongation	Mouse	Brain	HP_ad_rep7	1.4e-14
Aff4	GOBP_Gamete_Generation	Mouse	Brain	HP_ad_rep7	1.3e-11
Aff4	GOBP_Germ_Cell_Development	Mouse	Brain	HP_ad_rep7	3.3e-13
Aff4	GOBP_Multicellular_Organism_Reproduction	Mouse	Brain	HP_ad_rep7	6.1e-08
Aff4	GOBP_Reproduction	Mouse	Brain	HP_ad_rep7	7.9e-09
Aff4	GOBP_Spermatid_Differentiation	Mouse	Brain	HP_ad_rep7	1.5e-12
Aff4	GOBP_Transcription_Elongation_From_Rna_Polymerase_Ii_Promoter	Mouse	Brain	HP_ad_rep7	9.4e-09
Aff4	GOBP_Male_Gamete_Generation	Mouse	Brain	HP_ad_rep8	8.4e-07

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Aff4 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Aff4 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Aff4 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Aff4

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Aff4

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Aff4	C0000772	Multiple congenital anomalies	1	CTD_human
Aff4	C0005941	Bone Diseases, Developmental	1	CTD_human
Aff4	C0009241	Cognition Disorders	1	CTD_human
Aff4	C0018273	Growth Disorders	1	CTD_human
Aff4	C0018798	Congenital Heart Defects	1	CTD_human
Aff4	C0024115	Lung diseases	1	CTD_human
Aff4	C0028754	Obesity	1	CTD_human
Aff4	C0282631	Facies	1	CTD_human
Aff4	C4085597	CHOPS SYNDROME	1	CTD_human;ORPHANET;UNIPROT